LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
CS domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4IBY7_LEIIN
TriTrypDb:
LINF_350050500
Length:
199

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, Co-chaperone P23 |

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0005829 cytosol 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 48
Promastigote: 168

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IBY7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBY7

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0043933 protein-containing complex organization 4 1
GO:0051131 chaperone-mediated protein complex assembly 6 1
GO:0065003 protein-containing complex assembly 5 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 11
GO:0005515 protein binding 2 11
GO:0031072 heat shock protein binding 3 11
GO:0051879 Hsp90 protein binding 4 11
GO:0051087 protein-folding chaperone binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 179 183 PF00656 0.714
CLV_NRD_NRD_1 10 12 PF00675 0.220
DOC_MAPK_gen_1 11 19 PF00069 0.407
DOC_MAPK_MEF2A_6 11 19 PF00069 0.407
DOC_MAPK_MEF2A_6 71 79 PF00069 0.407
DOC_USP7_MATH_1 122 126 PF00917 0.537
DOC_USP7_MATH_1 45 49 PF00917 0.438
DOC_USP7_MATH_1 65 69 PF00917 0.321
DOC_USP7_MATH_1 99 103 PF00917 0.471
DOC_WW_Pin1_4 20 25 PF00397 0.564
LIG_14-3-3_CanoR_1 14 20 PF00244 0.453
LIG_BIR_II_1 1 5 PF00653 0.430
LIG_BIR_III_4 163 167 PF00653 0.483
LIG_deltaCOP1_diTrp_1 107 111 PF00928 0.365
LIG_FHA_1 33 39 PF00498 0.524
LIG_FHA_1 67 73 PF00498 0.463
LIG_FHA_2 184 190 PF00498 0.497
LIG_FHA_2 21 27 PF00498 0.451
LIG_LIR_Gen_1 13 24 PF02991 0.431
LIG_LIR_Nem_3 125 130 PF02991 0.514
LIG_LIR_Nem_3 13 19 PF02991 0.431
LIG_LIR_Nem_3 67 73 PF02991 0.422
LIG_PDZ_Class_2 194 199 PF00595 0.598
LIG_SH2_GRB2like 88 91 PF00017 0.367
LIG_SUMO_SIM_par_1 33 39 PF11976 0.441
LIG_TRAF2_1 186 189 PF00917 0.493
LIG_UBA3_1 156 162 PF00899 0.542
MOD_CK1_1 102 108 PF00069 0.406
MOD_CK1_1 22 28 PF00069 0.440
MOD_CK2_1 165 171 PF00069 0.640
MOD_CK2_1 183 189 PF00069 0.442
MOD_CMANNOS 108 111 PF00535 0.379
MOD_GlcNHglycan 104 107 PF01048 0.499
MOD_GlcNHglycan 38 41 PF01048 0.278
MOD_GSK3_1 15 22 PF00069 0.405
MOD_GSK3_1 152 159 PF00069 0.524
MOD_GSK3_1 32 39 PF00069 0.412
MOD_GSK3_1 41 48 PF00069 0.407
MOD_GSK3_1 93 100 PF00069 0.339
MOD_NEK2_1 156 161 PF00069 0.693
MOD_PIKK_1 45 51 PF00454 0.500
MOD_PK_1 34 40 PF00069 0.502
MOD_Plk_1 32 38 PF00069 0.410
MOD_Plk_1 65 71 PF00069 0.438
MOD_Plk_4 137 143 PF00069 0.513
MOD_Plk_4 152 158 PF00069 0.468
MOD_Plk_4 99 105 PF00069 0.476
MOD_ProDKin_1 20 26 PF00069 0.564
MOD_SUMO_for_1 53 56 PF00179 0.463
MOD_SUMO_for_1 82 85 PF00179 0.527
TRG_ENDOCYTIC_2 130 133 PF00928 0.474

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4JTH1 Bodo saltans 46% 100%
A0A1X0P6F3 Trypanosomatidae 67% 100%
A0A3Q8II57 Leishmania donovani 29% 95%
A0A3R7NTN0 Trypanosoma rangeli 61% 100%
A0A3S5H807 Leishmania donovani 100% 100%
A4HNB5 Leishmania braziliensis 82% 100%
A4I9J1 Leishmania infantum 29% 95%
C9ZYL8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
E9AFS4 Leishmania major 91% 100%
E9B4I9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 95%
E9B6X6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
G1TGF1 Oryctolagus cuniculus 35% 100%
P0C8Z0 Oryza sativa subsp. indica 30% 95%
P83868 Rattus norvegicus 35% 100%
Q11118 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 100%
Q15185 Homo sapiens 35% 100%
Q3ZBF7 Bos taurus 35% 100%
Q4Q3I7 Leishmania major 28% 95%
Q5NVM4 Pongo abelii 35% 100%
Q6PWL5 Macaca fascicularis 35% 100%
Q6YYB0 Oryza sativa subsp. japonica 30% 93%
Q90955 Gallus gallus 34% 100%
Q9FR62 Brassica napus 31% 100%
Q9R0Q7 Mus musculus 35% 100%
Q9VH95 Drosophila melanogaster 29% 100%
V5BCP6 Trypanosoma cruzi 59% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS