Putative DNA replication factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA replication licensing factor MCM9 - putative

Species:

Leishmania infantum

UniProt:

A4IC27_LEIIN

TriTrypDb:

LINF_350054700

Length:

908

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0042555	MCM complex	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IC27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC27

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0032392	DNA geometric change	7	11
GO:0032508	DNA duplex unwinding	8	11
GO:0051276	chromosome organization	5	11
GO:0071103	DNA conformation change	6	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003697	single-stranded DNA binding	5	1
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	684	688	PF00656	0.483
CLV_C14_Caspase3-7	715	719	PF00656	0.540
CLV_C14_Caspase3-7	724	728	PF00656	0.522
CLV_NRD_NRD_1	286	288	PF00675	0.596
CLV_NRD_NRD_1	309	311	PF00675	0.389
CLV_NRD_NRD_1	472	474	PF00675	0.273
CLV_NRD_NRD_1	733	735	PF00675	0.690
CLV_NRD_NRD_1	892	894	PF00675	0.601
CLV_PCSK_KEX2_1	143	145	PF00082	0.228
CLV_PCSK_KEX2_1	285	287	PF00082	0.598
CLV_PCSK_KEX2_1	309	311	PF00082	0.389
CLV_PCSK_KEX2_1	472	474	PF00082	0.247
CLV_PCSK_KEX2_1	835	837	PF00082	0.605
CLV_PCSK_KEX2_1	894	896	PF00082	0.546
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.228
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.471
CLV_PCSK_PC1ET2_1	835	837	PF00082	0.605
CLV_PCSK_PC1ET2_1	894	896	PF00082	0.604
CLV_PCSK_PC7_1	139	145	PF00082	0.228
CLV_PCSK_SKI1_1	12	16	PF00082	0.389
CLV_PCSK_SKI1_1	215	219	PF00082	0.215
CLV_PCSK_SKI1_1	246	250	PF00082	0.487
CLV_PCSK_SKI1_1	312	316	PF00082	0.307
CLV_PCSK_SKI1_1	51	55	PF00082	0.462
CLV_Separin_Metazoa	20	24	PF03568	0.407
DEG_APCC_DBOX_1	214	222	PF00400	0.415
DEG_COP1_1	800	807	PF00400	0.476
DEG_COP1_1	872	880	PF00400	0.672
DEG_Nend_UBRbox_2	1	3	PF02207	0.594
DEG_SCF_FBW7_2	495	502	PF00400	0.446
DEG_SPOP_SBC_1	274	278	PF00917	0.638
DEG_SPOP_SBC_1	37	41	PF00917	0.676
DEG_SPOP_SBC_1	380	384	PF00917	0.415
DEG_SPOP_SBC_1	712	716	PF00917	0.571
DEG_SPOP_SBC_1	76	80	PF00917	0.373
DOC_CKS1_1	496	501	PF01111	0.446
DOC_CYCLIN_yCln2_LP_2	624	630	PF00134	0.479
DOC_MAPK_gen_1	307	316	PF00069	0.474
DOC_MAPK_gen_1	472	481	PF00069	0.509
DOC_MAPK_MEF2A_6	109	117	PF00069	0.515
DOC_PP1_RVXF_1	532	539	PF00149	0.303
DOC_PP1_RVXF_1	900	907	PF00149	0.575
DOC_PP2B_LxvP_1	327	330	PF13499	0.428
DOC_PP2B_LxvP_1	845	848	PF13499	0.666
DOC_PP2B_LxvP_1	875	878	PF13499	0.653
DOC_PP4_FxxP_1	164	167	PF00568	0.452
DOC_SPAK_OSR1_1	331	335	PF12202	0.435
DOC_USP7_MATH_1	147	151	PF00917	0.509
DOC_USP7_MATH_1	176	180	PF00917	0.392
DOC_USP7_MATH_1	274	278	PF00917	0.575
DOC_USP7_MATH_1	37	41	PF00917	0.632
DOC_USP7_MATH_1	704	708	PF00917	0.647
DOC_USP7_MATH_1	712	716	PF00917	0.639
DOC_USP7_MATH_1	748	752	PF00917	0.517
DOC_USP7_MATH_1	780	784	PF00917	0.575
DOC_USP7_MATH_1	855	859	PF00917	0.742
DOC_USP7_MATH_1	871	875	PF00917	0.727
DOC_USP7_UBL2_3	307	311	PF12436	0.503
DOC_WW_Pin1_4	33	38	PF00397	0.688
DOC_WW_Pin1_4	427	432	PF00397	0.509
DOC_WW_Pin1_4	495	500	PF00397	0.446
DOC_WW_Pin1_4	569	574	PF00397	0.446
DOC_WW_Pin1_4	781	786	PF00397	0.577
DOC_WW_Pin1_4	811	816	PF00397	0.750
DOC_WW_Pin1_4	869	874	PF00397	0.698
LIG_14-3-3_CanoR_1	109	117	PF00244	0.364
LIG_14-3-3_CanoR_1	139	147	PF00244	0.529
LIG_14-3-3_CanoR_1	272	282	PF00244	0.676
LIG_14-3-3_CanoR_1	287	296	PF00244	0.466
LIG_14-3-3_CanoR_1	312	317	PF00244	0.473
LIG_14-3-3_CanoR_1	381	388	PF00244	0.415
LIG_14-3-3_CanoR_1	434	438	PF00244	0.429
LIG_14-3-3_CanoR_1	473	481	PF00244	0.463
LIG_14-3-3_CanoR_1	506	512	PF00244	0.450
LIG_14-3-3_CanoR_1	591	599	PF00244	0.430
LIG_14-3-3_CanoR_1	619	625	PF00244	0.577
LIG_14-3-3_CanoR_1	796	805	PF00244	0.651
LIG_14-3-3_CanoR_1	893	901	PF00244	0.624
LIG_AP2alpha_2	677	679	PF02296	0.500
LIG_BIR_III_2	577	581	PF00653	0.471
LIG_BRCT_BRCA1_1	324	328	PF00533	0.446
LIG_BRCT_BRCA1_1	902	906	PF00533	0.578
LIG_Clathr_ClatBox_1	218	222	PF01394	0.415
LIG_EH_1	165	169	PF12763	0.464
LIG_FHA_1	140	146	PF00498	0.466
LIG_FHA_1	158	164	PF00498	0.352
LIG_FHA_1	2	8	PF00498	0.409
LIG_FHA_1	367	373	PF00498	0.509
LIG_FHA_1	443	449	PF00498	0.426
LIG_FHA_1	76	82	PF00498	0.347
LIG_FHA_1	799	805	PF00498	0.667
LIG_FHA_2	218	224	PF00498	0.428
LIG_FHA_2	4	10	PF00498	0.526
LIG_FHA_2	518	524	PF00498	0.600
LIG_FHA_2	526	532	PF00498	0.476
LIG_FHA_2	604	610	PF00498	0.415
LIG_FHA_2	682	688	PF00498	0.683
LIG_FHA_2	78	84	PF00498	0.399
LIG_Integrin_RGD_1	685	687	PF01839	0.575
LIG_LIR_Apic_2	161	167	PF02991	0.450
LIG_LIR_Gen_1	487	495	PF02991	0.421
LIG_LIR_Gen_1	882	889	PF02991	0.571
LIG_LIR_Nem_3	299	305	PF02991	0.380
LIG_LIR_Nem_3	487	492	PF02991	0.421
LIG_LIR_Nem_3	882	888	PF02991	0.572
LIG_Pex14_1	245	249	PF04695	0.420
LIG_Pex14_2	164	168	PF04695	0.469
LIG_Pex14_2	301	305	PF04695	0.386
LIG_Pex14_2	328	332	PF04695	0.435
LIG_Pex14_2	489	493	PF04695	0.415
LIG_SH2_CRK	671	675	PF00017	0.588
LIG_SH2_CRK	885	889	PF00017	0.572
LIG_SH2_NCK_1	543	547	PF00017	0.503
LIG_SH2_STAP1	148	152	PF00017	0.509
LIG_SH2_STAT3	563	566	PF00017	0.428
LIG_SH2_STAT5	13	16	PF00017	0.439
LIG_SH2_STAT5	360	363	PF00017	0.469
LIG_SH2_STAT5	535	538	PF00017	0.307
LIG_SH2_STAT5	772	775	PF00017	0.533
LIG_SH3_3	118	124	PF00018	0.448
LIG_SH3_3	18	24	PF00018	0.538
LIG_SH3_3	358	364	PF00018	0.428
LIG_SH3_3	404	410	PF00018	0.415
LIG_SH3_3	478	484	PF00018	0.417
LIG_SH3_3	672	678	PF00018	0.437
LIG_SUMO_SIM_par_1	216	224	PF11976	0.417
LIG_SUMO_SIM_par_1	745	751	PF11976	0.548
LIG_TRFH_1	671	675	PF08558	0.400
LIG_TRFH_1	885	889	PF08558	0.620
LIG_TYR_ITIM	11	16	PF00017	0.483
LIG_TYR_ITIM	883	888	PF00017	0.572
LIG_UBA3_1	137	143	PF00899	0.384
LIG_UBA3_1	492	500	PF00899	0.365
LIG_WRC_WIRS_1	302	307	PF05994	0.412
LIG_WW_3	20	24	PF00397	0.407
MOD_CDK_SPK_2	495	500	PF00069	0.280
MOD_CDK_SPK_2	781	786	PF00069	0.549
MOD_CDK_SPxxK_3	427	434	PF00069	0.384
MOD_CK1_1	104	110	PF00069	0.416
MOD_CK1_1	207	213	PF00069	0.296
MOD_CK1_1	252	258	PF00069	0.560
MOD_CK1_1	36	42	PF00069	0.620
MOD_CK1_1	382	388	PF00069	0.258
MOD_CK1_1	620	626	PF00069	0.334
MOD_CK1_1	707	713	PF00069	0.654
MOD_CK1_1	811	817	PF00069	0.659
MOD_CK1_1	854	860	PF00069	0.702
MOD_CK2_1	3	9	PF00069	0.395
MOD_CK2_1	433	439	PF00069	0.252
MOD_CK2_1	517	523	PF00069	0.595
MOD_CK2_1	525	531	PF00069	0.496
MOD_CK2_1	635	641	PF00069	0.581
MOD_CK2_1	772	778	PF00069	0.732
MOD_CK2_1	873	879	PF00069	0.566
MOD_Cter_Amidation	833	836	PF01082	0.603
MOD_GlcNHglycan	209	212	PF01048	0.270
MOD_GlcNHglycan	278	281	PF01048	0.580
MOD_GlcNHglycan	31	34	PF01048	0.602
MOD_GlcNHglycan	324	327	PF01048	0.283
MOD_GlcNHglycan	336	339	PF01048	0.296
MOD_GlcNHglycan	391	394	PF01048	0.261
MOD_GlcNHglycan	40	43	PF01048	0.578
MOD_GlcNHglycan	464	467	PF01048	0.252
MOD_GlcNHglycan	618	622	PF01048	0.212
MOD_GlcNHglycan	661	664	PF01048	0.423
MOD_GlcNHglycan	737	740	PF01048	0.576
MOD_GlcNHglycan	750	753	PF01048	0.515
MOD_GlcNHglycan	762	765	PF01048	0.613
MOD_GlcNHglycan	805	808	PF01048	0.661
MOD_GlcNHglycan	853	856	PF01048	0.626
MOD_GlcNHglycan	857	860	PF01048	0.598
MOD_GlcNHglycan	895	898	PF01048	0.723
MOD_GSK3_1	100	107	PF00069	0.385
MOD_GSK3_1	115	122	PF00069	0.371
MOD_GSK3_1	158	165	PF00069	0.285
MOD_GSK3_1	213	220	PF00069	0.261
MOD_GSK3_1	223	230	PF00069	0.238
MOD_GSK3_1	24	31	PF00069	0.555
MOD_GSK3_1	248	255	PF00069	0.491
MOD_GSK3_1	312	319	PF00069	0.275
MOD_GSK3_1	33	40	PF00069	0.558
MOD_GSK3_1	341	348	PF00069	0.275
MOD_GSK3_1	362	369	PF00069	0.252
MOD_GSK3_1	379	386	PF00069	0.277
MOD_GSK3_1	389	396	PF00069	0.311
MOD_GSK3_1	413	420	PF00069	0.315
MOD_GSK3_1	452	459	PF00069	0.252
MOD_GSK3_1	513	520	PF00069	0.517
MOD_GSK3_1	538	545	PF00069	0.430
MOD_GSK3_1	707	714	PF00069	0.640
MOD_GSK3_1	799	806	PF00069	0.669
MOD_GSK3_1	847	854	PF00069	0.696
MOD_GSK3_1	855	862	PF00069	0.696
MOD_GSK3_1	869	876	PF00069	0.730
MOD_GSK3_1	879	886	PF00069	0.611
MOD_GSK3_1	889	896	PF00069	0.596
MOD_N-GLC_1	207	212	PF02516	0.384
MOD_N-GLC_1	710	715	PF02516	0.618
MOD_N-GLC_1	889	894	PF02516	0.713
MOD_NEK2_1	102	107	PF00069	0.501
MOD_NEK2_1	133	138	PF00069	0.321
MOD_NEK2_1	227	232	PF00069	0.331
MOD_NEK2_1	301	306	PF00069	0.385
MOD_NEK2_1	316	321	PF00069	0.235
MOD_NEK2_1	388	393	PF00069	0.331
MOD_NEK2_1	585	590	PF00069	0.252
MOD_NEK2_1	617	622	PF00069	0.252
MOD_NEK2_1	635	640	PF00069	0.503
MOD_NEK2_1	75	80	PF00069	0.367
MOD_NEK2_1	791	796	PF00069	0.577
MOD_NEK2_1	808	813	PF00069	0.548
MOD_NEK2_2	346	351	PF00069	0.328
MOD_PIKK_1	176	182	PF00454	0.356
MOD_PIKK_1	366	372	PF00454	0.252
MOD_PIKK_1	538	544	PF00454	0.368
MOD_PIKK_1	590	596	PF00454	0.272
MOD_PIKK_1	704	710	PF00454	0.612
MOD_PIKK_1	791	797	PF00454	0.585
MOD_PIKK_1	808	814	PF00454	0.674
MOD_PIKK_1	859	865	PF00454	0.693
MOD_PK_1	799	805	PF00069	0.534
MOD_PKA_1	835	841	PF00069	0.518
MOD_PKA_1	893	899	PF00069	0.614
MOD_PKA_2	108	114	PF00069	0.331
MOD_PKA_2	138	144	PF00069	0.366
MOD_PKA_2	169	175	PF00069	0.268
MOD_PKA_2	252	258	PF00069	0.448
MOD_PKA_2	352	358	PF00069	0.252
MOD_PKA_2	380	386	PF00069	0.282
MOD_PKA_2	433	439	PF00069	0.252
MOD_PKA_2	505	511	PF00069	0.195
MOD_PKA_2	590	596	PF00069	0.272
MOD_PKA_2	760	766	PF00069	0.662
MOD_PKA_2	770	776	PF00069	0.677
MOD_PKA_2	798	804	PF00069	0.664
MOD_PKA_2	835	841	PF00069	0.518
MOD_PKB_1	310	318	PF00069	0.333
MOD_Plk_1	223	229	PF00069	0.331
MOD_Plk_1	525	531	PF00069	0.455
MOD_Plk_1	617	623	PF00069	0.296
MOD_Plk_2-3	433	439	PF00069	0.252
MOD_Plk_2-3	525	531	PF00069	0.488
MOD_Plk_2-3	718	724	PF00069	0.507
MOD_Plk_4	133	139	PF00069	0.252
MOD_Plk_4	517	523	PF00069	0.485
MOD_Plk_4	585	591	PF00069	0.252
MOD_Plk_4	726	732	PF00069	0.595
MOD_Plk_4	742	748	PF00069	0.525
MOD_Plk_4	77	83	PF00069	0.366
MOD_Plk_4	799	805	PF00069	0.522
MOD_Plk_4	883	889	PF00069	0.756
MOD_ProDKin_1	33	39	PF00069	0.687
MOD_ProDKin_1	427	433	PF00069	0.384
MOD_ProDKin_1	495	501	PF00069	0.296
MOD_ProDKin_1	569	575	PF00069	0.296
MOD_ProDKin_1	781	787	PF00069	0.572
MOD_ProDKin_1	811	817	PF00069	0.752
MOD_ProDKin_1	869	875	PF00069	0.696
MOD_SUMO_for_1	499	502	PF00179	0.280
MOD_SUMO_rev_2	169	176	PF00179	0.384
TRG_DiLeu_BaEn_1	409	414	PF01217	0.252
TRG_DiLeu_BaEn_1	827	832	PF01217	0.748
TRG_DiLeu_BaEn_1	842	847	PF01217	0.682
TRG_DiLeu_BaLyEn_6	481	486	PF01217	0.252
TRG_ENDOCYTIC_2	13	16	PF00928	0.490
TRG_ENDOCYTIC_2	562	565	PF00928	0.270
TRG_ENDOCYTIC_2	885	888	PF00928	0.574
TRG_ER_diArg_1	10	13	PF00400	0.463
TRG_ER_diArg_1	284	287	PF00400	0.619
TRG_NES_CRM1_1	186	200	PF08389	0.272
TRG_NLS_MonoCore_2	308	313	PF00514	0.417
TRG_NLS_MonoExtC_3	892	898	PF00514	0.665
TRG_NLS_MonoExtN_4	307	314	PF00514	0.482
TRG_Pf-PMV_PEXEL_1	640	644	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P860	Leptomonas seymouri	28%	91%
A0A0N0P9H0	Leptomonas seymouri	75%	98%
A0A0S4J4D4	Bodo saltans	45%	97%
A0A1X0P4W1	Trypanosomatidae	59%	100%
A0A3Q8IAX4	Leishmania donovani	28%	93%
A0A3Q8IQ79	Leishmania donovani	100%	100%
A0A3R7MUG3	Trypanosoma rangeli	56%	100%
A0A3S5H7S8	Leishmania donovani	30%	100%
A4HGC9	Leishmania braziliensis	29%	94%
A4HKT9	Leishmania braziliensis	30%	100%
A4HNF5	Leishmania braziliensis	85%	100%
A4I3G2	Leishmania infantum	28%	93%
A4I8B8	Leishmania infantum	30%	100%
B8B406	Oryza sativa subsp. indica	32%	100%
C9ZYH2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AFW6	Leishmania major	94%	100%
E9B377	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B719	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P33991	Homo sapiens	29%	100%
P49717	Mus musculus	29%	100%
Q0WVF5	Arabidopsis thaliana	27%	100%
Q561P5	Xenopus tropicalis	27%	100%
Q69QA6	Oryza sativa subsp. japonica	32%	100%
Q9U1E0	Leishmania major	30%	100%