Putative small nuclear RNA gene activation protein (SNAP) 50

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4IC05_LEIIN

TriTrypDb:

Length:

430

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005667	transcription regulator complex	2	1
GO:0019185	snRNA-activating protein complex	3	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

A4IC05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC05

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006351	DNA-templated transcription	7	1
GO:0006366	transcription by RNA polymerase II	8	1
GO:0006383	transcription by RNA polymerase III	8	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009301	snRNA transcription	8	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016073	snRNA metabolic process	7	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0032774	RNA biosynthetic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0034660	ncRNA metabolic process	6	1
GO:0042795	snRNA transcription by RNA polymerase II	9	1
GO:0042796	snRNA transcription by RNA polymerase III	9	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0097659	nucleic acid-templated transcription	6	1
GO:0098781	ncRNA transcription	8	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0000976	transcription cis-regulatory region binding	5	1
GO:0000987	cis-regulatory region sequence-specific DNA binding	6	1
GO:0000992	RNA polymerase III cis-regulatory region sequence-specific DNA binding	7	1
GO:0001006	RNA polymerase III type 3 promoter sequence-specific DNA binding	8	1
GO:0001016	RNA polymerase III transcription regulatory region sequence-specific DNA binding	6	1
GO:0001067	transcription regulatory region nucleic acid binding	4	1
GO:0003681	bent DNA binding	5	1
GO:0003690	double-stranded DNA binding	5	1
GO:0043565	sequence-specific DNA binding	5	1
GO:1990837	sequence-specific double-stranded DNA binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	348	350	PF00675	0.363
CLV_NRD_NRD_1	367	369	PF00675	0.353
CLV_NRD_NRD_1	4	6	PF00675	0.478
CLV_NRD_NRD_1	416	418	PF00675	0.542
CLV_NRD_NRD_1	95	97	PF00675	0.479
CLV_PCSK_KEX2_1	192	194	PF00082	0.480
CLV_PCSK_KEX2_1	367	369	PF00082	0.353
CLV_PCSK_KEX2_1	4	6	PF00082	0.475
CLV_PCSK_KEX2_1	416	418	PF00082	0.542
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.480
CLV_PCSK_PC7_1	363	369	PF00082	0.416
CLV_PCSK_SKI1_1	251	255	PF00082	0.287
CLV_PCSK_SKI1_1	358	362	PF00082	0.286
CLV_PCSK_SKI1_1	368	372	PF00082	0.298
CLV_PCSK_SKI1_1	417	421	PF00082	0.485
DEG_APCC_DBOX_1	367	375	PF00400	0.427
DEG_APCC_KENBOX_2	165	169	PF00400	0.393
DEG_SPOP_SBC_1	246	250	PF00917	0.345
DOC_MAPK_gen_1	130	140	PF00069	0.493
DOC_MAPK_gen_1	40	47	PF00069	0.530
DOC_MAPK_gen_1	416	427	PF00069	0.501
DOC_MAPK_MEF2A_6	130	138	PF00069	0.482
DOC_MAPK_MEF2A_6	40	47	PF00069	0.578
DOC_PP4_FxxP_1	292	295	PF00568	0.207
DOC_USP7_MATH_1	25	29	PF00917	0.524
DOC_USP7_MATH_1	304	308	PF00917	0.366
DOC_WW_Pin1_4	182	187	PF00397	0.578
DOC_WW_Pin1_4	384	389	PF00397	0.287
DOC_WW_Pin1_4	404	409	PF00397	0.145
DOC_WW_Pin1_4	49	54	PF00397	0.576
LIG_14-3-3_CanoR_1	96	106	PF00244	0.578
LIG_Actin_WH2_2	3	21	PF00022	0.447
LIG_APCC_ABBA_1	379	384	PF00400	0.416
LIG_BRCT_BRCA1_1	389	393	PF00533	0.416
LIG_FHA_1	100	106	PF00498	0.435
LIG_FHA_1	376	382	PF00498	0.370
LIG_FHA_2	189	195	PF00498	0.437
LIG_FHA_2	405	411	PF00498	0.370
LIG_HP1_1	230	234	PF01393	0.345
LIG_LIR_Apic_2	290	295	PF02991	0.207
LIG_LIR_Gen_1	221	231	PF02991	0.326
LIG_LIR_Gen_1	272	280	PF02991	0.321
LIG_LIR_Nem_3	197	202	PF02991	0.509
LIG_LIR_Nem_3	221	226	PF02991	0.326
LIG_LIR_Nem_3	272	276	PF02991	0.321
LIG_LIR_Nem_3	310	316	PF02991	0.290
LIG_LIR_Nem_3	333	338	PF02991	0.337
LIG_LIR_Nem_3	421	425	PF02991	0.479
LIG_OCRL_FandH_1	253	265	PF00620	0.397
LIG_Pex14_1	81	85	PF04695	0.536
LIG_SH2_CRK	199	203	PF00017	0.426
LIG_SH2_CRK	394	398	PF00017	0.272
LIG_SH2_SRC	382	385	PF00017	0.416
LIG_SH2_STAT5	199	202	PF00017	0.520
LIG_SH2_STAT5	262	265	PF00017	0.306
LIG_SH2_STAT5	335	338	PF00017	0.281
LIG_SH2_STAT5	394	397	PF00017	0.273
LIG_SH2_STAT5	426	429	PF00017	0.466
LIG_SH3_1	382	388	PF00018	0.416
LIG_SH3_3	31	37	PF00018	0.460
LIG_SH3_3	38	44	PF00018	0.419
LIG_SH3_3	382	388	PF00018	0.283
LIG_SH3_3	8	14	PF00018	0.359
LIG_SUMO_SIM_par_1	134	139	PF11976	0.430
LIG_SUMO_SIM_par_1	230	236	PF11976	0.345
LIG_SUMO_SIM_par_1	377	384	PF11976	0.416
LIG_SUMO_SIM_par_1	43	48	PF11976	0.555
LIG_TRAF2_1	14	17	PF00917	0.547
LIG_TRAF2_1	149	152	PF00917	0.535
LIG_TRAF2_1	407	410	PF00917	0.422
LIG_WRC_WIRS_1	161	166	PF05994	0.587
LIG_WW_3	93	97	PF00397	0.571
MOD_CK1_1	129	135	PF00069	0.393
MOD_CK1_1	178	184	PF00069	0.501
MOD_CK1_1	188	194	PF00069	0.406
MOD_CK1_1	387	393	PF00069	0.287
MOD_CK1_1	404	410	PF00069	0.287
MOD_CK1_1	76	82	PF00069	0.526
MOD_CK2_1	304	310	PF00069	0.386
MOD_CK2_1	404	410	PF00069	0.370
MOD_CK2_1	76	82	PF00069	0.526
MOD_CK2_1	97	103	PF00069	0.452
MOD_GlcNHglycan	306	309	PF01048	0.416
MOD_GlcNHglycan	344	347	PF01048	0.295
MOD_GlcNHglycan	403	406	PF01048	0.388
MOD_GlcNHglycan	61	64	PF01048	0.518
MOD_GSK3_1	178	185	PF00069	0.504
MOD_GSK3_1	304	311	PF00069	0.407
MOD_GSK3_1	336	343	PF00069	0.287
MOD_GSK3_1	73	80	PF00069	0.564
MOD_LATS_1	340	346	PF00433	0.345
MOD_NEK2_1	247	252	PF00069	0.416
MOD_NEK2_1	320	325	PF00069	0.393
MOD_NEK2_1	336	341	PF00069	0.187
MOD_NEK2_1	73	78	PF00069	0.553
MOD_NEK2_2	160	165	PF00069	0.588
MOD_PIKK_1	97	103	PF00454	0.516
MOD_PKA_2	129	135	PF00069	0.480
MOD_Plk_1	150	156	PF00069	0.476
MOD_Plk_1	287	293	PF00069	0.458
MOD_Plk_4	73	79	PF00069	0.599
MOD_ProDKin_1	182	188	PF00069	0.569
MOD_ProDKin_1	384	390	PF00069	0.287
MOD_ProDKin_1	404	410	PF00069	0.145
MOD_ProDKin_1	49	55	PF00069	0.571
MOD_SUMO_for_1	164	167	PF00179	0.512
MOD_SUMO_rev_2	129	135	PF00179	0.370
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.490
TRG_ENDOCYTIC_2	199	202	PF00928	0.520
TRG_ENDOCYTIC_2	335	338	PF00928	0.299
TRG_ENDOCYTIC_2	394	397	PF00928	0.393
TRG_ER_diArg_1	3	5	PF00400	0.469
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JRS6	Bodo saltans	31%	89%
A0A1X0P603	Trypanosomatidae	40%	94%
A0A3Q8IJI9	Leishmania donovani	100%	100%
A0A3R7KX62	Trypanosoma rangeli	40%	97%
A4HND3	Leishmania braziliensis	90%	100%
C9ZYK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	96%
E9AFU3	Leishmania major	94%	100%
E9B6Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q8IS08	Leptomonas seymouri	72%	90%
V5BCJ0	Trypanosoma cruzi	40%	97%