LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IBV4_LEIIN
TriTrypDb:
LINF_350047200
Length:
306

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A4IBV4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBV4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 263 267 PF00656 0.743
CLV_NRD_NRD_1 142 144 PF00675 0.462
CLV_NRD_NRD_1 214 216 PF00675 0.547
CLV_NRD_NRD_1 219 221 PF00675 0.494
CLV_NRD_NRD_1 293 295 PF00675 0.497
CLV_PCSK_KEX2_1 142 144 PF00082 0.421
CLV_PCSK_KEX2_1 214 216 PF00082 0.474
CLV_PCSK_KEX2_1 293 295 PF00082 0.495
CLV_PCSK_SKI1_1 167 171 PF00082 0.415
CLV_PCSK_SKI1_1 214 218 PF00082 0.475
CLV_PCSK_SKI1_1 89 93 PF00082 0.411
DEG_APCC_DBOX_1 166 174 PF00400 0.562
DEG_APCC_DBOX_1 228 236 PF00400 0.749
DEG_Nend_Nbox_1 1 3 PF02207 0.456
DOC_CDC14_PxL_1 96 104 PF14671 0.487
DOC_CYCLIN_yCln2_LP_2 111 117 PF00134 0.626
DOC_MAPK_DCC_7 54 64 PF00069 0.654
DOC_MAPK_gen_1 142 149 PF00069 0.644
DOC_MAPK_MEF2A_6 142 149 PF00069 0.623
DOC_MAPK_MEF2A_6 50 59 PF00069 0.698
DOC_PP1_RVXF_1 87 93 PF00149 0.411
DOC_PP2B_LxvP_1 111 114 PF13499 0.551
DOC_PP2B_LxvP_1 97 100 PF13499 0.676
DOC_USP7_MATH_1 208 212 PF00917 0.667
DOC_USP7_MATH_1 250 254 PF00917 0.726
DOC_USP7_MATH_1 256 260 PF00917 0.683
DOC_WW_Pin1_4 122 127 PF00397 0.742
DOC_WW_Pin1_4 39 44 PF00397 0.736
LIG_14-3-3_CanoR_1 134 139 PF00244 0.664
LIG_14-3-3_CanoR_1 192 196 PF00244 0.705
LIG_14-3-3_CanoR_1 29 34 PF00244 0.693
LIG_APCC_ABBA_1 82 87 PF00400 0.411
LIG_BRCT_BRCA1_1 171 175 PF00533 0.636
LIG_BRCT_BRCA1_1 302 306 PF00533 0.636
LIG_deltaCOP1_diTrp_1 80 85 PF00928 0.419
LIG_FHA_1 126 132 PF00498 0.677
LIG_FHA_1 133 139 PF00498 0.674
LIG_FHA_1 181 187 PF00498 0.571
LIG_FHA_1 208 214 PF00498 0.690
LIG_FHA_1 249 255 PF00498 0.737
LIG_FHA_1 287 293 PF00498 0.725
LIG_FHA_1 29 35 PF00498 0.781
LIG_FHA_1 68 74 PF00498 0.487
LIG_FHA_2 261 267 PF00498 0.767
LIG_FHA_2 51 57 PF00498 0.692
LIG_LIR_Apic_2 95 101 PF02991 0.520
LIG_LIR_Gen_1 106 116 PF02991 0.593
LIG_LIR_Gen_1 19 26 PF02991 0.347
LIG_LIR_Gen_1 194 199 PF02991 0.594
LIG_LIR_Nem_3 106 111 PF02991 0.592
LIG_LIR_Nem_3 11 15 PF02991 0.381
LIG_LIR_Nem_3 19 23 PF02991 0.385
LIG_LIR_Nem_3 194 198 PF02991 0.596
LIG_LIR_Nem_3 80 85 PF02991 0.346
LIG_Pex14_1 81 85 PF04695 0.513
LIG_SH2_CRK 108 112 PF00017 0.624
LIG_SH2_CRK 195 199 PF00017 0.632
LIG_SH2_CRK 94 98 PF00017 0.411
LIG_SH2_NCK_1 195 199 PF00017 0.592
LIG_SH2_SRC 98 101 PF00017 0.653
LIG_SH2_STAP1 108 112 PF00017 0.537
LIG_SH2_STAP1 195 199 PF00017 0.615
LIG_SH2_STAP1 20 24 PF00017 0.299
LIG_SH2_STAP1 94 98 PF00017 0.390
LIG_SH2_STAT5 15 18 PF00017 0.411
LIG_SH2_STAT5 154 157 PF00017 0.616
LIG_SH2_STAT5 94 97 PF00017 0.397
LIG_SH3_3 35 41 PF00018 0.687
LIG_SUMO_SIM_par_1 6 11 PF11976 0.513
LIG_SUMO_SIM_par_1 64 70 PF11976 0.411
LIG_TRAF2_1 103 106 PF00917 0.626
LIG_WRC_WIRS_1 9 14 PF05994 0.377
MOD_CDK_SPxxK_3 122 129 PF00069 0.741
MOD_CK1_1 125 131 PF00069 0.650
MOD_CK1_1 258 264 PF00069 0.666
MOD_CK1_1 42 48 PF00069 0.798
MOD_CK2_1 276 282 PF00069 0.759
MOD_CK2_1 50 56 PF00069 0.702
MOD_GlcNHglycan 189 192 PF01048 0.457
MOD_GlcNHglycan 224 229 PF01048 0.482
MOD_GlcNHglycan 244 247 PF01048 0.547
MOD_GlcNHglycan 278 281 PF01048 0.543
MOD_GlcNHglycan 282 285 PF01048 0.536
MOD_GlcNHglycan 302 305 PF01048 0.437
MOD_GSK3_1 180 187 PF00069 0.680
MOD_GSK3_1 250 257 PF00069 0.716
MOD_GSK3_1 276 283 PF00069 0.690
MOD_GSK3_1 28 35 PF00069 0.700
MOD_N-GLC_1 152 157 PF02516 0.433
MOD_NEK2_1 1 6 PF00069 0.466
MOD_NEK2_1 16 21 PF00069 0.337
MOD_NEK2_1 180 185 PF00069 0.627
MOD_NEK2_1 254 259 PF00069 0.715
MOD_NEK2_1 260 265 PF00069 0.743
MOD_NEK2_1 268 273 PF00069 0.628
MOD_NEK2_1 67 72 PF00069 0.443
MOD_NEK2_1 8 13 PF00069 0.376
MOD_NEK2_1 92 97 PF00069 0.404
MOD_PKA_2 187 193 PF00069 0.664
MOD_PKA_2 28 34 PF00069 0.698
MOD_Plk_1 155 161 PF00069 0.590
MOD_Plk_4 134 140 PF00069 0.674
MOD_Plk_4 250 256 PF00069 0.718
MOD_Plk_4 29 35 PF00069 0.749
MOD_Plk_4 72 78 PF00069 0.443
MOD_Plk_4 8 14 PF00069 0.416
MOD_Plk_4 92 98 PF00069 0.183
MOD_ProDKin_1 122 128 PF00069 0.740
MOD_ProDKin_1 39 45 PF00069 0.737
TRG_DiLeu_BaLyEn_6 111 116 PF01217 0.630
TRG_DiLeu_BaLyEn_6 3 8 PF01217 0.436
TRG_ENDOCYTIC_2 108 111 PF00928 0.542
TRG_ENDOCYTIC_2 15 18 PF00928 0.411
TRG_ENDOCYTIC_2 195 198 PF00928 0.594
TRG_ENDOCYTIC_2 20 23 PF00928 0.411
TRG_ENDOCYTIC_2 94 97 PF00928 0.390
TRG_ER_diArg_1 141 143 PF00400 0.619
TRG_ER_diArg_1 213 215 PF00400 0.743
TRG_ER_diArg_1 292 294 PF00400 0.723
TRG_Pf-PMV_PEXEL_1 159 164 PF00026 0.439
TRG_Pf-PMV_PEXEL_1 178 182 PF00026 0.431

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4X0 Leptomonas seymouri 54% 99%
A0A3Q8IIP6 Leishmania donovani 99% 100%
A4HN86 Leishmania braziliensis 62% 100%
E9AFP1 Leishmania major 86% 100%
E9B6U4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS