LeishMANIAdb
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Cyclophilin 40

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cyclophilin 40
Gene product:
cyclophilin 40
Species:
Leishmania infantum
UniProt:
A4IC14_LEIIN
TriTrypDb:
LINF_350053300
Length:
354

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Annotations by Jardim et al.

Chaperone/Protein Folding, Cyclophilin 40 CYP40

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 24
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 2

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IC14
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC14

Function

Biological processes
Term Name Level Count
GO:0000413 protein peptidyl-prolyl isomerization 7 15
GO:0006457 protein folding 2 15
GO:0006807 nitrogen compound metabolic process 2 15
GO:0008152 metabolic process 1 15
GO:0009987 cellular process 1 15
GO:0018193 peptidyl-amino acid modification 5 15
GO:0018208 peptidyl-proline modification 6 15
GO:0019538 protein metabolic process 3 15
GO:0036211 protein modification process 4 15
GO:0043170 macromolecule metabolic process 3 15
GO:0043412 macromolecule modification 4 15
GO:0044238 primary metabolic process 2 15
GO:0071704 organic substance metabolic process 2 15
GO:1901564 organonitrogen compound metabolic process 3 15
Molecular functions
Term Name Level Count
GO:0003755 peptidyl-prolyl cis-trans isomerase activity 3 15
GO:0003824 catalytic activity 1 15
GO:0016853 isomerase activity 2 15
GO:0016859 cis-trans isomerase activity 3 15
GO:0140096 catalytic activity, acting on a protein 2 15
GO:0005488 binding 1 1
GO:0016018 cyclosporin A binding 4 1
GO:0033218 amide binding 2 1
GO:0042277 peptide binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 296 298 PF00675 0.332
CLV_PCSK_KEX2_1 17 19 PF00082 0.255
CLV_PCSK_KEX2_1 205 207 PF00082 0.459
CLV_PCSK_KEX2_1 296 298 PF00082 0.314
CLV_PCSK_PC1ET2_1 17 19 PF00082 0.237
CLV_PCSK_PC1ET2_1 205 207 PF00082 0.459
CLV_PCSK_SKI1_1 20 24 PF00082 0.245
CLV_PCSK_SKI1_1 232 236 PF00082 0.355
CLV_PCSK_SKI1_1 289 293 PF00082 0.327
CLV_PCSK_SKI1_1 350 354 PF00082 0.422
DOC_MAPK_gen_1 15 25 PF00069 0.258
DOC_MAPK_MEF2A_6 17 25 PF00069 0.349
DOC_MAPK_MEF2A_6 277 286 PF00069 0.471
DOC_PP1_RVXF_1 133 140 PF00149 0.264
DOC_PP4_FxxP_1 98 101 PF00568 0.244
DOC_USP7_MATH_1 209 213 PF00917 0.522
DOC_USP7_MATH_1 225 229 PF00917 0.351
DOC_USP7_UBL2_3 335 339 PF12436 0.372
DOC_WW_Pin1_4 152 157 PF00397 0.330
DOC_WW_Pin1_4 196 201 PF00397 0.410
DOC_WW_Pin1_4 27 32 PF00397 0.244
LIG_14-3-3_CanoR_1 144 150 PF00244 0.258
LIG_14-3-3_CanoR_1 277 283 PF00244 0.468
LIG_APCC_ABBA_1 23 28 PF00400 0.264
LIG_APCC_ABBA_1 86 91 PF00400 0.244
LIG_BIR_III_2 176 180 PF00653 0.553
LIG_BIR_III_4 306 310 PF00653 0.451
LIG_BRCT_BRCA1_1 119 123 PF00533 0.264
LIG_FHA_1 277 283 PF00498 0.422
LIG_FHA_1 297 303 PF00498 0.194
LIG_FHA_1 326 332 PF00498 0.403
LIG_FHA_1 81 87 PF00498 0.290
LIG_LIR_Apic_2 95 101 PF02991 0.244
LIG_LIR_Gen_1 24 31 PF02991 0.191
LIG_LIR_Gen_1 4 12 PF02991 0.317
LIG_LIR_Gen_1 62 71 PF02991 0.265
LIG_LIR_Nem_3 188 193 PF02991 0.420
LIG_LIR_Nem_3 24 29 PF02991 0.226
LIG_LIR_Nem_3 35 40 PF02991 0.264
LIG_LIR_Nem_3 4 10 PF02991 0.401
LIG_LIR_Nem_3 62 66 PF02991 0.265
LIG_MLH1_MIPbox_1 119 123 PF16413 0.264
LIG_PTB_Apo_2 215 222 PF02174 0.332
LIG_PTB_Phospho_1 220 226 PF10480 0.468
LIG_REV1ctd_RIR_1 292 301 PF16727 0.309
LIG_RPA_C_Fungi 292 304 PF08784 0.271
LIG_SH2_GRB2like 239 242 PF00017 0.451
LIG_SH2_SRC 7 10 PF00017 0.237
LIG_SH2_STAP1 226 230 PF00017 0.338
LIG_SH2_STAP1 233 237 PF00017 0.291
LIG_SH2_STAT3 239 242 PF00017 0.375
LIG_SH2_STAT5 239 242 PF00017 0.382
LIG_SH2_STAT5 5 8 PF00017 0.375
LIG_SH3_3 188 194 PF00018 0.390
LIG_TRAF2_1 179 182 PF00917 0.458
MOD_CDK_SPK_2 27 32 PF00069 0.258
MOD_CK2_1 225 231 PF00069 0.458
MOD_Cter_Amidation 45 48 PF01082 0.292
MOD_GlcNHglycan 103 107 PF01048 0.390
MOD_GlcNHglycan 227 230 PF01048 0.446
MOD_GSK3_1 123 130 PF00069 0.292
MOD_GSK3_1 278 285 PF00069 0.475
MOD_GSK3_1 325 332 PF00069 0.403
MOD_GSK3_1 80 87 PF00069 0.264
MOD_N-GLC_1 117 122 PF02516 0.264
MOD_N-GLC_1 80 85 PF02516 0.264
MOD_N-GLC_1 96 101 PF02516 0.264
MOD_NEK2_1 122 127 PF00069 0.278
MOD_NEK2_1 8 13 PF00069 0.288
MOD_NEK2_2 145 150 PF00069 0.258
MOD_NEK2_2 209 214 PF00069 0.309
MOD_NEK2_2 84 89 PF00069 0.264
MOD_PIKK_1 117 123 PF00454 0.264
MOD_PIKK_1 312 318 PF00454 0.353
MOD_PKA_1 296 302 PF00069 0.363
MOD_PKA_2 276 282 PF00069 0.430
MOD_PKA_2 296 302 PF00069 0.186
MOD_Plk_1 8 14 PF00069 0.336
MOD_Plk_1 96 102 PF00069 0.333
MOD_Plk_2-3 182 188 PF00069 0.552
MOD_Plk_4 84 90 PF00069 0.264
MOD_ProDKin_1 152 158 PF00069 0.330
MOD_ProDKin_1 196 202 PF00069 0.411
MOD_ProDKin_1 27 33 PF00069 0.244
MOD_SUMO_for_1 16 19 PF00179 0.237
MOD_SUMO_rev_2 198 207 PF00179 0.524
MOD_SUMO_rev_2 247 257 PF00179 0.393
MOD_SUMO_rev_2 281 291 PF00179 0.472
TRG_ENDOCYTIC_2 5 8 PF00928 0.405
TRG_ER_diArg_1 295 297 PF00400 0.303
TRG_ER_diLys_1 350 354 PF00400 0.394
TRG_Pf-PMV_PEXEL_1 238 242 PF00026 0.475

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IAQ4 Leptomonas seymouri 83% 100%
A0A0S4JAB5 Bodo saltans 59% 99%
A0A1X0P563 Trypanosomatidae 65% 100%
A0A3Q8IIG9 Leishmania donovani 100% 100%
A0A3Q8IPW3 Leishmania donovani 30% 100%
A0A3S5H7U6 Leishmania donovani 53% 100%
A0A3S7X325 Leishmania donovani 32% 100%
A0A3S7XB52 Leishmania donovani 40% 100%
A0A422P185 Trypanosoma rangeli 65% 100%
A4H8P7 Leishmania braziliensis 33% 100%
A4HCL8 Leishmania braziliensis 45% 100%
A4HHU7 Leishmania braziliensis 33% 100%
A4HNE1 Leishmania braziliensis 87% 100%
A4I4Z7 Leishmania infantum 32% 100%
A4I935 Leishmania infantum 53% 100%
A4IDA1 Leishmania infantum 40% 100%
C9ZYI8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 62% 100%
E9AFV2 Leishmania major 96% 100%
E9B0C7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9B400 Leishmania mexicana (strain MHOM/GT/2001/U1103) 52% 100%
E9B705 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
P0C1I1 Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) 48% 97%
P0CP80 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 40% 94%
P0CP81 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 40% 94%
P26882 Bos taurus 44% 96%
P47103 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 34% 90%
P53691 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 43% 95%
Q08752 Homo sapiens 45% 96%
Q11004 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 40% 99%
Q2U0E0 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 42% 95%
Q4HXF6 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 44% 95%
Q4P0V4 Ustilago maydis (strain 521 / FGSC 9021) 40% 89%
Q4Q1A6 Leishmania major 40% 100%
Q4Q7V7 Leishmania major 32% 100%
Q4WIF3 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 42% 94%
Q5ACI8 Candida albicans (strain SC5314 / ATCC MYA-2876) 43% 96%
Q5B4E7 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 42% 95%
Q5U8Z7 Amanita muscaria 41% 95%
Q6BXZ7 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 44% 96%
Q6CBP4 Yarrowia lipolytica (strain CLIB 122 / E 150) 41% 96%
Q6CL78 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 43% 95%
Q6DGG0 Rattus norvegicus 44% 96%
Q6FNU6 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 42% 95%
Q75A33 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 45% 96%
Q9C566 Arabidopsis thaliana 42% 98%
Q9CR16 Mus musculus 44% 96%
Q9P3X9 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 44% 94%
V5B2A0 Trypanosoma cruzi 45% 100%
V5D7H4 Trypanosoma cruzi 64% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS