LeishMANIAdb
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Secreted peptide

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Secreted peptide
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IC13_LEIIN
TriTrypDb:
LINF_350053200
Length:
148

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0016020 membrane 2 7
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4IC13
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 50 52 PF00675 0.380
CLV_PCSK_KEX2_1 50 52 PF00082 0.379
DEG_Nend_UBRbox_2 1 3 PF02207 0.389
DOC_MAPK_MEF2A_6 75 82 PF00069 0.349
DOC_PP2B_PxIxI_1 59 65 PF00149 0.466
LIG_14-3-3_CanoR_1 108 114 PF00244 0.534
LIG_FHA_1 133 139 PF00498 0.373
LIG_FHA_2 124 130 PF00498 0.531
LIG_LIR_Gen_1 12 22 PF02991 0.336
LIG_LIR_LC3C_4 76 79 PF02991 0.292
LIG_LIR_Nem_3 57 62 PF02991 0.604
LIG_LYPXL_yS_3 59 62 PF13949 0.568
LIG_PDZ_Class_2 143 148 PF00595 0.346
LIG_PTB_Apo_2 3 10 PF02174 0.426
LIG_PTB_Phospho_1 3 9 PF10480 0.425
LIG_SH2_NCK_1 128 132 PF00017 0.289
LIG_SH2_STAP1 128 132 PF00017 0.289
LIG_SH2_STAT3 92 95 PF00017 0.335
LIG_SH2_STAT5 15 18 PF00017 0.420
LIG_SH2_STAT5 42 45 PF00017 0.543
LIG_SUMO_SIM_anti_2 76 81 PF11976 0.335
LIG_SUMO_SIM_par_1 76 81 PF11976 0.449
LIG_TYR_ITSM 55 62 PF00017 0.588
MOD_CK1_1 65 71 PF00069 0.335
MOD_CK2_1 123 129 PF00069 0.531
MOD_GlcNHglycan 18 21 PF01048 0.389
MOD_GlcNHglycan 64 67 PF01048 0.376
MOD_GlcNHglycan 95 98 PF01048 0.335
MOD_GSK3_1 65 72 PF00069 0.341
MOD_N-GLC_1 86 91 PF02516 0.510
MOD_NEK2_1 16 21 PF00069 0.439
MOD_NEK2_1 69 74 PF00069 0.347
MOD_Plk_1 86 92 PF00069 0.312
MOD_Plk_4 4 10 PF00069 0.360
MOD_Plk_4 69 75 PF00069 0.310
MOD_Plk_4 78 84 PF00069 0.368
MOD_Plk_4 87 93 PF00069 0.262
TRG_ENDOCYTIC_2 15 18 PF00928 0.363
TRG_ENDOCYTIC_2 59 62 PF00928 0.585
TRG_ER_diArg_1 49 51 PF00400 0.587
TRG_ER_diLys_1 144 148 PF00400 0.371

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I454 Leptomonas seymouri 59% 100%
A0A0S4J9A3 Bodo saltans 36% 97%
A0A1X0P5Z3 Trypanosomatidae 39% 98%
A0A3S7XA03 Leishmania donovani 100% 100%
A0A422P158 Trypanosoma rangeli 39% 100%
A4HNE0 Leishmania braziliensis 87% 100%
C9ZYI9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 97%
E9B704 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q9N6L8 Leishmania major 98% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS