PHM7_ext domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IC20_LEIIN

TriTrypDb:

LINF_350054000

Length:

256

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4IC20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	254	256	PF00675	0.823
CLV_PCSK_SKI1_1	83	87	PF00082	0.466
DEG_APCC_DBOX_1	82	90	PF00400	0.658
DEG_Nend_Nbox_1	1	3	PF02207	0.527
DOC_CKS1_1	7	12	PF01111	0.505
DOC_CYCLIN_yCln2_LP_2	43	49	PF00134	0.459
DOC_CYCLIN_yCln2_LP_2	85	91	PF00134	0.664
DOC_PP2B_LxvP_1	85	88	PF13499	0.692
DOC_PP4_FxxP_1	221	224	PF00568	0.474
DOC_PP4_FxxP_1	228	231	PF00568	0.449
DOC_USP7_UBL2_3	133	137	PF12436	0.561
DOC_WW_Pin1_4	1	6	PF00397	0.528
DOC_WW_Pin1_4	238	243	PF00397	0.523
DOC_WW_Pin1_4	90	95	PF00397	0.680
LIG_14-3-3_CanoR_1	247	251	PF00244	0.658
LIG_BRCT_BRCA1_1	16	20	PF00533	0.491
LIG_BRCT_BRCA1_1	240	244	PF00533	0.536
LIG_BRCT_BRCA1_1	92	96	PF00533	0.398
LIG_EH_1	225	229	PF12763	0.499
LIG_FHA_1	189	195	PF00498	0.495
LIG_FHA_1	234	240	PF00498	0.516
LIG_FHA_1	72	78	PF00498	0.381
LIG_FHA_2	144	150	PF00498	0.514
LIG_FHA_2	176	182	PF00498	0.482
LIG_FHA_2	247	253	PF00498	0.583
LIG_LIR_Apic_2	219	224	PF02991	0.494
LIG_LIR_Gen_1	73	82	PF02991	0.376
LIG_LIR_Gen_1	93	104	PF02991	0.357
LIG_LIR_Nem_3	17	23	PF02991	0.484
LIG_LIR_Nem_3	178	183	PF02991	0.480
LIG_LIR_Nem_3	73	79	PF02991	0.376
LIG_LIR_Nem_3	93	99	PF02991	0.357
LIG_NRBOX	81	87	PF00104	0.650
LIG_Pex14_1	72	76	PF04695	0.371
LIG_Pex14_2	101	105	PF04695	0.391
LIG_PTB_Apo_2	215	222	PF02174	0.509
LIG_SH2_CRK	2	6	PF00017	0.620
LIG_SH2_NCK_1	2	6	PF00017	0.485
LIG_SH2_STAP1	113	117	PF00017	0.482
LIG_SH2_STAP1	167	171	PF00017	0.553
LIG_SH2_STAT3	159	162	PF00017	0.463
LIG_SH2_STAT3	54	57	PF00017	0.371
LIG_SH2_STAT5	113	116	PF00017	0.461
LIG_SH2_STAT5	159	162	PF00017	0.483
LIG_SH2_STAT5	167	170	PF00017	0.456
LIG_SH2_STAT5	54	57	PF00017	0.398
LIG_SH3_1	2	8	PF00018	0.483
LIG_SH3_3	2	8	PF00018	0.487
LIG_SH3_3	221	227	PF00018	0.484
LIG_SH3_3	43	49	PF00018	0.479
LIG_SH3_3	85	91	PF00018	0.770
LIG_SUMO_SIM_par_1	24	31	PF11976	0.447
LIG_TRAF2_1	139	142	PF00917	0.564
LIG_TRAF2_1	249	252	PF00917	0.535
MOD_CK1_1	132	138	PF00069	0.558
MOD_CK1_1	143	149	PF00069	0.480
MOD_CK1_1	28	34	PF00069	0.441
MOD_CK2_1	136	142	PF00069	0.663
MOD_CK2_1	143	149	PF00069	0.577
MOD_CK2_1	175	181	PF00069	0.489
MOD_CK2_1	246	252	PF00069	0.652
MOD_DYRK1A_RPxSP_1	90	94	PF00069	0.555
MOD_GlcNHglycan	134	137	PF01048	0.749
MOD_GlcNHglycan	30	33	PF01048	0.781
MOD_GSK3_1	132	139	PF00069	0.558
MOD_GSK3_1	188	195	PF00069	0.492
MOD_GSK3_1	21	28	PF00069	0.481
MOD_GSK3_1	233	240	PF00069	0.562
MOD_LATS_1	12	18	PF00433	0.464
MOD_NEK2_1	129	134	PF00069	0.544
MOD_NEK2_1	186	191	PF00069	0.478
MOD_NEK2_1	30	35	PF00069	0.467
MOD_NEK2_1	61	66	PF00069	0.427
MOD_NEK2_1	71	76	PF00069	0.374
MOD_PIKK_1	21	27	PF00454	0.512
MOD_PK_1	140	146	PF00069	0.547
MOD_PKA_2	246	252	PF00069	0.602
MOD_Plk_1	140	146	PF00069	0.547
MOD_Plk_2-3	246	252	PF00069	0.540
MOD_Plk_4	25	31	PF00069	0.430
MOD_Plk_4	61	67	PF00069	0.398
MOD_Plk_4	71	77	PF00069	0.323
MOD_ProDKin_1	1	7	PF00069	0.527
MOD_ProDKin_1	238	244	PF00069	0.526
MOD_ProDKin_1	90	96	PF00069	0.680
MOD_SUMO_rev_2	143	152	PF00179	0.556
TRG_ENDOCYTIC_2	183	186	PF00928	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJX6	Leishmania donovani	99%	100%
E9AFV9	Leishmania major	91%	100%
E9B712	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	73%