LeishMANIAdb
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Putative ATP-dependent RNA helicase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ATP-dependent RNA helicase
Gene product:
ATP-dependent RNA helicase - putative
Species:
Leishmania infantum
UniProt:
A4IBU1_LEIIN
TriTrypDb:
LINF_350045800
Length:
690

Annotations

Annotations by Jardim et al.

Helicases, ATP-dependent RNA helicase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

A4IBU1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBU1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003676 nucleic acid binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004386 helicase activity 2 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016787 hydrolase activity 2 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140640 catalytic activity, acting on a nucleic acid 2 12
GO:0140657 ATP-dependent activity 1 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12
GO:0003723 RNA binding 4 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 304 308 PF00656 0.510
CLV_C14_Caspase3-7 412 416 PF00656 0.436
CLV_C14_Caspase3-7 601 605 PF00656 0.763
CLV_NRD_NRD_1 202 204 PF00675 0.252
CLV_NRD_NRD_1 427 429 PF00675 0.540
CLV_NRD_NRD_1 438 440 PF00675 0.506
CLV_NRD_NRD_1 453 455 PF00675 0.558
CLV_NRD_NRD_1 456 458 PF00675 0.565
CLV_NRD_NRD_1 477 479 PF00675 0.591
CLV_NRD_NRD_1 495 497 PF00675 0.402
CLV_NRD_NRD_1 652 654 PF00675 0.606
CLV_NRD_NRD_1 679 681 PF00675 0.555
CLV_NRD_NRD_1 686 688 PF00675 0.505
CLV_PCSK_FUR_1 454 458 PF00082 0.679
CLV_PCSK_FUR_1 579 583 PF00082 0.564
CLV_PCSK_KEX2_1 196 198 PF00082 0.249
CLV_PCSK_KEX2_1 202 204 PF00082 0.249
CLV_PCSK_KEX2_1 320 322 PF00082 0.260
CLV_PCSK_KEX2_1 330 332 PF00082 0.260
CLV_PCSK_KEX2_1 427 429 PF00082 0.508
CLV_PCSK_KEX2_1 438 440 PF00082 0.562
CLV_PCSK_KEX2_1 453 455 PF00082 0.550
CLV_PCSK_KEX2_1 456 458 PF00082 0.531
CLV_PCSK_KEX2_1 477 479 PF00082 0.644
CLV_PCSK_KEX2_1 495 497 PF00082 0.364
CLV_PCSK_KEX2_1 554 556 PF00082 0.577
CLV_PCSK_KEX2_1 581 583 PF00082 0.513
CLV_PCSK_KEX2_1 606 608 PF00082 0.631
CLV_PCSK_KEX2_1 652 654 PF00082 0.551
CLV_PCSK_KEX2_1 98 100 PF00082 0.333
CLV_PCSK_PC1ET2_1 196 198 PF00082 0.260
CLV_PCSK_PC1ET2_1 320 322 PF00082 0.260
CLV_PCSK_PC1ET2_1 330 332 PF00082 0.260
CLV_PCSK_PC1ET2_1 438 440 PF00082 0.577
CLV_PCSK_PC1ET2_1 477 479 PF00082 0.651
CLV_PCSK_PC1ET2_1 554 556 PF00082 0.577
CLV_PCSK_PC1ET2_1 581 583 PF00082 0.553
CLV_PCSK_PC1ET2_1 606 608 PF00082 0.631
CLV_PCSK_PC1ET2_1 98 100 PF00082 0.333
CLV_PCSK_PC7_1 326 332 PF00082 0.307
CLV_PCSK_SKI1_1 129 133 PF00082 0.257
CLV_PCSK_SKI1_1 2 6 PF00082 0.459
CLV_PCSK_SKI1_1 213 217 PF00082 0.307
CLV_PCSK_SKI1_1 326 330 PF00082 0.260
CLV_PCSK_SKI1_1 333 337 PF00082 0.260
CLV_PCSK_SKI1_1 428 432 PF00082 0.588
CLV_PCSK_SKI1_1 474 478 PF00082 0.623
CLV_PCSK_SKI1_1 479 483 PF00082 0.533
CLV_PCSK_SKI1_1 525 529 PF00082 0.301
CLV_PCSK_SKI1_1 603 607 PF00082 0.649
CLV_PCSK_SKI1_1 620 624 PF00082 0.589
CLV_PCSK_SKI1_1 98 102 PF00082 0.260
DEG_APCC_DBOX_1 187 195 PF00400 0.535
DEG_Nend_UBRbox_1 1 4 PF02207 0.567
DOC_CKS1_1 147 152 PF01111 0.449
DOC_CYCLIN_RxL_1 422 434 PF00134 0.612
DOC_CYCLIN_RxL_1 96 107 PF00134 0.490
DOC_MAPK_DCC_7 344 353 PF00069 0.460
DOC_MAPK_gen_1 276 284 PF00069 0.440
DOC_MAPK_gen_1 330 337 PF00069 0.470
DOC_MAPK_gen_1 375 385 PF00069 0.524
DOC_MAPK_gen_1 554 563 PF00069 0.487
DOC_MAPK_gen_1 612 621 PF00069 0.534
DOC_MAPK_HePTP_8 341 353 PF00069 0.460
DOC_MAPK_MEF2A_6 224 233 PF00069 0.421
DOC_MAPK_MEF2A_6 276 284 PF00069 0.435
DOC_MAPK_MEF2A_6 344 353 PF00069 0.460
DOC_MAPK_MEF2A_6 5 13 PF00069 0.435
DOC_MAPK_MEF2A_6 554 563 PF00069 0.430
DOC_PP1_RVXF_1 179 186 PF00149 0.449
DOC_PP1_RVXF_1 265 272 PF00149 0.460
DOC_PP1_RVXF_1 379 386 PF00149 0.437
DOC_PP1_RVXF_1 97 104 PF00149 0.470
DOC_PP2B_LxvP_1 346 349 PF13499 0.449
DOC_PP2B_LxvP_1 559 562 PF13499 0.404
DOC_PP2B_LxvP_1 82 85 PF13499 0.554
DOC_PP4_FxxP_1 385 388 PF00568 0.335
DOC_PP4_FxxP_1 545 548 PF00568 0.301
DOC_USP7_MATH_1 487 491 PF00917 0.482
DOC_USP7_MATH_1 511 515 PF00917 0.313
DOC_USP7_UBL2_3 196 200 PF12436 0.438
DOC_USP7_UBL2_3 664 668 PF12436 0.408
DOC_WW_Pin1_4 109 114 PF00397 0.554
DOC_WW_Pin1_4 146 151 PF00397 0.449
DOC_WW_Pin1_4 485 490 PF00397 0.388
LIG_14-3-3_CanoR_1 224 230 PF00244 0.415
LIG_14-3-3_CanoR_1 232 237 PF00244 0.529
LIG_14-3-3_CanoR_1 260 268 PF00244 0.298
LIG_14-3-3_CanoR_1 378 384 PF00244 0.502
LIG_14-3-3_CanoR_1 427 431 PF00244 0.548
LIG_14-3-3_CanoR_1 510 516 PF00244 0.301
LIG_14-3-3_CanoR_1 607 616 PF00244 0.564
LIG_BRCT_BRCA1_1 252 256 PF00533 0.392
LIG_BRCT_BRCA1_1 381 385 PF00533 0.374
LIG_Clathr_ClatBox_1 173 177 PF01394 0.460
LIG_FHA_1 210 216 PF00498 0.460
LIG_FHA_1 228 234 PF00498 0.482
LIG_FHA_1 28 34 PF00498 0.449
LIG_FHA_2 34 40 PF00498 0.535
LIG_LIR_Apic_2 382 388 PF02991 0.340
LIG_LIR_Apic_2 51 57 PF02991 0.449
LIG_LIR_Gen_1 169 179 PF02991 0.450
LIG_LIR_Gen_1 291 301 PF02991 0.490
LIG_LIR_Gen_1 36 45 PF02991 0.535
LIG_LIR_Gen_1 390 399 PF02991 0.384
LIG_LIR_Gen_1 509 519 PF02991 0.190
LIG_LIR_Gen_1 539 548 PF02991 0.295
LIG_LIR_Gen_1 644 651 PF02991 0.585
LIG_LIR_Nem_3 121 125 PF02991 0.514
LIG_LIR_Nem_3 169 174 PF02991 0.450
LIG_LIR_Nem_3 253 258 PF02991 0.470
LIG_LIR_Nem_3 291 297 PF02991 0.490
LIG_LIR_Nem_3 36 41 PF02991 0.535
LIG_LIR_Nem_3 390 396 PF02991 0.355
LIG_LIR_Nem_3 509 515 PF02991 0.181
LIG_LIR_Nem_3 539 545 PF02991 0.303
LIG_LIR_Nem_3 565 570 PF02991 0.490
LIG_MLH1_MIPbox_1 252 256 PF16413 0.392
LIG_NRBOX 152 158 PF00104 0.460
LIG_NRBOX 190 196 PF00104 0.526
LIG_NRBOX 58 64 PF00104 0.510
LIG_NRBOX 637 643 PF00104 0.566
LIG_NRP_CendR_1 687 690 PF00754 0.579
LIG_PCNA_yPIPBox_3 629 642 PF02747 0.473
LIG_PTB_Apo_2 73 80 PF02174 0.526
LIG_Rb_LxCxE_1 51 73 PF01857 0.474
LIG_SH2_CRK 357 361 PF00017 0.460
LIG_SH2_CRK 38 42 PF00017 0.514
LIG_SH2_GRB2like 393 396 PF00017 0.465
LIG_SH2_SRC 357 360 PF00017 0.449
LIG_SH2_SRC 54 57 PF00017 0.509
LIG_SH2_STAP1 154 158 PF00017 0.449
LIG_SH2_STAP1 38 42 PF00017 0.472
LIG_SH2_STAT3 120 123 PF00017 0.449
LIG_SH2_STAT3 526 529 PF00017 0.317
LIG_SH2_STAT5 125 128 PF00017 0.429
LIG_SH2_STAT5 283 286 PF00017 0.446
LIG_SH2_STAT5 393 396 PF00017 0.357
LIG_SH2_STAT5 526 529 PF00017 0.317
LIG_SH2_STAT5 54 57 PF00017 0.448
LIG_SH2_STAT5 647 650 PF00017 0.434
LIG_SH3_1 357 363 PF00018 0.460
LIG_SH3_3 144 150 PF00018 0.510
LIG_SH3_3 243 249 PF00018 0.465
LIG_SH3_3 357 363 PF00018 0.460
LIG_SUMO_SIM_anti_2 172 178 PF11976 0.460
LIG_SUMO_SIM_par_1 172 178 PF11976 0.460
LIG_SUMO_SIM_par_1 225 230 PF11976 0.445
LIG_SUMO_SIM_par_1 531 537 PF11976 0.317
LIG_SUMO_SIM_par_1 80 86 PF11976 0.471
LIG_TRAF2_1 585 588 PF00917 0.609
LIG_TRAF2_2 403 408 PF00917 0.476
LIG_TYR_ITSM 34 41 PF00017 0.422
LIG_UBA3_1 173 181 PF00899 0.336
LIG_UBA3_1 194 200 PF00899 0.271
LIG_UBA3_1 621 626 PF00899 0.655
LIG_WRC_WIRS_1 512 517 PF05994 0.301
MOD_CDK_SPxK_1 146 152 PF00069 0.301
MOD_CK1_1 235 241 PF00069 0.518
MOD_CK1_1 379 385 PF00069 0.494
MOD_CK1_1 48 54 PF00069 0.294
MOD_CK1_1 627 633 PF00069 0.618
MOD_CK1_1 673 679 PF00069 0.618
MOD_CK1_1 7 13 PF00069 0.422
MOD_CK2_1 166 172 PF00069 0.336
MOD_CK2_1 449 455 PF00069 0.609
MOD_CK2_1 622 628 PF00069 0.496
MOD_CK2_1 673 679 PF00069 0.513
MOD_GlcNHglycan 207 210 PF01048 0.301
MOD_GlcNHglycan 237 240 PF01048 0.532
MOD_GlcNHglycan 297 300 PF01048 0.371
MOD_GlcNHglycan 378 381 PF01048 0.546
MOD_GlcNHglycan 47 50 PF01048 0.291
MOD_GlcNHglycan 587 592 PF01048 0.574
MOD_GlcNHglycan 675 678 PF01048 0.578
MOD_GSK3_1 201 208 PF00069 0.301
MOD_GSK3_1 209 216 PF00069 0.301
MOD_GSK3_1 426 433 PF00069 0.502
MOD_GSK3_1 583 590 PF00069 0.648
MOD_N-GLC_1 109 114 PF02516 0.408
MOD_NEK2_1 156 161 PF00069 0.301
MOD_NEK2_1 166 171 PF00069 0.301
MOD_NEK2_1 18 23 PF00069 0.502
MOD_NEK2_1 207 212 PF00069 0.301
MOD_NEK2_1 256 261 PF00069 0.501
MOD_NEK2_1 271 276 PF00069 0.288
MOD_NEK2_1 33 38 PF00069 0.386
MOD_NEK2_1 376 381 PF00069 0.515
MOD_NEK2_1 622 627 PF00069 0.569
MOD_NEK2_1 642 647 PF00069 0.256
MOD_PIKK_1 166 172 PF00454 0.448
MOD_PIKK_1 207 213 PF00454 0.301
MOD_PIKK_1 259 265 PF00454 0.338
MOD_PIKK_1 469 475 PF00454 0.646
MOD_PKA_2 201 207 PF00069 0.301
MOD_PKA_2 259 265 PF00069 0.352
MOD_PKA_2 410 416 PF00069 0.469
MOD_PKA_2 426 432 PF00069 0.486
MOD_PKA_2 583 589 PF00069 0.527
MOD_Plk_1 670 676 PF00069 0.631
MOD_Plk_2-3 410 416 PF00069 0.519
MOD_Plk_4 362 368 PF00069 0.301
MOD_Plk_4 379 385 PF00069 0.373
MOD_Plk_4 487 493 PF00069 0.392
MOD_Plk_4 511 517 PF00069 0.301
MOD_Plk_4 642 648 PF00069 0.456
MOD_Plk_4 670 676 PF00069 0.613
MOD_ProDKin_1 109 115 PF00069 0.448
MOD_ProDKin_1 146 152 PF00069 0.301
MOD_ProDKin_1 485 491 PF00069 0.381
MOD_SUMO_for_1 316 319 PF00179 0.317
MOD_SUMO_for_1 648 651 PF00179 0.439
MOD_SUMO_rev_2 274 281 PF00179 0.307
MOD_SUMO_rev_2 673 683 PF00179 0.529
MOD_SUMO_rev_2 69 77 PF00179 0.321
TRG_DiLeu_BaEn_1 178 183 PF01217 0.301
TRG_DiLeu_BaEn_1 617 622 PF01217 0.622
TRG_DiLeu_BaEn_1 637 642 PF01217 0.264
TRG_DiLeu_BaEn_2 391 397 PF01217 0.398
TRG_DiLeu_BaEn_2 565 571 PF01217 0.511
TRG_ENDOCYTIC_2 154 157 PF00928 0.301
TRG_ENDOCYTIC_2 294 297 PF00928 0.345
TRG_ENDOCYTIC_2 38 41 PF00928 0.353
TRG_ENDOCYTIC_2 393 396 PF00928 0.357
TRG_ENDOCYTIC_2 647 650 PF00928 0.580
TRG_ER_diArg_1 494 496 PF00400 0.423
TRG_ER_diArg_1 555 558 PF00400 0.607
TRG_ER_diArg_1 63 66 PF00400 0.422
TRG_ER_FFAT_2 671 679 PF00635 0.560
TRG_NES_CRM1_1 390 400 PF08389 0.387
TRG_NES_CRM1_1 552 565 PF08389 0.420
TRG_NES_CRM1_1 614 628 PF08389 0.643
TRG_NLS_Bipartite_1 320 334 PF00514 0.340
TRG_NLS_MonoExtC_3 605 611 PF00514 0.574
TRG_NLS_MonoExtN_4 603 610 PF00514 0.628
TRG_Pf-PMV_PEXEL_1 213 217 PF00026 0.315
TRG_Pf-PMV_PEXEL_1 525 529 PF00026 0.301
TRG_Pf-PMV_PEXEL_1 87 91 PF00026 0.301

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4X4 Leptomonas seymouri 84% 99%
A0A0S4IX79 Bodo saltans 56% 95%
A0A1X0P5E1 Trypanosomatidae 65% 97%
A0A1X0P9U0 Trypanosomatidae 27% 83%
A0A3Q8ID91 Leishmania donovani 30% 100%
A0A3R7M1K3 Trypanosoma rangeli 30% 96%
A0A3R7NR45 Trypanosoma rangeli 28% 84%
A0A3S5IQZ7 Trypanosoma rangeli 27% 87%
A0A3S7X9W0 Leishmania donovani 100% 100%
A0A3S7XAT8 Leishmania donovani 34% 100%
A0A422NKE3 Trypanosoma rangeli 65% 95%
A3LX02 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 31% 100%
A4HGR1 Leishmania braziliensis 31% 100%
A4HK38 Leishmania braziliensis 27% 100%
A4HN73 Leishmania braziliensis 91% 100%
A4HP49 Leishmania braziliensis 33% 100%
A4HT33 Leishmania infantum 31% 100%
A4HUC1 Leishmania infantum 27% 88%
A4HZF8 Leishmania infantum 26% 100%
A4I3T6 Leishmania infantum 30% 100%
A4IDF6 Leishmania infantum 34% 100%
A5DAR2 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 27% 92%
A6R918 Ajellomyces capsulatus (strain NAm1 / WU24) 35% 100%
A6RMZ2 Botryotinia fuckeliana (strain B05.10) 36% 100%
A7F2S3 Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) 36% 100%
C9ZYS3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 68% 89%
E9AFM8 Leishmania major 95% 100%
E9AJG4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9ASV7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B028 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B6T1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
P0CR08 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 32% 92%
P0CR09 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 32% 92%
Q1EB38 Coccidioides immitis (strain RS) 30% 74%
Q4Q1N9 Leishmania major 34% 100%
Q4Q858 Leishmania major 30% 100%
Q4QHK6 Leishmania major 26% 93%
Q59S50 Candida albicans (strain SC5314 / ATCC MYA-2876) 27% 95%
Q6NZQ2 Mus musculus 29% 100%
Q873H9 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 33% 100%
V5DUK0 Trypanosoma cruzi 65% 90%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS