DUF962-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF962) - putative

Species:

Leishmania infantum

UniProt:

A4IBZ2_LEIIN

TriTrypDb:

LINF_350051000

Length:

218

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0016020	membrane	2	7
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4IBZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBZ2

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006643	membrane lipid metabolic process	4	1
GO:0006665	sphingolipid metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0016042	lipid catabolic process	4	1
GO:0030149	sphingolipid catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0046466	membrane lipid catabolic process	5	1
GO:0046519	sphingoid metabolic process	5	1
GO:0046521	sphingoid catabolic process	6	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.531
CLV_NRD_NRD_1	206	208	PF00675	0.431
CLV_PCSK_KEX2_1	206	208	PF00082	0.431
CLV_PCSK_SKI1_1	167	171	PF00082	0.374
CLV_PCSK_SKI1_1	207	211	PF00082	0.362
DEG_Nend_Nbox_1	1	3	PF02207	0.433
DOC_CKS1_1	79	84	PF01111	0.236
DOC_CYCLIN_yCln2_LP_2	79	85	PF00134	0.392
DOC_PP2B_PxIxI_1	81	87	PF00149	0.236
DOC_USP7_MATH_1	192	196	PF00917	0.619
DOC_USP7_UBL2_3	175	179	PF12436	0.628
DOC_WW_Pin1_4	78	83	PF00397	0.236
LIG_14-3-3_CanoR_1	12	16	PF00244	0.369
LIG_14-3-3_CanoR_1	167	172	PF00244	0.503
LIG_BRCT_BRCA1_1	13	17	PF00533	0.297
LIG_FHA_1	194	200	PF00498	0.708
LIG_FHA_1	79	85	PF00498	0.422
LIG_LIR_Gen_1	68	76	PF02991	0.324
LIG_LIR_Nem_3	14	18	PF02991	0.297
LIG_LIR_Nem_3	6	11	PF02991	0.343
LIG_PCNA_PIPBox_1	83	92	PF02747	0.236
LIG_SH2_STAP1	65	69	PF00017	0.328
LIG_SH2_STAT5	4	7	PF00017	0.346
LIG_SH2_STAT5	8	11	PF00017	0.248
LIG_SH2_STAT5	80	83	PF00017	0.329
LIG_SH2_STAT5	89	92	PF00017	0.310
LIG_SUMO_SIM_par_1	81	88	PF11976	0.236
LIG_SxIP_EBH_1	194	208	PF03271	0.547
MOD_CK1_1	75	81	PF00069	0.469
MOD_GlcNHglycan	73	77	PF01048	0.552
MOD_GSK3_1	193	200	PF00069	0.746
MOD_GSK3_1	37	44	PF00069	0.337
MOD_GSK3_1	55	62	PF00069	0.207
MOD_N-GLC_1	55	60	PF02516	0.338
MOD_NEK2_1	11	16	PF00069	0.297
MOD_PKA_2	11	17	PF00069	0.369
MOD_PKA_2	152	158	PF00069	0.450
MOD_Plk_1	55	61	PF00069	0.307
MOD_Plk_4	11	17	PF00069	0.279
MOD_Plk_4	41	47	PF00069	0.377
MOD_Plk_4	65	71	PF00069	0.379
MOD_Plk_4	75	81	PF00069	0.313
MOD_ProDKin_1	78	84	PF00069	0.236
MOD_SUMO_for_1	156	159	PF00179	0.572
MOD_SUMO_for_1	209	212	PF00179	0.568
MOD_SUMO_for_1	70	73	PF00179	0.328
TRG_DiLeu_BaEn_2	144	150	PF01217	0.410
TRG_ENDOCYTIC_2	8	11	PF00928	0.297
TRG_ENDOCYTIC_2	80	83	PF00928	0.324
TRG_ER_diArg_1	205	207	PF00400	0.629
TRG_NES_CRM1_1	133	145	PF08389	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGQ0	Leptomonas seymouri	65%	100%
A0A0S4JU62	Bodo saltans	54%	100%
A0A1X0P4Z2	Trypanosomatidae	52%	100%
A0A3S7X9Y4	Leishmania donovani	100%	100%
A4HNB9	Leishmania braziliensis	75%	100%
E9AFS9	Leishmania major	89%	100%
E9B6Y1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O13737	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	98%
P25338	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%