Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IBW8_LEIIN

TriTrypDb:

LINF_350048600

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0043226	organelle	2	9
GO:0043229	intracellular organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0005814	centriole	5	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4IBW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBW8

PDB structure(s): 4ckm_A , 4ckm_B , 4ckm_C , 4ckn_A , 4ckn_B , 4ckn_C , 4ckn_D , 4ckp_A , 4ckp_B , 4ckp_C , 4ckp_D , 4ckp_E , 4ckp_F

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0007099	centriole replication	3	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022607	cellular component assembly	4	1
GO:0031023	microtubule organizing center organization	3	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0098534	centriole assembly	4	1
GO:0140694	non-membrane-bounded organelle assembly	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.537
CLV_C14_Caspase3-7	698	702	PF00656	0.692
CLV_NRD_NRD_1	32	34	PF00675	0.774
CLV_NRD_NRD_1	322	324	PF00675	0.511
CLV_NRD_NRD_1	553	555	PF00675	0.621
CLV_NRD_NRD_1	570	572	PF00675	0.632
CLV_NRD_NRD_1	749	751	PF00675	0.713
CLV_NRD_NRD_1	75	77	PF00675	0.749
CLV_PCSK_KEX2_1	276	278	PF00082	0.453
CLV_PCSK_KEX2_1	31	33	PF00082	0.779
CLV_PCSK_KEX2_1	553	555	PF00082	0.621
CLV_PCSK_KEX2_1	75	77	PF00082	0.706
CLV_PCSK_KEX2_1	775	777	PF00082	0.724
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.453
CLV_PCSK_PC1ET2_1	775	777	PF00082	0.567
CLV_PCSK_PC7_1	27	33	PF00082	0.776
CLV_PCSK_SKI1_1	171	175	PF00082	0.487
CLV_PCSK_SKI1_1	525	529	PF00082	0.570
CLV_PCSK_SKI1_1	791	795	PF00082	0.601
CLV_Separin_Metazoa	568	572	PF03568	0.625
DEG_APCC_DBOX_1	114	122	PF00400	0.732
DEG_APCC_DBOX_1	170	178	PF00400	0.476
DEG_APCC_DBOX_1	245	253	PF00400	0.503
DEG_Nend_Nbox_1	1	3	PF02207	0.694
DOC_ANK_TNKS_1	220	227	PF00023	0.575
DOC_ANK_TNKS_1	74	81	PF00023	0.759
DOC_MAPK_gen_1	323	331	PF00069	0.537
DOC_MAPK_gen_1	587	596	PF00069	0.633
DOC_MAPK_MEF2A_6	200	209	PF00069	0.478
DOC_MAPK_MEF2A_6	258	267	PF00069	0.478
DOC_MAPK_NFAT4_5	200	208	PF00069	0.478
DOC_PP4_FxxP_1	23	26	PF00568	0.745
DOC_PP4_MxPP_1	764	767	PF00568	0.557
DOC_USP7_MATH_1	100	104	PF00917	0.668
DOC_USP7_MATH_1	124	128	PF00917	0.778
DOC_USP7_MATH_1	358	362	PF00917	0.598
DOC_USP7_MATH_1	396	400	PF00917	0.477
DOC_USP7_MATH_1	467	471	PF00917	0.670
DOC_USP7_MATH_1	621	625	PF00917	0.707
DOC_USP7_MATH_1	630	634	PF00917	0.514
DOC_USP7_MATH_1	699	703	PF00917	0.673
DOC_USP7_MATH_1	717	721	PF00917	0.704
DOC_USP7_MATH_1	722	726	PF00917	0.729
DOC_USP7_MATH_1	759	763	PF00917	0.656
DOC_USP7_MATH_1	789	793	PF00917	0.670
DOC_USP7_MATH_1	810	814	PF00917	0.627
DOC_USP7_UBL2_3	508	512	PF12436	0.621
DOC_WD40_RPTOR_TOS_1	187	193	PF00400	0.503
DOC_WW_Pin1_4	120	125	PF00397	0.726
DOC_WW_Pin1_4	44	49	PF00397	0.674
DOC_WW_Pin1_4	675	680	PF00397	0.697
DOC_WW_Pin1_4	715	720	PF00397	0.702
DOC_WW_Pin1_4	744	749	PF00397	0.789
DOC_WW_Pin1_4	769	774	PF00397	0.780
DOC_WW_Pin1_4	780	785	PF00397	0.503
LIG_14-3-3_CanoR_1	112	121	PF00244	0.731
LIG_14-3-3_CanoR_1	176	180	PF00244	0.478
LIG_14-3-3_CanoR_1	319	323	PF00244	0.587
LIG_14-3-3_CanoR_1	397	405	PF00244	0.573
LIG_14-3-3_CanoR_1	53	60	PF00244	0.744
LIG_14-3-3_CanoR_1	571	580	PF00244	0.655
LIG_14-3-3_CanoR_1	670	674	PF00244	0.722
LIG_14-3-3_CanoR_1	675	679	PF00244	0.733
LIG_14-3-3_CanoR_1	728	737	PF00244	0.713
LIG_14-3-3_CanoR_1	743	748	PF00244	0.718
LIG_14-3-3_CanoR_1	750	754	PF00244	0.704
LIG_14-3-3_CanoR_1	802	811	PF00244	0.734
LIG_Actin_WH2_2	253	271	PF00022	0.503
LIG_Actin_WH2_2	304	321	PF00022	0.523
LIG_Actin_WH2_2	366	383	PF00022	0.604
LIG_Actin_WH2_2	398	415	PF00022	0.504
LIG_Actin_WH2_2	448	464	PF00022	0.599
LIG_AP2alpha_2	182	184	PF02296	0.478
LIG_BRCT_BRCA1_1	19	23	PF00533	0.743
LIG_BRCT_BRCA1_1	812	816	PF00533	0.593
LIG_CaM_IQ_9	563	579	PF13499	0.682
LIG_Clathr_ClatBox_1	186	190	PF01394	0.503
LIG_FHA_1	136	142	PF00498	0.501
LIG_FHA_1	168	174	PF00498	0.510
LIG_FHA_1	246	252	PF00498	0.478
LIG_FHA_1	299	305	PF00498	0.463
LIG_FHA_1	375	381	PF00498	0.576
LIG_FHA_1	396	402	PF00498	0.602
LIG_FHA_1	416	422	PF00498	0.624
LIG_FHA_1	456	462	PF00498	0.514
LIG_FHA_1	561	567	PF00498	0.653
LIG_FHA_1	605	611	PF00498	0.671
LIG_FHA_1	652	658	PF00498	0.623
LIG_FHA_1	732	738	PF00498	0.722
LIG_FHA_1	744	750	PF00498	0.727
LIG_FHA_2	332	338	PF00498	0.501
LIG_FHA_2	381	387	PF00498	0.574
LIG_FHA_2	426	432	PF00498	0.579
LIG_FHA_2	454	460	PF00498	0.598
LIG_FHA_2	62	68	PF00498	0.603
LIG_FHA_2	696	702	PF00498	0.735
LIG_Integrin_isoDGR_2	611	613	PF01839	0.564
LIG_LIR_Apic_2	20	26	PF02991	0.706
LIG_LIR_Gen_1	193	203	PF02991	0.575
LIG_LIR_Gen_1	451	461	PF02991	0.601
LIG_LIR_Gen_1	486	493	PF02991	0.515
LIG_LIR_Gen_1	50	59	PF02991	0.672
LIG_LIR_Gen_1	783	793	PF02991	0.615
LIG_LIR_Nem_3	181	187	PF02991	0.480
LIG_LIR_Nem_3	193	199	PF02991	0.474
LIG_LIR_Nem_3	208	212	PF02991	0.478
LIG_LIR_Nem_3	255	260	PF02991	0.476
LIG_LIR_Nem_3	281	286	PF02991	0.423
LIG_LIR_Nem_3	451	457	PF02991	0.598
LIG_LIR_Nem_3	486	491	PF02991	0.515
LIG_LIR_Nem_3	50	54	PF02991	0.663
LIG_LIR_Nem_3	783	788	PF02991	0.688
LIG_MLH1_MIPbox_1	812	816	PF16413	0.593
LIG_PCNA_PIPBox_1	475	484	PF02747	0.600
LIG_Pex14_2	646	650	PF04695	0.661
LIG_SH2_CRK	662	666	PF00017	0.608
LIG_SH2_PTP2	454	457	PF00017	0.597
LIG_SH2_PTP2	488	491	PF00017	0.518
LIG_SH2_STAP1	230	234	PF00017	0.478
LIG_SH2_STAP1	286	290	PF00017	0.521
LIG_SH2_STAT3	482	485	PF00017	0.513
LIG_SH2_STAT5	158	161	PF00017	0.501
LIG_SH2_STAT5	215	218	PF00017	0.478
LIG_SH2_STAT5	278	281	PF00017	0.399
LIG_SH2_STAT5	454	457	PF00017	0.597
LIG_SH2_STAT5	488	491	PF00017	0.518
LIG_SH3_1	144	150	PF00018	0.611
LIG_SH3_2	770	775	PF14604	0.563
LIG_SH3_3	102	108	PF00018	0.696
LIG_SH3_3	144	150	PF00018	0.558
LIG_SH3_3	177	183	PF00018	0.503
LIG_SH3_3	764	770	PF00018	0.594
LIG_SUMO_SIM_anti_2	170	176	PF11976	0.474
LIG_SUMO_SIM_anti_2	188	195	PF11976	0.377
LIG_SUMO_SIM_anti_2	261	267	PF11976	0.478
LIG_SUMO_SIM_par_1	136	143	PF11976	0.514
LIG_TRAF2_1	127	130	PF00917	0.738
LIG_TRAF2_1	325	328	PF00917	0.531
LIG_TRAF2_1	372	375	PF00917	0.566
LIG_TRAF2_1	470	473	PF00917	0.640
LIG_TRAF2_1	724	727	PF00917	0.717
LIG_TYR_ITIM	452	457	PF00017	0.599
LIG_WRC_WIRS_1	790	795	PF05994	0.686
MOD_CDC14_SPxK_1	678	681	PF00782	0.582
MOD_CDC14_SPxK_1	747	750	PF00782	0.570
MOD_CDC14_SPxK_1	772	775	PF00782	0.563
MOD_CDK_SPK_2	120	125	PF00069	0.784
MOD_CDK_SPxK_1	675	681	PF00069	0.590
MOD_CDK_SPxK_1	744	750	PF00069	0.574
MOD_CDK_SPxK_1	769	775	PF00069	0.565
MOD_CDK_SPxxK_3	744	751	PF00069	0.573
MOD_CDK_SPxxK_3	769	776	PF00069	0.566
MOD_CK1_1	10	16	PF00069	0.686
MOD_CK1_1	18	24	PF00069	0.708
MOD_CK1_1	293	299	PF00069	0.484
MOD_CK1_1	407	413	PF00069	0.546
MOD_CK1_1	47	53	PF00069	0.530
MOD_CK1_1	61	67	PF00069	0.547
MOD_CK1_1	669	675	PF00069	0.591
MOD_CK1_1	731	737	PF00069	0.763
MOD_CK1_1	777	783	PF00069	0.702
MOD_CK2_1	124	130	PF00069	0.697
MOD_CK2_1	225	231	PF00069	0.524
MOD_CK2_1	331	337	PF00069	0.504
MOD_CK2_1	380	386	PF00069	0.574
MOD_CK2_1	396	402	PF00069	0.429
MOD_CK2_1	425	431	PF00069	0.505
MOD_CK2_1	445	451	PF00069	0.535
MOD_CK2_1	453	459	PF00069	0.547
MOD_CK2_1	467	473	PF00069	0.470
MOD_CK2_1	721	727	PF00069	0.692
MOD_DYRK1A_RPxSP_1	675	679	PF00069	0.592
MOD_GlcNHglycan	102	105	PF01048	0.627
MOD_GlcNHglycan	126	129	PF01048	0.747
MOD_GlcNHglycan	193	199	PF01048	0.349
MOD_GlcNHglycan	227	230	PF01048	0.383
MOD_GlcNHglycan	237	240	PF01048	0.350
MOD_GlcNHglycan	413	416	PF01048	0.534
MOD_GlcNHglycan	619	622	PF01048	0.650
MOD_GlcNHglycan	632	635	PF01048	0.533
MOD_GlcNHglycan	685	688	PF01048	0.685
MOD_GlcNHglycan	701	704	PF01048	0.721
MOD_GlcNHglycan	730	733	PF01048	0.746
MOD_GlcNHglycan	755	758	PF01048	0.680
MOD_GlcNHglycan	761	764	PF01048	0.664
MOD_GlcNHglycan	812	815	PF01048	0.589
MOD_GSK3_1	120	127	PF00069	0.732
MOD_GSK3_1	135	142	PF00069	0.432
MOD_GSK3_1	230	237	PF00069	0.483
MOD_GSK3_1	241	248	PF00069	0.486
MOD_GSK3_1	252	259	PF00069	0.472
MOD_GSK3_1	286	293	PF00069	0.564
MOD_GSK3_1	391	398	PF00069	0.550
MOD_GSK3_1	407	414	PF00069	0.376
MOD_GSK3_1	441	448	PF00069	0.544
MOD_GSK3_1	463	470	PF00069	0.663
MOD_GSK3_1	54	61	PF00069	0.770
MOD_GSK3_1	6	13	PF00069	0.689
MOD_GSK3_1	617	624	PF00069	0.619
MOD_GSK3_1	651	658	PF00069	0.688
MOD_GSK3_1	669	676	PF00069	0.621
MOD_GSK3_1	691	698	PF00069	0.653
MOD_GSK3_1	717	724	PF00069	0.677
MOD_GSK3_1	727	734	PF00069	0.644
MOD_GSK3_1	749	756	PF00069	0.762
MOD_GSK3_1	797	804	PF00069	0.632
MOD_LATS_1	741	747	PF00433	0.658
MOD_N-GLC_1	7	12	PF02516	0.682
MOD_NEK2_1	1	6	PF00069	0.686
MOD_NEK2_1	134	139	PF00069	0.586
MOD_NEK2_1	140	145	PF00069	0.481
MOD_NEK2_1	234	239	PF00069	0.499
MOD_NEK2_1	318	323	PF00069	0.511
MOD_NEK2_1	380	385	PF00069	0.567
MOD_NEK2_1	391	396	PF00069	0.494
MOD_NEK2_1	461	466	PF00069	0.537
MOD_NEK2_1	54	59	PF00069	0.763
MOD_NEK2_1	580	585	PF00069	0.645
MOD_NEK2_1	604	609	PF00069	0.559
MOD_NEK2_1	721	726	PF00069	0.732
MOD_NEK2_2	286	291	PF00069	0.523
MOD_NEK2_2	789	794	PF00069	0.675
MOD_PIKK_1	396	402	PF00454	0.568
MOD_PIKK_1	407	413	PF00454	0.398
MOD_PIKK_1	537	543	PF00454	0.520
MOD_PIKK_1	594	600	PF00454	0.559
MOD_PIKK_1	655	661	PF00454	0.644
MOD_PIKK_1	722	728	PF00454	0.691
MOD_PIKK_1	797	803	PF00454	0.740
MOD_PIKK_1	90	96	PF00454	0.686
MOD_PKA_1	571	577	PF00069	0.644
MOD_PKA_2	175	181	PF00069	0.468
MOD_PKA_2	245	251	PF00069	0.497
MOD_PKA_2	290	296	PF00069	0.540
MOD_PKA_2	318	324	PF00069	0.502
MOD_PKA_2	358	364	PF00069	0.482
MOD_PKA_2	380	386	PF00069	0.607
MOD_PKA_2	396	402	PF00069	0.445
MOD_PKA_2	461	467	PF00069	0.610
MOD_PKA_2	52	58	PF00069	0.736
MOD_PKA_2	669	675	PF00069	0.725
MOD_PKA_2	707	713	PF00069	0.736
MOD_PKA_2	727	733	PF00069	0.773
MOD_PKA_2	742	748	PF00069	0.661
MOD_PKA_2	749	755	PF00069	0.717
MOD_PKA_2	801	807	PF00069	0.651
MOD_PKB_1	460	468	PF00069	0.612
MOD_Plk_1	135	141	PF00069	0.498
MOD_Plk_1	194	200	PF00069	0.501
MOD_Plk_1	230	236	PF00069	0.524
MOD_Plk_1	286	292	PF00069	0.524
MOD_Plk_1	7	13	PF00069	0.681
MOD_Plk_2-3	256	262	PF00069	0.478
MOD_Plk_2-3	425	431	PF00069	0.579
MOD_Plk_4	135	141	PF00069	0.523
MOD_Plk_4	18	24	PF00069	0.753
MOD_Plk_4	230	236	PF00069	0.548
MOD_Plk_4	669	675	PF00069	0.714
MOD_Plk_4	7	13	PF00069	0.712
MOD_Plk_4	701	707	PF00069	0.722
MOD_Plk_4	789	795	PF00069	0.629
MOD_ProDKin_1	120	126	PF00069	0.726
MOD_ProDKin_1	44	50	PF00069	0.671
MOD_ProDKin_1	675	681	PF00069	0.698
MOD_ProDKin_1	715	721	PF00069	0.706
MOD_ProDKin_1	744	750	PF00069	0.788
MOD_ProDKin_1	769	775	PF00069	0.778
MOD_ProDKin_1	780	786	PF00069	0.501
MOD_SUMO_for_1	439	442	PF00179	0.605
MOD_SUMO_rev_2	253	260	PF00179	0.537
MOD_SUMO_rev_2	360	366	PF00179	0.562
MOD_SUMO_rev_2	370	377	PF00179	0.565
MOD_SUMO_rev_2	399	406	PF00179	0.622
MOD_SUMO_rev_2	470	476	PF00179	0.673
MOD_SUMO_rev_2	588	597	PF00179	0.558
TRG_DiLeu_BaEn_1	130	135	PF01217	0.519
TRG_DiLeu_BaEn_1	261	266	PF01217	0.478
TRG_DiLeu_BaEn_1	337	342	PF01217	0.600
TRG_DiLeu_BaEn_3	326	332	PF01217	0.553
TRG_ENDOCYTIC_2	196	199	PF00928	0.469
TRG_ENDOCYTIC_2	454	457	PF00928	0.597
TRG_ENDOCYTIC_2	488	491	PF00928	0.518
TRG_ENDOCYTIC_2	51	54	PF00928	0.644
TRG_ENDOCYTIC_2	662	665	PF00928	0.739
TRG_ER_diArg_1	31	33	PF00400	0.779
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.337
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	490	494	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWL2	Leptomonas seymouri	58%	96%
A0A3S7X9W8	Leishmania donovani	99%	100%
A0A422NU91	Trypanosoma rangeli	41%	100%
A4HN97	Leishmania braziliensis	79%	99%
E9AFQ5	Leishmania major	93%	100%
E9B6V8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q6NRG6	Xenopus laevis	23%	100%
V5C2P0	Trypanosoma cruzi	39%	100%