LeishMANIAdb
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Coiled-coil domain-containing protein 86

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Coiled-coil domain-containing protein 86
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IC03_LEIIN
TriTrypDb:
LINF_350052200
Length:
114

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 9
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 8
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 8
GO:0043229 intracellular organelle 3 9
GO:0043231 intracellular membrane-bounded organelle 4 8
GO:0110165 cellular anatomical entity 1 9
GO:0005730 nucleolus 5 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1

Expansion

Sequence features

A4IC03
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC03

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 102 104 PF00675 0.260
CLV_NRD_NRD_1 67 69 PF00675 0.293
CLV_NRD_NRD_1 73 75 PF00675 0.283
CLV_NRD_NRD_1 94 96 PF00675 0.298
CLV_PCSK_KEX2_1 102 104 PF00082 0.404
CLV_PCSK_KEX2_1 62 64 PF00082 0.341
CLV_PCSK_PC1ET2_1 62 64 PF00082 0.289
CLV_PCSK_SKI1_1 35 39 PF00082 0.267
DOC_CYCLIN_yClb5_NLxxxL_5 45 53 PF00134 0.292
DOC_USP7_UBL2_3 26 30 PF12436 0.304
DOC_USP7_UBL2_3 36 40 PF12436 0.295
DOC_USP7_UBL2_3 92 96 PF12436 0.285
DOC_WW_Pin1_4 95 100 PF00397 0.271
LIG_BIR_II_1 1 5 PF00653 0.678
MOD_CDK_SPK_2 95 100 PF00069 0.271
MOD_CDK_SPxxK_3 95 102 PF00069 0.271
MOD_N-GLC_1 47 52 PF02516 0.363
MOD_PIKK_1 47 53 PF00454 0.404
MOD_PKB_1 45 53 PF00069 0.271
MOD_Plk_4 79 85 PF00069 0.215
MOD_ProDKin_1 95 101 PF00069 0.271
MOD_SUMO_for_1 2 5 PF00179 0.631
MOD_SUMO_for_1 53 56 PF00179 0.335
MOD_SUMO_for_1 88 91 PF00179 0.404
MOD_SUMO_rev_2 55 64 PF00179 0.289
MOD_SUMO_rev_2 77 83 PF00179 0.311
TRG_Pf-PMV_PEXEL_1 47 51 PF00026 0.367

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMV4 Leptomonas seymouri 83% 100%
A0A0S4JUA2 Bodo saltans 66% 100%
A0A1X0P578 Trypanosomatidae 63% 100%
A0A3R7NTL4 Trypanosoma rangeli 57% 100%
A0A3S7X9Z5 Leishmania donovani 100% 100%
A4HND1 Leishmania braziliensis 90% 100%
C9ZYK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 70%
E9AFU1 Leishmania major 96% 100%
E9B6Z3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS