LeishMANIAdb
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Bem46-like serine peptidase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Bem46-like serine peptidase
Gene product:
Bem46-like serine peptidase
Species:
Leishmania infantum
UniProt:
A4IBU0_LEIIN
TriTrypDb:
LINF_350045700
Length:
394

Annotations

LeishMANIAdb annotations

A signal-anchored protein probably with an extra re-entrant loop. Localization: ER (by homology)

Annotations by Jardim et al.

Proteases, Bem46-like serine peptidase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4IBU0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBU0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0008474 palmitoyl-(protein) hydrolase activity 3 1
GO:0016787 hydrolase activity 2 2
GO:0016788 hydrolase activity, acting on ester bonds 3 1
GO:0016790 thiolester hydrolase activity 4 1
GO:0098599 palmitoyl hydrolase activity 3 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 125 129 PF00656 0.644
CLV_NRD_NRD_1 248 250 PF00675 0.265
CLV_NRD_NRD_1 355 357 PF00675 0.279
CLV_PCSK_KEX2_1 248 250 PF00082 0.246
CLV_PCSK_KEX2_1 355 357 PF00082 0.291
CLV_PCSK_SKI1_1 141 145 PF00082 0.421
CLV_PCSK_SKI1_1 271 275 PF00082 0.260
CLV_PCSK_SKI1_1 336 340 PF00082 0.339
CLV_PCSK_SKI1_1 355 359 PF00082 0.208
DEG_APCC_DBOX_1 270 278 PF00400 0.525
DOC_CYCLIN_RxL_1 291 301 PF00134 0.515
DOC_CYCLIN_RxL_1 353 362 PF00134 0.524
DOC_MAPK_DCC_7 310 318 PF00069 0.554
DOC_MAPK_gen_1 219 227 PF00069 0.552
DOC_MAPK_gen_1 245 255 PF00069 0.447
DOC_MAPK_gen_1 307 317 PF00069 0.495
DOC_MAPK_JIP1_4 294 300 PF00069 0.513
DOC_MAPK_MEF2A_6 307 315 PF00069 0.472
DOC_PP1_RVXF_1 297 303 PF00149 0.500
DOC_PP1_RVXF_1 354 361 PF00149 0.542
DOC_PP2B_LxvP_1 350 353 PF13499 0.627
DOC_PP2B_LxvP_1 59 62 PF13499 0.597
DOC_USP7_MATH_1 122 126 PF00917 0.668
DOC_USP7_MATH_1 137 141 PF00917 0.638
DOC_USP7_MATH_1 86 90 PF00917 0.688
DOC_USP7_UBL2_3 336 340 PF12436 0.572
LIG_14-3-3_CanoR_1 141 146 PF00244 0.714
LIG_14-3-3_CanoR_1 299 303 PF00244 0.629
LIG_14-3-3_CanoR_1 31 40 PF00244 0.599
LIG_14-3-3_CanoR_1 66 75 PF00244 0.542
LIG_Actin_WH2_2 286 301 PF00022 0.503
LIG_Actin_WH2_2 327 345 PF00022 0.601
LIG_BIR_II_1 1 5 PF00653 0.337
LIG_BIR_III_4 121 125 PF00653 0.668
LIG_FHA_1 200 206 PF00498 0.467
LIG_FHA_1 307 313 PF00498 0.557
LIG_FHA_1 337 343 PF00498 0.635
LIG_FHA_1 349 355 PF00498 0.552
LIG_FHA_1 56 62 PF00498 0.561
LIG_FHA_2 114 120 PF00498 0.621
LIG_FHA_2 68 74 PF00498 0.579
LIG_IRF3_LxIS_1 295 301 PF10401 0.515
LIG_LIR_Apic_2 212 218 PF02991 0.485
LIG_LIR_Apic_2 290 295 PF02991 0.489
LIG_LIR_Gen_1 151 157 PF02991 0.529
LIG_LIR_Gen_1 22 32 PF02991 0.325
LIG_LIR_Gen_1 256 266 PF02991 0.430
LIG_LIR_Nem_3 151 155 PF02991 0.546
LIG_LIR_Nem_3 186 190 PF02991 0.439
LIG_LIR_Nem_3 2 6 PF02991 0.362
LIG_LIR_Nem_3 22 27 PF02991 0.150
LIG_LIR_Nem_3 256 262 PF02991 0.430
LIG_LYPXL_yS_3 42 45 PF13949 0.604
LIG_Pex14_2 20 24 PF04695 0.346
LIG_Pex14_2 211 215 PF04695 0.530
LIG_SH2_PTP2 292 295 PF00017 0.505
LIG_SH2_STAP1 246 250 PF00017 0.506
LIG_SH2_STAP1 63 67 PF00017 0.580
LIG_SH2_STAT3 213 216 PF00017 0.440
LIG_SH2_STAT3 32 35 PF00017 0.540
LIG_SH2_STAT3 41 44 PF00017 0.481
LIG_SH2_STAT5 13 16 PF00017 0.346
LIG_SH2_STAT5 156 159 PF00017 0.433
LIG_SH2_STAT5 213 216 PF00017 0.455
LIG_SH2_STAT5 292 295 PF00017 0.520
LIG_SH3_3 215 221 PF00018 0.469
LIG_SH3_3 308 314 PF00018 0.522
LIG_SH3_3 366 372 PF00018 0.547
LIG_SH3_3 40 46 PF00018 0.500
LIG_SUMO_SIM_anti_2 223 231 PF11976 0.525
LIG_SUMO_SIM_par_1 201 206 PF11976 0.467
LIG_TRFH_1 80 84 PF08558 0.562
LIG_TYR_ITIM 40 45 PF00017 0.535
LIG_WRC_WIRS_1 149 154 PF05994 0.511
MOD_CK1_1 131 137 PF00069 0.682
MOD_CK1_1 139 145 PF00069 0.645
MOD_CK1_1 193 199 PF00069 0.440
MOD_CK1_1 258 264 PF00069 0.539
MOD_CK1_1 267 273 PF00069 0.504
MOD_CK1_1 301 307 PF00069 0.497
MOD_CK1_1 348 354 PF00069 0.554
MOD_CK2_1 113 119 PF00069 0.578
MOD_CK2_1 94 100 PF00069 0.755
MOD_GlcNHglycan 121 125 PF01048 0.569
MOD_GlcNHglycan 130 133 PF01048 0.502
MOD_GlcNHglycan 146 149 PF01048 0.349
MOD_GlcNHglycan 266 269 PF01048 0.325
MOD_GlcNHglycan 303 306 PF01048 0.297
MOD_GlcNHglycan 318 321 PF01048 0.249
MOD_GlcNHglycan 375 378 PF01048 0.301
MOD_GlcNHglycan 77 80 PF01048 0.352
MOD_GlcNHglycan 8 11 PF01048 0.372
MOD_GlcNHglycan 91 95 PF01048 0.499
MOD_GSK3_1 104 111 PF00069 0.672
MOD_GSK3_1 120 127 PF00069 0.702
MOD_GSK3_1 137 144 PF00069 0.661
MOD_GSK3_1 260 267 PF00069 0.450
MOD_GSK3_1 272 279 PF00069 0.478
MOD_GSK3_1 86 93 PF00069 0.621
MOD_GSK3_1 94 101 PF00069 0.780
MOD_N-GLC_1 345 350 PF02516 0.414
MOD_N-GLC_1 94 99 PF02516 0.598
MOD_NEK2_1 228 233 PF00069 0.444
MOD_NEK2_1 298 303 PF00069 0.510
MOD_NEK2_1 316 321 PF00069 0.446
MOD_NEK2_1 6 11 PF00069 0.355
MOD_NEK2_2 234 239 PF00069 0.467
MOD_PIKK_1 196 202 PF00454 0.485
MOD_PIKK_1 276 282 PF00454 0.405
MOD_PIKK_1 31 37 PF00454 0.556
MOD_PKA_2 103 109 PF00069 0.634
MOD_PKA_2 298 304 PF00069 0.623
MOD_PKA_2 75 81 PF00069 0.513
MOD_Plk_1 255 261 PF00069 0.430
MOD_Plk_1 348 354 PF00069 0.615
MOD_Plk_1 94 100 PF00069 0.654
MOD_Plk_4 131 137 PF00069 0.744
MOD_Plk_4 148 154 PF00069 0.499
MOD_Plk_4 19 25 PF00069 0.330
TRG_DiLeu_BaLyEn_6 35 40 PF01217 0.572
TRG_ENDOCYTIC_2 13 16 PF00928 0.395
TRG_ENDOCYTIC_2 187 190 PF00928 0.457
TRG_ENDOCYTIC_2 42 45 PF00928 0.604
TRG_ER_diArg_1 248 250 PF00400 0.465
TRG_ER_diArg_1 354 356 PF00400 0.499
TRG_Pf-PMV_PEXEL_1 356 361 PF00026 0.322

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IK32 Leptomonas seymouri 61% 96%
A0A1X0P675 Trypanosomatidae 42% 100%
A0A3Q8IMT8 Leishmania donovani 100% 100%
A0A3R7NFR6 Trypanosoma rangeli 43% 100%
A4HN72 Leishmania braziliensis 83% 100%
C9ZYS4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9AFM7 Leishmania major 94% 100%
E9B6T0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
V5BXX8 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS