LeishMANIAdb
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FAM184 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
FAM184 domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IC23_LEIIN
TriTrypDb:
LINF_350054300
Length:
1000

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0097542 ciliary tip 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IC23
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC23

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 172 176 PF00656 0.565
CLV_C14_Caspase3-7 190 194 PF00656 0.572
CLV_C14_Caspase3-7 468 472 PF00656 0.562
CLV_C14_Caspase3-7 695 699 PF00656 0.609
CLV_NRD_NRD_1 263 265 PF00675 0.594
CLV_NRD_NRD_1 310 312 PF00675 0.466
CLV_NRD_NRD_1 617 619 PF00675 0.616
CLV_NRD_NRD_1 703 705 PF00675 0.625
CLV_NRD_NRD_1 854 856 PF00675 0.648
CLV_NRD_NRD_1 892 894 PF00675 0.666
CLV_PCSK_KEX2_1 145 147 PF00082 0.555
CLV_PCSK_KEX2_1 185 187 PF00082 0.585
CLV_PCSK_KEX2_1 263 265 PF00082 0.658
CLV_PCSK_KEX2_1 286 288 PF00082 0.636
CLV_PCSK_KEX2_1 310 312 PF00082 0.466
CLV_PCSK_KEX2_1 437 439 PF00082 0.615
CLV_PCSK_KEX2_1 617 619 PF00082 0.616
CLV_PCSK_KEX2_1 703 705 PF00082 0.625
CLV_PCSK_KEX2_1 841 843 PF00082 0.599
CLV_PCSK_KEX2_1 854 856 PF00082 0.582
CLV_PCSK_KEX2_1 892 894 PF00082 0.666
CLV_PCSK_KEX2_1 983 985 PF00082 0.671
CLV_PCSK_PC1ET2_1 145 147 PF00082 0.555
CLV_PCSK_PC1ET2_1 185 187 PF00082 0.585
CLV_PCSK_PC1ET2_1 286 288 PF00082 0.585
CLV_PCSK_PC1ET2_1 437 439 PF00082 0.693
CLV_PCSK_PC1ET2_1 841 843 PF00082 0.701
CLV_PCSK_PC1ET2_1 983 985 PF00082 0.671
CLV_PCSK_SKI1_1 167 171 PF00082 0.558
CLV_PCSK_SKI1_1 177 181 PF00082 0.555
CLV_PCSK_SKI1_1 223 227 PF00082 0.613
CLV_PCSK_SKI1_1 287 291 PF00082 0.637
CLV_PCSK_SKI1_1 329 333 PF00082 0.588
CLV_PCSK_SKI1_1 340 344 PF00082 0.687
CLV_PCSK_SKI1_1 384 388 PF00082 0.692
CLV_PCSK_SKI1_1 467 471 PF00082 0.619
CLV_PCSK_SKI1_1 650 654 PF00082 0.629
CLV_PCSK_SKI1_1 785 789 PF00082 0.685
CLV_PCSK_SKI1_1 868 872 PF00082 0.588
CLV_Separin_Metazoa 443 447 PF03568 0.635
CLV_Separin_Metazoa 711 715 PF03568 0.536
DEG_APCC_DBOX_1 176 184 PF00400 0.365
DOC_CYCLIN_RxL_1 933 941 PF00134 0.594
DOC_CYCLIN_yClb5_NLxxxL_5 819 827 PF00134 0.450
DOC_MAPK_gen_1 145 155 PF00069 0.654
DOC_MAPK_gen_1 667 676 PF00069 0.508
DOC_MAPK_gen_1 916 925 PF00069 0.574
DOC_MIT_MIM_1 275 283 PF04212 0.591
DOC_USP7_MATH_1 202 206 PF00917 0.655
DOC_USP7_MATH_1 297 301 PF00917 0.582
DOC_USP7_MATH_1 3 7 PF00917 0.667
DOC_USP7_MATH_1 410 414 PF00917 0.617
DOC_USP7_MATH_1 497 501 PF00917 0.619
DOC_USP7_MATH_1 572 576 PF00917 0.483
DOC_USP7_UBL2_3 16 20 PF12436 0.619
DOC_USP7_UBL2_3 23 27 PF12436 0.523
DOC_USP7_UBL2_3 581 585 PF12436 0.511
LIG_14-3-3_CanoR_1 223 228 PF00244 0.714
LIG_14-3-3_CanoR_1 279 284 PF00244 0.616
LIG_14-3-3_CanoR_1 411 415 PF00244 0.658
LIG_14-3-3_CanoR_1 446 454 PF00244 0.633
