DUF2500 domain-containing protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IC29_LEIIN

TriTrypDb:

LINF_350054900

Length:

205

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Phosphorylation

Amastigote: 162, 75

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IC29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC29

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.353
CLV_NRD_NRD_1	170	172	PF00675	0.407
CLV_NRD_NRD_1	38	40	PF00675	0.496
CLV_NRD_NRD_1	95	97	PF00675	0.383
CLV_PCSK_FUR_1	42	46	PF00082	0.520
CLV_PCSK_FUR_1	93	97	PF00082	0.458
CLV_PCSK_KEX2_1	44	46	PF00082	0.518
CLV_PCSK_KEX2_1	82	84	PF00082	0.462
CLV_PCSK_KEX2_1	95	97	PF00082	0.390
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.519
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.479
CLV_PCSK_SKI1_1	171	175	PF00082	0.488
DEG_Nend_Nbox_1	1	3	PF02207	0.353
DOC_MAPK_gen_1	159	165	PF00069	0.588
DOC_MAPK_gen_1	174	184	PF00069	0.645
DOC_USP7_MATH_1	109	113	PF00917	0.714
DOC_USP7_UBL2_3	116	120	PF12436	0.643
DOC_USP7_UBL2_3	40	44	PF12436	0.706
DOC_WW_Pin1_4	126	131	PF00397	0.660
LIG_14-3-3_CanoR_1	114	124	PF00244	0.699
LIG_14-3-3_CanoR_1	159	164	PF00244	0.649
LIG_BRCT_BRCA1_1	161	165	PF00533	0.593
LIG_FHA_1	52	58	PF00498	0.641
LIG_FHA_1	60	66	PF00498	0.546
LIG_FHA_2	150	156	PF00498	0.632
LIG_LIR_Apic_2	3	7	PF02991	0.313
LIG_LIR_Nem_3	121	127	PF02991	0.611
LIG_MLH1_MIPbox_1	161	165	PF16413	0.600
LIG_Pex14_2	16	20	PF04695	0.334
LIG_REV1ctd_RIR_1	162	170	PF16727	0.626
LIG_SH2_SRC	4	7	PF00017	0.398
LIG_SH2_STAP1	53	57	PF00017	0.660
LIG_SH2_STAT5	4	7	PF00017	0.323
LIG_SH2_STAT5	53	56	PF00017	0.688
LIG_SH3_3	124	130	PF00018	0.708
LIG_SH3_4	40	47	PF00018	0.727
LIG_SUMO_SIM_par_1	54	63	PF11976	0.636
LIG_TRAF2_1	153	156	PF00917	0.609
LIG_TRAF2_1	178	181	PF00917	0.698
LIG_TRAF2_1	98	101	PF00917	0.674
LIG_UBA3_1	21	27	PF00899	0.471
MOD_CDK_SPK_2	126	131	PF00069	0.702
MOD_CK1_1	167	173	PF00069	0.701
MOD_CK1_1	43	49	PF00069	0.709
MOD_CK2_1	149	155	PF00069	0.621
MOD_CK2_1	23	29	PF00069	0.628
MOD_GlcNHglycan	117	120	PF01048	0.470
MOD_GlcNHglycan	185	188	PF01048	0.501
MOD_GlcNHglycan	74	77	PF01048	0.453
MOD_GSK3_1	145	152	PF00069	0.731
MOD_GSK3_1	197	204	PF00069	0.629
MOD_GSK3_1	21	28	PF00069	0.510
MOD_GSK3_1	43	50	PF00069	0.702
MOD_GSK3_1	72	79	PF00069	0.646
MOD_NEK2_1	164	169	PF00069	0.595
MOD_PIKK_1	43	49	PF00454	0.745
MOD_PKA_1	159	165	PF00069	0.627
MOD_PKA_2	145	151	PF00069	0.692
MOD_PKA_2	47	53	PF00069	0.692
MOD_Plk_4	159	165	PF00069	0.621
MOD_ProDKin_1	126	132	PF00069	0.665
MOD_SUMO_rev_2	153	162	PF00179	0.560
MOD_SUMO_rev_2	169	178	PF00179	0.599
MOD_SUMO_rev_2	75	84	PF00179	0.679
TRG_ER_diArg_1	92	95	PF00400	0.606
TRG_ER_diLys_1	201	205	PF00400	0.713
TRG_NLS_MonoCore_2	38	43	PF00514	0.729
TRG_NLS_MonoExtN_4	37	43	PF00514	0.750

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICF1	Leptomonas seymouri	57%	94%
A0A0S4J7Q9	Bodo saltans	28%	100%
A0A1X0P5X3	Trypanosomatidae	37%	100%
A0A3Q8IN24	Leishmania donovani	100%	100%
A0A3R7KQ70	Trypanosoma rangeli	39%	100%
A4HNF7	Leishmania braziliensis	77%	100%
C9ZYH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	97%
E9AFW8	Leishmania major	91%	100%
E9B721	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%