Putative Bardet-Biedl syndrome 1 protein homolog (BBS1-like protein 1)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bardet-Biedl syndrome 1 protein homolog (BBS1-like protein 1) - putative

Species:

Leishmania infantum

UniProt:

A4IBV8_LEIIN

TriTrypDb:

LINF_350047600

Length:

593

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1

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Expansion

Sequence features

A4IBV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBV8

Function

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Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006826	iron ion transport	8	1
GO:0006897	endocytosis	5	1
GO:0006907	pinocytosis	6	1
GO:0006996	organelle organization	4	12
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	12

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Molecular functions
Term	Name	Level	Count
GO:0001664	G protein-coupled receptor binding	4	1
GO:0005102	signaling receptor binding	3	1
GO:0005113	patched binding	4	1
GO:0005119	smoothened binding	5	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.428
CLV_C14_Caspase3-7	324	328	PF00656	0.420
CLV_C14_Caspase3-7	84	88	PF00656	0.365
CLV_NRD_NRD_1	432	434	PF00675	0.472
CLV_PCSK_KEX2_1	55	57	PF00082	0.336
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.369
CLV_PCSK_SKI1_1	206	210	PF00082	0.391
CLV_PCSK_SKI1_1	231	235	PF00082	0.409
CLV_PCSK_SKI1_1	55	59	PF00082	0.273
DEG_APCC_DBOX_1	21	29	PF00400	0.290

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJK5	Leptomonas seymouri	74%	100%
A0A0S4KEX6	Bodo saltans	41%	97%
A0A1X0P534	Trypanosomatidae	47%	97%
A0A3Q8IVI7	Leishmania donovani	99%	100%
A0A3R7KG84	Trypanosoma rangeli	47%	100%
A4HN90	Leishmania braziliensis	85%	100%
C9ZYQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	97%
E9AFP5	Leishmania major	95%	100%
E9B6U8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q3V3N7	Mus musculus	32%	100%

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