LeishMANIAdb
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C2H2-type domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
C2H2-type domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IC00_LEIIN
TriTrypDb:
LINF_350051800
Length:
512

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IC00
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC00

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 213 217 PF00656 0.662
CLV_C14_Caspase3-7 396 400 PF00656 0.689
CLV_C14_Caspase3-7 455 459 PF00656 0.521
CLV_C14_Caspase3-7 88 92 PF00656 0.561
CLV_NRD_NRD_1 21 23 PF00675 0.492
CLV_NRD_NRD_1 426 428 PF00675 0.630
CLV_NRD_NRD_1 462 464 PF00675 0.567
CLV_PCSK_FUR_1 324 328 PF00082 0.456
CLV_PCSK_KEX2_1 127 129 PF00082 0.613
CLV_PCSK_KEX2_1 23 25 PF00082 0.434
CLV_PCSK_KEX2_1 326 328 PF00082 0.536
CLV_PCSK_KEX2_1 461 463 PF00082 0.604
CLV_PCSK_PC1ET2_1 127 129 PF00082 0.602
CLV_PCSK_PC1ET2_1 23 25 PF00082 0.434
CLV_PCSK_PC1ET2_1 326 328 PF00082 0.536
CLV_PCSK_PC7_1 457 463 PF00082 0.450
CLV_PCSK_SKI1_1 110 114 PF00082 0.708
CLV_PCSK_SKI1_1 127 131 PF00082 0.455
CLV_PCSK_SKI1_1 200 204 PF00082 0.613
CLV_PCSK_SKI1_1 462 466 PF00082 0.606
CLV_PCSK_SKI1_1 75 79 PF00082 0.579
DEG_APCC_DBOX_1 74 82 PF00400 0.589
DEG_SPOP_SBC_1 506 510 PF00917 0.664
DOC_CYCLIN_RxL_1 197 207 PF00134 0.550
DOC_MAPK_gen_1 262 271 PF00069 0.549
DOC_USP7_MATH_1 105 109 PF00917 0.658
DOC_USP7_MATH_1 256 260 PF00917 0.608
DOC_USP7_MATH_1 282 286 PF00917 0.658
DOC_USP7_MATH_1 293 297 PF00917 0.682
DOC_USP7_MATH_1 346 350 PF00917 0.773
DOC_USP7_MATH_1 393 397 PF00917 0.588
DOC_USP7_MATH_1 506 510 PF00917 0.684
DOC_USP7_MATH_1 86 90 PF00917 0.674
DOC_USP7_UBL2_3 372 376 PF12436 0.535
DOC_USP7_UBL2_3 394 398 PF12436 0.660
DOC_WW_Pin1_4 285 290 PF00397 0.612
DOC_WW_Pin1_4 336 341 PF00397 0.640
DOC_WW_Pin1_4 403 408 PF00397 0.652
DOC_WW_Pin1_4 412 417 PF00397 0.695
DOC_WW_Pin1_4 95 100 PF00397 0.671
LIG_14-3-3_CanoR_1 327 335 PF00244 0.542
LIG_14-3-3_CanoR_1 498 504 PF00244 0.569
LIG_Actin_WH2_2 70 85 PF00022 0.627
LIG_APCC_ABBA_1 71 76 PF00400 0.553
LIG_BIR_II_1 1 5 PF00653 0.658
LIG_eIF4E_1 26 32 PF01652 0.528
LIG_FHA_1 124 130 PF00498 0.531
LIG_FHA_1 210 216 PF00498 0.552
LIG_FHA_1 230 236 PF00498 0.559
LIG_FHA_1 286 292 PF00498 0.613
LIG_FHA_2 350 356 PF00498 0.675
LIG_FHA_2 55 61 PF00498 0.525
LIG_LIR_Apic_2 500 504 PF02991 0.495
LIG_LIR_Nem_3 41 46 PF02991 0.565
LIG_NRBOX 112 118 PF00104 0.625
LIG_NRBOX 16 22 PF00104 0.542
LIG_NRBOX 187 193 PF00104 0.551
LIG_SH2_CRK 43 47 PF00017 0.583
LIG_SH2_CRK 501 505 PF00017 0.503
LIG_SH2_NCK_1 501 505 PF00017 0.503
LIG_SH2_STAT5 19 22 PF00017 0.498
LIG_SH3_3 117 123 PF00018 0.587
LIG_SH3_3 163 169 PF00018 0.525
LIG_SH3_3 287 293 PF00018 0.720
LIG_SH3_3 337 343 PF00018 0.657
LIG_SH3_3 417 423 PF00018 0.669
LIG_SH3_3 74 80 PF00018 0.490
LIG_TRAF2_1 252 255 PF00917 0.590
LIG_TRAF2_1 38 41 PF00917 0.546
LIG_TRAF2_1 45 48 PF00917 0.567
LIG_TRAF2_1 98 101 PF00917 0.551
LIG_UBA3_1 112 119 PF00899 0.560
LIG_UBA3_1 191 200 PF00899 0.650
LIG_UBA3_1 78 83 PF00899 0.517
MOD_CDK_SPxK_1 412 418 PF00069 0.676
MOD_CK1_1 194 200 PF00069 0.548
MOD_CK1_1 222 228 PF00069 0.699
MOD_CK1_1 285 291 PF00069 0.541
MOD_CK1_1 349 355 PF00069 0.633
MOD_CK1_1 401 407 PF00069 0.684
MOD_CK1_1 497 503 PF00069 0.644
MOD_CK1_1 85 91 PF00069 0.534
MOD_CK2_1 293 299 PF00069 0.651
MOD_CK2_1 327 333 PF00069 0.602
MOD_CK2_1 349 355 PF00069 0.597
MOD_CK2_1 54 60 PF00069 0.607
MOD_CK2_1 95 101 PF00069 0.669
MOD_GlcNHglycan 143 146 PF01048 0.785
MOD_GlcNHglycan 177 180 PF01048 0.584
MOD_GlcNHglycan 284 287 PF01048 0.620
MOD_GlcNHglycan 336 339 PF01048 0.503
MOD_GlcNHglycan 343 346 PF01048 0.718
MOD_GlcNHglycan 403 406 PF01048 0.703
MOD_GlcNHglycan 501 504 PF01048 0.581
MOD_GlcNHglycan 84 87 PF01048 0.683
MOD_GlcNHglycan 88 91 PF01048 0.697
MOD_GSK3_1 101 108 PF00069 0.720
MOD_GSK3_1 418 425 PF00069 0.735
MOD_GSK3_1 82 89 PF00069 0.652
MOD_GSK3_1 91 98 PF00069 0.656
MOD_N-GLC_1 101 106 PF02516 0.756
MOD_N-GLC_1 152 157 PF02516 0.777
MOD_NEK2_1 129 134 PF00069 0.652
MOD_NEK2_1 177 182 PF00069 0.591
MOD_NEK2_1 191 196 PF00069 0.567
MOD_NEK2_1 499 504 PF00069 0.574
MOD_NEK2_1 82 87 PF00069 0.560
MOD_NEK2_2 393 398 PF00069 0.573
MOD_PIKK_1 194 200 PF00454 0.527
MOD_PIKK_1 219 225 PF00454 0.529
MOD_PIKK_1 327 333 PF00454 0.600
MOD_PKA_2 141 147 PF00069 0.747
MOD_PKA_2 263 269 PF00069 0.499
MOD_PKA_2 497 503 PF00069 0.612
MOD_Plk_1 101 107 PF00069 0.775
MOD_Plk_1 152 158 PF00069 0.609
MOD_Plk_1 293 299 PF00069 0.710
MOD_Plk_1 398 404 PF00069 0.708
MOD_Plk_4 152 158 PF00069 0.606
MOD_Plk_4 177 183 PF00069 0.586
MOD_Plk_4 293 299 PF00069 0.598
MOD_ProDKin_1 285 291 PF00069 0.613
MOD_ProDKin_1 336 342 PF00069 0.644
MOD_ProDKin_1 403 409 PF00069 0.657
MOD_ProDKin_1 412 418 PF00069 0.689
MOD_ProDKin_1 95 101 PF00069 0.669
MOD_SUMO_rev_2 124 129 PF00179 0.576
MOD_SUMO_rev_2 421 429 PF00179 0.646
TRG_DiLeu_BaEn_1 125 130 PF01217 0.623
TRG_DiLeu_BaEn_4 299 305 PF01217 0.558
TRG_DiLeu_LyEn_5 125 130 PF01217 0.561
TRG_ENDOCYTIC_2 43 46 PF00928 0.583
TRG_ER_diArg_1 21 24 PF00400 0.495
TRG_ER_diArg_1 461 463 PF00400 0.556
TRG_ER_diArg_1 472 475 PF00400 0.472
TRG_NES_CRM1_1 380 395 PF08389 0.527
TRG_NES_CRM1_1 442 456 PF08389 0.558
TRG_Pf-PMV_PEXEL_1 110 114 PF00026 0.598
TRG_Pf-PMV_PEXEL_1 251 255 PF00026 0.524
TRG_Pf-PMV_PEXEL_1 314 318 PF00026 0.566
TRG_Pf-PMV_PEXEL_1 427 431 PF00026 0.550
TRG_Pf-PMV_PEXEL_1 462 466 PF00026 0.609

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P962 Leptomonas seymouri 48% 91%
A0A1X0P582 Trypanosomatidae 26% 100%
A0A3S7X9X8 Leishmania donovani 100% 100%
A4HNC7 Leishmania braziliensis 67% 100%
E9AFT7 Leishmania major 92% 100%
E9B6Y9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
V5C2K9 Trypanosoma cruzi 25% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS