SP-RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted zinc finger protein

Species:

Leishmania infantum

UniProt:

A4IBT5_LEIIN

TriTrypDb:

LINF_350045200

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBT5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.584
CLV_C14_Caspase3-7	614	618	PF00656	0.648
CLV_NRD_NRD_1	156	158	PF00675	0.631
CLV_NRD_NRD_1	309	311	PF00675	0.399
CLV_NRD_NRD_1	682	684	PF00675	0.661
CLV_NRD_NRD_1	7	9	PF00675	0.409
CLV_NRD_NRD_1	95	97	PF00675	0.611
CLV_PCSK_KEX2_1	156	158	PF00082	0.631
CLV_PCSK_KEX2_1	309	311	PF00082	0.343
CLV_PCSK_KEX2_1	373	375	PF00082	0.480
CLV_PCSK_KEX2_1	684	686	PF00082	0.660
CLV_PCSK_KEX2_1	7	9	PF00082	0.418
CLV_PCSK_KEX2_1	95	97	PF00082	0.611
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.480
CLV_PCSK_PC1ET2_1	684	686	PF00082	0.660
CLV_PCSK_SKI1_1	449	453	PF00082	0.423
CLV_PCSK_SKI1_1	49	53	PF00082	0.360
DEG_SPOP_SBC_1	191	195	PF00917	0.711
DEG_SPOP_SBC_1	264	268	PF00917	0.597
DEG_SPOP_SBC_1	463	467	PF00917	0.480
DOC_CKS1_1	283	288	PF01111	0.525
DOC_CKS1_1	347	352	PF01111	0.527
DOC_CKS1_1	368	373	PF01111	0.472
DOC_CKS1_1	414	419	PF01111	0.397
DOC_MAPK_gen_1	156	164	PF00069	0.637
DOC_MAPK_gen_1	309	315	PF00069	0.412
DOC_MAPK_gen_1	335	344	PF00069	0.349
DOC_PP2B_LxvP_1	141	144	PF13499	0.571
DOC_PP2B_LxvP_1	279	282	PF13499	0.612
DOC_PP2B_LxvP_1	305	308	PF13499	0.377
DOC_PP2B_LxvP_1	513	516	PF13499	0.483
DOC_PP2B_LxvP_1	662	665	PF13499	0.624
DOC_PP4_FxxP_1	322	325	PF00568	0.332
DOC_SPAK_OSR1_1	321	325	PF12202	0.396
DOC_USP7_MATH_1	146	150	PF00917	0.634
DOC_USP7_MATH_1	155	159	PF00917	0.645
DOC_USP7_MATH_1	215	219	PF00917	0.638
DOC_USP7_MATH_1	222	226	PF00917	0.712
DOC_USP7_MATH_1	245	249	PF00917	0.624
DOC_USP7_MATH_1	255	259	PF00917	0.675
DOC_USP7_MATH_1	265	269	PF00917	0.526
DOC_USP7_MATH_1	461	465	PF00917	0.545
DOC_USP7_MATH_1	627	631	PF00917	0.732
DOC_USP7_MATH_1	633	637	PF00917	0.732
DOC_USP7_MATH_1	666	670	PF00917	0.685
DOC_USP7_UBL2_3	39	43	PF12436	0.412
DOC_WW_Pin1_4	113	118	PF00397	0.756
DOC_WW_Pin1_4	151	156	PF00397	0.636
DOC_WW_Pin1_4	195	200	PF00397	0.740
DOC_WW_Pin1_4	268	273	PF00397	0.766
DOC_WW_Pin1_4	282	287	PF00397	0.499
DOC_WW_Pin1_4	346	351	PF00397	0.542
DOC_WW_Pin1_4	367	372	PF00397	0.456
DOC_WW_Pin1_4	413	418	PF00397	0.424
LIG_14-3-3_CanoR_1	156	164	PF00244	0.603
LIG_14-3-3_CanoR_1	17	21	PF00244	0.378
LIG_14-3-3_CanoR_1	246	252	PF00244	0.665
LIG_14-3-3_CanoR_1	303	308	PF00244	0.383
LIG_14-3-3_CanoR_1	314	320	PF00244	0.322
LIG_14-3-3_CanoR_1	398	405	PF00244	0.425
LIG_14-3-3_CanoR_1	455	462	PF00244	0.437
LIG_14-3-3_CanoR_1	521	528	PF00244	0.486
LIG_14-3-3_CanoR_1	581	588	PF00244	0.432
LIG_14-3-3_CanoR_1	75	84	PF00244	0.438
LIG_Actin_WH2_2	298	316	PF00022	0.345
LIG_Actin_WH2_2	44	61	PF00022	0.391
LIG_Actin_WH2_2	566	583	PF00022	0.340
LIG_BIR_III_2	89	93	PF00653	0.462
LIG_BRCT_BRCA1_1	229	233	PF00533	0.576
LIG_EVH1_1	662	666	PF00568	0.581
LIG_FHA_1	103	109	PF00498	0.571
LIG_FHA_1	148	154	PF00498	0.616
LIG_FHA_1	163	169	PF00498	0.541
LIG_FHA_1	278	284	PF00498	0.660
LIG_FHA_1	391	397	PF00498	0.335
LIG_FHA_1	414	420	PF00498	0.391
LIG_FHA_2	29	35	PF00498	0.414
LIG_FHA_2	353	359	PF00498	0.471
LIG_FHA_2	601	607	PF00498	0.487
LIG_FHA_2	697	703	PF00498	0.619
LIG_GBD_Chelix_1	37	45	PF00786	0.407
LIG_LIR_Apic_2	413	417	PF02991	0.434
LIG_LIR_Gen_1	257	265	PF02991	0.739
LIG_LIR_Gen_1	481	487	PF02991	0.412
LIG_LIR_Gen_1	561	571	PF02991	0.359
LIG_LIR_Nem_3	22	26	PF02991	0.357
LIG_LIR_Nem_3	257	262	PF02991	0.740
LIG_LIR_Nem_3	3	9	PF02991	0.363
LIG_LIR_Nem_3	385	390	PF02991	0.391
LIG_LIR_Nem_3	481	485	PF02991	0.477
LIG_LIR_Nem_3	561	567	PF02991	0.378
LIG_LIR_Nem_3	569	573	PF02991	0.476
LIG_NRBOX	47	53	PF00104	0.401
LIG_PDZ_Class_2	701	706	PF00595	0.599
LIG_Pex14_2	233	237	PF04695	0.547
LIG_Pex14_2	311	315	PF04695	0.412
LIG_PTB_Apo_2	408	415	PF02174	0.449
LIG_PTB_Phospho_1	408	414	PF10480	0.446
LIG_REV1ctd_RIR_1	299	307	PF16727	0.391
LIG_SH2_CRK	259	263	PF00017	0.582
LIG_SH2_CRK	340	344	PF00017	0.395
LIG_SH2_CRK	414	418	PF00017	0.404
LIG_SH2_CRK	482	486	PF00017	0.410
LIG_SH2_GRB2like	362	365	PF00017	0.403
LIG_SH2_GRB2like	542	545	PF00017	0.443
LIG_SH2_NCK_1	259	263	PF00017	0.582
LIG_SH2_SRC	328	331	PF00017	0.404
LIG_SH2_SRC	53	56	PF00017	0.444
LIG_SH2_STAP1	482	486	PF00017	0.359
LIG_SH2_STAT5	328	331	PF00017	0.375
LIG_SH2_STAT5	36	39	PF00017	0.423
LIG_SH2_STAT5	362	365	PF00017	0.432
LIG_SH2_STAT5	387	390	PF00017	0.367
LIG_SH2_STAT5	394	397	PF00017	0.319
LIG_SH2_STAT5	566	569	PF00017	0.494
LIG_SH2_STAT5	579	582	PF00017	0.373
LIG_SH3_2	347	352	PF14604	0.536
LIG_SH3_3	186	192	PF00018	0.774
LIG_SH3_3	259	265	PF00018	0.612
LIG_SH3_3	269	275	PF00018	0.557
LIG_SH3_3	344	350	PF00018	0.508
LIG_SH3_3	365	371	PF00018	0.463
LIG_SH3_3	626	632	PF00018	0.720
LIG_SH3_3	651	657	PF00018	0.590
LIG_SH3_3	660	666	PF00018	0.543
LIG_SUMO_SIM_par_1	149	154	PF11976	0.591
LIG_SUMO_SIM_par_1	388	393	PF11976	0.332
LIG_TRAF2_1	427	430	PF00917	0.415
LIG_TRAF2_1	692	695	PF00917	0.687
LIG_TRAF2_2	325	330	PF00917	0.413
LIG_TYR_ITSM	255	262	PF00017	0.557
LIG_WRC_WIRS_1	567	572	PF05994	0.379
MOD_CDC14_SPxK_1	154	157	PF00782	0.629
MOD_CDK_SPK_2	151	156	PF00069	0.627
MOD_CDK_SPxK_1	151	157	PF00069	0.636
MOD_CDK_SPxK_1	346	352	PF00069	0.522
MOD_CDK_SPxK_1	367	373	PF00069	0.464
MOD_CDK_SPxxK_3	367	374	PF00069	0.479
MOD_CK1_1	149	155	PF00069	0.588
MOD_CK1_1	177	183	PF00069	0.577
MOD_CK1_1	198	204	PF00069	0.744
MOD_CK1_1	225	231	PF00069	0.725
MOD_CK1_1	25	31	PF00069	0.382
MOD_CK1_1	266	272	PF00069	0.593
MOD_CK1_1	277	283	PF00069	0.568
MOD_CK1_1	284	290	PF00069	0.425
MOD_CK1_1	397	403	PF00069	0.410
MOD_CK1_1	454	460	PF00069	0.524
MOD_CK1_1	464	470	PF00069	0.439
MOD_CK1_1	520	526	PF00069	0.321
MOD_CK1_1	600	606	PF00069	0.621
MOD_CK1_1	638	644	PF00069	0.580
MOD_CK1_1	649	655	PF00069	0.559
MOD_CK1_1	98	104	PF00069	0.604
MOD_CK2_1	16	22	PF00069	0.562
MOD_CK2_1	284	290	PF00069	0.533
MOD_CK2_1	352	358	PF00069	0.482
MOD_CK2_1	424	430	PF00069	0.377
MOD_CK2_1	613	619	PF00069	0.790
MOD_CK2_1	637	643	PF00069	0.603
MOD_CK2_1	689	695	PF00069	0.637
MOD_Cter_Amidation	67	70	PF01082	0.475
MOD_GlcNHglycan	101	104	PF01048	0.561
MOD_GlcNHglycan	120	123	PF01048	0.569
MOD_GlcNHglycan	133	136	PF01048	0.589
MOD_GlcNHglycan	176	179	PF01048	0.614
MOD_GlcNHglycan	224	227	PF01048	0.650
MOD_GlcNHglycan	229	232	PF01048	0.700
MOD_GlcNHglycan	268	271	PF01048	0.558
MOD_GlcNHglycan	296	299	PF01048	0.432
MOD_GlcNHglycan	457	460	PF01048	0.642
MOD_GlcNHglycan	466	469	PF01048	0.364
MOD_GlcNHglycan	582	585	PF01048	0.377
MOD_GlcNHglycan	629	632	PF01048	0.682
MOD_GlcNHglycan	637	640	PF01048	0.687
MOD_GlcNHglycan	654	657	PF01048	0.713
MOD_GlcNHglycan	66	69	PF01048	0.404
MOD_GSK3_1	111	118	PF00069	0.522
MOD_GSK3_1	147	154	PF00069	0.626
MOD_GSK3_1	191	198	PF00069	0.700
MOD_GSK3_1	199	206	PF00069	0.704
MOD_GSK3_1	227	234	PF00069	0.654
MOD_GSK3_1	264	271	PF00069	0.623
MOD_GSK3_1	277	284	PF00069	0.559
MOD_GSK3_1	390	397	PF00069	0.391
MOD_GSK3_1	451	458	PF00069	0.505
MOD_GSK3_1	462	469	PF00069	0.458
MOD_GSK3_1	534	541	PF00069	0.364
MOD_GSK3_1	558	565	PF00069	0.343
MOD_GSK3_1	633	640	PF00069	0.765
MOD_GSK3_1	642	649	PF00069	0.484
MOD_GSK3_1	95	102	PF00069	0.746
MOD_N-GLC_1	294	299	PF02516	0.503
MOD_NEK2_1	111	116	PF00069	0.704
MOD_NEK2_1	294	299	PF00069	0.470
MOD_NEK2_1	315	320	PF00069	0.471
MOD_NEK2_1	390	395	PF00069	0.330
MOD_NEK2_1	435	440	PF00069	0.384
MOD_NEK2_1	451	456	PF00069	0.512
MOD_NEK2_1	462	467	PF00069	0.438
MOD_NEK2_1	470	475	PF00069	0.245
MOD_NEK2_1	533	538	PF00069	0.330
MOD_NEK2_1	580	585	PF00069	0.378
MOD_NEK2_1	642	647	PF00069	0.707
MOD_PIKK_1	506	512	PF00454	0.273
MOD_PK_1	303	309	PF00069	0.386
MOD_PK_1	59	65	PF00069	0.437
MOD_PKA_1	156	162	PF00069	0.624
MOD_PKA_1	95	101	PF00069	0.583
MOD_PKA_2	125	131	PF00069	0.595
MOD_PKA_2	155	161	PF00069	0.691
MOD_PKA_2	16	22	PF00069	0.452
MOD_PKA_2	245	251	PF00069	0.598
MOD_PKA_2	397	403	PF00069	0.410
MOD_PKA_2	454	460	PF00069	0.431
MOD_PKA_2	517	523	PF00069	0.321
MOD_PKA_2	580	586	PF00069	0.408
MOD_PKA_2	696	702	PF00069	0.641
MOD_PKA_2	95	101	PF00069	0.583
MOD_Plk_1	390	396	PF00069	0.330
MOD_Plk_1	59	65	PF00069	0.437
MOD_Plk_1	649	655	PF00069	0.616
MOD_Plk_2-3	613	619	PF00069	0.665
MOD_Plk_2-3	690	696	PF00069	0.625
MOD_Plk_4	171	177	PF00069	0.614
MOD_Plk_4	185	191	PF00069	0.639
MOD_Plk_4	22	28	PF00069	0.400
MOD_Plk_4	274	280	PF00069	0.608
MOD_Plk_4	315	321	PF00069	0.383
MOD_Plk_4	383	389	PF00069	0.437
MOD_Plk_4	466	472	PF00069	0.389
MOD_Plk_4	538	544	PF00069	0.392
MOD_Plk_4	558	564	PF00069	0.355
MOD_Plk_4	59	65	PF00069	0.437
MOD_ProDKin_1	113	119	PF00069	0.608
MOD_ProDKin_1	151	157	PF00069	0.632
MOD_ProDKin_1	195	201	PF00069	0.741
MOD_ProDKin_1	268	274	PF00069	0.768
MOD_ProDKin_1	282	288	PF00069	0.489
MOD_ProDKin_1	346	352	PF00069	0.522
MOD_ProDKin_1	367	373	PF00069	0.464
MOD_ProDKin_1	413	419	PF00069	0.417
MOD_SUMO_rev_2	19	26	PF00179	0.439
TRG_DiLeu_BaEn_1	171	176	PF01217	0.703
TRG_DiLeu_BaEn_1	47	52	PF01217	0.364
TRG_DiLeu_BaEn_4	490	496	PF01217	0.484
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.396
TRG_ENDOCYTIC_2	259	262	PF00928	0.582
TRG_ENDOCYTIC_2	387	390	PF00928	0.466
TRG_ENDOCYTIC_2	482	485	PF00928	0.413
TRG_ENDOCYTIC_2	579	582	PF00928	0.364
TRG_ER_diArg_1	155	157	PF00400	0.629
TRG_ER_diArg_1	308	310	PF00400	0.411
TRG_ER_diArg_1	6	8	PF00400	0.410
TRG_ER_diArg_1	682	685	PF00400	0.633
TRG_ER_diArg_1	94	96	PF00400	0.573
TRG_NLS_MonoExtC_3	682	687	PF00514	0.618
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	49	54	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0M6	Leptomonas seymouri	51%	97%
A0A0S4J3Y9	Bodo saltans	29%	100%
A0A3Q8IPZ9	Leishmania donovani	99%	100%
E9AFM2	Leishmania major	91%	100%
E9B6S5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%