LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IC19_LEIIN
TriTrypDb:
LINF_350053900
Length:
389

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IC19
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC19

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 114 118 PF00656 0.422
CLV_NRD_NRD_1 365 367 PF00675 0.577
CLV_NRD_NRD_1 40 42 PF00675 0.461
CLV_PCSK_KEX2_1 365 367 PF00082 0.577
CLV_PCSK_KEX2_1 40 42 PF00082 0.435
CLV_PCSK_SKI1_1 275 279 PF00082 0.487
CLV_PCSK_SKI1_1 317 321 PF00082 0.588
CLV_PCSK_SKI1_1 4 8 PF00082 0.522
DOC_CKS1_1 131 136 PF01111 0.499
DOC_CYCLIN_yCln2_LP_2 242 248 PF00134 0.519
DOC_MAPK_gen_1 188 196 PF00069 0.502
DOC_MAPK_MEF2A_6 188 196 PF00069 0.516
DOC_MAPK_MEF2A_6 74 81 PF00069 0.568
DOC_PP1_RVXF_1 2 8 PF00149 0.584
DOC_PP2B_LxvP_1 169 172 PF13499 0.488
DOC_PP2B_LxvP_1 279 282 PF13499 0.472
DOC_PP2B_PxIxI_1 191 197 PF00149 0.522
DOC_PP4_FxxP_1 312 315 PF00568 0.582
DOC_PP4_FxxP_1 7 10 PF00568 0.454
DOC_SPAK_OSR1_1 214 218 PF12202 0.445
DOC_USP7_MATH_1 267 271 PF00917 0.454
DOC_WW_Pin1_4 130 135 PF00397 0.488
DOC_WW_Pin1_4 188 193 PF00397 0.467
LIG_14-3-3_CanoR_1 365 369 PF00244 0.607
LIG_Actin_WH2_2 350 367 PF00022 0.660
LIG_APCC_ABBA_1 170 175 PF00400 0.433
LIG_BIR_III_4 59 63 PF00653 0.559
LIG_Clathr_ClatBox_1 86 90 PF01394 0.371
LIG_EH1_1 226 234 PF00400 0.461
LIG_FHA_1 189 195 PF00498 0.452
LIG_FHA_1 26 32 PF00498 0.532
LIG_FHA_1 359 365 PF00498 0.636
LIG_FHA_1 66 72 PF00498 0.491
LIG_FHA_1 94 100 PF00498 0.442
LIG_FHA_2 108 114 PF00498 0.414
LIG_FHA_2 131 137 PF00498 0.573
LIG_FHA_2 145 151 PF00498 0.421
LIG_FHA_2 353 359 PF00498 0.672
LIG_LIR_Apic_2 101 105 PF02991 0.435
LIG_LIR_Apic_2 310 315 PF02991 0.587
LIG_LIR_Apic_2 44 49 PF02991 0.559
LIG_LIR_Gen_1 255 265 PF02991 0.440
LIG_LIR_Gen_1 273 284 PF02991 0.393
LIG_LIR_Gen_1 306 315 PF02991 0.584
LIG_LIR_Gen_1 377 388 PF02991 0.538
LIG_LIR_Gen_1 95 105 PF02991 0.387
LIG_LIR_Nem_3 255 260 PF02991 0.422
LIG_LIR_Nem_3 273 279 PF02991 0.303
LIG_LIR_Nem_3 306 312 PF02991 0.630
LIG_LIR_Nem_3 377 383 PF02991 0.545
LIG_LIR_Nem_3 78 84 PF02991 0.416
LIG_LIR_Nem_3 95 100 PF02991 0.323
LIG_Pex14_2 142 146 PF04695 0.455
LIG_Rb_LxCxE_1 83 101 PF01857 0.523
LIG_SH2_CRK 102 106 PF00017 0.487
LIG_SH2_CRK 276 280 PF00017 0.396
LIG_SH2_CRK 284 288 PF00017 0.410
LIG_SH2_CRK 289 293 PF00017 0.433
LIG_SH2_CRK 46 50 PF00017 0.513
LIG_SH2_CRK 8 12 PF00017 0.485
LIG_SH2_CRK 84 88 PF00017 0.459
LIG_SH2_NCK_1 102 106 PF00017 0.520
LIG_SH2_STAP1 276 280 PF00017 0.371
LIG_SH2_STAP1 305 309 PF00017 0.576
LIG_SH2_STAT3 176 179 PF00017 0.448
LIG_SH3_3 180 186 PF00018 0.424
LIG_SH3_5 172 176 PF00018 0.488
LIG_TRAF2_1 253 256 PF00917 0.387
LIG_TYR_ITAM 273 292 PF00017 0.438
LIG_TYR_ITIM 6 11 PF00017 0.520
LIG_WRC_WIRS_1 104 109 PF05994 0.423
MOD_CDK_SPK_2 130 135 PF00069 0.550
MOD_CDK_SPxxK_3 130 137 PF00069 0.567
MOD_CK1_1 268 274 PF00069 0.484
MOD_CK1_1 352 358 PF00069 0.742
MOD_CK2_1 122 128 PF00069 0.394
MOD_CK2_1 220 226 PF00069 0.388
MOD_CK2_1 250 256 PF00069 0.392
MOD_CK2_1 267 273 PF00069 0.432
MOD_CK2_1 352 358 PF00069 0.684
MOD_GlcNHglycan 124 127 PF01048 0.384
MOD_GlcNHglycan 16 19 PF01048 0.562
MOD_GlcNHglycan 267 270 PF01048 0.469
MOD_GlcNHglycan 59 63 PF01048 0.535
MOD_GSK3_1 103 110 PF00069 0.385
MOD_GSK3_1 157 164 PF00069 0.397
MOD_GSK3_1 352 359 PF00069 0.647
MOD_GSK3_1 364 371 PF00069 0.522
MOD_N-GLC_1 161 166 PF02516 0.505
MOD_N-GLC_1 344 349 PF02516 0.722
MOD_NEK2_1 107 112 PF00069 0.479
MOD_NEK2_1 122 127 PF00069 0.267
MOD_NEK2_1 157 162 PF00069 0.471
MOD_NEK2_1 260 265 PF00069 0.488
MOD_NEK2_1 364 369 PF00069 0.547
MOD_PIKK_1 107 113 PF00454 0.517
MOD_PKA_2 364 370 PF00069 0.607
MOD_Plk_1 120 126 PF00069 0.387
MOD_Plk_1 161 167 PF00069 0.462
MOD_Plk_1 250 256 PF00069 0.397
MOD_Plk_4 260 266 PF00069 0.461
MOD_ProDKin_1 130 136 PF00069 0.492
MOD_ProDKin_1 188 194 PF00069 0.458
MOD_SUMO_for_1 187 190 PF00179 0.538
TRG_DiLeu_BaEn_1 95 100 PF01217 0.426
TRG_DiLeu_BaLyEn_6 27 32 PF01217 0.574
TRG_ENDOCYTIC_2 276 279 PF00928 0.438
TRG_ENDOCYTIC_2 289 292 PF00928 0.439
TRG_ENDOCYTIC_2 309 312 PF00928 0.368
TRG_ENDOCYTIC_2 8 11 PF00928 0.479
TRG_ENDOCYTIC_2 84 87 PF00928 0.459
TRG_ER_diArg_1 364 366 PF00400 0.565
TRG_ER_diArg_1 39 41 PF00400 0.459
TRG_NES_CRM1_1 114 128 PF08389 0.390
TRG_Pf-PMV_PEXEL_1 290 294 PF00026 0.436
TRG_Pf-PMV_PEXEL_1 366 370 PF00026 0.659

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDR1 Leptomonas seymouri 84% 82%
A0A0S4J7W9 Bodo saltans 50% 98%
A0A1X0P558 Trypanosomatidae 67% 84%
A0A3Q8IFL6 Leishmania donovani 100% 100%
A4HNE7 Leishmania braziliensis 92% 100%
C9ZYI1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 85%
E9AFV8 Leishmania major 98% 100%
E9B711 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
V5BBH8 Trypanosoma cruzi 63% 84%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS