N6_Mtase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4IBW0_LEIIN

TriTrypDb:

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBW0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.796
CLV_NRD_NRD_1	119	121	PF00675	0.552
CLV_NRD_NRD_1	85	87	PF00675	0.759
CLV_PCSK_KEX2_1	118	120	PF00082	0.551
CLV_PCSK_KEX2_1	336	338	PF00082	0.575
CLV_PCSK_KEX2_1	85	87	PF00082	0.759
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.477
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.575
CLV_PCSK_SKI1_1	119	123	PF00082	0.669
CLV_PCSK_SKI1_1	12	16	PF00082	0.352
CLV_PCSK_SKI1_1	410	414	PF00082	0.545
CLV_PCSK_SKI1_1	459	463	PF00082	0.760
CLV_PCSK_SKI1_1	62	66	PF00082	0.414
CLV_PCSK_SKI1_1	86	90	PF00082	0.705
DEG_SCF_FBW7_1	347	353	PF00400	0.741
DOC_CKS1_1	347	352	PF01111	0.746
DOC_CYCLIN_RxL_1	12	23	PF00134	0.350
DOC_MAPK_gen_1	12	21	PF00069	0.347
DOC_MAPK_gen_1	159	168	PF00069	0.378
DOC_MAPK_gen_1	188	197	PF00069	0.383
DOC_MAPK_MEF2A_6	12	21	PF00069	0.347
DOC_SPAK_OSR1_1	25	29	PF12202	0.374
DOC_USP7_MATH_1	171	175	PF00917	0.600
DOC_WW_Pin1_4	340	345	PF00397	0.718
DOC_WW_Pin1_4	346	351	PF00397	0.722
LIG_BIR_II_1	1	5	PF00653	0.497
LIG_Clathr_ClatBox_1	396	400	PF01394	0.712
LIG_FHA_1	110	116	PF00498	0.633
LIG_FHA_1	178	184	PF00498	0.436
LIG_FHA_1	196	202	PF00498	0.676
LIG_FHA_1	347	353	PF00498	0.547
LIG_FHA_1	390	396	PF00498	0.578
LIG_FHA_1	460	466	PF00498	0.573
LIG_FHA_1	475	481	PF00498	0.672
LIG_FHA_2	122	128	PF00498	0.501
LIG_FHA_2	312	318	PF00498	0.696
LIG_FHA_2	449	455	PF00498	0.585
LIG_LIR_Gen_1	416	424	PF02991	0.765
LIG_LIR_Gen_1	65	76	PF02991	0.410
LIG_LIR_LC3C_4	297	302	PF02991	0.505
LIG_LIR_Nem_3	102	108	PF02991	0.682
LIG_LIR_Nem_3	23	29	PF02991	0.364
LIG_LIR_Nem_3	236	242	PF02991	0.404
LIG_LIR_Nem_3	416	422	PF02991	0.765
LIG_LIR_Nem_3	423	429	PF02991	0.659
LIG_LIR_Nem_3	65	71	PF02991	0.409
LIG_LIR_Nem_3	72	76	PF02991	0.399
LIG_MYND_1	205	209	PF01753	0.519
LIG_NRBOX	16	22	PF00104	0.347
LIG_PDZ_Class_2	481	486	PF00595	0.508
LIG_Pex14_1	253	257	PF04695	0.692
LIG_Pex14_2	289	293	PF04695	0.738
LIG_PTB_Apo_2	191	198	PF02174	0.397
LIG_SH2_CRK	105	109	PF00017	0.614
LIG_SH2_CRK	192	196	PF00017	0.384
LIG_SH2_GRB2like	192	195	PF00017	0.379
LIG_SH2_NCK_1	192	196	PF00017	0.384
LIG_SH2_NCK_1	388	392	PF00017	0.443
LIG_SH2_SRC	192	195	PF00017	0.379
LIG_SH2_STAP1	192	196	PF00017	0.384
LIG_SH2_STAT5	184	187	PF00017	0.618
LIG_SH2_STAT5	257	260	PF00017	0.697
LIG_SH3_3	198	204	PF00018	0.780
LIG_SH3_3	244	250	PF00018	0.706
LIG_SH3_3	302	308	PF00018	0.693
LIG_SH3_3	349	355	PF00018	0.698
LIG_SH3_3	477	483	PF00018	0.497
LIG_SUMO_SIM_par_1	17	23	PF11976	0.349
LIG_TRAF2_1	288	291	PF00917	0.755
LIG_TRAF2_1	432	435	PF00917	0.592
LIG_TYR_ITIM	103	108	PF00017	0.616
LIG_UBA3_1	396	402	PF00899	0.723
LIG_WRC_WIRS_1	217	222	PF05994	0.724
LIG_WW_1	355	358	PF00397	0.767
MOD_CK1_1	129	135	PF00069	0.795
MOD_CK1_1	42	48	PF00069	0.497
MOD_CK1_1	430	436	PF00069	0.780
MOD_CK1_1	6	12	PF00069	0.403
MOD_CK2_1	175	181	PF00069	0.607
MOD_CK2_1	311	317	PF00069	0.419
MOD_CK2_1	460	466	PF00069	0.599
MOD_Cter_Amidation	115	118	PF01082	0.455
MOD_GlcNHglycan	177	180	PF01048	0.599
MOD_GlcNHglycan	223	226	PF01048	0.735
MOD_GlcNHglycan	41	44	PF01048	0.494
MOD_GlcNHglycan	443	446	PF01048	0.792
MOD_GlcNHglycan	462	465	PF01048	0.462
MOD_GlcNHglycan	52	56	PF01048	0.435
MOD_GSK3_1	171	178	PF00069	0.651
MOD_GSK3_1	195	202	PF00069	0.512
MOD_GSK3_1	336	343	PF00069	0.791
MOD_GSK3_1	346	353	PF00069	0.703
MOD_GSK3_1	446	453	PF00069	0.748
MOD_GSK3_1	470	477	PF00069	0.799
MOD_LATS_1	173	179	PF00433	0.600
MOD_N-GLC_1	446	451	PF02516	0.755
MOD_N-GLC_1	459	464	PF02516	0.628
MOD_NEK2_1	126	131	PF00069	0.593
MOD_NEK2_1	221	226	PF00069	0.490
MOD_NEK2_1	233	238	PF00069	0.393
MOD_NEK2_1	300	305	PF00069	0.508
MOD_NEK2_1	422	427	PF00069	0.699
MOD_PIKK_1	207	213	PF00454	0.578
MOD_PIKK_1	300	306	PF00454	0.699
MOD_PIKK_1	430	436	PF00454	0.739
MOD_PKA_1	336	342	PF00069	0.577
MOD_PKA_2	336	342	PF00069	0.577
MOD_PKA_2	6	12	PF00069	0.403
MOD_PKB_1	48	56	PF00069	0.481
MOD_Plk_1	126	132	PF00069	0.787
MOD_Plk_1	317	323	PF00069	0.387
MOD_Plk_1	422	428	PF00069	0.541
MOD_Plk_1	99	105	PF00069	0.611
MOD_Plk_4	150	156	PF00069	0.463
MOD_Plk_4	216	222	PF00069	0.727
MOD_Plk_4	342	348	PF00069	0.571
MOD_ProDKin_1	340	346	PF00069	0.714
MOD_SUMO_rev_2	291	301	PF00179	0.525
MOD_SUMO_rev_2	370	376	PF00179	0.809
TRG_DiLeu_BaEn_1	290	295	PF01217	0.653
TRG_DiLeu_BaEn_2	480	486	PF01217	0.506
TRG_DiLeu_BaEn_4	265	271	PF01217	0.732
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.373
TRG_ENDOCYTIC_2	105	108	PF00928	0.617
TRG_ENDOCYTIC_2	192	195	PF00928	0.379
TRG_ENDOCYTIC_2	419	422	PF00928	0.766
TRG_ER_diArg_1	84	86	PF00400	0.757
TRG_NLS_MonoCore_2	116	121	PF00514	0.470
TRG_NLS_MonoExtN_4	117	122	PF00514	0.469
TRG_Pf-PMV_PEXEL_1	27	32	PF00026	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AFP7	Leishmania major	79%	73%
E9B6V0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	68%