LeishMANIAdb
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Splicing factor 3B subunit 5

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Splicing factor 3B subunit 5
Gene product:
Splicing factor 3B subunit 10 (SF3b10) - putative
Species:
Leishmania infantum
UniProt:
A4IBU8_LEIIN
TriTrypDb:
LINF_350046600
Length:
84

Annotations

Annotations by Jardim et al.

RNA Processing, Splicing factor 3B subunit 10 (SF3b10), putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005681 spliceosomal complex 3 1
GO:0005686 U2 snRNP 5 1
GO:0030532 small nuclear ribonucleoprotein complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0071011 precatalytic spliceosome 4 1
GO:0097525 spliceosomal snRNP complex 4 1
GO:0120114 Sm-like protein family complex 2 1
GO:0140513 nuclear protein-containing complex 2 1
GO:1990904 ribonucleoprotein complex 2 1

Expansion

Sequence features

A4IBU8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBU8

Function

Biological processes
Term Name Level Count
GO:0000375 RNA splicing, via transesterification reactions 8 1
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 9 1
GO:0000398 mRNA splicing, via spliceosome 8 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006396 RNA processing 6 1
GO:0006397 mRNA processing 7 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0008380 RNA splicing 7 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0016071 mRNA metabolic process 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 71 75 PF00082 0.257
DEG_APCC_DBOX_1 41 49 PF00400 0.315
DEG_APCC_DBOX_1 51 59 PF00400 0.255
DEG_APCC_DBOX_1 70 78 PF00400 0.290
DOC_CYCLIN_RxL_1 68 75 PF00134 0.260
DOC_PP4_FxxP_1 5 8 PF00568 0.482
LIG_AP2alpha_2 3 5 PF02296 0.475
LIG_FHA_1 24 30 PF00498 0.290
LIG_FHA_2 29 35 PF00498 0.258
LIG_FHA_2 45 51 PF00498 0.243
LIG_LIR_Apic_2 3 8 PF02991 0.477
LIG_LIR_Gen_1 56 65 PF02991 0.258
LIG_LIR_Nem_3 34 39 PF02991 0.290
LIG_LIR_Nem_3 56 60 PF02991 0.258
LIG_NRP_CendR_1 83 84 PF00754 0.548
LIG_SH2_SRC 12 15 PF00017 0.427
LIG_SH2_STAT5 57 60 PF00017 0.290
LIG_TYR_ITIM 55 60 PF00017 0.255
MOD_CK2_1 44 50 PF00069 0.369
MOD_GSK3_1 25 32 PF00069 0.297
MOD_PKA_2 41 47 PF00069 0.255
MOD_Plk_4 44 50 PF00069 0.222
MOD_SUMO_for_1 21 24 PF00179 0.255
MOD_SUMO_for_1 67 70 PF00179 0.349
TRG_ENDOCYTIC_2 57 60 PF00928 0.255
TRG_Pf-PMV_PEXEL_1 71 75 PF00026 0.255

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2K0 Leptomonas seymouri 89% 100%
A0A0S4IXB6 Bodo saltans 56% 83%
A0A3S5H805 Leishmania donovani 100% 100%
A4HN80 Leishmania braziliensis 95% 100%
C9ZYR3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 74% 94%
E9AFN5 Leishmania major 98% 100%
E9B6T8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q56K13 Bos taurus 36% 98%
Q923D4 Mus musculus 37% 98%
Q9BWJ5 Homo sapiens 36% 98%
Q9P7R6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 36% 99%
Q9VHI4 Drosophila melanogaster 40% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS