PIH1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-RNA processing PIH1/Nop17 - putative

Species:

Leishmania infantum

UniProt:

A4IBX3_LEIIN

TriTrypDb:

LINF_350049100

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IBX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBX3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.667
CLV_C14_Caspase3-7	358	362	PF00656	0.499
CLV_NRD_NRD_1	181	183	PF00675	0.341
CLV_NRD_NRD_1	349	351	PF00675	0.342
CLV_NRD_NRD_1	411	413	PF00675	0.261
CLV_NRD_NRD_1	468	470	PF00675	0.558
CLV_NRD_NRD_1	480	482	PF00675	0.426
CLV_NRD_NRD_1	520	522	PF00675	0.511
CLV_NRD_NRD_1	557	559	PF00675	0.661
CLV_PCSK_KEX2_1	181	183	PF00082	0.360
CLV_PCSK_KEX2_1	311	313	PF00082	0.591
CLV_PCSK_KEX2_1	349	351	PF00082	0.314
CLV_PCSK_KEX2_1	468	470	PF00082	0.595
CLV_PCSK_KEX2_1	480	482	PF00082	0.607
CLV_PCSK_KEX2_1	50	52	PF00082	0.544
CLV_PCSK_KEX2_1	520	522	PF00082	0.552
CLV_PCSK_KEX2_1	599	601	PF00082	0.707
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.600
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.613
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.707
CLV_PCSK_PC7_1	345	351	PF00082	0.341
CLV_PCSK_SKI1_1	297	301	PF00082	0.533
CLV_PCSK_SKI1_1	438	442	PF00082	0.600
CLV_PCSK_SKI1_1	629	633	PF00082	0.550
CLV_PCSK_SKI1_1	68	72	PF00082	0.313
DEG_APCC_KENBOX_2	319	323	PF00400	0.459
DEG_Kelch_Keap1_1	372	377	PF01344	0.411
DEG_Nend_UBRbox_2	1	3	PF02207	0.562
DOC_CYCLIN_RxL_1	626	635	PF00134	0.551
DOC_MAPK_gen_1	157	166	PF00069	0.444
DOC_MAPK_gen_1	409	419	PF00069	0.490
DOC_MAPK_MEF2A_6	412	421	PF00069	0.473
DOC_MAPK_RevD_3	334	350	PF00069	0.541
DOC_PP1_RVXF_1	204	211	PF00149	0.541
DOC_PP2B_LxvP_1	331	334	PF13499	0.513
DOC_PP4_FxxP_1	87	90	PF00568	0.536
DOC_USP7_MATH_1	23	27	PF00917	0.429
DOC_USP7_MATH_1	242	246	PF00917	0.725
DOC_USP7_MATH_1	273	277	PF00917	0.678
DOC_USP7_MATH_1	295	299	PF00917	0.489
DOC_USP7_MATH_1	369	373	PF00917	0.536
DOC_USP7_MATH_1	489	493	PF00917	0.526
DOC_USP7_MATH_1	594	598	PF00917	0.732
DOC_USP7_UBL2_3	211	215	PF12436	0.509
DOC_USP7_UBL2_3	409	413	PF12436	0.461
DOC_WW_Pin1_4	281	286	PF00397	0.673
DOC_WW_Pin1_4	387	392	PF00397	0.541
DOC_WW_Pin1_4	570	575	PF00397	0.743
DOC_WW_Pin1_4	582	587	PF00397	0.733
LIG_14-3-3_CanoR_1	140	150	PF00244	0.541
LIG_14-3-3_CanoR_1	222	227	PF00244	0.489
LIG_14-3-3_CanoR_1	412	417	PF00244	0.475
LIG_14-3-3_CanoR_1	480	484	PF00244	0.468
LIG_14-3-3_CanoR_1	600	609	PF00244	0.553
LIG_Clathr_ClatBox_1	631	635	PF01394	0.558
LIG_DLG_GKlike_1	412	419	PF00625	0.564
LIG_FHA_1	285	291	PF00498	0.683
LIG_FHA_1	328	334	PF00498	0.533
LIG_FHA_1	412	418	PF00498	0.541
LIG_FHA_1	579	585	PF00498	0.687
LIG_FHA_2	269	275	PF00498	0.661
LIG_FHA_2	336	342	PF00498	0.491
LIG_FHA_2	358	364	PF00498	0.439
LIG_FHA_2	432	438	PF00498	0.608
LIG_FHA_2	439	445	PF00498	0.544
LIG_FHA_2	614	620	PF00498	0.641
LIG_GBD_Chelix_1	543	551	PF00786	0.356
LIG_KLC1_Yacidic_2	352	357	PF13176	0.491
LIG_LIR_Apic_2	136	142	PF02991	0.461
LIG_LIR_Gen_1	14	24	PF02991	0.572
LIG_LIR_Gen_1	390	400	PF02991	0.542
LIG_LIR_Nem_3	14	19	PF02991	0.575
LIG_LIR_Nem_3	177	183	PF02991	0.461
LIG_LIR_Nem_3	203	208	PF02991	0.523
LIG_LIR_Nem_3	390	395	PF02991	0.542
LIG_Pex14_2	16	20	PF04695	0.418
LIG_PTB_Apo_2	10	17	PF02174	0.445
LIG_PTB_Apo_2	204	211	PF02174	0.475
LIG_SH2_CRK	139	143	PF00017	0.541
LIG_SH2_CRK	162	166	PF00017	0.461
LIG_SH2_SRC	332	335	PF00017	0.509
LIG_SH2_STAP1	162	166	PF00017	0.461
LIG_SH2_STAP1	305	309	PF00017	0.551
LIG_SH2_STAT5	318	321	PF00017	0.460
LIG_SH2_STAT5	332	335	PF00017	0.449
LIG_SH2_STAT5	355	358	PF00017	0.461
LIG_SH2_STAT5	410	413	PF00017	0.541
LIG_SH2_STAT5	483	486	PF00017	0.457
LIG_SH2_STAT5	546	549	PF00017	0.444
LIG_SH2_STAT5	630	633	PF00017	0.553
LIG_SH3_3	262	268	PF00018	0.673
LIG_SH3_3	420	426	PF00018	0.461
LIG_TRAF2_1	454	457	PF00917	0.555
LIG_UBA3_1	416	420	PF00899	0.357
MOD_CK1_1	196	202	PF00069	0.387
MOD_CK1_1	250	256	PF00069	0.714
MOD_CK1_1	276	282	PF00069	0.632
MOD_CK1_1	372	378	PF00069	0.288
MOD_CK1_1	387	393	PF00069	0.332
MOD_CK1_1	572	578	PF00069	0.735
MOD_CK1_1	582	588	PF00069	0.630
MOD_CK1_1	602	608	PF00069	0.629
MOD_CK2_1	335	341	PF00069	0.314
MOD_CK2_1	357	363	PF00069	0.284
MOD_CK2_1	39	45	PF00069	0.666
MOD_CK2_1	438	444	PF00069	0.579
MOD_CK2_1	479	485	PF00069	0.486
MOD_CK2_1	613	619	PF00069	0.666
MOD_GlcNHglycan	244	247	PF01048	0.691
MOD_GlcNHglycan	25	28	PF01048	0.618
MOD_GlcNHglycan	274	278	PF01048	0.727
MOD_GlcNHglycan	371	374	PF01048	0.446
MOD_GlcNHglycan	381	384	PF01048	0.274
MOD_GlcNHglycan	386	389	PF01048	0.201
MOD_GlcNHglycan	487	490	PF01048	0.561
MOD_GlcNHglycan	491	494	PF01048	0.588
MOD_GlcNHglycan	560	563	PF01048	0.729
MOD_GlcNHglycan	581	584	PF01048	0.670
MOD_GSK3_1	238	245	PF00069	0.650
MOD_GSK3_1	273	280	PF00069	0.653
MOD_GSK3_1	387	394	PF00069	0.421
MOD_GSK3_1	485	492	PF00069	0.584
MOD_GSK3_1	566	573	PF00069	0.752
MOD_GSK3_1	578	585	PF00069	0.664
MOD_LATS_1	310	316	PF00433	0.618
MOD_N-GLC_1	485	490	PF02516	0.560
MOD_N-GLC_2	109	111	PF02516	0.314
MOD_NEK2_1	327	332	PF00069	0.375
MOD_NEK2_1	39	44	PF00069	0.633
MOD_NEK2_1	612	617	PF00069	0.633
MOD_NEK2_2	335	340	PF00069	0.459
MOD_PIKK_1	222	228	PF00454	0.409
MOD_PIKK_1	247	253	PF00454	0.722
MOD_PIKK_1	426	432	PF00454	0.645
MOD_PIKK_1	602	608	PF00454	0.724
MOD_PIKK_1	613	619	PF00454	0.613
MOD_PK_1	524	530	PF00069	0.514
MOD_PKA_1	412	418	PF00069	0.459
MOD_PKA_1	558	564	PF00069	0.689
MOD_PKA_1	599	605	PF00069	0.565
MOD_PKA_2	221	227	PF00069	0.314
MOD_PKA_2	411	417	PF00069	0.314
MOD_PKA_2	479	485	PF00069	0.470
MOD_PKA_2	599	605	PF00069	0.565
MOD_PKB_1	220	228	PF00069	0.310
MOD_PKB_1	556	564	PF00069	0.677
MOD_Plk_1	485	491	PF00069	0.568
MOD_Plk_2-3	357	363	PF00069	0.397
MOD_Plk_2-3	479	485	PF00069	0.490
MOD_Plk_2-3	549	555	PF00069	0.641
MOD_Plk_4	412	418	PF00069	0.459
MOD_ProDKin_1	281	287	PF00069	0.674
MOD_ProDKin_1	387	393	PF00069	0.426
MOD_ProDKin_1	570	576	PF00069	0.742
MOD_ProDKin_1	582	588	PF00069	0.733
MOD_SUMO_for_1	290	293	PF00179	0.698
MOD_SUMO_for_1	49	52	PF00179	0.617
MOD_SUMO_for_1	563	566	PF00179	0.705
MOD_SUMO_rev_2	402	411	PF00179	0.387
TRG_DiLeu_BaEn_2	178	184	PF01217	0.357
TRG_ENDOCYTIC_2	162	165	PF00928	0.314
TRG_ER_diArg_1	180	182	PF00400	0.426
TRG_ER_diArg_1	220	223	PF00400	0.314
TRG_ER_diArg_1	349	351	PF00400	0.454
TRG_ER_diArg_1	520	523	PF00400	0.553
TRG_ER_diArg_1	555	558	PF00400	0.708

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6F3	Leptomonas seymouri	62%	100%
A0A1X0P509	Trypanosomatidae	46%	100%
A0A3Q8IIQ5	Leishmania donovani	99%	100%
A0A422NU93	Trypanosoma rangeli	46%	100%
A4HNA2	Leishmania braziliensis	80%	100%
B6F1W5	Oryzias latipes	21%	100%
C9ZYN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AFR0	Leishmania major	93%	100%
E9B6W3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%
V5BT79	Trypanosoma cruzi	47%	100%