Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IC01_LEIIN

TriTrypDb:

LINF_350051900

Length:

287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IC01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC01

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.396
CLV_NRD_NRD_1	152	154	PF00675	0.472
CLV_NRD_NRD_1	199	201	PF00675	0.503
CLV_NRD_NRD_1	203	205	PF00675	0.407
CLV_PCSK_KEX2_1	199	201	PF00082	0.503
CLV_PCSK_KEX2_1	203	205	PF00082	0.576
CLV_PCSK_PC7_1	199	205	PF00082	0.546
CLV_PCSK_SKI1_1	194	198	PF00082	0.528
CLV_PCSK_SKI1_1	82	86	PF00082	0.395
CLV_Separin_Metazoa	217	221	PF03568	0.522
DOC_CYCLIN_RxL_1	79	87	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	278	284	PF00134	0.404
DOC_MAPK_gen_1	153	161	PF00069	0.474
DOC_PP4_FxxP_1	226	229	PF00568	0.511
DOC_USP7_MATH_1	256	260	PF00917	0.420
DOC_USP7_UBL2_3	11	15	PF12436	0.547
DOC_USP7_UBL2_3	82	86	PF12436	0.404
DOC_WW_Pin1_4	140	145	PF00397	0.583
DOC_WW_Pin1_4	2	7	PF00397	0.632
DOC_WW_Pin1_4	254	259	PF00397	0.460
DOC_WW_Pin1_4	44	49	PF00397	0.524
DOC_WW_Pin1_4	99	104	PF00397	0.469
LIG_14-3-3_CanoR_1	41	45	PF00244	0.420
LIG_14-3-3_CanoR_1	65	70	PF00244	0.405
LIG_BIR_II_1	1	5	PF00653	0.612
LIG_Clathr_ClatBox_1	30	34	PF01394	0.537
LIG_deltaCOP1_diTrp_1	162	167	PF00928	0.505
LIG_EVH1_2	50	54	PF00568	0.494
LIG_FHA_1	100	106	PF00498	0.540
LIG_FHA_1	245	251	PF00498	0.380
LIG_FHA_1	3	9	PF00498	0.564
LIG_FHA_1	41	47	PF00498	0.423
LIG_FHA_2	274	280	PF00498	0.512
LIG_HCF-1_HBM_1	176	179	PF13415	0.476
LIG_LIR_Gen_1	71	80	PF02991	0.504
LIG_LIR_Gen_1	87	95	PF02991	0.361
LIG_LIR_Nem_3	109	113	PF02991	0.467
LIG_LIR_Nem_3	162	167	PF02991	0.448
LIG_LIR_Nem_3	176	182	PF02991	0.358
LIG_LIR_Nem_3	231	236	PF02991	0.444
LIG_LIR_Nem_3	243	248	PF02991	0.381
LIG_LIR_Nem_3	71	75	PF02991	0.511
LIG_LIR_Nem_3	87	92	PF02991	0.355
LIG_PCNA_PIPBox_1	216	225	PF02747	0.429
LIG_PTB_Apo_2	61	68	PF02174	0.378
LIG_PTB_Phospho_1	61	67	PF10480	0.374
LIG_REV1ctd_RIR_1	282	287	PF16727	0.428
LIG_SH2_CRK	67	71	PF00017	0.412
LIG_SH2_NCK_1	67	71	PF00017	0.431
LIG_SH2_STAP1	180	184	PF00017	0.439
LIG_SH2_STAT3	261	264	PF00017	0.408
LIG_SH2_STAT5	107	110	PF00017	0.431
LIG_SH2_STAT5	261	264	PF00017	0.408
LIG_SH2_STAT5	67	70	PF00017	0.414
LIG_SH3_2	48	53	PF14604	0.543
LIG_SH3_2	6	11	PF14604	0.546
LIG_SH3_3	138	144	PF00018	0.485
LIG_SH3_3	3	9	PF00018	0.560
LIG_SH3_3	45	51	PF00018	0.542
LIG_SUMO_SIM_anti_2	28	34	PF11976	0.445
LIG_SUMO_SIM_par_1	157	162	PF11976	0.419
LIG_SUMO_SIM_par_1	28	34	PF11976	0.445
LIG_TRAF2_1	212	215	PF00917	0.507
LIG_TYR_ITIM	75	80	PF00017	0.481
MOD_CDC14_SPxK_1	257	260	PF00782	0.466
MOD_CDK_SPxK_1	254	260	PF00069	0.480
MOD_CK1_1	2	8	PF00069	0.657
MOD_CK1_1	78	84	PF00069	0.374
MOD_CK2_1	209	215	PF00069	0.527
MOD_CK2_1	274	280	PF00069	0.485
MOD_CK2_1	49	55	PF00069	0.562
MOD_GlcNHglycan	167	170	PF01048	0.388
MOD_GSK3_1	236	243	PF00069	0.340
MOD_GSK3_1	40	47	PF00069	0.414
MOD_N-GLC_1	236	241	PF02516	0.368
MOD_N-GLC_1	99	104	PF02516	0.469
MOD_NEK2_1	165	170	PF00069	0.388
MOD_NEK2_1	240	245	PF00069	0.391
MOD_NEK2_1	266	271	PF00069	0.554
MOD_NEK2_1	273	278	PF00069	0.209
MOD_NEK2_1	84	89	PF00069	0.410
MOD_PKA_1	199	205	PF00069	0.511
MOD_PKA_2	199	205	PF00069	0.498
MOD_PKA_2	40	46	PF00069	0.419
MOD_Plk_2-3	157	163	PF00069	0.453
MOD_Plk_4	236	242	PF00069	0.355
MOD_Plk_4	25	31	PF00069	0.509
MOD_Plk_4	75	81	PF00069	0.383
MOD_ProDKin_1	140	146	PF00069	0.582
MOD_ProDKin_1	2	8	PF00069	0.624
MOD_ProDKin_1	254	260	PF00069	0.457
MOD_ProDKin_1	44	50	PF00069	0.524
MOD_ProDKin_1	99	105	PF00069	0.462
TRG_ENDOCYTIC_2	107	110	PF00928	0.431
TRG_ENDOCYTIC_2	179	182	PF00928	0.400
TRG_ENDOCYTIC_2	248	251	PF00928	0.501
TRG_ENDOCYTIC_2	77	80	PF00928	0.382
TRG_Pf-PMV_PEXEL_1	133	138	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I461	Leptomonas seymouri	79%	100%
A0A0S4JTE6	Bodo saltans	43%	93%
A0A1X0P4X8	Trypanosomatidae	54%	100%
A0A3Q8IVK6	Leishmania donovani	100%	100%
A4HNC8	Leishmania braziliensis	89%	100%
C9ZYK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	91%
E9AFT8	Leishmania major	96%	100%
E9B6Z0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BXR3	Trypanosoma cruzi	56%	100%