Putative MCAK-like kinesin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinesin-13 6 - putative

Species:

Leishmania infantum

UniProt:

A4IC09_LEIIN

TriTrypDb:

LINF_350052800

Length:

480

Annotations

Annotations by Jardim et al.

Structural Proteins, MCAK-like kinesin

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005871	kinesin complex	3	1
GO:0005874	microtubule	6	6
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	6

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Expansion

Sequence features

A4IC09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC09

Function

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Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003774	cytoskeletal motor activity	1	12
GO:0003777	microtubule motor activity	2	12
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005524	ATP binding	5	12
GO:0008017	microtubule binding	5	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0015631	tubulin binding	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	45	49	PF00656	0.412
CLV_NRD_NRD_1	321	323	PF00675	0.316
CLV_NRD_NRD_1	338	340	PF00675	0.246
CLV_NRD_NRD_1	430	432	PF00675	0.401
CLV_NRD_NRD_1	462	464	PF00675	0.520
CLV_PCSK_KEX2_1	321	323	PF00082	0.316
CLV_PCSK_KEX2_1	338	340	PF00082	0.246
CLV_PCSK_KEX2_1	430	432	PF00082	0.401
CLV_PCSK_KEX2_1	453	455	PF00082	0.517
CLV_PCSK_KEX2_1	470	472	PF00082	0.669

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P6	Leptomonas seymouri	34%	72%
A0A0N0P959	Leptomonas seymouri	88%	100%
A0A0S4IYI8	Bodo saltans	33%	78%
A0A0S4J1I2	Bodo saltans	27%	73%
A0A0S4J971	Bodo saltans	62%	87%
A0A0S4JLC6	Bodo saltans	26%	86%
A0A0S4JMJ1	Bodo saltans	25%	79%
A0A1X0NIJ1	Trypanosomatidae	30%	82%
A0A1X0NL76	Trypanosomatidae	34%	67%
A0A1X0NNY0	Trypanosomatidae	33%	73%

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