Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IBZ3_LEIIN

TriTrypDb:

LINF_350051100

Length:

718

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBZ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	452	456	PF00656	0.521
CLV_NRD_NRD_1	307	309	PF00675	0.654
CLV_NRD_NRD_1	445	447	PF00675	0.588
CLV_NRD_NRD_1	543	545	PF00675	0.630
CLV_NRD_NRD_1	558	560	PF00675	0.705
CLV_NRD_NRD_1	76	78	PF00675	0.502
CLV_PCSK_KEX2_1	306	308	PF00082	0.554
CLV_PCSK_KEX2_1	419	421	PF00082	0.627
CLV_PCSK_KEX2_1	445	447	PF00082	0.588
CLV_PCSK_KEX2_1	543	545	PF00082	0.620
CLV_PCSK_KEX2_1	76	78	PF00082	0.450
CLV_PCSK_PC1ET2_1	419	421	PF00082	0.535
CLV_PCSK_SKI1_1	183	187	PF00082	0.408
CLV_PCSK_SKI1_1	401	405	PF00082	0.452
CLV_PCSK_SKI1_1	537	541	PF00082	0.562
CLV_PCSK_SKI1_1	606	610	PF00082	0.437
DEG_APCC_DBOX_1	307	315	PF00400	0.471
DEG_APCC_DBOX_1	390	398	PF00400	0.429
DEG_APCC_DBOX_1	543	551	PF00400	0.591
DEG_SPOP_SBC_1	374	378	PF00917	0.443
DEG_SPOP_SBC_1	513	517	PF00917	0.546
DOC_CYCLIN_RxL_1	602	612	PF00134	0.452
DOC_CYCLIN_yCln2_LP_2	88	94	PF00134	0.483
DOC_MAPK_gen_1	306	314	PF00069	0.492
DOC_MAPK_gen_1	691	700	PF00069	0.504
DOC_MAPK_MEF2A_6	307	316	PF00069	0.430
DOC_MAPK_MEF2A_6	691	700	PF00069	0.472
DOC_MAPK_NFAT4_5	693	701	PF00069	0.463
DOC_MAPK_RevD_3	404	420	PF00069	0.428
DOC_PP1_RVXF_1	84	90	PF00149	0.410
DOC_PP4_FxxP_1	226	229	PF00568	0.355
DOC_PP4_FxxP_1	539	542	PF00568	0.498
DOC_USP7_MATH_1	112	116	PF00917	0.734
DOC_USP7_MATH_1	218	222	PF00917	0.441
DOC_USP7_MATH_1	301	305	PF00917	0.760
DOC_USP7_MATH_1	348	352	PF00917	0.489
DOC_USP7_MATH_1	373	377	PF00917	0.477
DOC_USP7_MATH_1	482	486	PF00917	0.507
DOC_USP7_MATH_1	512	516	PF00917	0.625
DOC_USP7_MATH_1	524	528	PF00917	0.567
DOC_USP7_MATH_1	572	576	PF00917	0.762
DOC_WW_Pin1_4	329	334	PF00397	0.750
DOC_WW_Pin1_4	538	543	PF00397	0.728
DOC_WW_Pin1_4	564	569	PF00397	0.726
DOC_WW_Pin1_4	578	583	PF00397	0.577
DOC_WW_Pin1_4	635	640	PF00397	0.442
DOC_WW_Pin1_4	649	654	PF00397	0.416
LIG_14-3-3_CanoR_1	685	694	PF00244	0.485
LIG_Actin_WH2_2	168	185	PF00022	0.463
LIG_Actin_WH2_2	390	407	PF00022	0.410
LIG_AP2alpha_1	661	665	PF02296	0.383
LIG_BIR_III_2	212	216	PF00653	0.483
LIG_BRCT_BRCA1_1	526	530	PF00533	0.593
LIG_BRCT_BRCA1_1	633	637	PF00533	0.400
LIG_Clathr_ClatBox_1	468	472	PF01394	0.330
LIG_CtBP_PxDLS_1	70	76	PF00389	0.459
LIG_EH1_1	172	180	PF00400	0.421
LIG_eIF4E_1	78	84	PF01652	0.504
LIG_FHA_1	117	123	PF00498	0.641
LIG_FHA_1	134	140	PF00498	0.233
LIG_FHA_1	157	163	PF00498	0.455
LIG_FHA_1	376	382	PF00498	0.478
LIG_FHA_1	488	494	PF00498	0.521
LIG_FHA_1	515	521	PF00498	0.541
LIG_FHA_1	578	584	PF00498	0.645
LIG_FHA_1	676	682	PF00498	0.332
LIG_FHA_1	83	89	PF00498	0.428
LIG_FHA_2	103	109	PF00498	0.695
LIG_FHA_2	152	158	PF00498	0.591
LIG_FHA_2	24	30	PF00498	0.474
LIG_FHA_2	590	596	PF00498	0.605
LIG_FHA_2	687	693	PF00498	0.573
LIG_Integrin_isoDGR_2	422	424	PF01839	0.506
LIG_IRF3_LxIS_1	402	407	PF10401	0.328
LIG_LIR_Gen_1	247	257	PF02991	0.516
LIG_LIR_Gen_1	310	321	PF02991	0.401
LIG_LIR_Gen_1	464	471	PF02991	0.388
LIG_LIR_Gen_1	509	518	PF02991	0.635
LIG_LIR_Gen_1	527	536	PF02991	0.645
LIG_LIR_LC3C_4	622	625	PF02991	0.450
LIG_LIR_Nem_3	247	252	PF02991	0.471
LIG_LIR_Nem_3	310	316	PF02991	0.379
LIG_LIR_Nem_3	464	468	PF02991	0.411
LIG_LIR_Nem_3	509	513	PF02991	0.707
LIG_LIR_Nem_3	527	533	PF02991	0.611
LIG_NRBOX	696	702	PF00104	0.454
LIG_NRBOX	83	89	PF00104	0.411
LIG_PCNA_PIPBox_1	219	228	PF02747	0.426
LIG_PCNA_yPIPBox_3	424	436	PF02747	0.618
LIG_Pex14_1	359	363	PF04695	0.463
LIG_Pex14_2	657	661	PF04695	0.389
LIG_SH2_CRK	249	253	PF00017	0.489
LIG_SH2_STAT5	393	396	PF00017	0.427
LIG_SH2_STAT5	658	661	PF00017	0.445
LIG_SH3_3	212	218	PF00018	0.491
LIG_SH3_3	31	37	PF00018	0.465
LIG_SH3_3	565	571	PF00018	0.660
LIG_SH3_3	630	636	PF00018	0.411
LIG_SH3_3	88	94	PF00018	0.387
LIG_Sin3_3	621	628	PF02671	0.464
LIG_SUMO_SIM_anti_2	156	164	PF11976	0.462
LIG_SUMO_SIM_anti_2	64	70	PF11976	0.438
LIG_SUMO_SIM_par_1	131	136	PF11976	0.434
LIG_SUMO_SIM_par_1	467	473	PF11976	0.340
LIG_TRAF2_1	439	442	PF00917	0.487
LIG_UBA3_1	696	704	PF00899	0.486
MOD_CDC14_SPxK_1	541	544	PF00782	0.516
MOD_CDK_SPK_2	538	543	PF00069	0.476
MOD_CDK_SPxK_1	538	544	PF00069	0.507
MOD_CK1_1	102	108	PF00069	0.743
MOD_CK1_1	128	134	PF00069	0.573
MOD_CK1_1	167	173	PF00069	0.535
MOD_CK1_1	247	253	PF00069	0.562
MOD_CK1_1	270	276	PF00069	0.638
MOD_CK1_1	283	289	PF00069	0.546
MOD_CK1_1	376	382	PF00069	0.455
MOD_CK1_1	449	455	PF00069	0.550
MOD_CK1_1	516	522	PF00069	0.646
MOD_CK1_1	564	570	PF00069	0.798
MOD_CK1_1	576	582	PF00069	0.622
MOD_CK1_1	586	592	PF00069	0.571
MOD_CK1_1	7	13	PF00069	0.645
MOD_CK2_1	102	108	PF00069	0.760
MOD_CK2_1	23	29	PF00069	0.469
MOD_CK2_1	589	595	PF00069	0.595
MOD_GlcNHglycan	110	113	PF01048	0.702
MOD_GlcNHglycan	116	119	PF01048	0.706
MOD_GlcNHglycan	189	192	PF01048	0.637
MOD_GlcNHglycan	196	199	PF01048	0.707
MOD_GlcNHglycan	257	260	PF01048	0.695
MOD_GlcNHglycan	272	275	PF01048	0.538
MOD_GlcNHglycan	288	291	PF01048	0.703
MOD_GlcNHglycan	299	302	PF01048	0.604
MOD_GlcNHglycan	316	319	PF01048	0.300
MOD_GlcNHglycan	336	339	PF01048	0.697
MOD_GlcNHglycan	406	409	PF01048	0.477
MOD_GlcNHglycan	472	475	PF01048	0.427
MOD_GlcNHglycan	484	487	PF01048	0.514
MOD_GlcNHglycan	55	58	PF01048	0.351
MOD_GlcNHglycan	9	12	PF01048	0.710
MOD_GSK3_1	108	115	PF00069	0.637
MOD_GSK3_1	18	25	PF00069	0.503
MOD_GSK3_1	231	238	PF00069	0.492
MOD_GSK3_1	244	251	PF00069	0.493
MOD_GSK3_1	297	304	PF00069	0.654
MOD_GSK3_1	325	332	PF00069	0.624
MOD_GSK3_1	373	380	PF00069	0.491
MOD_GSK3_1	508	515	PF00069	0.609
MOD_GSK3_1	572	579	PF00069	0.730
MOD_GSK3_1	585	592	PF00069	0.676
MOD_GSK3_1	631	638	PF00069	0.421
MOD_GSK3_1	681	688	PF00069	0.459
MOD_N-GLC_1	102	107	PF02516	0.695
MOD_N-GLC_1	235	240	PF02516	0.565
MOD_N-GLC_1	446	451	PF02516	0.594
MOD_N-GLC_1	513	518	PF02516	0.696
MOD_N-GLC_1	583	588	PF02516	0.706
MOD_N-GLC_2	341	343	PF02516	0.582
MOD_NEK2_1	252	257	PF00069	0.638
MOD_NEK2_1	296	301	PF00069	0.753
MOD_NEK2_1	312	317	PF00069	0.373
MOD_NEK2_1	395	400	PF00069	0.419
MOD_NEK2_1	4	9	PF00069	0.730
MOD_NEK2_1	404	409	PF00069	0.464
MOD_NEK2_1	415	420	PF00069	0.292
MOD_NEK2_1	573	578	PF00069	0.700
MOD_NEK2_1	609	614	PF00069	0.376
MOD_NEK2_1	623	628	PF00069	0.331
MOD_NEK2_1	681	686	PF00069	0.461
MOD_NEK2_2	686	691	PF00069	0.544
MOD_PIKK_1	396	402	PF00454	0.483
MOD_PIKK_1	422	428	PF00454	0.583
MOD_PIKK_1	449	455	PF00454	0.667
MOD_PIKK_1	487	493	PF00454	0.517
MOD_PIKK_1	545	551	PF00454	0.594
MOD_PIKK_1	71	77	PF00454	0.539
MOD_PK_1	5	11	PF00069	0.585
MOD_PKA_2	404	410	PF00069	0.426
MOD_Plk_1	156	162	PF00069	0.440
MOD_Plk_1	167	173	PF00069	0.483
MOD_Plk_1	531	537	PF00069	0.524
MOD_Plk_1	583	589	PF00069	0.705
MOD_Plk_1	595	601	PF00069	0.595
MOD_Plk_4	128	134	PF00069	0.452
MOD_Plk_4	18	24	PF00069	0.575
MOD_Plk_4	218	224	PF00069	0.372
MOD_Plk_4	244	250	PF00069	0.455
MOD_Plk_4	377	383	PF00069	0.489
MOD_Plk_4	668	674	PF00069	0.541
MOD_ProDKin_1	329	335	PF00069	0.745
MOD_ProDKin_1	538	544	PF00069	0.732
MOD_ProDKin_1	564	570	PF00069	0.728
MOD_ProDKin_1	578	584	PF00069	0.578
MOD_ProDKin_1	635	641	PF00069	0.448
MOD_ProDKin_1	649	655	PF00069	0.416
MOD_SUMO_rev_2	234	239	PF00179	0.504
TRG_DiLeu_BaLyEn_6	696	701	PF01217	0.494
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.394
TRG_ENDOCYTIC_2	249	252	PF00928	0.563
TRG_ENDOCYTIC_2	658	661	PF00928	0.445
TRG_ER_diArg_1	306	308	PF00400	0.593
TRG_ER_diArg_1	542	544	PF00400	0.560
TRG_ER_diArg_1	76	78	PF00400	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMN1	Leptomonas seymouri	53%	98%
A0A1X0P552	Trypanosomatidae	29%	100%
A0A3Q8IIF7	Leishmania donovani	100%	100%
A4HNC0	Leishmania braziliensis	72%	100%
C9ZYL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AFT0	Leishmania major	91%	100%
E9B6Y2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%