Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IBU9_LEIIN

TriTrypDb:

LINF_350046700

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBU9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.605
CLV_NRD_NRD_1	218	220	PF00675	0.671
CLV_NRD_NRD_1	222	224	PF00675	0.692
CLV_NRD_NRD_1	311	313	PF00675	0.526
CLV_NRD_NRD_1	330	332	PF00675	0.560
CLV_PCSK_FUR_1	309	313	PF00082	0.571
CLV_PCSK_KEX2_1	109	111	PF00082	0.496
CLV_PCSK_KEX2_1	218	220	PF00082	0.634
CLV_PCSK_KEX2_1	222	224	PF00082	0.675
CLV_PCSK_KEX2_1	262	264	PF00082	0.486
CLV_PCSK_KEX2_1	311	313	PF00082	0.508
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.569
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.575
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.544
CLV_PCSK_PC7_1	307	313	PF00082	0.500
CLV_PCSK_SKI1_1	201	205	PF00082	0.413
CLV_PCSK_SKI1_1	311	315	PF00082	0.528
CLV_PCSK_SKI1_1	335	339	PF00082	0.454
CLV_PCSK_SKI1_1	53	57	PF00082	0.526
DEG_APCC_DBOX_1	52	60	PF00400	0.533
DEG_Nend_UBRbox_1	1	4	PF02207	0.731
DEG_SCF_FBW7_1	224	231	PF00400	0.592
DEG_SPOP_SBC_1	36	40	PF00917	0.571
DOC_CYCLIN_yCln2_LP_2	163	169	PF00134	0.481
DOC_MAPK_gen_1	109	117	PF00069	0.526
DOC_MAPK_gen_1	48	56	PF00069	0.638
DOC_MAPK_MEF2A_6	109	116	PF00069	0.453
DOC_MAPK_MEF2A_6	48	56	PF00069	0.638
DOC_MAPK_MEF2A_6	68	76	PF00069	0.313
DOC_MAPK_MEF2A_6	95	103	PF00069	0.559
DOC_PP4_FxxP_1	148	151	PF00568	0.523
DOC_PP4_FxxP_1	402	405	PF00568	0.655
DOC_USP7_MATH_1	183	187	PF00917	0.545
DOC_USP7_MATH_1	228	232	PF00917	0.737
DOC_USP7_MATH_1	333	337	PF00917	0.599
DOC_USP7_MATH_1	87	91	PF00917	0.641
DOC_USP7_UBL2_3	258	262	PF12436	0.580
DOC_USP7_UBL2_3	44	48	PF12436	0.575
DOC_WW_Pin1_4	224	229	PF00397	0.710
DOC_WW_Pin1_4	325	330	PF00397	0.487
LIG_14-3-3_CanoR_1	386	392	PF00244	0.493
LIG_14-3-3_CanoR_1	417	422	PF00244	0.653
LIG_14-3-3_CanoR_1	77	85	PF00244	0.553
LIG_Actin_WH2_2	39	55	PF00022	0.665
LIG_APCC_ABBA_1	291	296	PF00400	0.537
LIG_BRCT_BRCA1_1	144	148	PF00533	0.554
LIG_BRCT_BRCA1_1	198	202	PF00533	0.481
LIG_BRCT_BRCA1_1	89	93	PF00533	0.637
LIG_BRCT_BRCA1_2	89	95	PF00533	0.680
LIG_deltaCOP1_diTrp_1	67	75	PF00928	0.522
LIG_FHA_1	168	174	PF00498	0.490
LIG_FHA_1	179	185	PF00498	0.396
LIG_FHA_1	254	260	PF00498	0.503
LIG_FHA_1	5	11	PF00498	0.709
LIG_FHA_1	81	87	PF00498	0.630
LIG_FHA_2	126	132	PF00498	0.610
LIG_FHA_2	153	159	PF00498	0.572
LIG_FHA_2	202	208	PF00498	0.416
LIG_FHA_2	228	234	PF00498	0.736
LIG_FHA_2	319	325	PF00498	0.431
LIG_FHA_2	393	399	PF00498	0.709
LIG_LIR_Apic_2	145	151	PF02991	0.544
LIG_LIR_Gen_1	155	165	PF02991	0.509
LIG_LIR_Gen_1	369	380	PF02991	0.550
LIG_LIR_Gen_1	67	76	PF02991	0.531
LIG_LIR_Nem_3	144	150	PF02991	0.598
LIG_LIR_Nem_3	155	160	PF02991	0.522
LIG_LIR_Nem_3	199	205	PF02991	0.480
LIG_LIR_Nem_3	336	341	PF02991	0.456
LIG_LIR_Nem_3	369	375	PF02991	0.573
LIG_LIR_Nem_3	416	421	PF02991	0.677
LIG_LIR_Nem_3	67	72	PF02991	0.508
LIG_LYPXL_yS_3	205	208	PF13949	0.429
LIG_NRBOX	286	292	PF00104	0.391
LIG_PCNA_yPIPBox_3	29	37	PF02747	0.578
LIG_PDZ_Class_1	417	422	PF00595	0.716
LIG_Pex14_1	69	73	PF04695	0.500
LIG_Pex14_2	346	350	PF04695	0.463
LIG_SH2_GRB2like	376	379	PF00017	0.560
LIG_SH2_NCK_1	294	298	PF00017	0.386
LIG_SH2_SRC	294	297	PF00017	0.438
LIG_SH2_STAP1	143	147	PF00017	0.683
LIG_SH2_STAP1	376	380	PF00017	0.535
LIG_SH2_STAP1	415	419	PF00017	0.679
LIG_SH2_STAT5	136	139	PF00017	0.530
LIG_SH2_STAT5	23	26	PF00017	0.619
LIG_SH2_STAT5	301	304	PF00017	0.470
LIG_SH2_STAT5	418	421	PF00017	0.707
LIG_SH2_STAT5	73	76	PF00017	0.520
LIG_SH3_2	330	335	PF14604	0.521
LIG_SH3_3	119	125	PF00018	0.467
LIG_SH3_3	274	280	PF00018	0.469
LIG_SH3_3	302	308	PF00018	0.450
LIG_SH3_3	323	329	PF00018	0.550
LIG_SUMO_SIM_anti_2	321	328	PF11976	0.428
LIG_SUMO_SIM_par_1	180	186	PF11976	0.488
LIG_SUMO_SIM_par_1	207	212	PF11976	0.567
LIG_TRAF2_1	128	131	PF00917	0.493
LIG_TRAF2_1	240	243	PF00917	0.655
LIG_TRAF2_1	363	366	PF00917	0.639
LIG_UBA3_1	384	392	PF00899	0.453
LIG_WRC_WIRS_1	251	256	PF05994	0.549
LIG_WRC_WIRS_1	388	393	PF05994	0.525
LIG_WRC_WIRS_1	5	10	PF05994	0.747
LIG_WW_3	328	332	PF00397	0.535
MOD_CDC14_SPxK_1	328	331	PF00782	0.535
MOD_CDK_SPxK_1	325	331	PF00069	0.496
MOD_CDK_SPxxK_3	325	332	PF00069	0.501
MOD_CK1_1	135	141	PF00069	0.647
MOD_CK1_1	368	374	PF00069	0.657
MOD_CK1_1	387	393	PF00069	0.330
MOD_CK2_1	125	131	PF00069	0.457
MOD_CK2_1	13	19	PF00069	0.734
MOD_CK2_1	152	158	PF00069	0.534
MOD_CK2_1	201	207	PF00069	0.417
MOD_CK2_1	227	233	PF00069	0.717
MOD_Cter_Amidation	95	98	PF01082	0.632
MOD_GlcNHglycan	15	18	PF01048	0.764
MOD_GlcNHglycan	152	155	PF01048	0.692
MOD_GSK3_1	174	181	PF00069	0.468
MOD_GSK3_1	197	204	PF00069	0.433
MOD_GSK3_1	224	231	PF00069	0.741
MOD_GSK3_1	314	321	PF00069	0.474
MOD_GSK3_1	76	83	PF00069	0.613
MOD_N-GLC_1	13	18	PF02516	0.643
MOD_N-GLC_1	87	92	PF02516	0.686
MOD_NEK2_1	137	142	PF00069	0.682
MOD_NEK2_1	197	202	PF00069	0.565
MOD_NEK2_1	37	42	PF00069	0.678
MOD_NEK2_1	384	389	PF00069	0.429
MOD_NEK2_2	333	338	PF00069	0.523
MOD_PIKK_1	152	158	PF00454	0.607
MOD_PIKK_1	209	215	PF00454	0.567
MOD_PIKK_1	318	324	PF00454	0.461
MOD_PIKK_1	37	43	PF00454	0.679
MOD_PKA_2	197	203	PF00069	0.450
MOD_PKA_2	76	82	PF00069	0.535
MOD_Plk_1	333	339	PF00069	0.596
MOD_Plk_4	132	138	PF00069	0.634
MOD_Plk_4	333	339	PF00069	0.580
MOD_Plk_4	368	374	PF00069	0.579
MOD_ProDKin_1	224	230	PF00069	0.715
MOD_ProDKin_1	325	331	PF00069	0.496
MOD_SUMO_rev_2	102	111	PF00179	0.582
MOD_SUMO_rev_2	377	385	PF00179	0.457
TRG_DiLeu_BaEn_1	286	291	PF01217	0.438
TRG_DiLeu_BaEn_2	70	76	PF01217	0.521
TRG_DiLeu_BaEn_4	158	164	PF01217	0.521
TRG_ENDOCYTIC_2	205	208	PF00928	0.429
TRG_ENDOCYTIC_2	294	297	PF00928	0.410
TRG_ENDOCYTIC_2	73	76	PF00928	0.520
TRG_ER_diArg_1	222	224	PF00400	0.753
TRG_ER_diArg_1	29	32	PF00400	0.721
TRG_ER_diArg_1	307	310	PF00400	0.515
TRG_ER_diArg_1	311	313	PF00400	0.535
TRG_ER_diArg_1	51	54	PF00400	0.644
TRG_NLS_MonoExtC_3	217	222	PF00514	0.637
TRG_NLS_MonoExtN_4	215	222	PF00514	0.658
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.690

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBR9	Leptomonas seymouri	69%	90%
A0A0S4J059	Bodo saltans	44%	94%
A0A1X0P5E2	Trypanosomatidae	55%	93%
A0A3S7X9S4	Leishmania donovani	100%	100%
A4HN81	Leishmania braziliensis	86%	100%
C9ZYR2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	92%
E9AFN6	Leishmania major	94%	100%
E9B6T9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BCS7	Trypanosoma cruzi	55%	93%