HAD-superfamily hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Haloacid dehalogenase-like hydrolase/HAD-hyrolase-like - putative

Species:

Leishmania infantum

UniProt:

A4IBX2_LEIIN

TriTrypDb:

LINF_350049000

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IBX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBX2

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.538
CLV_NRD_NRD_1	20	22	PF00675	0.519
CLV_NRD_NRD_1	212	214	PF00675	0.254
CLV_NRD_NRD_1	290	292	PF00675	0.479
CLV_NRD_NRD_1	482	484	PF00675	0.456
CLV_NRD_NRD_1	51	53	PF00675	0.523
CLV_NRD_NRD_1	76	78	PF00675	0.549
CLV_NRD_NRD_1	92	94	PF00675	0.404
CLV_PCSK_KEX2_1	13	15	PF00082	0.534
CLV_PCSK_KEX2_1	20	22	PF00082	0.507
CLV_PCSK_KEX2_1	290	292	PF00082	0.436
CLV_PCSK_KEX2_1	315	317	PF00082	0.502
CLV_PCSK_KEX2_1	426	428	PF00082	0.286
CLV_PCSK_KEX2_1	482	484	PF00082	0.456
CLV_PCSK_KEX2_1	51	53	PF00082	0.491
CLV_PCSK_KEX2_1	76	78	PF00082	0.666
CLV_PCSK_KEX2_1	92	94	PF00082	0.404
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.543
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.302
CLV_PCSK_PC7_1	9	15	PF00082	0.606
CLV_PCSK_SKI1_1	393	397	PF00082	0.365
CLV_PCSK_SKI1_1	443	447	PF00082	0.269
CLV_PCSK_SKI1_1	515	519	PF00082	0.346
CLV_PCSK_SKI1_1	9	13	PF00082	0.545
CLV_PCSK_SKI1_1	93	97	PF00082	0.575
DEG_APCC_DBOX_1	392	400	PF00400	0.370
DEG_Nend_UBRbox_1	1	4	PF02207	0.622
DEG_ODPH_VHL_1	263	275	PF01847	0.445
DEG_SPOP_SBC_1	171	175	PF00917	0.688
DOC_CKS1_1	365	370	PF01111	0.469
DOC_CKS1_1	500	505	PF01111	0.357
DOC_CYCLIN_RxL_1	512	522	PF00134	0.342
DOC_CYCLIN_RxL_1	6	15	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	218	224	PF00134	0.437
DOC_MAPK_gen_1	213	220	PF00069	0.445
DOC_MAPK_MEF2A_6	213	222	PF00069	0.447
DOC_PP2B_LxvP_1	218	221	PF13499	0.437
DOC_PP2B_LxvP_1	262	265	PF13499	0.448
DOC_PP2B_LxvP_1	350	353	PF13499	0.398
DOC_PP4_FxxP_1	22	25	PF00568	0.462
DOC_USP7_MATH_1	134	138	PF00917	0.666
DOC_USP7_MATH_1	169	173	PF00917	0.684
DOC_USP7_MATH_1	359	363	PF00917	0.433
DOC_WW_Pin1_4	12	17	PF00397	0.676
DOC_WW_Pin1_4	130	135	PF00397	0.608
DOC_WW_Pin1_4	139	144	PF00397	0.507
DOC_WW_Pin1_4	167	172	PF00397	0.696
DOC_WW_Pin1_4	255	260	PF00397	0.442
DOC_WW_Pin1_4	364	369	PF00397	0.442
DOC_WW_Pin1_4	499	504	PF00397	0.429
DOC_WW_Pin1_4	68	73	PF00397	0.494
DOC_WW_Pin1_4	98	103	PF00397	0.668
LIG_14-3-3_CanoR_1	2	7	PF00244	0.649
LIG_14-3-3_CanoR_1	213	219	PF00244	0.539
LIG_14-3-3_CanoR_1	290	296	PF00244	0.427
LIG_14-3-3_CanoR_1	482	486	PF00244	0.439
LIG_EH1_1	511	519	PF00400	0.425
LIG_eIF4E_1	199	205	PF01652	0.480
LIG_FHA_1	116	122	PF00498	0.424
LIG_FHA_1	215	221	PF00498	0.539
LIG_FHA_1	482	488	PF00498	0.504
LIG_FHA_2	30	36	PF00498	0.570
LIG_FHA_2	343	349	PF00498	0.369
LIG_LIR_Apic_2	162	167	PF02991	0.576
LIG_LIR_Apic_2	502	508	PF02991	0.372
LIG_LIR_Gen_1	337	347	PF02991	0.378
LIG_LIR_Gen_1	398	408	PF02991	0.387
LIG_LIR_LC3C_4	270	275	PF02991	0.491
LIG_LIR_Nem_3	321	327	PF02991	0.368
LIG_LIR_Nem_3	337	343	PF02991	0.312
LIG_LIR_Nem_3	34	40	PF02991	0.494
LIG_LIR_Nem_3	398	403	PF02991	0.387
LIG_LIR_Nem_3	5	11	PF02991	0.600
LIG_LYPXL_SIV_4	368	376	PF13949	0.468
LIG_LYPXL_SIV_4	420	428	PF13949	0.368
LIG_NRBOX	239	245	PF00104	0.539
LIG_NRBOX	346	352	PF00104	0.365
LIG_Pex14_2	22	26	PF04695	0.466
LIG_Pex14_2	442	446	PF04695	0.302
LIG_SH2_CRK	413	417	PF00017	0.289
LIG_SH2_CRK	8	12	PF00017	0.662
LIG_SH2_NCK_1	400	404	PF00017	0.507
LIG_SH2_PTP2	164	167	PF00017	0.605
LIG_SH2_PTP2	505	508	PF00017	0.351
LIG_SH2_SRC	164	167	PF00017	0.581
LIG_SH2_STAP1	117	121	PF00017	0.387
LIG_SH2_STAP1	161	165	PF00017	0.548
LIG_SH2_STAP1	490	494	PF00017	0.350
LIG_SH2_STAT5	105	108	PF00017	0.486
LIG_SH2_STAT5	117	120	PF00017	0.452
LIG_SH2_STAT5	164	167	PF00017	0.605
LIG_SH2_STAT5	18	21	PF00017	0.602
LIG_SH2_STAT5	360	363	PF00017	0.416
LIG_SH2_STAT5	369	372	PF00017	0.286
LIG_SH2_STAT5	505	508	PF00017	0.351
LIG_SH3_3	177	183	PF00018	0.584
LIG_SH3_3	272	278	PF00018	0.462
LIG_SH3_3	319	325	PF00018	0.386
LIG_SH3_3	497	503	PF00018	0.374
LIG_SUMO_SIM_anti_2	269	276	PF11976	0.542
LIG_SUMO_SIM_anti_2	345	351	PF11976	0.369
LIG_SUMO_SIM_par_1	190	195	PF11976	0.394
LIG_SUMO_SIM_par_1	483	489	PF11976	0.462
LIG_TRAF2_1	32	35	PF00917	0.594
LIG_TRAF2_1	71	74	PF00917	0.515
MOD_CDC14_SPxK_1	258	261	PF00782	0.539
MOD_CDK_SPxK_1	255	261	PF00069	0.504
MOD_CDK_SPxK_1	98	104	PF00069	0.665
MOD_CK1_1	128	134	PF00069	0.710
MOD_CK1_1	137	143	PF00069	0.655
MOD_CK1_1	170	176	PF00069	0.698
MOD_CK2_1	132	138	PF00069	0.733
MOD_CK2_1	29	35	PF00069	0.492
MOD_CK2_1	331	337	PF00069	0.474
MOD_CK2_1	395	401	PF00069	0.490
MOD_CK2_1	68	74	PF00069	0.515
MOD_GlcNHglycan	127	130	PF01048	0.643
MOD_GlcNHglycan	174	177	PF01048	0.696
MOD_GlcNHglycan	186	189	PF01048	0.318
MOD_GlcNHglycan	227	230	PF01048	0.272
MOD_GlcNHglycan	238	243	PF01048	0.230
MOD_GlcNHglycan	361	364	PF01048	0.494
MOD_GlcNHglycan	430	434	PF01048	0.370
MOD_GlcNHglycan	472	475	PF01048	0.274
MOD_GSK3_1	128	135	PF00069	0.649
MOD_GSK3_1	137	144	PF00069	0.652
MOD_GSK3_1	167	174	PF00069	0.697
MOD_GSK3_1	225	232	PF00069	0.590
MOD_GSK3_1	359	366	PF00069	0.406
MOD_GSK3_1	395	402	PF00069	0.496
MOD_N-GLC_1	125	130	PF02516	0.706
MOD_NEK2_1	1	6	PF00069	0.609
MOD_NEK2_1	106	111	PF00069	0.523
MOD_NEK2_1	127	132	PF00069	0.662
MOD_NEK2_1	184	189	PF00069	0.326
MOD_NEK2_1	225	230	PF00069	0.428
MOD_NEK2_1	395	400	PF00069	0.445
MOD_NEK2_1	41	46	PF00069	0.561
MOD_NEK2_1	465	470	PF00069	0.368
MOD_NEK2_1	525	530	PF00069	0.599
MOD_PIKK_1	128	134	PF00454	0.571
MOD_PK_1	291	297	PF00069	0.391
MOD_PK_1	483	489	PF00069	0.588
MOD_PKA_1	213	219	PF00069	0.527
MOD_PKA_2	1	7	PF00069	0.573
MOD_PKA_2	481	487	PF00069	0.461
MOD_PKB_1	427	435	PF00069	0.217
MOD_Plk_1	137	143	PF00069	0.682
MOD_Plk_1	238	244	PF00069	0.480
MOD_Plk_2-3	342	348	PF00069	0.384
MOD_Plk_4	2	8	PF00069	0.623
MOD_Plk_4	342	348	PF00069	0.377
MOD_Plk_4	395	401	PF00069	0.490
MOD_ProDKin_1	12	18	PF00069	0.678
MOD_ProDKin_1	130	136	PF00069	0.612
MOD_ProDKin_1	139	145	PF00069	0.500
MOD_ProDKin_1	167	173	PF00069	0.697
MOD_ProDKin_1	255	261	PF00069	0.442
MOD_ProDKin_1	364	370	PF00069	0.438
MOD_ProDKin_1	499	505	PF00069	0.415
MOD_ProDKin_1	68	74	PF00069	0.491
MOD_ProDKin_1	98	104	PF00069	0.665
MOD_SUMO_rev_2	151	158	PF00179	0.615
MOD_SUMO_rev_2	27	33	PF00179	0.461
TRG_DiLeu_BaEn_1	239	244	PF01217	0.462
TRG_DiLeu_BaEn_1	269	274	PF01217	0.491
TRG_DiLeu_BaEn_3	90	96	PF01217	0.593
TRG_DiLeu_BaEn_4	73	79	PF01217	0.593
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.569
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.539
TRG_ENDOCYTIC_2	400	403	PF00928	0.511
TRG_ENDOCYTIC_2	8	11	PF00928	0.662
TRG_ER_diArg_1	12	14	PF00400	0.542
TRG_ER_diArg_1	20	22	PF00400	0.497
TRG_ER_diArg_1	289	291	PF00400	0.484
TRG_ER_diArg_1	76	78	PF00400	0.549
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.302
TRG_Pf-PMV_PEXEL_1	483	488	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5I3	Leptomonas seymouri	73%	100%
A0A0S4JPF8	Bodo saltans	54%	100%
A0A1X0P5B2	Trypanosomatidae	59%	100%
A0A3Q8IMX2	Leishmania donovani	100%	100%
A0A3R7L7A5	Trypanosoma rangeli	61%	100%
A4HNA1	Leishmania braziliensis	84%	100%
C9ZYN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AFQ9	Leishmania major	95%	100%
E9B6W2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BCR1	Trypanosoma cruzi	62%	100%