Putative mitochondrial phosphate transporter

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial phosphate transporter - putative

Species:

Leishmania infantum

UniProt:

A4IBY2_LEIIN

TriTrypDb:

LINF_350050000

Length:

317

Annotations

LeishMANIAdb annotations

Forms a well-defined channel with 6 helices. Some paralogs tend to have an additional hydrophobic segment that might be a transit or signal peptide. It is unclear if the N-peptide is a signal or transit peptide. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	14
GO:0016020	membrane	2	14
GO:0019866	organelle inner membrane	4	14
GO:0031090	organelle membrane	3	14
GO:0031966	mitochondrial membrane	4	14
GO:0110165	cellular anatomical entity	1	16
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4IBY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBY2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	16
GO:0006811	monoatomic ion transport	4	16
GO:0006817	phosphate ion transport	7	16
GO:0006820	monoatomic anion transport	5	16
GO:0009987	cellular process	1	16
GO:0015698	inorganic anion transport	6	16
GO:0034220	monoatomic ion transmembrane transport	3	16
GO:0035435	phosphate ion transmembrane transport	6	16
GO:0051179	localization	1	16
GO:0051234	establishment of localization	2	16
GO:0055085	transmembrane transport	2	16
GO:0098656	monoatomic anion transmembrane transport	4	16
GO:0098660	inorganic ion transmembrane transport	4	16
GO:0098661	inorganic anion transmembrane transport	5	16
GO:1990542	mitochondrial transmembrane transport	3	16
GO:1990547	mitochondrial phosphate ion transmembrane transport	4	16

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	16
GO:0005315	inorganic phosphate transmembrane transporter activity	4	16
GO:0015291	secondary active transmembrane transporter activity	4	16
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	16
GO:0022804	active transmembrane transporter activity	3	16
GO:0022857	transmembrane transporter activity	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	201	205	PF00082	0.378
CLV_PCSK_SKI1_1	307	311	PF00082	0.456
DEG_Nend_UBRbox_1	1	4	PF02207	0.437
DOC_AGCK_PIF_2	103	108	PF00069	0.441
DOC_MAPK_gen_1	123	131	PF00069	0.506
DOC_MAPK_MEF2A_6	226	234	PF00069	0.379
DOC_PP4_FxxP_1	217	220	PF00568	0.413
DOC_USP7_MATH_1	170	174	PF00917	0.430
DOC_USP7_MATH_1	176	180	PF00917	0.369
DOC_USP7_MATH_1	183	187	PF00917	0.169
DOC_USP7_MATH_1	245	249	PF00917	0.372
DOC_USP7_MATH_1	264	268	PF00917	0.558
DOC_USP7_UBL2_3	82	86	PF12436	0.197
DOC_WW_Pin1_4	155	160	PF00397	0.309
DOC_WW_Pin1_4	56	61	PF00397	0.334
LIG_14-3-3_CanoR_1	62	67	PF00244	0.461
LIG_APCC_ABBA_1	72	77	PF00400	0.178
LIG_BRCT_BRCA1_1	135	139	PF00533	0.335
LIG_BRCT_BRCA1_1	178	182	PF00533	0.412
LIG_BRCT_BRCA1_1	230	234	PF00533	0.381
LIG_BRCT_BRCA1_1	89	93	PF00533	0.178
LIG_DLG_GKlike_1	62	70	PF00625	0.461
LIG_eIF4E_1	79	85	PF01652	0.178
LIG_FHA_1	163	169	PF00498	0.439
LIG_FHA_1	285	291	PF00498	0.418
LIG_LIR_Apic_2	13	19	PF02991	0.428
LIG_LIR_Gen_1	111	117	PF02991	0.335
LIG_LIR_Gen_1	138	148	PF02991	0.319
LIG_LIR_Gen_1	274	285	PF02991	0.421
LIG_LIR_Nem_3	107	112	PF02991	0.333
LIG_LIR_Nem_3	267	271	PF02991	0.433
LIG_LIR_Nem_3	274	280	PF02991	0.378
LIG_LIR_Nem_3	61	66	PF02991	0.308
LIG_Pex14_1	12	16	PF04695	0.413
LIG_REV1ctd_RIR_1	201	211	PF16727	0.322
LIG_SH2_CRK	184	188	PF00017	0.449
LIG_SH2_CRK	213	217	PF00017	0.305
LIG_SH2_CRK	268	272	PF00017	0.400
LIG_SH2_GRB2like	113	116	PF00017	0.335
LIG_SH2_GRB2like	16	19	PF00017	0.462
LIG_SH2_GRB2like	277	280	PF00017	0.443
LIG_SH2_NCK_1	224	228	PF00017	0.458
LIG_SH2_PTP2	16	19	PF00017	0.535
LIG_SH2_PTP2	277	280	PF00017	0.466
LIG_SH2_SRC	16	19	PF00017	0.462
LIG_SH2_SRC	213	216	PF00017	0.399
LIG_SH2_SRC	277	280	PF00017	0.335
LIG_SH2_STAP1	113	117	PF00017	0.335
LIG_SH2_STAT3	95	98	PF00017	0.319
LIG_SH2_STAT5	108	111	PF00017	0.451
LIG_SH2_STAT5	16	19	PF00017	0.482
LIG_SH2_STAT5	197	200	PF00017	0.306
LIG_SH2_STAT5	215	218	PF00017	0.398
LIG_SH2_STAT5	238	241	PF00017	0.355
LIG_SH2_STAT5	277	280	PF00017	0.350
LIG_SH3_1	16	22	PF00018	0.435
LIG_SH3_3	16	22	PF00018	0.435
LIG_SH3_3	244	250	PF00018	0.366
LIG_SH3_4	219	226	PF00018	0.535
LIG_SUMO_SIM_par_1	287	294	PF11976	0.384
LIG_TRAF2_1	117	120	PF00917	0.507
MOD_CDC14_SPxK_1	59	62	PF00782	0.334
MOD_CDK_SPK_2	155	160	PF00069	0.402
MOD_CDK_SPxK_1	56	62	PF00069	0.334
MOD_GlcNHglycan	133	136	PF01048	0.312
MOD_GlcNHglycan	179	182	PF01048	0.456
MOD_GlcNHglycan	2	5	PF01048	0.624
MOD_GlcNHglycan	235	238	PF01048	0.335
MOD_GlcNHglycan	255	258	PF01048	0.444
MOD_GlcNHglycan	314	317	PF01048	0.398
MOD_GSK3_1	155	162	PF00069	0.331
MOD_N-GLC_2	279	281	PF02516	0.426
MOD_NEK2_1	131	136	PF00069	0.308
MOD_NEK2_1	148	153	PF00069	0.267
MOD_NEK2_1	230	235	PF00069	0.449
MOD_NEK2_1	291	296	PF00069	0.386
MOD_NEK2_1	312	317	PF00069	0.406
MOD_NEK2_1	93	98	PF00069	0.193
MOD_NEK2_2	170	175	PF00069	0.422
MOD_PIKK_1	225	231	PF00454	0.398
MOD_Plk_1	23	29	PF00069	0.498
MOD_Plk_4	183	189	PF00069	0.293
MOD_Plk_4	23	29	PF00069	0.416
MOD_Plk_4	250	256	PF00069	0.419
MOD_Plk_4	62	68	PF00069	0.164
MOD_Plk_4	87	93	PF00069	0.181
MOD_ProDKin_1	155	161	PF00069	0.309
MOD_ProDKin_1	56	62	PF00069	0.334
TRG_ENDOCYTIC_2	106	109	PF00928	0.309
TRG_ENDOCYTIC_2	113	116	PF00928	0.300
TRG_ENDOCYTIC_2	125	128	PF00928	0.322
TRG_ENDOCYTIC_2	184	187	PF00928	0.461
TRG_ENDOCYTIC_2	213	216	PF00928	0.311
TRG_ENDOCYTIC_2	268	271	PF00928	0.413
TRG_ENDOCYTIC_2	277	280	PF00928	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I993	Leptomonas seymouri	82%	100%
A0A0S4JBC4	Bodo saltans	38%	82%
A0A0S4JNX4	Bodo saltans	72%	94%
A0A0S4KJX8	Bodo saltans	25%	91%
A0A1X0P0K9	Trypanosomatidae	38%	100%
A0A1X0P561	Trypanosomatidae	76%	99%
A0A3S5IRV4	Trypanosoma rangeli	77%	100%
A0A3S7X9V4	Leishmania donovani	93%	100%
A0A3S7X9Y0	Leishmania donovani	94%	100%
A4HNB1	Leishmania braziliensis	89%	100%
A4HNB2	Leishmania braziliensis	88%	100%
A4IBY3	Leishmania infantum	94%	100%
C9ZYM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
D0A4I3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	83%
E9AFR9	Leishmania major	93%	100%
E9AFS0	Leishmania major	94%	100%
E9B6X2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O61703	Choristoneura fumiferana	51%	91%
P10566	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P12234	Bos taurus	49%	88%
P16036	Rattus norvegicus	49%	89%
P16260	Homo sapiens	25%	95%
P16261	Rattus norvegicus	25%	98%
P23500	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P23641	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
P32089	Rattus norvegicus	23%	100%
P40035	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
P40614	Caenorhabditis elegans	55%	93%
Q00325	Homo sapiens	46%	88%
Q01888	Bos taurus	27%	96%
Q03829	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	86%
Q54BF6	Dictyostelium discoideum	39%	100%
Q5R7W2	Pongo abelii	49%	88%
Q7DNC3	Arabidopsis thaliana	40%	100%
Q8VEM8	Mus musculus	49%	89%
Q9FMU6	Arabidopsis thaliana	50%	85%
Q9M2Z8	Arabidopsis thaliana	48%	87%
Q9P7V8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	100%
V5BT68	Trypanosoma cruzi	77%	100%