Protein kinase A catalytic subunit isoform 1

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase A catalytic subunit isoform 1

Species:

Leishmania infantum

UniProt:

A4IBT9_LEIIN

TriTrypDb:

LINF_350045600

Length:

371

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Annotations by Jardim et al.

Protein kinase, kinase A catalytic subunit isoform 1

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 28

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 26
NetGPI	no	yes: 0, no: 26

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	4
GO:0005737	cytoplasm	2	3
GO:0005930	axoneme	2	2
GO:0005952	cAMP-dependent protein kinase complex	3	3
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	3
GO:0043233	organelle lumen	3	2
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	3
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0140535	intracellular protein-containing complex	2	3
GO:1902494	catalytic complex	2	3
GO:1902554	serine/threonine protein kinase complex	6	3
GO:1902911	protein kinase complex	5	3
GO:1990234	transferase complex	3	3
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1

Phosphorylation

Promastigote: 216, 352

Expansion

Sequence features

A4IBT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBT9

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	27
GO:0006793	phosphorus metabolic process	3	27
GO:0006796	phosphate-containing compound metabolic process	4	27
GO:0006807	nitrogen compound metabolic process	2	27
GO:0008152	metabolic process	1	27
GO:0009987	cellular process	1	27
GO:0016310	phosphorylation	5	27
GO:0019538	protein metabolic process	3	27
GO:0036211	protein modification process	4	27
GO:0043170	macromolecule metabolic process	3	27
GO:0043412	macromolecule modification	4	27
GO:0044237	cellular metabolic process	2	27
GO:0044238	primary metabolic process	2	27
GO:0071704	organic substance metabolic process	2	27
GO:1901564	organonitrogen compound metabolic process	3	27
GO:0007165	signal transduction	2	3
GO:0018105	peptidyl-serine phosphorylation	6	3
GO:0018193	peptidyl-amino acid modification	5	3
GO:0018209	peptidyl-serine modification	6	3
GO:0050789	regulation of biological process	2	3
GO:0050794	regulation of cellular process	3	3
GO:0065007	biological regulation	1	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	27
GO:0003824	catalytic activity	1	27
GO:0004672	protein kinase activity	3	27
GO:0004674	protein serine/threonine kinase activity	4	27
GO:0005488	binding	1	27
GO:0005524	ATP binding	5	27
GO:0016301	kinase activity	4	27
GO:0016740	transferase activity	2	27
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	27
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	27
GO:0017076	purine nucleotide binding	4	27
GO:0030554	adenyl nucleotide binding	5	27
GO:0032553	ribonucleotide binding	3	27
GO:0032555	purine ribonucleotide binding	4	27
GO:0032559	adenyl ribonucleotide binding	5	27
GO:0035639	purine ribonucleoside triphosphate binding	4	27
GO:0036094	small molecule binding	2	27
GO:0043167	ion binding	2	27
GO:0043168	anion binding	3	27
GO:0097159	organic cyclic compound binding	2	27
GO:0097367	carbohydrate derivative binding	2	27
GO:0140096	catalytic activity, acting on a protein	2	27
GO:1901265	nucleoside phosphate binding	3	27
GO:1901363	heterocyclic compound binding	2	27
GO:0004679	AMP-activated protein kinase activity	5	1
GO:0004690	cyclic nucleotide-dependent protein kinase activity	5	4
GO:0004691	cAMP-dependent protein kinase activity	6	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	80	82	PF00675	0.364
CLV_NRD_NRD_1	93	95	PF00675	0.240
CLV_PCSK_KEX2_1	298	300	PF00082	0.349
CLV_PCSK_KEX2_1	95	97	PF00082	0.363
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.349
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.363
CLV_PCSK_SKI1_1	111	115	PF00082	0.475
CLV_PCSK_SKI1_1	184	188	PF00082	0.349
CLV_PCSK_SKI1_1	213	217	PF00082	0.361
CLV_PCSK_SKI1_1	289	293	PF00082	0.316
DEG_SCF_FBW7_1	354	361	PF00400	0.520
DEG_SPOP_SBC_1	52	56	PF00917	0.626
DOC_AGCK_PIF_3	368	371	PF00069	0.460
DOC_CYCLIN_RxL_1	283	295	PF00134	0.357
DOC_CYCLIN_yCln2_LP_2	117	123	PF00134	0.303
DOC_MAPK_DCC_7	327	337	PF00069	0.456
DOC_MAPK_gen_1	133	141	PF00069	0.436
DOC_MAPK_gen_1	184	193	PF00069	0.349
DOC_MAPK_JIP1_4	187	193	PF00069	0.318
DOC_PP1_RVXF_1	131	138	PF00149	0.449
DOC_PP1_RVXF_1	234	241	PF00149	0.357
DOC_PP1_RVXF_1	271	277	PF00149	0.384
DOC_PP4_FxxP_1	49	52	PF00568	0.470
DOC_USP7_MATH_1	10	14	PF00917	0.740
DOC_USP7_MATH_1	32	36	PF00917	0.491
DOC_USP7_MATH_1	359	363	PF00917	0.538
DOC_USP7_MATH_1	38	42	PF00917	0.702
DOC_USP7_MATH_1	5	9	PF00917	0.785
DOC_USP7_MATH_1	52	56	PF00917	0.496
DOC_USP7_UBL2_3	196	200	PF12436	0.363
DOC_USP7_UBL2_3	232	236	PF12436	0.384
DOC_USP7_UBL2_3	91	95	PF12436	0.356
DOC_WW_Pin1_4	217	222	PF00397	0.349
DOC_WW_Pin1_4	258	263	PF00397	0.349
DOC_WW_Pin1_4	336	341	PF00397	0.539
DOC_WW_Pin1_4	349	354	PF00397	0.519
LIG_14-3-3_CanoR_1	213	218	PF00244	0.349
LIG_Actin_WH2_2	136	154	PF00022	0.357
LIG_ActinCP_TwfCPI_2	49	58	PF01115	0.448
LIG_BIR_II_1	1	5	PF00653	0.569
LIG_FHA_1	212	218	PF00498	0.351
LIG_FHA_1	240	246	PF00498	0.349
LIG_FHA_1	295	301	PF00498	0.357
LIG_FHA_1	355	361	PF00498	0.659
LIG_LIR_Apic_2	220	226	PF02991	0.349
LIG_LIR_Apic_2	48	52	PF02991	0.425
LIG_LIR_Gen_1	146	154	PF02991	0.376
LIG_LIR_Nem_3	146	151	PF02991	0.376
LIG_LIR_Nem_3	180	186	PF02991	0.383
LIG_LIR_Nem_3	260	266	PF02991	0.308
LIG_LIR_Nem_3	322	328	PF02991	0.443
LIG_LIR_Nem_3	343	349	PF02991	0.486
LIG_LIR_Nem_3	367	371	PF02991	0.455
LIG_LIR_Nem_3	70	76	PF02991	0.346
LIG_LIR_Nem_3	84	90	PF02991	0.321
LIG_Pex14_1	321	325	PF04695	0.412
LIG_Pex14_2	137	141	PF04695	0.446
LIG_Pex14_2	276	280	PF04695	0.363
LIG_SH2_SRC	175	178	PF00017	0.347
LIG_SH2_STAP1	248	252	PF00017	0.356
LIG_SH2_STAP1	266	270	PF00017	0.301
LIG_SH2_STAP1	325	329	PF00017	0.481
LIG_SH2_STAT5	136	139	PF00017	0.349
LIG_SH2_STAT5	175	178	PF00017	0.327
LIG_SH2_STAT5	223	226	PF00017	0.358
LIG_SH2_STAT5	315	318	PF00017	0.493
LIG_SH3_3	334	340	PF00018	0.508
LIG_SH3_3	347	353	PF00018	0.523
LIG_SUMO_SIM_anti_2	178	183	PF11976	0.364
LIG_TYR_ITIM	181	186	PF00017	0.349
LIG_TYR_ITIM	246	251	PF00017	0.357
LIG_UBA3_1	98	102	PF00899	0.355
LIG_WRC_WIRS_1	126	131	PF05994	0.378
LIG_WW_1	255	258	PF00397	0.397
MOD_CDK_SPxK_1	258	264	PF00069	0.349
MOD_CDK_SPxxK_3	349	356	PF00069	0.537
MOD_CK2_1	341	347	PF00069	0.483
MOD_CK2_1	57	63	PF00069	0.473
MOD_DYRK1A_RPxSP_1	336	340	PF00069	0.507
MOD_GlcNHglycan	12	16	PF01048	0.688
MOD_GlcNHglycan	2	5	PF01048	0.720
MOD_GlcNHglycan	361	364	PF01048	0.580
MOD_GSK3_1	146	153	PF00069	0.350
MOD_GSK3_1	213	220	PF00069	0.349
MOD_GSK3_1	22	29	PF00069	0.792
MOD_GSK3_1	336	343	PF00069	0.531
MOD_GSK3_1	354	361	PF00069	0.643
MOD_GSK3_1	53	60	PF00069	0.507
MOD_NEK2_1	125	130	PF00069	0.438
MOD_NEK2_1	64	69	PF00069	0.351
MOD_PKA_1	81	87	PF00069	0.364
MOD_Plk_1	211	217	PF00069	0.349
MOD_Plk_1	52	58	PF00069	0.542
MOD_ProDKin_1	217	223	PF00069	0.349
MOD_ProDKin_1	258	264	PF00069	0.349
MOD_ProDKin_1	336	342	PF00069	0.532
MOD_ProDKin_1	349	355	PF00069	0.513
MOD_SUMO_for_1	186	189	PF00179	0.349
MOD_SUMO_rev_2	128	135	PF00179	0.486
MOD_SUMO_rev_2	180	188	PF00179	0.344
MOD_SUMO_rev_2	60	67	PF00179	0.446
TRG_DiLeu_BaEn_1	110	115	PF01217	0.378
TRG_ENDOCYTIC_2	136	139	PF00928	0.353
TRG_ENDOCYTIC_2	183	186	PF00928	0.347
TRG_ENDOCYTIC_2	248	251	PF00928	0.351
TRG_ENDOCYTIC_2	254	257	PF00928	0.346
TRG_ENDOCYTIC_2	266	269	PF00928	0.329
TRG_ENDOCYTIC_2	87	90	PF00928	0.349
TRG_ER_diArg_1	75	78	PF00400	0.349
TRG_ER_diArg_1	93	96	PF00400	0.332
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6T0	Leptomonas seymouri	25%	68%
A0A0N0P787	Leptomonas seymouri	31%	96%
A0A0N0P8H5	Leptomonas seymouri	58%	100%
A0A0N1HWQ2	Leptomonas seymouri	33%	100%
A0A0N1I6T8	Leptomonas seymouri	35%	100%
A0A0N1IIF9	Leptomonas seymouri	35%	100%
A0A0N1PBE9	Leptomonas seymouri	28%	74%
A0A0N1PC31	Leptomonas seymouri	34%	95%
A0A0N1PD05	Leptomonas seymouri	25%	83%
A0A0N1PDW7	Leptomonas seymouri	31%	94%
A0A0N1PEV2	Leptomonas seymouri	29%	69%
A0A0S4IKH2	Bodo saltans	29%	75%
A0A0S4IMB7	Bodo saltans	26%	84%
A0A0S4IX86	Bodo saltans	28%	86%
A0A0S4IZY3	Bodo saltans	78%	100%
A0A0S4J3Y5	Bodo saltans	26%	86%
A0A0S4J4B3	Bodo saltans	35%	83%
A0A0S4J6L4	Bodo saltans	35%	97%
A0A0S4J7K4	Bodo saltans	28%	76%
A0A0S4J842	Bodo saltans	28%	69%
A0A0S4JBR3	Bodo saltans	32%	100%
A0A0S4JCG2	Bodo saltans	37%	83%
A0A0S4JER5	Bodo saltans	44%	82%
A0A0S4JI67	Bodo saltans	33%	81%
A0A0S4JK24	Bodo saltans	29%	85%
A0A0S4JTJ8	Bodo saltans	32%	81%
A0A0S4JUJ2	Bodo saltans	29%	100%
A0A0S4JWD5	Bodo saltans	34%	95%
A0A0S4KFT7	Bodo saltans	62%	100%
A0A0S4KMV7	Bodo saltans	28%	100%
A0A1X0NF53	Trypanosomatidae	27%	80%
A0A1X0NIA0	Trypanosomatidae	29%	86%
A0A1X0NJV4	Trypanosomatidae	27%	72%
A0A1X0NNE5	Trypanosomatidae	35%	73%
A0A1X0NQ63	Trypanosomatidae	34%	100%
A0A1X0NTR6	Trypanosomatidae	29%	100%
A0A1X0NUQ4	Trypanosomatidae	30%	98%
A0A1X0NW24	Trypanosomatidae	26%	100%
A0A1X0NY93	Trypanosomatidae	32%	95%
A0A1X0NYK8	Trypanosomatidae	34%	100%
A0A1X0P1A2	Trypanosomatidae	28%	80%
A0A1X0P3J5	Trypanosomatidae	46%	81%
A0A1X0P4Z7	Trypanosomatidae	29%	67%
A0A1X0P527	Trypanosomatidae	28%	84%
A0A1X0P549	Trypanosomatidae	29%	78%
A0A1X0P5B1	Trypanosomatidae	83%	100%
A0A1X0P5F2	Trypanosomatidae	82%	100%
A0A1X0P6V1	Trypanosomatidae	35%	100%
A0A1X0P735	Trypanosomatidae	35%	100%
A0A1X0P7V0	Trypanosomatidae	60%	100%
A0A1X0P8F7	Trypanosomatidae	30%	85%
A0A1X0P963	Trypanosomatidae	27%	77%
A0A1X0P9C4	Trypanosomatidae	28%	74%
A0A3Q8IB30	Leishmania donovani	58%	100%
A0A3Q8IBT5	Leishmania donovani	26%	100%
A0A3Q8IC87	Leishmania donovani	31%	100%
A0A3Q8IDK8	Leishmania donovani	27%	66%
A0A3Q8IEH3	Leishmania donovani	33%	100%
A0A3Q8INQ4	Leishmania donovani	34%	95%
A0A3Q8IRT6	Leishmania donovani	41%	73%
A0A3R7LT21	Trypanosoma rangeli	30%	67%
A0A3R7M5C7	Trypanosoma rangeli	34%	100%
A0A3R7M819	Trypanosoma rangeli	30%	100%
A0A3R7MHW5	Trypanosoma rangeli	30%	93%
A0A3R7MKJ1	Trypanosoma rangeli	32%	69%
A0A3R7N4D8	Trypanosoma rangeli	34%	92%
A0A3R7N5S4	Trypanosoma rangeli	30%	98%
A0A3R7NKI8	Trypanosoma rangeli	29%	100%
A0A3R7RIN5	Trypanosoma rangeli	28%	74%
A0A3R7RLL1	Trypanosoma rangeli	33%	86%
A0A3S5H5G0	Leishmania donovani	25%	100%
A0A3S5H5U5	Leishmania donovani	32%	82%
A0A3S5H606	Leishmania donovani	35%	100%
A0A3S5H7M0	Leishmania donovani	30%	71%
A0A3S7WTN9	Leishmania donovani	31%	96%
A0A3S7WUE7	Leishmania donovani	30%	67%
A0A3S7WUX5	Leishmania donovani	35%	100%
A0A3S7WVE9	Leishmania donovani	31%	100%
A0A3S7WWE7	Leishmania donovani	24%	100%
A0A3S7WYP4	Leishmania donovani	32%	100%
A0A3S7X123	Leishmania donovani	26%	100%
A0A3S7X6T8	Leishmania donovani	26%	83%
A0A3S7X8Z8	Leishmania donovani	27%	76%
A0A3S7X9R4	Leishmania donovani	99%	100%
A0A3S7X9S2	Leishmania donovani	94%	100%
A0A3S7XAL3	Leishmania donovani	29%	75%
A0A3S7XAT9	Leishmania donovani	28%	74%
A0A3S7XAX0	Leishmania donovani	26%	100%
A0A422MYB4	Trypanosoma rangeli	84%	100%
A0A422NCP0	Trypanosoma rangeli	28%	74%
A0A422NU88	Trypanosoma rangeli	30%	67%
A0A422NUF0	Trypanosoma rangeli	26%	93%
A0A422P0J2	Trypanosoma rangeli	59%	100%
A0A422P0N6	Trypanosoma rangeli	30%	100%
A0A422P1R5	Trypanosoma rangeli	34%	100%
A0A422P270	Trypanosoma rangeli	31%	84%
A0A422P4V9	Trypanosoma rangeli	45%	81%
A0A8I3S724	Canis lupus familiaris	38%	92%
A2VDV2	Bos taurus	34%	80%
A2XFF4	Oryza sativa subsp. indica	37%	73%
A4H459	Leishmania braziliensis	24%	100%
A4H4S9	Leishmania braziliensis	31%	82%
A4H539	Leishmania braziliensis	36%	100%
A4H8C4	Leishmania braziliensis	32%	100%
A4H9H4	Leishmania braziliensis	35%	100%
A4H9L8	Leishmania braziliensis	58%	100%
A4H9X2	Leishmania braziliensis	30%	100%
A4HBL4	Leishmania braziliensis	24%	100%
A4HDU3	Leishmania braziliensis	29%	100%
A4HED7	Leishmania braziliensis	35%	100%
A4HFF3	Leishmania braziliensis	27%	100%
A4HG26	Leishmania braziliensis	26%	100%
A4HG27	Leishmania braziliensis	27%	68%
A4HG92	Leishmania braziliensis	32%	100%
A4HHR5	Leishmania braziliensis	30%	72%
A4HI35	Leishmania braziliensis	40%	73%
A4HN71	Leishmania braziliensis	89%	100%
A4HP12	Leishmania braziliensis	29%	73%
A4HSE2	Leishmania infantum	25%	100%
A4HTB4	Leishmania infantum	35%	100%
A4HWP5	Leishmania infantum	31%	100%
A4HX71	Leishmania infantum	30%	67%
A4HXU0	Leishmania infantum	35%	100%
A4HXY2	Leishmania infantum	58%	100%
A4HZA2	Leishmania infantum	24%	100%
A4HZV1	Leishmania infantum	31%	100%
A4I140	Leishmania infantum	32%	100%
A4I1T4	Leishmania infantum	34%	100%
A4I3C6	Leishmania infantum	33%	100%
A4I4X5	Leishmania infantum	30%	71%
A4I5B1	Leishmania infantum	41%	73%
A4I960	Leishmania infantum	26%	83%
A4IB02	Leishmania infantum	27%	100%
A4IBT4	Leishmania infantum	95%	100%
A4IDC1	Leishmania infantum	29%	73%
A4IDC2	Leishmania infantum	28%	74%
A4IDK3	Leishmania infantum	27%	100%
A4IGM9	Xenopus tropicalis	37%	100%
A5GFW1	Sus scrofa	36%	92%
A7MB74	Bos taurus	42%	86%
A8X6H4	Caenorhabditis briggsae	33%	100%
A8XJL7	Caenorhabditis briggsae	36%	79%
A8XJQ6	Caenorhabditis briggsae	47%	96%
A8XNJ6	Caenorhabditis briggsae	44%	80%
A8XW88	Caenorhabditis briggsae	50%	99%
B8BBT7	Oryza sativa subsp. indica	37%	73%
C6K3W8	Leptomonas seymouri	42%	70%
C9ZKE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	91%
C9ZL78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	88%
C9ZMA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	66%
C9ZN29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	76%
C9ZQP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	81%
C9ZSI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZTU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	68%
C9ZUK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZW68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZWI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	86%
C9ZXP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	95%
C9ZYS7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	94%
C9ZYT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	93%
C9ZZX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZZX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D0A2M0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	79%
D0A5C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
D0A820	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D7UQM5	Patiria pectinifera	39%	91%
E9ACW6	Leishmania major	24%	100%
E9ACW7	Leishmania major	29%	66%
E9AEC9	Leishmania major	30%	71%
E9AET0	Leishmania major	28%	100%
E9AFM1	Leishmania major	95%	100%
E9AG71	Leishmania infantum	32%	82%
E9AGR7	Leishmania infantum	31%	100%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AKZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	82%
E9ALA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ALF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	71%
E9AQF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ARC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	67%
E9ARK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ARP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E9ARW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ASL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	76%
E9ASS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	73%
E9ASS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	74%
E9AUY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AVR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AX78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AXW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AZF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AZF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	68%
E9AZL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B0K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	73%
E9B436	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	83%
E9B5Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B6S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B6S9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O00141	Homo sapiens	43%	86%
O01427	Caenorhabditis elegans	39%	100%
O08875	Rattus norvegicus	32%	86%
O13310	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	79%
O14965	Homo sapiens	37%	92%
O15530	Homo sapiens	36%	67%
O22932	Arabidopsis thaliana	35%	85%
O22971	Arabidopsis thaliana	38%	74%
O55099	Rattus norvegicus	33%	100%
O55173	Rattus norvegicus	37%	66%
O59790	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
O64629	Arabidopsis thaliana	37%	100%
O65554	Arabidopsis thaliana	39%	84%
O70126	Mus musculus	36%	100%
O70150	Rattus norvegicus	36%	100%
O74426	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
O88445	Mus musculus	37%	100%
O96017	Homo sapiens	36%	68%
P00517	Bos taurus	53%	100%
P05131	Bos taurus	54%	100%
P05132	Mus musculus	53%	100%
P05383	Sus scrofa	54%	100%
P05986	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	93%
P06244	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	93%
P06245	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	50%	98%
P08414	Mus musculus	34%	79%
P12370	Drosophila melanogaster	53%	100%
P13234	Rattus norvegicus	35%	78%
P16911	Drosophila melanogaster	41%	100%
P17612	Homo sapiens	54%	100%
P21137	Caenorhabditis elegans	51%	92%
P21901	Aplysia californica	41%	100%
P22612	Homo sapiens	49%	100%
P22694	Homo sapiens	53%	100%
P23443	Homo sapiens	41%	71%
P25321	Cricetulus griseus	53%	100%
P25323	Dictyostelium discoideum	36%	100%
P27791	Rattus norvegicus	53%	100%
P28178	Dictyostelium discoideum	48%	77%
P31748	AKT8 murine leukemia virus	41%	74%
P31749	Homo sapiens	40%	77%
P31750	Mus musculus	41%	77%
P31751	Homo sapiens	41%	77%
P36887	Sus scrofa	53%	100%
P38070	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	71%
P38991	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P40376	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	72%
P42818	Arabidopsis thaliana	41%	80%
P47196	Rattus norvegicus	41%	77%
P47197	Rattus norvegicus	39%	77%
P49673	Ascaris suum	50%	100%
P51817	Homo sapiens	49%	100%
P54644	Dictyostelium discoideum	46%	84%
P54645	Rattus norvegicus	33%	66%
P54646	Homo sapiens	34%	67%
P59241	Rattus norvegicus	36%	93%
P67998	Oryctolagus cuniculus	41%	71%
P67999	Rattus norvegicus	41%	71%
P68180	Cricetulus griseus	55%	100%
P68181	Mus musculus	55%	100%
P68182	Rattus norvegicus	55%	100%
P92937	Arabidopsis thaliana	39%	88%
P92958	Arabidopsis thaliana	37%	72%
P97477	Mus musculus	36%	94%
Q01314	Bos taurus	41%	77%
Q02723	Secale cereale	33%	74%
Q06226	Rattus norvegicus	44%	86%
Q09137	Rattus norvegicus	34%	67%
Q0D4B2	Oryza sativa subsp. japonica	30%	71%
Q0JI49	Oryza sativa subsp. japonica	35%	74%
Q10LQ2	Oryza sativa subsp. japonica	36%	82%
Q10SC8	Oryza sativa subsp. japonica	36%	81%
Q12706	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	85%
Q13131	Homo sapiens	33%	66%
Q14012	Homo sapiens	34%	100%
Q15208	Homo sapiens	34%	80%
Q17941	Caenorhabditis elegans	40%	69%
Q27687	Leishmania major	58%	100%
Q28948	Sus scrofa	34%	67%
Q2L6W9	Caenorhabditis elegans	36%	78%
Q2LZZ7	Drosophila pseudoobscura pseudoobscura	36%	81%
Q2PJ68	Caenorhabditis elegans	45%	80%
Q2QY53	Oryza sativa subsp. japonica	37%	85%
Q2QYM3	Oryza sativa subsp. japonica	35%	85%
Q2RAX3	Oryza sativa subsp. japonica	37%	82%
Q2RBF0	Oryza sativa subsp. japonica	35%	85%
Q2TA06	Bos taurus	38%	92%
Q2V452	Arabidopsis thaliana	36%	84%
Q38997	Arabidopsis thaliana	37%	72%
Q39030	Arabidopsis thaliana	40%	79%
Q4Q1J2	Leishmania major	27%	100%
Q4Q1S3	Leishmania major	28%	74%
Q4Q1S4	Leishmania major	29%	73%
Q4Q3Y9	Leishmania major	25%	83%
Q4Q7M5	Leishmania major	41%	73%
Q4Q9K2	Leishmania major	34%	100%
Q4QBR6	Leishmania major	31%	100%
Q4QCK0	Leishmania major	23%	100%
Q4QCR2	Leishmania major	26%	100%
Q4QDK6	Leishmania major	31%	100%
Q4QDX7	Leishmania major	35%	100%
Q4QEJ2	Leishmania major	30%	67%
Q4QF23	Leishmania major	32%	100%
Q4QIJ7	Leishmania major	35%	100%
Q4QIV8	Leishmania major	30%	82%
Q4QJJ0	Leishmania major	25%	100%
Q4R633	Macaca fascicularis	43%	86%
Q4V3C8	Arabidopsis thaliana	38%	76%
Q501V0	Danio rerio	36%	88%
Q54C18	Dictyostelium discoideum	35%	72%
Q54CY9	Dictyostelium discoideum	35%	100%
Q54IH8	Dictyostelium discoideum	34%	68%
Q54L81	Dictyostelium discoideum	37%	80%
Q54UZ1	Dictyostelium discoideum	36%	90%
Q54WX4	Dictyostelium discoideum	37%	97%
Q54Y26	Dictyostelium discoideum	34%	70%
Q59S66	Candida albicans (strain SC5314 / ATCC MYA-2876)	34%	70%
Q5BKK4	Xenopus tropicalis	42%	89%
Q5EG47	Mus musculus	32%	66%
Q5JLQ9	Oryza sativa subsp. japonica	35%	78%
Q5JLS2	Oryza sativa subsp. japonica	39%	69%
Q5Q0U5	Fundulus heteroclitus	43%	86%
Q5R7A7	Pongo abelii	42%	75%
Q5R8M1	Pongo abelii	34%	80%
Q5RD00	Pongo abelii	34%	67%
Q5RDH5	Pongo abelii	33%	67%
Q5W736	Oryza sativa subsp. japonica	39%	81%
Q60823	Mus musculus	41%	77%
Q60EY8	Oryza sativa subsp. japonica	36%	80%
Q63450	Rattus norvegicus	34%	99%
Q63484	Rattus norvegicus	41%	77%
Q683C9	Arabidopsis thaliana	37%	100%
Q68Y49	Oryza sativa subsp. japonica	37%	73%
Q6A1A2	Homo sapiens	40%	94%
Q6BVA0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	34%	90%
Q6C3J2	Yarrowia lipolytica (strain CLIB 122 / E 150)	36%	100%
Q6CWQ4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	33%	100%
Q6DE08	Xenopus laevis	36%	100%
Q6ERS4	Oryza sativa subsp. japonica	36%	81%
Q6FV07	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	35%	100%
Q6GLY8	Xenopus laevis	38%	85%
Q6GPL3	Xenopus laevis	36%	100%
Q6GPN6	Xenopus laevis	42%	85%
Q6H7U5	Oryza sativa subsp. japonica	35%	75%
Q6IP76	Xenopus laevis	41%	76%
Q6NW76	Danio rerio	35%	100%
Q6P2M8	Homo sapiens	36%	100%
Q6TGC6	Pneumocystis carinii	34%	73%
Q6TJY3	Bos taurus	41%	70%
Q6U1I9	Gallus gallus	43%	86%
Q6X4A2	Oryza sativa subsp. japonica	37%	83%
Q6Z9F4	Oryza sativa subsp. japonica	37%	82%
Q6ZLP5	Oryza sativa subsp. japonica	38%	82%
Q755C4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	35%	100%
Q75L42	Oryza sativa subsp. japonica	35%	82%
Q7JP68	Caenorhabditis elegans	45%	93%
Q7TNJ7	Rattus norvegicus	32%	78%
Q7TSE6	Mus musculus	34%	80%
Q7X996	Oryza sativa subsp. japonica	35%	84%
Q7XIW5	Oryza sativa subsp. japonica	38%	84%
Q7YRC6	Bos taurus	36%	100%
Q7ZTW4	Danio rerio	43%	86%
Q7ZX15	Xenopus laevis	41%	76%
Q84VQ3	Arabidopsis thaliana	37%	85%
Q852Q0	Oryza sativa subsp. japonica	37%	73%
Q852Q1	Oryza sativa subsp. japonica	37%	73%
Q852Q2	Oryza sativa subsp. japonica	37%	73%
Q869W6	Dictyostelium discoideum	32%	100%
Q86UX6	Homo sapiens	34%	76%
Q8BGW6	Mus musculus	34%	93%
Q8BRK8	Mus musculus	34%	67%
Q8BSK8	Mus musculus	41%	71%
Q8BW96	Mus musculus	34%	96%
Q8IU85	Homo sapiens	34%	96%
Q8LIG4	Oryza sativa subsp. japonica	37%	83%
Q8MJ44	Canis lupus familiaris	53%	100%
Q8MYF1	Dictyostelium discoideum	42%	81%
Q8QZV4	Mus musculus	35%	76%
Q8R4U9	Rattus norvegicus	44%	100%
Q8R4V0	Rattus norvegicus	42%	75%
Q8RWC9	Arabidopsis thaliana	34%	84%
Q8SRK8	Encephalitozoon cuniculi (strain GB-M1)	37%	100%
Q8W1D5	Arabidopsis thaliana	35%	76%
Q8WU08	Homo sapiens	34%	94%
Q91819	Xenopus laevis	38%	91%
Q91820	Xenopus laevis	38%	91%
Q91VB2	Mus musculus	32%	78%
Q91VJ4	Mus musculus	33%	80%
Q91YS8	Mus musculus	34%	99%
Q922R0	Mus musculus	49%	100%
Q94C40	Arabidopsis thaliana	32%	86%
Q96BR1	Homo sapiens	42%	75%
Q96GD4	Homo sapiens	36%	100%
Q96NX5	Homo sapiens	33%	78%
Q96QS6	Homo sapiens	37%	96%
Q98TY9	Xenopus laevis	38%	77%
Q9ERE3	Mus musculus	42%	75%
Q9FJ54	Arabidopsis thaliana	36%	85%
Q9FJ55	Arabidopsis thaliana	38%	77%
Q9FLZ3	Arabidopsis thaliana	35%	75%
Q9GNR4	Leishmania major	97%	100%
Q9HBY8	Homo sapiens	44%	100%
Q9JJX8	Mus musculus	35%	90%
Q9LDI3	Arabidopsis thaliana	35%	83%
Q9LGV5	Oryza sativa subsp. japonica	35%	80%
Q9LP51	Arabidopsis thaliana	38%	71%
Q9LWM4	Oryza sativa subsp. japonica	34%	80%
Q9LYQ8	Arabidopsis thaliana	35%	81%
Q9MAM1	Arabidopsis thaliana	36%	83%
Q9MZD9	Ovis aries	53%	100%
Q9N0X0	Sus scrofa	36%	100%
Q9N2N1	Leishmania major	33%	100%
Q9NAH6	Caenorhabditis elegans	41%	67%
Q9NBK5	Drosophila melanogaster	35%	80%
Q9NY57	Homo sapiens	35%	90%
Q9QYK9	Mus musculus	36%	100%
Q9QZS5	Mus musculus	44%	100%
Q9SEZ7	Arabidopsis thaliana	34%	79%
Q9SN43	Arabidopsis thaliana	39%	76%
Q9STV4	Arabidopsis thaliana	36%	83%
Q9SUL7	Arabidopsis thaliana	35%	87%
Q9TXJ0	Caenorhabditis elegans	34%	100%
Q9UBS0	Homo sapiens	42%	77%
Q9UQB9	Homo sapiens	34%	100%
Q9USX7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	71%
Q9VKN7	Drosophila melanogaster	34%	100%
Q9WUA6	Mus musculus	42%	77%
Q9WVC6	Mus musculus	43%	86%
Q9XF67	Arabidopsis thaliana	38%	76%
Q9XIW0	Arabidopsis thaliana	34%	86%
Q9XT18	Oryctolagus cuniculus	43%	86%
Q9XTG7	Caenorhabditis elegans	35%	70%
Q9Y243	Homo sapiens	42%	77%
Q9Y2H1	Homo sapiens	34%	80%
Q9Y7J6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	67%
Q9Z1M4	Mus musculus	42%	76%
Q9Z265	Mus musculus	36%	68%
Q9Z2A0	Mus musculus	36%	66%
V5B871	Trypanosoma cruzi	32%	87%
V5BAZ8	Trypanosoma cruzi	29%	97%
V5BCH2	Trypanosoma cruzi	34%	95%
V5BEK5	Trypanosoma cruzi	57%	100%
V5BG98	Trypanosoma cruzi	32%	100%
V5BH88	Trypanosoma cruzi	31%	68%
V5BI43	Trypanosoma cruzi	30%	74%
V5BNV8	Trypanosoma cruzi	33%	100%
V5BPJ0	Trypanosoma cruzi	28%	75%
V5BQH6	Trypanosoma cruzi	31%	85%
V5BWC2	Trypanosoma cruzi	34%	100%
V5C224	Trypanosoma cruzi	27%	74%
V5C234	Trypanosoma cruzi	27%	68%
V5D579	Trypanosoma cruzi	30%	86%
V5DI55	Trypanosoma cruzi	30%	89%
V5DPP5	Trypanosoma cruzi	33%	86%
V5DQT5	Trypanosoma cruzi	42%	81%
W0LYS5	Macrobrachium nipponense	36%	100%