LIG_14-3-3_CanoR_1 650 659 PF00244 0.650
LIG_14-3-3_CanoR_1 903 907 PF00244 0.608
LIG_14-3-3_CanoR_1 984 989 PF00244 0.720
LIG_14-3-3_CterR_2 995 1000 PF00244 0.710
LIG_Actin_WH2_2 634 652 PF00022 0.685
LIG_BIR_II_1 1 5 PF00653 0.718
LIG_CaM_IQ_9 71 87 PF13499 0.564
LIG_FHA_1 142 148 PF00498 0.627
LIG_FHA_1 30 36 PF00498 0.528
LIG_FHA_1 459 465 PF00498 0.727
LIG_FHA_1 47 53 PF00498 0.569
LIG_FHA_1 654 660 PF00498 0.667
LIG_FHA_2 272 278 PF00498 0.469
LIG_FHA_2 325 331 PF00498 0.684
LIG_FHA_2 466 472 PF00498 0.676
LIG_FHA_2 693 699 PF00498 0.656
LIG_FHA_2 903 909 PF00498 0.622
LIG_LIR_Gen_1 66 74 PF02991 0.419
LIG_LIR_Gen_1 941 952 PF02991 0.534
LIG_LIR_Gen_1 958 969 PF02991 0.622
LIG_LIR_Gen_1 973 981 PF02991 0.669
LIG_LIR_Nem_3 66 70 PF02991 0.417
LIG_LIR_Nem_3 958 964 PF02991 0.601
LIG_LIR_Nem_3 973 977 PF02991 0.628
LIG_NRBOX 822 828 PF00104 0.663
LIG_RPA_C_Fungi 306 318 PF08784 0.486
LIG_SH2_CRK 961 965 PF00017 0.616
LIG_SH2_CRK 974 978 PF00017 0.686
LIG_SH2_NCK_1 961 965 PF00017 0.616
LIG_SH2_NCK_1 974 978 PF00017 0.710
LIG_SH2_STAP1 125 129 PF00017 0.562
LIG_SH2_STAP1 620 624 PF00017 0.684
LIG_SH2_STAP1 67 71 PF00017 0.531
LIG_SH2_STAP1 725 729 PF00017 0.579
LIG_SH2_STAP1 974 978 PF00017 0.710
LIG_SH2_STAT5 36 39 PF00017 0.542
LIG_SUMO_SIM_anti_2 673 678 PF11976 0.633
LIG_SUMO_SIM_anti_2 921 927 PF11976 0.571
LIG_TRAF2_1 102 105 PF00917 0.657
LIG_TRAF2_1 119 122 PF00917 0.325
LIG_TRAF2_1 179 182 PF00917 0.539
LIG_TRAF2_1 460 463 PF00917 0.650
LIG_TRAF2_1 818 821 PF00917 0.644
LIG_TRAF2_1 905 908 PF00917 0.649
LIG_UBA3_1 812 819 PF00899 0.659
LIG_UBA3_1 925 934 PF00899 0.564
MOD_CK1_1 234 240 PF00069 0.706
MOD_CK1_1 282 288 PF00069 0.633
MOD_CK1_1 324 330 PF00069 0.663
MOD_CK1_1 363 369 PF00069 0.684
MOD_CK1_1 413 419 PF00069 0.598
MOD_CK1_1 815 821 PF00069 0.552
MOD_CK2_1 116 122 PF00069 0.658
MOD_CK2_1 234 240 PF00069 0.678
MOD_CK2_1 271 277 PF00069 0.523
MOD_CK2_1 324 330 PF00069 0.684
MOD_CK2_1 415 421 PF00069 0.578
MOD_CK2_1 492 498 PF00069 0.710
MOD_CK2_1 66 72 PF00069 0.633
MOD_CK2_1 815 821 PF00069 0.656
MOD_CK2_1 901 907 PF00069 0.616
MOD_CK2_1 915 921 PF00069 0.479
MOD_CK2_1 92 98 PF00069 0.520
MOD_Cter_Amidation 981 984 PF01082 0.719
MOD_GlcNHglycan 1 4 PF01048 0.741
MOD_GlcNHglycan 126 129 PF01048 0.598
MOD_GlcNHglycan 204 207 PF01048 0.719
MOD_GlcNHglycan 232 236 PF01048 0.706
MOD_GlcNHglycan 363 366 PF01048 0.638
MOD_GlcNHglycan 498 502 PF01048 0.619
MOD_GlcNHglycan 562 567 PF01048 0.710
MOD_GlcNHglycan 570 573 PF01048 0.571
MOD_GlcNHglycan 587 590 PF01048 0.551
MOD_GlcNHglycan 973 977 PF01048 0.640
MOD_GSK3_1 112 119 PF00069 0.620
MOD_GSK3_1 120 127 PF00069 0.560
MOD_GSK3_1 240 247 PF00069 0.578
MOD_GSK3_1 321 328 PF00069 0.677
MOD_GSK3_1 369 376 PF00069 0.662
MOD_GSK3_1 413 420 PF00069 0.594
MOD_GSK3_1 5 12 PF00069 0.564
MOD_GSK3_1 568 575 PF00069 0.493
MOD_GSK3_1 811 818 PF00069 0.593
MOD_GSK3_1 88 95 PF00069 0.560
MOD_GSK3_1 991 998 PF00069 0.752
MOD_N-GLC_1 416 421 PF02516 0.710
MOD_N-GLC_2 40 42 PF02516 0.635
MOD_NEK2_1 343 348 PF00069 0.703
MOD_NEK2_1 360 365 PF00069 0.483
MOD_NEK2_1 371 376 PF00069 0.496
MOD_NEK2_1 465 470 PF00069 0.714
MOD_NEK2_1 492 497 PF00069 0.695
MOD_NEK2_1 5 10 PF00069 0.569
MOD_NEK2_1 653 658 PF00069 0.706
MOD_NEK2_1 659 664 PF00069 0.712
MOD_NEK2_1 692 697 PF00069 0.625
MOD_NEK2_1 754 759 PF00069 0.663
MOD_NEK2_1 798 803 PF00069 0.650
MOD_NEK2_1 812 817 PF00069 0.417
MOD_NEK2_1 92 97 PF00069 0.668
MOD_NEK2_1 938 943 PF00069 0.548
MOD_NEK2_2 410 415 PF00069 0.521
MOD_PIKK_1 240 246 PF00454 0.580
MOD_PIKK_1 373 379 PF00454 0.716
MOD_PIKK_1 396 402 PF00454 0.646
MOD_PIKK_1 458 464 PF00454 0.578
MOD_PIKK_1 608 614 PF00454 0.522
MOD_PIKK_1 92 98 PF00454 0.566
MOD_PKA_1 430 436 PF00069 0.626
MOD_PKA_1 983 989 PF00069 0.721
MOD_PKA_2 396 402 PF00069 0.705
MOD_PKA_2 410 416 PF00069 0.500
MOD_PKA_2 902 908 PF00069 0.614
MOD_PKA_2 915 921 PF00069 0.489
MOD_PKA_2 983 989 PF00069 0.721
MOD_PKB_1 264 272 PF00069 0.613
MOD_PKB_1 783 791 PF00069 0.605
MOD_Plk_1 972 978 PF00069 0.704
MOD_Plk_2-3 116 122 PF00069 0.579
MOD_Plk_2-3 271 277 PF00069 0.643
MOD_Plk_2-3 66 72 PF00069 0.419
MOD_Plk_4 366 372 PF00069 0.677
MOD_Plk_4 637 643 PF00069 0.608
MOD_Plk_4 66 72 PF00069 0.419
MOD_SUMO_for_1 184 187 PF00179 0.662
MOD_SUMO_for_1 272 275 PF00179 0.596
MOD_SUMO_for_1 401 404 PF00179 0.667
MOD_SUMO_rev_2 105 109 PF00179 0.578
MOD_SUMO_rev_2 139 147 PF00179 0.557
MOD_SUMO_rev_2 269 274 PF00179 0.605
MOD_SUMO_rev_2 560 566 PF00179 0.617
MOD_SUMO_rev_2 800 809 PF00179 0.591
MOD_SUMO_rev_2 865 873 PF00179 0.586
TRG_DiLeu_BaEn_1 154 159 PF01217 0.542
TRG_DiLeu_BaEn_1 421 426 PF01217 0.626
TRG_DiLeu_BaEn_1 488 493 PF01217 0.717
TRG_DiLeu_BaEn_1 66 71 PF01217 0.418
TRG_DiLeu_BaEn_1 921 926 PF01217 0.572
TRG_DiLeu_BaLyEn_6 212 217 PF01217 0.671
TRG_DiLeu_BaLyEn_6 822 827 PF01217 0.586
TRG_DiLeu_LyEn_5 421 426 PF01217 0.592
TRG_ENDOCYTIC_2 166 169 PF00928 0.559
TRG_ENDOCYTIC_2 67 70 PF00928 0.418
TRG_ENDOCYTIC_2 944 947 PF00928 0.549
TRG_ENDOCYTIC_2 961 964 PF00928 0.612
TRG_ENDOCYTIC_2 974 977 PF00928 0.686
TRG_ER_diArg_1 263 266 PF00400 0.657
TRG_ER_diArg_1 616 618 PF00400 0.621
TRG_ER_diArg_1 713 716 PF00400 0.674
TRG_ER_diArg_1 722 725 PF00400 0.569
TRG_ER_diArg_1 782 785 PF00400 0.636
TRG_Pf-PMV_PEXEL_1 215 219 PF00026 0.636
TRG_Pf-PMV_PEXEL_1 556 560 PF00026 0.591
TRG_Pf-PMV_PEXEL_1 79 84 PF00026 0.573
TRG_Pf-PMV_PEXEL_1 825 829 PF00026 0.585

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I973 Leptomonas seymouri 47% 99%
A0A3S7XA02 Leishmania donovani 100% 100%
A4HNF1 Leishmania braziliensis 70% 99%
E9AFW2 Leishmania major 93% 100%
E9B715 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS