LeishMANIAdb
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4E-interacting_protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
4E-interacting_protein
Gene product:
4E-interacting protein - putative
Species:
Leishmania infantum
UniProt:
A4IBT6_LEIIN
TriTrypDb:
LINF_350045300
Length:
791

Annotations

Annotations by Jardim et al.

Translation, 4E-interacting Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 318

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IBT6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBT6

PDB structure(s): 5wb5_B

Function

Biological processes
Term Name Level Count
GO:0006417 regulation of translation 6 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0034248 regulation of amide metabolic process 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:2000112 obsolete regulation of cellular macromolecule biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0045182 translation regulator activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 205 209 PF00656 0.619
CLV_NRD_NRD_1 120 122 PF00675 0.661
CLV_NRD_NRD_1 189 191 PF00675 0.558
CLV_NRD_NRD_1 30 32 PF00675 0.659
CLV_NRD_NRD_1 47 49 PF00675 0.502
CLV_NRD_NRD_1 745 747 PF00675 0.626
CLV_PCSK_KEX2_1 120 122 PF00082 0.661
CLV_PCSK_KEX2_1 179 181 PF00082 0.541
CLV_PCSK_KEX2_1 46 48 PF00082 0.646
CLV_PCSK_KEX2_1 745 747 PF00082 0.626
CLV_PCSK_PC1ET2_1 179 181 PF00082 0.541
CLV_PCSK_PC1ET2_1 46 48 PF00082 0.646
CLV_PCSK_SKI1_1 15 19 PF00082 0.570
CLV_PCSK_SKI1_1 196 200 PF00082 0.503
CLV_PCSK_SKI1_1 501 505 PF00082 0.707
CLV_PCSK_SKI1_1 546 550 PF00082 0.659
CLV_Separin_Metazoa 12 16 PF03568 0.624
CLV_Separin_Metazoa 28 32 PF03568 0.393
DEG_APCC_DBOX_1 9 17 PF00400 0.526
DEG_COP1_1 479 489 PF00400 0.759
DEG_SCF_FBW7_1 294 301 PF00400 0.620
DEG_SCF_FBW7_1 449 456 PF00400 0.679
DEG_SIAH_1 289 297 PF03145 0.687
DEG_SPOP_SBC_1 283 287 PF00917 0.684
DEG_SPOP_SBC_1 366 370 PF00917 0.711
DOC_CKS1_1 295 300 PF01111 0.666
DOC_CKS1_1 450 455 PF01111 0.740
DOC_CYCLIN_yClb3_PxF_3 557 563 PF00134 0.759
DOC_CYCLIN_yClb5_NLxxxL_5 191 199 PF00134 0.564
DOC_CYCLIN_yCln2_LP_2 713 719 PF00134 0.630
DOC_MAPK_gen_1 31 38 PF00069 0.707
DOC_PP2B_LxvP_1 627 630 PF13499 0.703
DOC_PP2B_LxvP_1 713 716 PF13499 0.632
DOC_PP4_FxxP_1 146 149 PF00568 0.598
DOC_PP4_FxxP_1 275 278 PF00568 0.675
DOC_PP4_FxxP_1 399 402 PF00568 0.646
DOC_PP4_FxxP_1 563 566 PF00568 0.660
DOC_PP4_FxxP_1 576 579 PF00568 0.676
DOC_PP4_FxxP_1 726 729 PF00568 0.535
DOC_PP4_FxxP_1 744 747 PF00568 0.381
DOC_USP7_MATH_1 267 271 PF00917 0.686
DOC_USP7_MATH_1 278 282 PF00917 0.602
DOC_USP7_MATH_1 290 294 PF00917 0.646
DOC_USP7_MATH_1 298 302 PF00917 0.559
DOC_USP7_MATH_1 310 314 PF00917 0.410
DOC_USP7_MATH_1 344 348 PF00917 0.706
DOC_USP7_MATH_1 367 371 PF00917 0.732
DOC_USP7_MATH_1 381 385 PF00917 0.552
DOC_USP7_MATH_1 412 416 PF00917 0.623
DOC_USP7_MATH_1 439 443 PF00917 0.751
DOC_USP7_MATH_1 462 466 PF00917 0.718
DOC_USP7_MATH_1 477 481 PF00917 0.584
DOC_USP7_MATH_1 577 581 PF00917 0.716
DOC_USP7_MATH_1 586 590 PF00917 0.650
DOC_USP7_MATH_1 639 643 PF00917 0.693
DOC_WW_Pin1_4 103 108 PF00397 0.665
DOC_WW_Pin1_4 260 265 PF00397 0.642
DOC_WW_Pin1_4 294 299 PF00397 0.591
DOC_WW_Pin1_4 342 347 PF00397 0.609
DOC_WW_Pin1_4 405 410 PF00397 0.658
DOC_WW_Pin1_4 449 454 PF00397 0.744
DOC_WW_Pin1_4 515 520 PF00397 0.605
DOC_WW_Pin1_4 556 561 PF00397 0.767
DOC_WW_Pin1_4 579 584 PF00397 0.755
DOC_WW_Pin1_4 595 600 PF00397 0.679
DOC_WW_Pin1_4 684 689 PF00397 0.765
LIG_14-3-3_CanoR_1 15 20 PF00244 0.646
LIG_14-3-3_CanoR_1 242 249 PF00244 0.615
LIG_BIR_III_2 343 347 PF00653 0.698
LIG_BRCT_BRCA1_1 240 244 PF00533 0.595
LIG_EH_1 774 778 PF12763 0.716
LIG_eIF4E_1 8 14 PF01652 0.522
LIG_EVH1_1 627 631 PF00568 0.702
LIG_FHA_1 216 222 PF00498 0.558
LIG_FHA_1 524 530 PF00498 0.672
LIG_FHA_1 690 696 PF00498 0.770
LIG_FHA_2 160 166 PF00498 0.658
LIG_FHA_2 205 211 PF00498 0.492
LIG_FHA_2 227 233 PF00498 0.693
LIG_FHA_2 250 256 PF00498 0.685
LIG_FHA_2 528 534 PF00498 0.667
LIG_FHA_2 7 13 PF00498 0.530
LIG_LIR_Apic_2 144 149 PF02991 0.606
LIG_LIR_Apic_2 272 278 PF02991 0.677
LIG_LIR_Apic_2 398 402 PF02991 0.645
LIG_LIR_Gen_1 141 149 PF02991 0.716
LIG_LIR_Nem_3 141 146 PF02991 0.630
LIG_MLH1_MIPbox_1 240 244 PF16413 0.595
LIG_MYND_1 693 697 PF01753 0.769
LIG_NRBOX 494 500 PF00104 0.547
LIG_NRP_CendR_1 790 791 PF00754 0.702
LIG_SH2_STAP1 143 147 PF00017 0.614
LIG_SH2_STAT5 725 728 PF00017 0.599
LIG_SH2_STAT5 8 11 PF00017 0.526
LIG_SH3_3 259 265 PF00018 0.624
LIG_SH3_3 349 355 PF00018 0.684
LIG_SH3_3 35 41 PF00018 0.626
LIG_SH3_3 398 404 PF00018 0.733
LIG_SH3_3 406 412 PF00018 0.621
LIG_SH3_3 414 420 PF00018 0.509
LIG_SH3_3 447 453 PF00018 0.732
LIG_SH3_3 461 467 PF00018 0.694
LIG_SH3_3 507 513 PF00018 0.684
LIG_SH3_3 554 560 PF00018 0.761
LIG_SH3_3 563 569 PF00018 0.600
LIG_SH3_3 580 586 PF00018 0.654
LIG_SH3_3 614 620 PF00018 0.751
LIG_SH3_3 623 629 PF00018 0.590
LIG_SH3_3 630 636 PF00018 0.452
LIG_SH3_3 668 674 PF00018 0.718
LIG_SH3_3 691 697 PF00018 0.716
LIG_SH3_3 704 710 PF00018 0.539
LIG_SH3_3 770 776 PF00018 0.715
LIG_SUMO_SIM_anti_2 494 499 PF11976 0.570
LIG_SUMO_SIM_par_1 34 40 PF11976 0.625
LIG_TRAF2_1 162 165 PF00917 0.568
LIG_TRAF2_1 9 12 PF00917 0.625
MOD_CK1_1 103 109 PF00069 0.652
MOD_CK1_1 281 287 PF00069 0.617
MOD_CK1_1 313 319 PF00069 0.703
MOD_CK1_1 326 332 PF00069 0.503
MOD_CK1_1 357 363 PF00069 0.738
MOD_CK1_1 384 390 PF00069 0.714
MOD_CK1_1 479 485 PF00069 0.616
MOD_CK1_1 515 521 PF00069 0.668
MOD_CK1_1 57 63 PF00069 0.695
MOD_CK1_1 589 595 PF00069 0.686
MOD_CK1_1 64 70 PF00069 0.629
MOD_CK1_1 95 101 PF00069 0.654
MOD_CK2_1 159 165 PF00069 0.667
MOD_CK2_1 204 210 PF00069 0.488
MOD_CK2_1 249 255 PF00069 0.683
MOD_CK2_1 527 533 PF00069 0.702
MOD_CK2_1 6 12 PF00069 0.594
MOD_GlcNHglycan 140 143 PF01048 0.654
MOD_GlcNHglycan 173 176 PF01048 0.506
MOD_GlcNHglycan 20 23 PF01048 0.569
MOD_GlcNHglycan 244 247 PF01048 0.617
MOD_GlcNHglycan 252 255 PF01048 0.668
MOD_GlcNHglycan 300 303 PF01048 0.664
MOD_GlcNHglycan 328 331 PF01048 0.611
MOD_GlcNHglycan 346 349 PF01048 0.682
MOD_GlcNHglycan 383 386 PF01048 0.732
MOD_GlcNHglycan 393 396 PF01048 0.659
MOD_GlcNHglycan 441 444 PF01048 0.737
MOD_GlcNHglycan 479 482 PF01048 0.695
MOD_GlcNHglycan 490 493 PF01048 0.638
MOD_GlcNHglycan 507 510 PF01048 0.548
MOD_GlcNHglycan 592 595 PF01048 0.685
MOD_GlcNHglycan 71 74 PF01048 0.688
MOD_GlcNHglycan 79 82 PF01048 0.763
MOD_GlcNHglycan 87 90 PF01048 0.674
MOD_GSK3_1 130 137 PF00069 0.727
MOD_GSK3_1 238 245 PF00069 0.592
MOD_GSK3_1 256 263 PF00069 0.605
MOD_GSK3_1 267 274 PF00069 0.609
MOD_GSK3_1 277 284 PF00069 0.631
MOD_GSK3_1 290 297 PF00069 0.620
MOD_GSK3_1 309 316 PF00069 0.489
MOD_GSK3_1 319 326 PF00069 0.557
MOD_GSK3_1 331 338 PF00069 0.498
MOD_GSK3_1 357 364 PF00069 0.735
MOD_GSK3_1 377 384 PF00069 0.436
MOD_GSK3_1 391 398 PF00069 0.573
MOD_GSK3_1 424 431 PF00069 0.685
MOD_GSK3_1 434 441 PF00069 0.633
MOD_GSK3_1 449 456 PF00069 0.636
MOD_GSK3_1 476 483 PF00069 0.639
MOD_GSK3_1 484 491 PF00069 0.625
MOD_GSK3_1 501 508 PF00069 0.645
MOD_GSK3_1 515 522 PF00069 0.731
MOD_GSK3_1 523 530 PF00069 0.552
MOD_GSK3_1 548 555 PF00069 0.715
MOD_GSK3_1 57 64 PF00069 0.705
MOD_GSK3_1 585 592 PF00069 0.681
MOD_GSK3_1 639 646 PF00069 0.711
MOD_GSK3_1 65 72 PF00069 0.623
MOD_GSK3_1 94 101 PF00069 0.646
MOD_N-GLC_1 381 386 PF02516 0.635
MOD_N-GLC_1 61 66 PF02516 0.638
MOD_N-GLC_1 684 689 PF02516 0.765
MOD_N-GLC_1 98 103 PF02516 0.719
MOD_NEK2_1 171 176 PF00069 0.510
MOD_NEK2_1 320 325 PF00069 0.629
MOD_NEK2_1 331 336 PF00069 0.516
MOD_NEK2_1 505 510 PF00069 0.681
MOD_NEK2_1 54 59 PF00069 0.733
MOD_NEK2_1 63 68 PF00069 0.633
MOD_NEK2_2 3 8 PF00069 0.576
MOD_NEK2_2 310 315 PF00069 0.639
MOD_NEK2_2 747 752 PF00069 0.639
MOD_PIKK_1 300 306 PF00454 0.690
MOD_PIKK_1 354 360 PF00454 0.749
MOD_PIKK_1 410 416 PF00454 0.554
MOD_PIKK_1 443 449 PF00454 0.628
MOD_PIKK_1 457 463 PF00454 0.723
MOD_PIKK_1 523 529 PF00454 0.758
MOD_PIKK_1 639 645 PF00454 0.666
MOD_PKA_2 171 177 PF00069 0.537
MOD_PKA_2 215 221 PF00069 0.454
MOD_PKA_2 477 483 PF00069 0.682
MOD_PKB_1 240 248 PF00069 0.608
MOD_Plk_2-3 215 221 PF00069 0.668
MOD_Plk_4 290 296 PF00069 0.765
MOD_Plk_4 413 419 PF00069 0.775
MOD_Plk_4 501 507 PF00069 0.666
MOD_Plk_4 533 539 PF00069 0.563
MOD_Plk_4 54 60 PF00069 0.744
MOD_Plk_4 747 753 PF00069 0.547
MOD_ProDKin_1 103 109 PF00069 0.668
MOD_ProDKin_1 260 266 PF00069 0.736
MOD_ProDKin_1 294 300 PF00069 0.592
MOD_ProDKin_1 342 348 PF00069 0.610
MOD_ProDKin_1 405 411 PF00069 0.660
MOD_ProDKin_1 449 455 PF00069 0.747
MOD_ProDKin_1 515 521 PF00069 0.606
MOD_ProDKin_1 556 562 PF00069 0.769
MOD_ProDKin_1 579 585 PF00069 0.757
MOD_ProDKin_1 595 601 PF00069 0.681
MOD_ProDKin_1 684 690 PF00069 0.767
MOD_SUMO_for_1 202 205 PF00179 0.680
TRG_DiLeu_BaEn_1 220 225 PF01217 0.643
TRG_DiLeu_BaLyEn_6 570 575 PF01217 0.653
TRG_DiLeu_LyEn_5 220 225 PF01217 0.643
TRG_ENDOCYTIC_2 143 146 PF00928 0.623
TRG_ER_diArg_1 239 242 PF00400 0.536
TRG_ER_diArg_1 744 746 PF00400 0.502
TRG_NES_CRM1_1 24 37 PF08389 0.677
TRG_NLS_MonoExtC_3 177 183 PF00514 0.537

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HU08 Leptomonas seymouri 42% 100%
A0A3S7X9R7 Leishmania donovani 99% 100%
A4HN68 Leishmania braziliensis 73% 100%
E9AFM3 Leishmania major 90% 100%
E9B6S6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS