LeishMANIAdb
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TPR_REGION domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_REGION domain-containing protein
Gene product:
TPR repeat/Tetratricopeptide repeat/Uncharacterised protein family (UPF0121) - putative
Species:
Leishmania infantum
UniProt:
A4IC24_LEIIN
TriTrypDb:
LINF_350054400
Length:
382

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005783 endoplasmic reticulum 5 1
GO:0016020 membrane 2 9
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0072379 ER membrane insertion complex 2 1
GO:0072380 TRC complex 3 1
GO:0110165 cellular anatomical entity 1 9

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IC24
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC24

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006605 protein targeting 5 1
GO:0006612 protein targeting to membrane 5 1
GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane 6 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006810 transport 3 1
GO:0006886 intracellular protein transport 4 1
GO:0006950 response to stress 2 1
GO:0008104 protein localization 4 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009987 cellular process 1 3
GO:0010033 response to organic substance 3 1
GO:0010243 response to organonitrogen compound 4 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0015031 protein transport 4 1
GO:0019538 protein metabolic process 3 1
GO:0019941 modification-dependent protein catabolic process 6 1
GO:0030163 protein catabolic process 4 1
GO:0030433 ubiquitin-dependent ERAD pathway 6 1
GO:0033036 macromolecule localization 2 1
GO:0033365 protein localization to organelle 5 1
GO:0033554 cellular response to stress 3 1
GO:0034976 response to endoplasmic reticulum stress 4 1
GO:0036503 ERAD pathway 5 1
GO:0042221 response to chemical 2 1
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043632 modification-dependent macromolecule catabolic process 5 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0045047 protein targeting to ER 6 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0050896 response to stimulus 1 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051603 proteolysis involved in protein catabolic process 5 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0051668 localization within membrane 3 1
GO:0051716 cellular response to stimulus 2 1
GO:0070727 cellular macromolecule localization 3 1
GO:0070972 protein localization to endoplasmic reticulum 6 1
GO:0071702 organic substance transport 4 1
GO:0071704 organic substance metabolic process 2 1
GO:0071705 nitrogen compound transport 4 1
GO:0072594 establishment of protein localization to organelle 4 1
GO:0072599 establishment of protein localization to endoplasmic reticulum 5 1
GO:0072657 protein localization to membrane 4 1
GO:0090150 establishment of protein localization to membrane 4 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
GO:1901698 response to nitrogen compound 3 1
GO:0006457 protein folding 2 2
Molecular functions
Term Name Level Count
GO:0060090 molecular adaptor activity 1 1
GO:0005488 binding 1 2
GO:0005515 protein binding 2 2
GO:0030544 Hsp70 protein binding 4 2
GO:0031072 heat shock protein binding 3 2
GO:0051879 Hsp90 protein binding 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 108 112 PF00656 0.564
CLV_NRD_NRD_1 132 134 PF00675 0.480
CLV_PCSK_KEX2_1 132 134 PF00082 0.480
CLV_PCSK_KEX2_1 269 271 PF00082 0.546
CLV_PCSK_KEX2_1 64 66 PF00082 0.210
CLV_PCSK_PC1ET2_1 269 271 PF00082 0.535
CLV_PCSK_PC1ET2_1 64 66 PF00082 0.286
CLV_PCSK_SKI1_1 215 219 PF00082 0.268
CLV_PCSK_SKI1_1 299 303 PF00082 0.475
CLV_PCSK_SKI1_1 340 344 PF00082 0.236
CLV_PCSK_SKI1_1 90 94 PF00082 0.340
DOC_MAPK_gen_1 213 220 PF00069 0.519
DOC_MAPK_MEF2A_6 249 258 PF00069 0.448
DOC_PP1_RVXF_1 247 254 PF00149 0.300
DOC_PP1_RVXF_1 338 344 PF00149 0.461
DOC_PP2B_LxvP_1 188 191 PF13499 0.213
DOC_PP2B_LxvP_1 283 286 PF13499 0.276
DOC_USP7_MATH_1 122 126 PF00917 0.627
DOC_USP7_MATH_1 191 195 PF00917 0.215
DOC_USP7_MATH_1 63 67 PF00917 0.494
DOC_USP7_UBL2_3 106 110 PF12436 0.494
DOC_USP7_UBL2_3 340 344 PF12436 0.530
DOC_USP7_UBL2_3 54 58 PF12436 0.523
LIG_14-3-3_CanoR_1 299 308 PF00244 0.365
LIG_14-3-3_CanoR_1 352 360 PF00244 0.566
LIG_BRCT_BRCA1_1 233 237 PF00533 0.356
LIG_BRCT_BRCA1_1 36 40 PF00533 0.442
LIG_EH1_1 260 268 PF00400 0.269
LIG_eIF4E_1 261 267 PF01652 0.305
LIG_FHA_1 162 168 PF00498 0.478
LIG_FHA_1 196 202 PF00498 0.286
LIG_FHA_1 300 306 PF00498 0.282
LIG_FHA_1 36 42 PF00498 0.503
LIG_LIR_Gen_1 158 167 PF02991 0.555
LIG_LIR_Gen_1 194 205 PF02991 0.397
LIG_LIR_Gen_1 230 239 PF02991 0.475
LIG_LIR_Gen_1 319 329 PF02991 0.335
LIG_LIR_Gen_1 336 346 PF02991 0.430
LIG_LIR_Nem_3 158 162 PF02991 0.562
LIG_LIR_Nem_3 194 200 PF02991 0.385
LIG_LIR_Nem_3 230 235 PF02991 0.455
LIG_LIR_Nem_3 319 324 PF02991 0.239
LIG_LIR_Nem_3 336 341 PF02991 0.417
LIG_LIR_Nem_3 37 43 PF02991 0.481
LIG_Pex14_1 155 159 PF04695 0.444
LIG_Pex14_1 228 232 PF04695 0.495
LIG_Pex14_2 237 241 PF04695 0.356
LIG_Pex14_2 253 257 PF04695 0.306
LIG_Pex14_2 311 315 PF04695 0.257
LIG_SH2_CRK 281 285 PF00017 0.297
LIG_SH2_GRB2like 129 132 PF00017 0.648
LIG_SH2_GRB2like 42 45 PF00017 0.481
LIG_SH2_NCK_1 141 145 PF00017 0.597
LIG_SH2_PTP2 199 202 PF00017 0.300
LIG_SH2_PTP2 338 341 PF00017 0.521
LIG_SH2_SRC 139 142 PF00017 0.625
LIG_SH2_STAP1 141 145 PF00017 0.606
LIG_SH2_STAP1 29 33 PF00017 0.398
LIG_SH2_STAP1 366 370 PF00017 0.564
LIG_SH2_STAP1 56 60 PF00017 0.477
LIG_SH2_STAT3 287 290 PF00017 0.307
LIG_SH2_STAT5 199 202 PF00017 0.332
LIG_SH2_STAT5 325 328 PF00017 0.271
LIG_SH2_STAT5 338 341 PF00017 0.427
LIG_SH3_3 132 138 PF00018 0.606
LIG_SUMO_SIM_anti_2 198 204 PF11976 0.333
LIG_SUMO_SIM_anti_2 262 268 PF11976 0.281
LIG_SUMO_SIM_par_1 198 204 PF11976 0.358
MOD_CK1_1 105 111 PF00069 0.542
MOD_CK1_1 161 167 PF00069 0.506
MOD_CK1_1 227 233 PF00069 0.538
MOD_GlcNHglycan 126 129 PF01048 0.449
MOD_GSK3_1 191 198 PF00069 0.294
MOD_GSK3_1 223 230 PF00069 0.557
MOD_GSK3_1 231 238 PF00069 0.513
MOD_GSK3_1 309 316 PF00069 0.244
MOD_GSK3_1 348 355 PF00069 0.523
MOD_GSK3_1 98 105 PF00069 0.510
MOD_NEK2_1 123 128 PF00069 0.620
MOD_NEK2_1 183 188 PF00069 0.299
MOD_NEK2_1 192 197 PF00069 0.285
MOD_NEK2_1 201 206 PF00069 0.275
MOD_NEK2_1 235 240 PF00069 0.438
MOD_NEK2_1 309 314 PF00069 0.206
MOD_NEK2_1 346 351 PF00069 0.525
MOD_PIKK_1 376 382 PF00454 0.519
MOD_PKA_2 346 352 PF00069 0.490
MOD_Plk_2-3 158 164 PF00069 0.556
MOD_Plk_4 183 189 PF00069 0.269
MOD_Plk_4 192 198 PF00069 0.268
MOD_Plk_4 224 230 PF00069 0.490
MOD_Plk_4 231 237 PF00069 0.418
MOD_Plk_4 259 265 PF00069 0.248
MOD_Plk_4 272 278 PF00069 0.286
MOD_Plk_4 316 322 PF00069 0.257
MOD_Plk_4 354 360 PF00069 0.533
MOD_SUMO_for_1 92 95 PF00179 0.539
MOD_SUMO_rev_2 61 66 PF00179 0.441
MOD_SUMO_rev_2 7 11 PF00179 0.538
TRG_DiLeu_BaEn_4 23 29 PF01217 0.489
TRG_DiLeu_BaLyEn_6 279 284 PF01217 0.254
TRG_ENDOCYTIC_2 199 202 PF00928 0.300
TRG_ENDOCYTIC_2 261 264 PF00928 0.214
TRG_ENDOCYTIC_2 281 284 PF00928 0.340
TRG_ENDOCYTIC_2 338 341 PF00928 0.506
TRG_ENDOCYTIC_2 50 53 PF00928 0.481
TRG_ER_diArg_1 212 215 PF00400 0.597
TRG_Pf-PMV_PEXEL_1 215 219 PF00026 0.330

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PGM1 Leptomonas seymouri 71% 100%
A0A0S4J3T8 Bodo saltans 30% 100%
A0A1X0P4V4 Trypanosomatidae 35% 100%
A0A3S7X9Z6 Leishmania donovani 99% 100%
A0A422P159 Trypanosoma rangeli 36% 100%
A4HNF2 Leishmania braziliensis 83% 100%
C9ZYH5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E9AFW3 Leishmania major 93% 100%
E9B716 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS