Mitochondrial fission process protein 1

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IBW7_LEIIN

TriTrypDb:

LINF_350048500

Length:

169

Annotations

Annotations by Jardim et al.

Mitochondrial protein, outer mitochondrial membrane proteome 6 (POMP6) Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Show entries

Cellular components
Term	Name	Level	Count
GO:0000331	contractile vacuole	6	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0005773	vacuole	5	1
GO:0016020	membrane	2	2
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0031982	vesicle	4	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IBW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBW7

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	129	131	PF00675	0.453
CLV_NRD_NRD_1	161	163	PF00675	0.458
CLV_NRD_NRD_1	63	65	PF00675	0.425
CLV_NRD_NRD_1	67	69	PF00675	0.406
CLV_PCSK_FUR_1	159	163	PF00082	0.562
CLV_PCSK_KEX2_1	129	131	PF00082	0.452
CLV_PCSK_KEX2_1	159	161	PF00082	0.448
CLV_PCSK_KEX2_1	67	69	PF00082	0.430
CLV_PCSK_SKI1_1	130	134	PF00082	0.464
DEG_Nend_UBRbox_2	1	3	PF02207	0.472

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Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD34	Leptomonas seymouri	80%	100%
A0A1X0P529	Trypanosomatidae	48%	100%
A0A3Q8IQ29	Leishmania donovani	100%	100%
A0A422NU90	Trypanosoma rangeli	46%	100%
A4HN96	Leishmania braziliensis	91%	100%
C9ZYP2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AFQ4	Leishmania major	96%	100%
E9B6V7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%

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