LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
predicted zinc finger protein
Species:
Leishmania infantum
UniProt:
A4IBW6_LEIIN
TriTrypDb:
LINF_350048400
Length:
377

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBW6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBW6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 8
GO:0043167 ion binding 2 8
GO:0043169 cation binding 3 8
GO:0046872 metal ion binding 4 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 244 248 PF00656 0.719
CLV_NRD_NRD_1 113 115 PF00675 0.469
CLV_NRD_NRD_1 136 138 PF00675 0.480
CLV_NRD_NRD_1 142 144 PF00675 0.490
CLV_NRD_NRD_1 183 185 PF00675 0.508
CLV_NRD_NRD_1 189 191 PF00675 0.482
CLV_NRD_NRD_1 192 194 PF00675 0.487
CLV_NRD_NRD_1 306 308 PF00675 0.514
CLV_NRD_NRD_1 85 87 PF00675 0.458
CLV_NRD_NRD_1 92 94 PF00675 0.444
CLV_PCSK_FUR_1 140 144 PF00082 0.482
CLV_PCSK_FUR_1 190 194 PF00082 0.524
CLV_PCSK_KEX2_1 113 115 PF00082 0.475
CLV_PCSK_KEX2_1 136 138 PF00082 0.489
CLV_PCSK_KEX2_1 140 142 PF00082 0.481
CLV_PCSK_KEX2_1 189 191 PF00082 0.509
CLV_PCSK_KEX2_1 192 194 PF00082 0.521
CLV_PCSK_KEX2_1 305 307 PF00082 0.452
CLV_PCSK_KEX2_1 353 355 PF00082 0.383
CLV_PCSK_KEX2_1 92 94 PF00082 0.481
CLV_PCSK_PC1ET2_1 189 191 PF00082 0.514
CLV_PCSK_PC1ET2_1 305 307 PF00082 0.394
CLV_PCSK_PC1ET2_1 353 355 PF00082 0.383
CLV_PCSK_PC7_1 136 142 PF00082 0.480
CLV_PCSK_SKI1_1 260 264 PF00082 0.642
CLV_PCSK_SKI1_1 310 314 PF00082 0.419
CLV_PCSK_SKI1_1 37 41 PF00082 0.488
CLV_PCSK_SKI1_1 80 84 PF00082 0.453
DOC_CKS1_1 362 367 PF01111 0.360
DOC_MAPK_gen_1 305 314 PF00069 0.433
DOC_PP2B_LxvP_1 266 269 PF13499 0.651
DOC_PP4_FxxP_1 292 295 PF00568 0.452
DOC_USP7_MATH_1 270 274 PF00917 0.622
DOC_USP7_MATH_1 287 291 PF00917 0.416
DOC_USP7_MATH_1 348 352 PF00917 0.383
DOC_USP7_UBL2_3 185 189 PF12436 0.539
DOC_USP7_UBL2_3 217 221 PF12436 0.536
DOC_USP7_UBL2_3 305 309 PF12436 0.502
DOC_USP7_UBL2_3 57 61 PF12436 0.411
DOC_WW_Pin1_4 279 284 PF00397 0.459
DOC_WW_Pin1_4 361 366 PF00397 0.360
DOC_WW_Pin1_4 4 9 PF00397 0.704
LIG_14-3-3_CanoR_1 34 40 PF00244 0.508
LIG_14-3-3_CterR_2 374 377 PF00244 0.509
LIG_Actin_WH2_2 250 265 PF00022 0.669
LIG_deltaCOP1_diTrp_1 228 232 PF00928 0.638
LIG_LIR_Apic_2 239 243 PF02991 0.566
LIG_LIR_Apic_2 290 295 PF02991 0.453
LIG_LIR_Apic_2 298 302 PF02991 0.428
LIG_LIR_Apic_2 359 365 PF02991 0.383
LIG_LIR_Gen_1 22 32 PF02991 0.448
LIG_LIR_Gen_1 228 237 PF02991 0.653
LIG_LIR_Gen_1 52 60 PF02991 0.432
LIG_LIR_Gen_1 73 83 PF02991 0.429
LIG_LIR_Nem_3 22 28 PF02991 0.471
LIG_LIR_Nem_3 228 232 PF02991 0.520
LIG_LIR_Nem_3 52 56 PF02991 0.433
LIG_LIR_Nem_3 73 79 PF02991 0.438
LIG_SH2_CRK 308 312 PF00017 0.489
LIG_SH2_CRK 362 366 PF00017 0.383
LIG_SH2_NCK_1 240 244 PF00017 0.570
LIG_SH2_PTP2 53 56 PF00017 0.487
LIG_SH2_SRC 240 243 PF00017 0.567
LIG_SH2_STAP1 63 67 PF00017 0.519
LIG_SH2_STAT5 281 284 PF00017 0.399
LIG_SH2_STAT5 53 56 PF00017 0.487
LIG_SH3_3 13 19 PF00018 0.590
LIG_SH3_3 311 317 PF00018 0.323
LIG_SH3_3 5 11 PF00018 0.667
LIG_TRAF2_1 106 109 PF00917 0.504
LIG_TRAF2_1 128 131 PF00917 0.566
LIG_TRAF2_1 153 156 PF00917 0.498
LIG_TRAF2_1 165 168 PF00917 0.508
LIG_TRAF2_1 169 172 PF00917 0.512
LIG_TRAF2_1 176 179 PF00917 0.501
LIG_TYR_ITIM 51 56 PF00017 0.487
LIG_UBA3_1 35 40 PF00899 0.446
MOD_CDK_SPK_2 4 9 PF00069 0.652
MOD_CDK_SPxK_1 361 367 PF00069 0.360
MOD_CK1_1 3 9 PF00069 0.745
MOD_GlcNHglycan 16 19 PF01048 0.560
MOD_GlcNHglycan 171 176 PF01048 0.441
MOD_GlcNHglycan 80 83 PF01048 0.486
MOD_GSK3_1 275 282 PF00069 0.557
MOD_GSK3_1 61 68 PF00069 0.513
MOD_N-GLC_1 348 353 PF02516 0.383
MOD_NEK2_1 232 237 PF00069 0.671
MOD_NEK2_1 262 267 PF00069 0.734
MOD_NEK2_1 277 282 PF00069 0.470
MOD_NEK2_1 35 40 PF00069 0.446
MOD_NEK2_2 19 24 PF00069 0.653
MOD_PKA_2 19 25 PF00069 0.577
MOD_PKA_2 332 338 PF00069 0.383
MOD_Plk_2-3 52 58 PF00069 0.431
MOD_ProDKin_1 279 285 PF00069 0.448
MOD_ProDKin_1 361 367 PF00069 0.360
MOD_ProDKin_1 4 10 PF00069 0.704
MOD_SUMO_rev_2 258 265 PF00179 0.644
TRG_DiLeu_BaEn_1 46 51 PF01217 0.419
TRG_DiLeu_BaEn_4 202 208 PF01217 0.494
TRG_DiLeu_BaLyEn_6 31 36 PF01217 0.404
TRG_ENDOCYTIC_2 308 311 PF00928 0.514
TRG_ENDOCYTIC_2 370 373 PF00928 0.429
TRG_ENDOCYTIC_2 53 56 PF00928 0.452
TRG_ENDOCYTIC_2 63 66 PF00928 0.419
TRG_ER_diArg_1 113 116 PF00400 0.477
TRG_ER_diArg_1 140 143 PF00400 0.502
TRG_ER_diArg_1 190 193 PF00400 0.503
TRG_ER_diArg_1 306 308 PF00400 0.514
TRG_ER_diArg_1 373 376 PF00400 0.481
TRG_NES_CRM1_1 46 58 PF08389 0.425
TRG_NLS_MonoCore_2 188 193 PF00514 0.492
TRG_NLS_MonoExtC_3 188 193 PF00514 0.492
TRG_NLS_MonoExtC_3 304 309 PF00514 0.478
TRG_NLS_MonoExtN_4 188 193 PF00514 0.496
TRG_NLS_MonoExtN_4 302 309 PF00514 0.411
TRG_Pf-PMV_PEXEL_1 102 107 PF00026 0.591
TRG_Pf-PMV_PEXEL_1 113 117 PF00026 0.451
TRG_Pf-PMV_PEXEL_1 198 202 PF00026 0.492
TRG_Pf-PMV_PEXEL_1 354 358 PF00026 0.397
TRG_Pf-PMV_PEXEL_1 37 42 PF00026 0.599

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3I7 Leptomonas seymouri 80% 95%
A0A0S4JE94 Bodo saltans 55% 100%
A0A3S5H806 Leishmania donovani 100% 100%
E9AFQ3 Leishmania major 96% 100%
E9AIX0 Leishmania braziliensis 88% 100%
E9B6V6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS