LeishMANIAdb
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Bem46-like serine peptidase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Bem46-like serine peptidase
Gene product:
Bem46-like serine peptidase
Species:
Leishmania infantum
UniProt:
A4IBU0_LEIIN
TriTrypDb:
LINF_350045700
Length:
394

Annotations

LeishMANIAdb annotations

A signal-anchored protein probably with an extra re-entrant loop. Localization: ER (by homology)

Annotations by Jardim et al.

Proteases, Bem46-like serine peptidase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
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Expansion

Sequence features

A4IBU0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBU0

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 2
GO:0008474 palmitoyl-(protein) hydrolase activity 3 1
GO:0016787 hydrolase activity 2 2
GO:0016788 hydrolase activity, acting on ester bonds 3 1
GO:0016790 thiolester hydrolase activity 4 1
GO:0098599 palmitoyl hydrolase activity 3 1
GO:0140096 catalytic activity, acting on a protein 2 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 125 129 PF00656 0.644
CLV_NRD_NRD_1 248 250 PF00675 0.265
CLV_NRD_NRD_1 355 357 PF00675 0.279
CLV_PCSK_KEX2_1 248 250 PF00082 0.246
CLV_PCSK_KEX2_1 355 357 PF00082 0.291
CLV_PCSK_SKI1_1 141 145 PF00082 0.421
CLV_PCSK_SKI1_1 271 275 PF00082 0.260
CLV_PCSK_SKI1_1 336 340 PF00082 0.339
CLV_PCSK_SKI1_1 355 359 PF00082 0.208
DEG_APCC_DBOX_1 270 278 PF00400 0.525
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1IK32 Leptomonas seymouri 61% 96%
A0A1X0P675 Trypanosomatidae 42% 100%
A0A3Q8IMT8 Leishmania donovani 100% 100%
A0A3R7NFR6 Trypanosoma rangeli 43% 100%
A4HN72 Leishmania braziliensis 83% 100%
C9ZYS4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9AFM7 Leishmania major 94% 100%
E9B6T0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
V5BXX8 Trypanosoma cruzi 43% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS