LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IBW4_LEIIN
TriTrypDb:
LINF_350048200
Length:
298

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBW4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBW4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 189 193 PF00656 0.588
CLV_NRD_NRD_1 267 269 PF00675 0.403
CLV_PCSK_KEX2_1 267 269 PF00082 0.403
CLV_PCSK_KEX2_1 286 288 PF00082 0.447
CLV_PCSK_PC1ET2_1 286 288 PF00082 0.447
CLV_PCSK_SKI1_1 133 137 PF00082 0.383
CLV_PCSK_SKI1_1 177 181 PF00082 0.601
CLV_PCSK_SKI1_1 257 261 PF00082 0.479
CLV_Separin_Metazoa 238 242 PF03568 0.444
DEG_APCC_DBOX_1 60 68 PF00400 0.451
DEG_SCF_FBW7_2 231 238 PF00400 0.424
DOC_CKS1_1 232 237 PF01111 0.419
DOC_CYCLIN_yCln2_LP_2 114 120 PF00134 0.533
DOC_MAPK_MEF2A_6 206 214 PF00069 0.435
DOC_PP2B_LxvP_1 210 213 PF13499 0.375
DOC_PP4_FxxP_1 5 8 PF00568 0.578
DOC_USP7_MATH_1 175 179 PF00917 0.682
DOC_USP7_MATH_1 201 205 PF00917 0.602
DOC_USP7_MATH_1 290 294 PF00917 0.484
DOC_USP7_MATH_1 8 12 PF00917 0.579
DOC_WW_Pin1_4 138 143 PF00397 0.426
DOC_WW_Pin1_4 168 173 PF00397 0.707
DOC_WW_Pin1_4 231 236 PF00397 0.340
LIG_14-3-3_CanoR_1 160 164 PF00244 0.521
LIG_14-3-3_CanoR_1 226 232 PF00244 0.395
LIG_14-3-3_CanoR_1 29 35 PF00244 0.511
LIG_14-3-3_CanoR_1 36 40 PF00244 0.426
LIG_14-3-3_CanoR_1 7 13 PF00244 0.535
LIG_CSL_BTD_1 42 45 PF09270 0.304
LIG_deltaCOP1_diTrp_1 40 46 PF00928 0.428
LIG_FHA_1 149 155 PF00498 0.659
LIG_FHA_1 192 198 PF00498 0.679
LIG_FHA_1 207 213 PF00498 0.389
LIG_FHA_1 277 283 PF00498 0.486
LIG_FHA_1 73 79 PF00498 0.371
LIG_FHA_1 83 89 PF00498 0.374
LIG_FHA_2 214 220 PF00498 0.454
LIG_FHA_2 240 246 PF00498 0.442
LIG_LIR_Gen_1 89 99 PF02991 0.298
LIG_LIR_Nem_3 124 129 PF02991 0.467
LIG_LIR_Nem_3 40 46 PF02991 0.423
LIG_LIR_Nem_3 89 95 PF02991 0.296
LIG_LIR_Nem_3 97 102 PF02991 0.308
LIG_SH2_SRC 217 220 PF00017 0.482
LIG_SH2_STAT5 123 126 PF00017 0.380
LIG_SH2_STAT5 127 130 PF00017 0.311
LIG_SH2_STAT5 217 220 PF00017 0.482
LIG_SH3_1 241 247 PF00018 0.410
LIG_SH3_3 241 247 PF00018 0.410
MOD_CK1_1 141 147 PF00069 0.579
MOD_CK1_1 205 211 PF00069 0.556
MOD_CK1_1 225 231 PF00069 0.323
MOD_CK2_1 18 24 PF00069 0.509
MOD_CK2_1 213 219 PF00069 0.435
MOD_CK2_1 239 245 PF00069 0.538
MOD_GlcNHglycan 12 15 PF01048 0.613
MOD_GlcNHglycan 151 154 PF01048 0.614
MOD_GlcNHglycan 177 180 PF01048 0.628
MOD_GlcNHglycan 282 285 PF01048 0.426
MOD_GlcNHglycan 292 295 PF01048 0.416
MOD_GlcNHglycan 96 99 PF01048 0.378
MOD_GSK3_1 102 109 PF00069 0.520
MOD_GSK3_1 140 147 PF00069 0.604
MOD_GSK3_1 154 161 PF00069 0.667
MOD_GSK3_1 171 178 PF00069 0.473
MOD_GSK3_1 201 208 PF00069 0.552
MOD_GSK3_1 276 283 PF00069 0.506
MOD_N-GLC_1 121 126 PF02516 0.477
MOD_N-GLC_2 183 185 PF02516 0.453
MOD_NEK2_1 129 134 PF00069 0.362
MOD_NEK2_1 145 150 PF00069 0.603
MOD_NEK2_1 239 244 PF00069 0.494
MOD_NEK2_1 282 287 PF00069 0.483
MOD_NEK2_1 82 87 PF00069 0.453
MOD_NEK2_1 91 96 PF00069 0.321
MOD_NEK2_2 155 160 PF00069 0.496
MOD_OFUCOSY 69 76 PF10250 0.442
MOD_PIKK_1 44 50 PF00454 0.542
MOD_PKA_2 145 151 PF00069 0.759
MOD_PKA_2 159 165 PF00069 0.449
MOD_PKA_2 225 231 PF00069 0.443
MOD_PKA_2 28 34 PF00069 0.546
MOD_PKA_2 35 41 PF00069 0.477
MOD_Plk_1 222 228 PF00069 0.527
MOD_Plk_4 206 212 PF00069 0.481
MOD_Plk_4 213 219 PF00069 0.425
MOD_Plk_4 277 283 PF00069 0.423
MOD_Plk_4 91 97 PF00069 0.436
MOD_ProDKin_1 138 144 PF00069 0.443
MOD_ProDKin_1 168 174 PF00069 0.708
MOD_ProDKin_1 231 237 PF00069 0.341
MOD_SUMO_for_1 271 274 PF00179 0.503
TRG_ENDOCYTIC_2 126 129 PF00928 0.466
TRG_ENDOCYTIC_2 20 23 PF00928 0.518
TRG_ER_diArg_1 240 243 PF00400 0.402
TRG_ER_diArg_1 266 268 PF00400 0.386
TRG_Pf-PMV_PEXEL_1 86 90 PF00026 0.381

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HY73 Leptomonas seymouri 52% 100%
A0A0S4JF57 Bodo saltans 32% 100%
A0A1X0P581 Trypanosomatidae 35% 100%
A0A3R7NNI3 Trypanosoma rangeli 36% 100%
A0A3S7X9V8 Leishmania donovani 99% 100%
A4HN94 Leishmania braziliensis 72% 100%
C9ZYP7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9AFQ1 Leishmania major 92% 100%
E9B6V4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
V5BCR5 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS