LeishMANIAdb
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Histidine phosphatase superfamily (Branch 1)

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Histidine phosphatase superfamily (Branch 1)
Gene product:
Histidine phosphatase superfamily (branch 1) - putative
Species:
Leishmania infantum
UniProt:
A4IC18_LEIIN
TriTrypDb:
LINF_350053800
Length:
335

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 7, no: 4
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IC18
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC18

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016787 hydrolase activity 2 1
GO:0016788 hydrolase activity, acting on ester bonds 3 1
GO:0016791 phosphatase activity 5 1
GO:0042578 phosphoric ester hydrolase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 58 62 PF00656 0.666
CLV_NRD_NRD_1 158 160 PF00675 0.362
CLV_NRD_NRD_1 285 287 PF00675 0.455
CLV_PCSK_KEX2_1 126 128 PF00082 0.532
CLV_PCSK_KEX2_1 158 160 PF00082 0.362
CLV_PCSK_KEX2_1 285 287 PF00082 0.394
CLV_PCSK_KEX2_1 66 68 PF00082 0.432
CLV_PCSK_PC1ET2_1 126 128 PF00082 0.491
CLV_PCSK_PC1ET2_1 66 68 PF00082 0.451
CLV_PCSK_PC7_1 281 287 PF00082 0.396
CLV_PCSK_SKI1_1 102 106 PF00082 0.414
CLV_PCSK_SKI1_1 137 141 PF00082 0.511
CLV_PCSK_SKI1_1 281 285 PF00082 0.364
CLV_PCSK_SKI1_1 70 74 PF00082 0.353
CLV_PCSK_SKI1_1 95 99 PF00082 0.420
DEG_Nend_Nbox_1 1 3 PF02207 0.461
DOC_CKS1_1 16 21 PF01111 0.535
DOC_CYCLIN_yCln2_LP_2 90 96 PF00134 0.555
DOC_MAPK_gen_1 137 145 PF00069 0.487
DOC_MAPK_gen_1 66 74 PF00069 0.393
DOC_MAPK_MEF2A_6 66 73 PF00069 0.412
DOC_PP1_RVXF_1 140 146 PF00149 0.483
DOC_PP1_RVXF_1 68 74 PF00149 0.362
DOC_PP2B_LxvP_1 90 93 PF13499 0.563
DOC_PP4_FxxP_1 108 111 PF00568 0.410
DOC_PP4_FxxP_1 287 290 PF00568 0.479
DOC_USP7_MATH_1 111 115 PF00917 0.399
DOC_USP7_MATH_1 120 124 PF00917 0.411
DOC_USP7_MATH_1 147 151 PF00917 0.460
DOC_USP7_MATH_1 261 265 PF00917 0.530
DOC_USP7_UBL2_3 328 332 PF12436 0.509
DOC_WW_Pin1_4 116 121 PF00397 0.382
DOC_WW_Pin1_4 15 20 PF00397 0.512
DOC_WW_Pin1_4 166 171 PF00397 0.502
LIG_14-3-3_CanoR_1 148 152 PF00244 0.454
LIG_14-3-3_CanoR_1 171 181 PF00244 0.416
LIG_14-3-3_CanoR_1 55 60 PF00244 0.558
LIG_14-3-3_CanoR_1 75 81 PF00244 0.352
LIG_AP2alpha_1 104 108 PF02296 0.494
LIG_BRCT_BRCA1_1 276 280 PF00533 0.342
LIG_CtBP_PxDLS_1 215 219 PF00389 0.532
LIG_EH_1 109 113 PF12763 0.429
LIG_FHA_1 147 153 PF00498 0.409
LIG_FHA_1 161 167 PF00498 0.297
LIG_FHA_1 211 217 PF00498 0.509
LIG_FHA_1 324 330 PF00498 0.472
LIG_FHA_1 49 55 PF00498 0.557
LIG_FHA_2 310 316 PF00498 0.505
LIG_FHA_2 56 62 PF00498 0.664
LIG_LIR_Apic_2 105 111 PF02991 0.522
LIG_LIR_Gen_1 103 112 PF02991 0.422
LIG_LIR_Gen_1 236 246 PF02991 0.448
LIG_LIR_Gen_1 51 59 PF02991 0.510
LIG_LIR_Gen_1 79 85 PF02991 0.384
LIG_LIR_Nem_3 103 107 PF02991 0.462
LIG_LIR_Nem_3 277 283 PF02991 0.347
LIG_LIR_Nem_3 79 84 PF02991 0.374
LIG_MLH1_MIPbox_1 276 280 PF16413 0.358
LIG_Pex14_1 81 85 PF04695 0.395
LIG_Pex14_2 104 108 PF04695 0.494
LIG_Pex14_2 280 284 PF04695 0.354
LIG_PTB_Apo_2 79 86 PF02174 0.393
LIG_REV1ctd_RIR_1 281 288 PF16727 0.383
LIG_SH2_GRB2like 225 228 PF00017 0.503
LIG_SH2_SRC 225 228 PF00017 0.503
LIG_SH2_SRC 31 34 PF00017 0.475
LIG_SH2_STAT5 225 228 PF00017 0.461
LIG_SH2_STAT5 279 282 PF00017 0.406
LIG_SH2_STAT5 53 56 PF00017 0.551
LIG_SH3_3 13 19 PF00018 0.552
LIG_SH3_3 218 224 PF00018 0.508
LIG_SUMO_SIM_anti_2 217 223 PF11976 0.507
LIG_SUMO_SIM_anti_2 270 275 PF11976 0.347
LIG_TRAF2_1 184 187 PF00917 0.387
LIG_TRAF2_1 321 324 PF00917 0.432
LIG_WRC_WIRS_1 132 137 PF05994 0.465
LIG_WRC_WIRS_1 280 285 PF05994 0.293
MOD_CDK_SPK_2 166 171 PF00069 0.502
MOD_CDK_SPxxK_3 15 22 PF00069 0.540
MOD_CK1_1 119 125 PF00069 0.401
MOD_CK1_1 196 202 PF00069 0.519
MOD_CK1_1 296 302 PF00069 0.484
MOD_CK2_1 181 187 PF00069 0.424
MOD_CK2_1 309 315 PF00069 0.427
MOD_Cter_Amidation 124 127 PF01082 0.541
MOD_Cter_Amidation 64 67 PF01082 0.519
MOD_GlcNHglycan 251 254 PF01048 0.557
MOD_GlcNHglycan 276 279 PF01048 0.365
MOD_GSK3_1 102 109 PF00069 0.509
MOD_GSK3_1 116 123 PF00069 0.334
MOD_GSK3_1 131 138 PF00069 0.391
MOD_GSK3_1 147 154 PF00069 0.504
MOD_GSK3_1 166 173 PF00069 0.550
MOD_GSK3_1 289 296 PF00069 0.508
MOD_GSK3_1 309 316 PF00069 0.453
MOD_GSK3_1 76 83 PF00069 0.377
MOD_N-GLC_2 86 88 PF02516 0.533
MOD_NEK2_1 135 140 PF00069 0.425
MOD_NEK2_1 181 186 PF00069 0.425
MOD_NEK2_1 84 89 PF00069 0.462
MOD_NEK2_2 279 284 PF00069 0.281
MOD_PIKK_1 172 178 PF00454 0.572
MOD_PIKK_1 186 192 PF00454 0.470
MOD_PKA_2 147 153 PF00069 0.503
MOD_PKA_2 170 176 PF00069 0.421
MOD_PKA_2 48 54 PF00069 0.476
MOD_Plk_1 181 187 PF00069 0.380
MOD_Plk_1 322 328 PF00069 0.407
MOD_Plk_2-3 314 320 PF00069 0.522
MOD_Plk_4 131 137 PF00069 0.518
MOD_Plk_4 147 153 PF00069 0.348
MOD_Plk_4 76 82 PF00069 0.356
MOD_ProDKin_1 116 122 PF00069 0.383
MOD_ProDKin_1 15 21 PF00069 0.503
MOD_ProDKin_1 166 172 PF00069 0.502
MOD_SUMO_for_1 39 42 PF00179 0.494
TRG_ENDOCYTIC_2 238 241 PF00928 0.368
TRG_ENDOCYTIC_2 331 334 PF00928 0.407
TRG_ENDOCYTIC_2 53 56 PF00928 0.483
TRG_ER_diArg_1 157 159 PF00400 0.365
TRG_ER_diArg_1 284 286 PF00400 0.454
TRG_NLS_Bipartite_1 285 301 PF00514 0.490

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P956 Leptomonas seymouri 76% 100%
A0A0S4J7E1 Bodo saltans 56% 100%
A0A1X0P4X0 Trypanosomatidae 58% 100%
A0A3Q8IVL2 Leishmania donovani 100% 100%
A0A422P1A4 Trypanosoma rangeli 60% 99%
A4HNE6 Leishmania braziliensis 89% 100%
C9ZYI2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 100%
E9AFV7 Leishmania major 96% 100%
E9B710 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
V5BG29 Trypanosoma cruzi 56% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS