Uncharacterized protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IBW2_LEIIN

TriTrypDb:

LINF_350048000

Length:

600

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 358, 364, 366

Expansion

Sequence features

A4IBW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.668
CLV_NRD_NRD_1	273	275	PF00675	0.689
CLV_NRD_NRD_1	36	38	PF00675	0.728
CLV_NRD_NRD_1	579	581	PF00675	0.732
CLV_NRD_NRD_1	592	594	PF00675	0.558
CLV_PCSK_KEX2_1	216	218	PF00082	0.782
CLV_PCSK_KEX2_1	36	38	PF00082	0.728
CLV_PCSK_KEX2_1	587	589	PF00082	0.712
CLV_PCSK_KEX2_1	591	593	PF00082	0.692
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.782
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.642
CLV_PCSK_PC7_1	588	594	PF00082	0.696
CLV_PCSK_SKI1_1	216	220	PF00082	0.794
CLV_PCSK_SKI1_1	24	28	PF00082	0.649
CLV_PCSK_SKI1_1	388	392	PF00082	0.701
CLV_PCSK_SKI1_1	498	502	PF00082	0.605
DEG_SPOP_SBC_1	160	164	PF00917	0.616
DEG_SPOP_SBC_1	321	325	PF00917	0.651
DEG_SPOP_SBC_1	436	440	PF00917	0.687
DOC_CKS1_1	125	130	PF01111	0.647
DOC_CYCLIN_yCln2_LP_2	250	256	PF00134	0.741
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.669
DOC_MAPK_MEF2A_6	326	334	PF00069	0.583
DOC_MAPK_MEF2A_6	75	84	PF00069	0.663
DOC_PP2B_LxvP_1	250	253	PF13499	0.738
DOC_USP7_MATH_1	111	115	PF00917	0.810
DOC_USP7_MATH_1	118	122	PF00917	0.741
DOC_USP7_MATH_1	138	142	PF00917	0.541
DOC_USP7_MATH_1	206	210	PF00917	0.698
DOC_USP7_MATH_1	226	230	PF00917	0.782
DOC_USP7_MATH_1	231	235	PF00917	0.711
DOC_USP7_MATH_1	254	258	PF00917	0.758
DOC_USP7_MATH_1	321	325	PF00917	0.754
DOC_USP7_MATH_1	338	342	PF00917	0.505
DOC_USP7_MATH_1	349	353	PF00917	0.589
DOC_USP7_MATH_1	361	365	PF00917	0.836
DOC_USP7_MATH_1	374	378	PF00917	0.620
DOC_USP7_MATH_1	397	401	PF00917	0.739
DOC_USP7_MATH_1	436	440	PF00917	0.667
DOC_USP7_MATH_1	511	515	PF00917	0.643
DOC_USP7_MATH_1	551	555	PF00917	0.661
DOC_USP7_UBL2_3	30	34	PF12436	0.644
DOC_WW_Pin1_4	120	125	PF00397	0.738
DOC_WW_Pin1_4	278	283	PF00397	0.729
DOC_WW_Pin1_4	49	54	PF00397	0.743
DOC_WW_Pin1_4	92	97	PF00397	0.712
LIG_14-3-3_CanoR_1	161	169	PF00244	0.714
LIG_14-3-3_CanoR_1	220	228	PF00244	0.704
LIG_14-3-3_CanoR_1	267	276	PF00244	0.690
LIG_14-3-3_CanoR_1	363	370	PF00244	0.766
LIG_14-3-3_CanoR_1	382	387	PF00244	0.509
LIG_14-3-3_CanoR_1	512	522	PF00244	0.698
LIG_14-3-3_CanoR_1	523	528	PF00244	0.690
LIG_Actin_WH2_2	465	482	PF00022	0.614
LIG_BIR_II_1	1	5	PF00653	0.714
LIG_BRCT_BRCA1_1	569	573	PF00533	0.615
LIG_FHA_1	125	131	PF00498	0.701
LIG_FHA_1	135	141	PF00498	0.664
LIG_FHA_1	268	274	PF00498	0.594
LIG_FHA_1	425	431	PF00498	0.736
LIG_FHA_1	457	463	PF00498	0.633
LIG_FHA_1	481	487	PF00498	0.733
LIG_FHA_2	233	239	PF00498	0.757
LIG_FHA_2	593	599	PF00498	0.724
LIG_LIR_Apic_2	19	23	PF02991	0.605
LIG_LIR_Gen_1	439	449	PF02991	0.721
LIG_LIR_Gen_1	595	600	PF02991	0.730
LIG_LIR_Nem_3	403	409	PF02991	0.702
LIG_LIR_Nem_3	439	445	PF02991	0.716
LIG_LIR_Nem_3	448	452	PF02991	0.604
LIG_LIR_Nem_3	595	600	PF02991	0.730
LIG_MYND_1	124	128	PF01753	0.600
LIG_PDZ_Class_3	595	600	PF00595	0.730
LIG_SH2_CRK	442	446	PF00017	0.727
LIG_SH2_SRC	20	23	PF00017	0.662
LIG_SH2_SRC	404	407	PF00017	0.649
LIG_SH2_SRC	452	455	PF00017	0.625
LIG_SH2_STAP1	449	453	PF00017	0.637
LIG_SH2_STAT5	20	23	PF00017	0.662
LIG_SH3_2	211	216	PF14604	0.722
LIG_SH3_3	122	128	PF00018	0.665
LIG_SH3_3	208	214	PF00018	0.727
LIG_SH3_3	299	305	PF00018	0.694
LIG_SH3_3	315	321	PF00018	0.534
LIG_SH3_3	324	330	PF00018	0.597
LIG_SH3_3	350	356	PF00018	0.752
LIG_SH3_3	484	490	PF00018	0.789
LIG_SH3_3	502	508	PF00018	0.567
LIG_SH3_3	91	97	PF00018	0.707
LIG_SH3_3	98	104	PF00018	0.740
LIG_WW_3	152	156	PF00397	0.607
LIG_WW_3	509	513	PF00397	0.664
MOD_CDK_SPK_2	49	54	PF00069	0.749
MOD_CK1_1	129	135	PF00069	0.628
MOD_CK1_1	163	169	PF00069	0.737
MOD_CK1_1	194	200	PF00069	0.743
MOD_CK1_1	209	215	PF00069	0.585
MOD_CK1_1	224	230	PF00069	0.664
MOD_CK1_1	234	240	PF00069	0.690
MOD_CK1_1	257	263	PF00069	0.584
MOD_CK1_1	278	284	PF00069	0.726
MOD_CK1_1	291	297	PF00069	0.658
MOD_CK1_1	378	384	PF00069	0.684
MOD_CK1_1	435	441	PF00069	0.677
MOD_CK1_1	471	477	PF00069	0.698
MOD_CK1_1	516	522	PF00069	0.747
MOD_CK1_1	545	551	PF00069	0.666
MOD_CK1_1	92	98	PF00069	0.743
MOD_CK2_1	232	238	PF00069	0.759
MOD_CK2_1	239	245	PF00069	0.666
MOD_CK2_1	392	398	PF00069	0.667
MOD_CK2_1	551	557	PF00069	0.714
MOD_GlcNHglycan	109	112	PF01048	0.793
MOD_GlcNHglycan	120	123	PF01048	0.646
MOD_GlcNHglycan	140	143	PF01048	0.642
MOD_GlcNHglycan	157	160	PF01048	0.763
MOD_GlcNHglycan	163	166	PF01048	0.735
MOD_GlcNHglycan	189	192	PF01048	0.707
MOD_GlcNHglycan	229	232	PF01048	0.734
MOD_GlcNHglycan	24	27	PF01048	0.436
MOD_GlcNHglycan	250	253	PF01048	0.728
MOD_GlcNHglycan	277	280	PF01048	0.744
MOD_GlcNHglycan	299	302	PF01048	0.818
MOD_GlcNHglycan	400	403	PF01048	0.701
MOD_GlcNHglycan	434	437	PF01048	0.665
MOD_GlcNHglycan	473	476	PF01048	0.748
MOD_GlcNHglycan	49	52	PF01048	0.625
MOD_GlcNHglycan	492	495	PF01048	0.736
MOD_GlcNHglycan	501	504	PF01048	0.656
MOD_GlcNHglycan	515	518	PF01048	0.629
MOD_GlcNHglycan	547	550	PF01048	0.621
MOD_GlcNHglycan	8	11	PF01048	0.761
MOD_GSK3_1	107	114	PF00069	0.716
MOD_GSK3_1	116	123	PF00069	0.636
MOD_GSK3_1	129	136	PF00069	0.623
MOD_GSK3_1	155	162	PF00069	0.726
MOD_GSK3_1	181	188	PF00069	0.803
MOD_GSK3_1	220	227	PF00069	0.756
MOD_GSK3_1	234	241	PF00069	0.582
MOD_GSK3_1	293	300	PF00069	0.798
MOD_GSK3_1	355	362	PF00069	0.735
MOD_GSK3_1	372	379	PF00069	0.623
MOD_GSK3_1	382	389	PF00069	0.626
MOD_GSK3_1	420	427	PF00069	0.784
MOD_GSK3_1	428	435	PF00069	0.656
MOD_GSK3_1	436	443	PF00069	0.565
MOD_GSK3_1	45	52	PF00069	0.708
MOD_GSK3_1	467	474	PF00069	0.736
MOD_GSK3_1	521	528	PF00069	0.684
MOD_GSK3_1	538	545	PF00069	0.526
MOD_GSK3_1	85	92	PF00069	0.725
MOD_N-GLC_1	111	116	PF02516	0.692
MOD_N-GLC_1	338	343	PF02516	0.578
MOD_N-GLC_1	567	572	PF02516	0.589
MOD_NEK2_1	219	224	PF00069	0.749
MOD_NEK2_1	386	391	PF00069	0.596
MOD_NEK2_1	424	429	PF00069	0.753
MOD_NEK2_1	479	484	PF00069	0.610
MOD_NEK2_1	536	541	PF00069	0.698
MOD_NEK2_2	239	244	PF00069	0.695
MOD_NEK2_2	330	335	PF00069	0.685
MOD_PIKK_1	116	122	PF00454	0.697
MOD_PIKK_1	424	430	PF00454	0.752
MOD_PIKK_1	99	105	PF00454	0.652
MOD_PK_1	376	382	PF00069	0.688
MOD_PK_1	542	548	PF00069	0.586
MOD_PKA_1	44	50	PF00069	0.629
MOD_PKA_1	592	598	PF00069	0.720
MOD_PKA_2	144	150	PF00069	0.811
MOD_PKA_2	154	160	PF00069	0.668
MOD_PKA_2	219	225	PF00069	0.770
MOD_PKA_2	297	303	PF00069	0.744
MOD_PKA_2	344	350	PF00069	0.801
MOD_PKA_2	362	368	PF00069	0.765
MOD_PKA_2	372	378	PF00069	0.633
MOD_PKA_2	381	387	PF00069	0.538
MOD_PKA_2	445	451	PF00069	0.692
MOD_PKA_2	479	485	PF00069	0.782
MOD_PKA_2	511	517	PF00069	0.664
MOD_PKA_2	592	598	PF00069	0.663
MOD_Plk_1	239	245	PF00069	0.709
MOD_Plk_1	330	336	PF00069	0.581
MOD_Plk_1	440	446	PF00069	0.721
MOD_Plk_1	45	51	PF00069	0.658
MOD_Plk_4	440	446	PF00069	0.661
MOD_ProDKin_1	120	126	PF00069	0.738
MOD_ProDKin_1	278	284	PF00069	0.727
MOD_ProDKin_1	49	55	PF00069	0.740
MOD_ProDKin_1	92	98	PF00069	0.716
MOD_SUMO_for_1	393	396	PF00179	0.724
MOD_SUMO_for_1	559	562	PF00179	0.777
TRG_DiLeu_BaLyEn_6	458	463	PF01217	0.586
TRG_ENDOCYTIC_2	406	409	PF00928	0.699
TRG_ENDOCYTIC_2	442	445	PF00928	0.723
TRG_ER_diArg_1	35	37	PF00400	0.732
TRG_ER_diArg_1	370	373	PF00400	0.608
TRG_ER_diArg_1	591	593	PF00400	0.716

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJF9	Leishmania donovani	99%	100%
A4HN92	Leishmania braziliensis	54%	100%
E9AFP9	Leishmania major	85%	100%
E9B6V2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	99%