Protein kinase A catalytic subunit isoform 2

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase A catalytic subunit isoform 1

Species:

Leishmania infantum

UniProt:

A4IBT4_LEIIN

TriTrypDb:

LINF_350045100

Length:

382

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 28

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 26
NetGPI	no	yes: 0, no: 26

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	4
GO:0005737	cytoplasm	2	3
GO:0005930	axoneme	2	2
GO:0005952	cAMP-dependent protein kinase complex	3	3
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	3
GO:0043233	organelle lumen	3	2
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	3
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0140535	intracellular protein-containing complex	2	3
GO:1902494	catalytic complex	2	3
GO:1902554	serine/threonine protein kinase complex	6	3
GO:1902911	protein kinase complex	5	3
GO:1990234	transferase complex	3	3
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1

Phosphorylation

Promastigote: 227, 363

Expansion

Sequence features

A4IBT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBT4

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	27
GO:0006793	phosphorus metabolic process	3	27
GO:0006796	phosphate-containing compound metabolic process	4	27
GO:0006807	nitrogen compound metabolic process	2	27
GO:0008152	metabolic process	1	27
GO:0009987	cellular process	1	27
GO:0016310	phosphorylation	5	27
GO:0019538	protein metabolic process	3	27
GO:0036211	protein modification process	4	27
GO:0043170	macromolecule metabolic process	3	27
GO:0043412	macromolecule modification	4	27
GO:0044237	cellular metabolic process	2	27
GO:0044238	primary metabolic process	2	27
GO:0071704	organic substance metabolic process	2	27
GO:1901564	organonitrogen compound metabolic process	3	27
GO:0007165	signal transduction	2	3
GO:0018105	peptidyl-serine phosphorylation	6	3
GO:0018193	peptidyl-amino acid modification	5	3
GO:0018209	peptidyl-serine modification	6	3
GO:0050789	regulation of biological process	2	3
GO:0050794	regulation of cellular process	3	3
GO:0065007	biological regulation	1	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	27
GO:0003824	catalytic activity	1	27
GO:0004672	protein kinase activity	3	27
GO:0004674	protein serine/threonine kinase activity	4	27
GO:0005488	binding	1	27
GO:0005524	ATP binding	5	27
GO:0016301	kinase activity	4	27
GO:0016740	transferase activity	2	27
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	27
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	27
GO:0017076	purine nucleotide binding	4	27
GO:0030554	adenyl nucleotide binding	5	27
GO:0032553	ribonucleotide binding	3	27
GO:0032555	purine ribonucleotide binding	4	27
GO:0032559	adenyl ribonucleotide binding	5	27
GO:0035639	purine ribonucleoside triphosphate binding	4	27
GO:0036094	small molecule binding	2	27
GO:0043167	ion binding	2	27
GO:0043168	anion binding	3	27
GO:0097159	organic cyclic compound binding	2	27
GO:0097367	carbohydrate derivative binding	2	27
GO:0140096	catalytic activity, acting on a protein	2	27
GO:1901265	nucleoside phosphate binding	3	27
GO:1901363	heterocyclic compound binding	2	27
GO:0004679	AMP-activated protein kinase activity	5	1
GO:0004690	cyclic nucleotide-dependent protein kinase activity	5	4
GO:0004691	cAMP-dependent protein kinase activity	6	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.459
CLV_NRD_NRD_1	91	93	PF00675	0.314
CLV_PCSK_KEX2_1	106	108	PF00082	0.302
CLV_PCSK_KEX2_1	309	311	PF00082	0.299
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.302
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.299
CLV_PCSK_SKI1_1	122	126	PF00082	0.431
CLV_PCSK_SKI1_1	195	199	PF00082	0.297
CLV_PCSK_SKI1_1	224	228	PF00082	0.319
CLV_PCSK_SKI1_1	300	304	PF00082	0.270
DEG_Nend_Nbox_1	1	3	PF02207	0.631
DEG_SCF_FBW7_1	365	372	PF00400	0.472
DEG_SPOP_SBC_1	63	67	PF00917	0.574
DOC_AGCK_PIF_3	379	382	PF00069	0.407
DOC_CYCLIN_RxL_1	294	306	PF00134	0.307
DOC_CYCLIN_yCln2_LP_2	128	134	PF00134	0.253
DOC_MAPK_DCC_7	338	348	PF00069	0.407
DOC_MAPK_gen_1	144	152	PF00069	0.386
DOC_MAPK_gen_1	195	204	PF00069	0.299
DOC_MAPK_JIP1_4	198	204	PF00069	0.268
DOC_PP1_RVXF_1	142	149	PF00149	0.399
DOC_PP1_RVXF_1	245	252	PF00149	0.307
DOC_PP1_RVXF_1	282	288	PF00149	0.334
DOC_USP7_MATH_1	34	38	PF00917	0.721
DOC_USP7_MATH_1	370	374	PF00917	0.491
DOC_USP7_MATH_1	63	67	PF00917	0.447
DOC_USP7_UBL2_3	102	106	PF12436	0.300
DOC_USP7_UBL2_3	207	211	PF12436	0.312
DOC_USP7_UBL2_3	243	247	PF12436	0.334
DOC_WW_Pin1_4	228	233	PF00397	0.292
DOC_WW_Pin1_4	269	274	PF00397	0.299
DOC_WW_Pin1_4	27	32	PF00397	0.445
DOC_WW_Pin1_4	347	352	PF00397	0.485
DOC_WW_Pin1_4	360	365	PF00397	0.468
DOC_WW_Pin1_4	41	46	PF00397	0.463
LIG_14-3-3_CanoR_1	224	229	PF00244	0.298
LIG_Actin_WH2_2	147	165	PF00022	0.307
LIG_FHA_1	12	18	PF00498	0.636
LIG_FHA_1	223	229	PF00498	0.299
LIG_FHA_1	251	257	PF00498	0.299
LIG_FHA_1	306	312	PF00498	0.305
LIG_FHA_1	366	372	PF00498	0.466
LIG_FHA_2	59	65	PF00498	0.446
LIG_LIR_Apic_2	231	237	PF02991	0.294
LIG_LIR_Gen_1	157	165	PF02991	0.326
LIG_LIR_Nem_3	157	162	PF02991	0.326
LIG_LIR_Nem_3	191	197	PF02991	0.334
LIG_LIR_Nem_3	271	277	PF02991	0.267
LIG_LIR_Nem_3	333	339	PF02991	0.428
LIG_LIR_Nem_3	354	360	PF02991	0.425
LIG_LIR_Nem_3	378	382	PF02991	0.400
LIG_LIR_Nem_3	81	87	PF02991	0.295
LIG_LIR_Nem_3	95	101	PF02991	0.299
LIG_Pex14_1	332	336	PF04695	0.362
LIG_Pex14_2	148	152	PF04695	0.396
LIG_Pex14_2	287	291	PF04695	0.312
LIG_SH2_SRC	186	189	PF00017	0.287
LIG_SH2_STAP1	259	263	PF00017	0.307
LIG_SH2_STAP1	277	281	PF00017	0.299
LIG_SH2_STAP1	336	340	PF00017	0.437
LIG_SH2_STAT5	147	150	PF00017	0.299
LIG_SH2_STAT5	186	189	PF00017	0.292
LIG_SH2_STAT5	234	237	PF00017	0.308
LIG_SH2_STAT5	326	329	PF00017	0.444
LIG_SH3_2	18	23	PF14604	0.454
LIG_SH3_3	15	21	PF00018	0.638
LIG_SH3_3	345	351	PF00018	0.456
LIG_SH3_3	358	364	PF00018	0.468
LIG_SH3_3	57	63	PF00018	0.577
LIG_SUMO_SIM_anti_2	189	194	PF11976	0.314
LIG_TYR_ITIM	192	197	PF00017	0.299
LIG_TYR_ITIM	257	262	PF00017	0.307
LIG_UBA3_1	109	113	PF00899	0.305
LIG_WRC_WIRS_1	137	142	PF05994	0.328
LIG_WW_1	266	269	PF00397	0.347
MOD_CDK_SPxK_1	269	275	PF00069	0.299
MOD_CDK_SPxxK_3	360	367	PF00069	0.487
MOD_CK1_1	36	42	PF00069	0.420
MOD_CK1_1	44	50	PF00069	0.629
MOD_CK2_1	352	358	PF00069	0.413
MOD_CK2_1	68	74	PF00069	0.438
MOD_DYRK1A_RPxSP_1	347	351	PF00069	0.453
MOD_GlcNHglycan	372	375	PF01048	0.553
MOD_GlcNHglycan	38	41	PF01048	0.437
MOD_GSK3_1	157	164	PF00069	0.312
MOD_GSK3_1	224	231	PF00069	0.293
MOD_GSK3_1	347	354	PF00069	0.475
MOD_GSK3_1	365	372	PF00069	0.595
MOD_GSK3_1	44	51	PF00069	0.688
MOD_GSK3_1	58	65	PF00069	0.497
MOD_N-GLC_1	58	63	PF02516	0.400
MOD_NEK2_1	1	6	PF00069	0.440
MOD_NEK2_1	136	141	PF00069	0.383
MOD_NEK2_1	75	80	PF00069	0.307
MOD_NEK2_2	48	53	PF00069	0.434
MOD_PKA_1	92	98	PF00069	0.448
MOD_Plk_1	222	228	PF00069	0.298
MOD_Plk_1	63	69	PF00069	0.502
MOD_ProDKin_1	228	234	PF00069	0.292
MOD_ProDKin_1	269	275	PF00069	0.299
MOD_ProDKin_1	27	33	PF00069	0.445
MOD_ProDKin_1	347	353	PF00069	0.478
MOD_ProDKin_1	360	366	PF00069	0.462
MOD_ProDKin_1	41	47	PF00069	0.464
MOD_SUMO_for_1	197	200	PF00179	0.299
MOD_SUMO_for_1	54	57	PF00179	0.377
MOD_SUMO_for_1	7	10	PF00179	0.455
MOD_SUMO_rev_2	139	146	PF00179	0.435
MOD_SUMO_rev_2	191	199	PF00179	0.294
MOD_SUMO_rev_2	373	382	PF00179	0.546
MOD_SUMO_rev_2	71	78	PF00179	0.396
TRG_DiLeu_BaEn_1	121	126	PF01217	0.328
TRG_ENDOCYTIC_2	147	150	PF00928	0.302
TRG_ENDOCYTIC_2	194	197	PF00928	0.292
TRG_ENDOCYTIC_2	259	262	PF00928	0.297
TRG_ENDOCYTIC_2	265	268	PF00928	0.288
TRG_ENDOCYTIC_2	277	280	PF00928	0.298
TRG_ENDOCYTIC_2	98	101	PF00928	0.299
TRG_ER_diArg_1	104	107	PF00400	0.282
TRG_ER_diArg_1	86	89	PF00400	0.293
TRG_Pf-PMV_PEXEL_1	195	200	PF00026	0.299

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q8	Leptomonas seymouri	29%	100%
A0A0N0P6T0	Leptomonas seymouri	25%	70%
A0A0N0P787	Leptomonas seymouri	31%	99%
A0A0N0P8H5	Leptomonas seymouri	57%	100%
A0A0N1HWQ2	Leptomonas seymouri	33%	100%
A0A0N1I6T8	Leptomonas seymouri	36%	100%
A0A0N1IIF9	Leptomonas seymouri	35%	100%
A0A0N1PBE9	Leptomonas seymouri	28%	76%
A0A0N1PC31	Leptomonas seymouri	36%	98%
A0A0S4IZY3	Bodo saltans	79%	100%
A0A0S4J3Y5	Bodo saltans	26%	89%
A0A0S4J4B3	Bodo saltans	35%	85%
A0A0S4J6L4	Bodo saltans	36%	100%
A0A0S4J7K4	Bodo saltans	28%	79%
A0A0S4J842	Bodo saltans	28%	71%
A0A0S4JBR3	Bodo saltans	32%	100%
A0A0S4JCG2	Bodo saltans	37%	85%
A0A0S4JER5	Bodo saltans	44%	84%
A0A0S4JI67	Bodo saltans	33%	84%
A0A0S4JK24	Bodo saltans	29%	88%
A0A0S4JWD5	Bodo saltans	34%	98%
A0A0S4KFT7	Bodo saltans	63%	100%
A0A0S4KMV7	Bodo saltans	28%	100%
A0A1X0NF53	Trypanosomatidae	27%	82%
A0A1X0NIX2	Trypanosomatidae	28%	87%
A0A1X0NJV4	Trypanosomatidae	27%	74%
A0A1X0NQ63	Trypanosomatidae	34%	100%
A0A1X0NUQ4	Trypanosomatidae	30%	100%
A0A1X0NY93	Trypanosomatidae	33%	97%
A0A1X0NYK8	Trypanosomatidae	34%	100%
A0A1X0P1A2	Trypanosomatidae	28%	83%
A0A1X0P3J5	Trypanosomatidae	47%	83%
A0A1X0P4Z7	Trypanosomatidae	29%	69%
A0A1X0P527	Trypanosomatidae	28%	86%
A0A1X0P5B1	Trypanosomatidae	84%	100%
A0A1X0P5F2	Trypanosomatidae	82%	100%
A0A1X0P6V1	Trypanosomatidae	35%	100%
A0A1X0P735	Trypanosomatidae	35%	100%
A0A1X0P7V0	Trypanosomatidae	60%	100%
A0A1X0P8F7	Trypanosomatidae	29%	88%
A0A1X0P963	Trypanosomatidae	27%	79%
A0A3Q8IB30	Leishmania donovani	58%	100%
A0A3Q8IBT5	Leishmania donovani	26%	100%
A0A3Q8IC87	Leishmania donovani	31%	100%
A0A3Q8IDK8	Leishmania donovani	27%	68%
A0A3Q8IEH3	Leishmania donovani	33%	100%
A0A3Q8INQ4	Leishmania donovani	35%	98%
A0A3Q8IRT6	Leishmania donovani	41%	75%
A0A3R7M5C7	Trypanosoma rangeli	34%	100%
A0A3R7M819	Trypanosoma rangeli	29%	100%
A0A3R7MHW5	Trypanosoma rangeli	30%	96%
A0A3R7N4D8	Trypanosoma rangeli	34%	95%
A0A3R7N5S4	Trypanosoma rangeli	31%	100%
A0A3R7NKI8	Trypanosoma rangeli	29%	100%
A0A3R7RIN5	Trypanosoma rangeli	28%	76%
A0A3R7RLL1	Trypanosoma rangeli	32%	88%
A0A3S5H5G0	Leishmania donovani	25%	100%
A0A3S5H5U5	Leishmania donovani	32%	84%
A0A3S5H606	Leishmania donovani	35%	100%
A0A3S5H7M0	Leishmania donovani	30%	73%
A0A3S7WTN9	Leishmania donovani	32%	99%
A0A3S7WUE7	Leishmania donovani	30%	69%
A0A3S7WUX5	Leishmania donovani	35%	100%
A0A3S7WVE9	Leishmania donovani	31%	100%
A0A3S7WWE7	Leishmania donovani	24%	100%
A0A3S7WYP4	Leishmania donovani	32%	100%
A0A3S7X123	Leishmania donovani	26%	100%
A0A3S7X6T8	Leishmania donovani	26%	85%
A0A3S7X8Z8	Leishmania donovani	28%	78%
A0A3S7X9R4	Leishmania donovani	94%	100%
A0A3S7X9S2	Leishmania donovani	99%	100%
A0A3S7XAL3	Leishmania donovani	28%	77%
A0A3S7XAT9	Leishmania donovani	28%	76%
A0A3S7XAX0	Leishmania donovani	26%	100%
A0A422MYB4	Trypanosoma rangeli	83%	100%
A0A422NU88	Trypanosoma rangeli	30%	69%
A0A422P0J2	Trypanosoma rangeli	59%	100%
A0A422P0N6	Trypanosoma rangeli	30%	100%
A0A422P1R5	Trypanosoma rangeli	34%	100%
A0A422P270	Trypanosoma rangeli	31%	86%
A0A422P4V9	Trypanosoma rangeli	45%	83%
A0A8I3S724	Canis lupus familiaris	39%	94%
A2VDV2	Bos taurus	35%	82%
A2XFF4	Oryza sativa subsp. indica	37%	75%
A4H459	Leishmania braziliensis	24%	100%
A4H4S9	Leishmania braziliensis	31%	84%
A4H539	Leishmania braziliensis	36%	100%
A4H8C4	Leishmania braziliensis	32%	100%
A4H9H4	Leishmania braziliensis	35%	100%
A4H9L8	Leishmania braziliensis	59%	100%
A4H9X2	Leishmania braziliensis	30%	100%
A4HBL4	Leishmania braziliensis	24%	100%
A4HDU3	Leishmania braziliensis	27%	100%
A4HED7	Leishmania braziliensis	36%	100%
A4HFF3	Leishmania braziliensis	27%	100%
A4HG26	Leishmania braziliensis	26%	100%
A4HG27	Leishmania braziliensis	27%	70%
A4HG92	Leishmania braziliensis	32%	100%
A4HHR5	Leishmania braziliensis	30%	74%
A4HI35	Leishmania braziliensis	40%	75%
A4HN71	Leishmania braziliensis	88%	100%
A4HP12	Leishmania braziliensis	29%	75%
A4HSE2	Leishmania infantum	25%	100%
A4HTB4	Leishmania infantum	35%	100%
A4HWP5	Leishmania infantum	32%	100%
A4HX71	Leishmania infantum	30%	69%
A4HXU0	Leishmania infantum	35%	100%
A4HXY2	Leishmania infantum	58%	100%
A4HZA2	Leishmania infantum	24%	100%
A4HZV1	Leishmania infantum	31%	100%
A4I140	Leishmania infantum	32%	100%
A4I1T4	Leishmania infantum	35%	100%
A4I349	Leishmania infantum	27%	68%
A4I3C6	Leishmania infantum	33%	100%
A4I4X5	Leishmania infantum	30%	73%
A4I5B1	Leishmania infantum	41%	75%
A4I960	Leishmania infantum	26%	85%
A4IB02	Leishmania infantum	28%	100%
A4IBT9	Leishmania infantum	95%	100%
A4IDC1	Leishmania infantum	27%	75%
A4IDC2	Leishmania infantum	28%	76%
A4IDK3	Leishmania infantum	26%	100%
A4IGM9	Xenopus tropicalis	35%	100%
A5GFW1	Sus scrofa	35%	95%
A7MB74	Bos taurus	41%	89%
A8X6H4	Caenorhabditis briggsae	32%	100%
A8XJL7	Caenorhabditis briggsae	36%	81%
A8XJQ6	Caenorhabditis briggsae	47%	99%
A8XNJ6	Caenorhabditis briggsae	44%	82%
A8XW88	Caenorhabditis briggsae	51%	100%
B8BBT7	Oryza sativa subsp. indica	37%	75%
C6K3W8	Leptomonas seymouri	41%	72%
C9ZKE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	94%
C9ZL78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	91%
C9ZMA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	68%
C9ZQP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	83%
C9ZUK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZW68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZXP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	97%
C9ZYS7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	97%
C9ZYT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	96%
C9ZZX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZZX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D0A2M0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	81%
D0A2Z1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	78%
D0A5C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
D0A820	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D7UQM5	Patiria pectinifera	39%	94%
E9ACW6	Leishmania major	23%	100%
E9ACW7	Leishmania major	29%	68%
E9AEC9	Leishmania major	29%	73%
E9AET0	Leishmania major	28%	100%
E9AFM1	Leishmania major	96%	100%
E9AG71	Leishmania infantum	32%	84%
E9AGR7	Leishmania infantum	31%	100%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AKZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	84%
E9ALA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ALF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	73%
E9AQF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ARC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	69%
E9ARK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ARP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
E9ARW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ASL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	79%
E9ASS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	75%
E9ASS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	76%
E9AUY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AVR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AX78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AXW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AZF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AZF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	70%
E9AZL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B0K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	75%
E9B436	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	85%
E9B5Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B6S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B6S9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
J9W0G9	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	44%	66%
O00141	Homo sapiens	42%	89%
O01427	Caenorhabditis elegans	38%	100%
O08875	Rattus norvegicus	32%	88%
O13310	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	81%
O15530	Homo sapiens	40%	69%
O22932	Arabidopsis thaliana	34%	88%
O22971	Arabidopsis thaliana	35%	76%
O55099	Rattus norvegicus	36%	100%
O55173	Rattus norvegicus	41%	68%
O59790	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
O64629	Arabidopsis thaliana	37%	100%
O65554	Arabidopsis thaliana	39%	87%
O70126	Mus musculus	36%	100%
O70293	Mus musculus	35%	66%
O74426	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
O88445	Mus musculus	37%	100%
O96017	Homo sapiens	35%	70%
P00517	Bos taurus	49%	100%
P05131	Bos taurus	54%	100%
P05132	Mus musculus	48%	100%
P05383	Sus scrofa	54%	100%
P05986	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	96%
P06244	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	96%
P06245	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	50%	100%
P12370	Drosophila melanogaster	53%	100%
P16911	Drosophila melanogaster	41%	100%
P17612	Homo sapiens	49%	100%
P21137	Caenorhabditis elegans	51%	95%
P21901	Aplysia californica	41%	100%
P22204	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	67%
P22612	Homo sapiens	49%	100%
P22694	Homo sapiens	53%	100%
P23443	Homo sapiens	40%	73%
P25321	Cricetulus griseus	49%	100%
P25323	Dictyostelium discoideum	36%	100%
P27791	Rattus norvegicus	48%	100%
P28178	Dictyostelium discoideum	46%	80%
P31748	AKT8 murine leukemia virus	40%	76%
P31749	Homo sapiens	39%	80%
P31750	Mus musculus	40%	80%
P31751	Homo sapiens	41%	79%
P36887	Sus scrofa	49%	100%
P38070	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	73%
P38991	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
P40376	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	75%
P42818	Arabidopsis thaliana	41%	82%
P47196	Rattus norvegicus	41%	80%
P47197	Rattus norvegicus	40%	79%
P49673	Ascaris suum	49%	100%
P51817	Homo sapiens	49%	100%
P54644	Dictyostelium discoideum	46%	86%
P54645	Rattus norvegicus	33%	68%
P54646	Homo sapiens	34%	69%
P59241	Rattus norvegicus	33%	96%
P67998	Oryctolagus cuniculus	40%	73%
P67999	Rattus norvegicus	40%	73%
P68180	Cricetulus griseus	53%	100%
P68181	Mus musculus	53%	100%
P68182	Rattus norvegicus	53%	100%
P92958	Arabidopsis thaliana	37%	75%
P97477	Mus musculus	38%	97%
Q01314	Bos taurus	40%	80%
Q02723	Secale cereale	33%	76%
Q05999	Arabidopsis thaliana	31%	66%
Q06226	Rattus norvegicus	42%	89%
Q09137	Rattus norvegicus	34%	69%
Q09831	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	67%
Q0D4B2	Oryza sativa subsp. japonica	31%	73%
Q10LQ2	Oryza sativa subsp. japonica	36%	85%
Q10SC8	Oryza sativa subsp. japonica	36%	84%
Q12706	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	88%
Q13131	Homo sapiens	33%	68%
Q14012	Homo sapiens	34%	100%
Q15208	Homo sapiens	36%	82%
Q15835	Homo sapiens	32%	68%
Q17941	Caenorhabditis elegans	38%	71%
Q27687	Leishmania major	58%	100%
Q28948	Sus scrofa	34%	69%
Q2L6W9	Caenorhabditis elegans	36%	80%
Q2LZZ7	Drosophila pseudoobscura pseudoobscura	36%	83%
Q2PJ68	Caenorhabditis elegans	45%	83%
Q2TA06	Bos taurus	39%	95%
Q38997	Arabidopsis thaliana	37%	75%
Q39030	Arabidopsis thaliana	40%	81%
Q4Q1J2	Leishmania major	27%	100%
Q4Q1S3	Leishmania major	28%	76%
Q4Q1S4	Leishmania major	27%	75%
Q4Q3Y9	Leishmania major	25%	85%
Q4Q7M5	Leishmania major	40%	75%
Q4Q9K2	Leishmania major	36%	100%
Q4QA98	Leishmania major	31%	100%
Q4QBR6	Leishmania major	31%	100%
Q4QCK0	Leishmania major	23%	100%
Q4QCR2	Leishmania major	26%	100%
Q4QDK6	Leishmania major	31%	100%
Q4QDX7	Leishmania major	35%	100%
Q4QEJ2	Leishmania major	30%	69%
Q4QF23	Leishmania major	32%	100%
Q4QIJ7	Leishmania major	35%	100%
Q4QIV8	Leishmania major	30%	84%
Q4QJJ0	Leishmania major	25%	100%
Q4R633	Macaca fascicularis	42%	89%
Q4V3C8	Arabidopsis thaliana	39%	79%
Q501V0	Danio rerio	36%	91%
Q54C18	Dictyostelium discoideum	35%	74%
Q54IH8	Dictyostelium discoideum	34%	70%
Q54L81	Dictyostelium discoideum	35%	83%
Q54UZ1	Dictyostelium discoideum	36%	93%
Q54WX4	Dictyostelium discoideum	37%	99%
Q54Y26	Dictyostelium discoideum	34%	72%
Q59S66	Candida albicans (strain SC5314 / ATCC MYA-2876)	34%	72%
Q5BKK4	Xenopus tropicalis	42%	91%
Q5EG47	Mus musculus	32%	68%
Q5JLQ9	Oryza sativa subsp. japonica	34%	80%
Q5Q0U5	Fundulus heteroclitus	42%	89%
Q5R7A7	Pongo abelii	39%	77%
Q5R8M1	Pongo abelii	36%	82%
Q5RD00	Pongo abelii	34%	69%
Q5RDH5	Pongo abelii	33%	69%
Q60823	Mus musculus	41%	79%
Q60EY8	Oryza sativa subsp. japonica	36%	82%
Q63450	Rattus norvegicus	34%	100%
Q63484	Rattus norvegicus	41%	80%
Q68Y49	Oryza sativa subsp. japonica	38%	75%
Q6A1A2	Homo sapiens	40%	96%
Q6BVA0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	36%	93%
Q6C3J2	Yarrowia lipolytica (strain CLIB 122 / E 150)	36%	100%
Q6CWQ4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	33%	100%
Q6DE08	Xenopus laevis	36%	100%
Q6FV07	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	37%	100%
Q6GLY8	Xenopus laevis	42%	88%
Q6GPL3	Xenopus laevis	38%	100%
Q6GPN6	Xenopus laevis	42%	88%
Q6IP76	Xenopus laevis	40%	79%
Q6NW76	Danio rerio	33%	100%
Q6TGC6	Pneumocystis carinii	34%	75%
Q6TJY3	Bos taurus	41%	72%
Q6U1I9	Gallus gallus	42%	88%
Q6X4A2	Oryza sativa subsp. japonica	37%	85%
Q755C4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	35%	100%
Q75L42	Oryza sativa subsp. japonica	35%	84%
Q7JP68	Caenorhabditis elegans	50%	96%
Q7TNJ7	Rattus norvegicus	32%	80%
Q7TSE6	Mus musculus	36%	82%
Q7X996	Oryza sativa subsp. japonica	35%	86%
Q7XIW5	Oryza sativa subsp. japonica	38%	86%
Q7YRC6	Bos taurus	36%	100%
Q7ZTW4	Danio rerio	42%	88%
Q7ZX15	Xenopus laevis	40%	79%
Q852Q0	Oryza sativa subsp. japonica	37%	75%
Q852Q1	Oryza sativa subsp. japonica	37%	75%
Q852Q2	Oryza sativa subsp. japonica	37%	76%
Q86UX6	Homo sapiens	34%	79%
Q8BGW6	Mus musculus	34%	96%
Q8BRK8	Mus musculus	34%	69%
Q8BSK8	Mus musculus	40%	73%
Q8BW96	Mus musculus	34%	99%
Q8IU85	Homo sapiens	34%	99%
Q8LIG4	Oryza sativa subsp. japonica	36%	86%
Q8MJ44	Canis lupus familiaris	49%	100%
Q8MYF1	Dictyostelium discoideum	42%	84%
Q8QZV4	Mus musculus	34%	78%
Q8R4U9	Rattus norvegicus	44%	100%
Q8R4V0	Rattus norvegicus	42%	77%
Q8SRK8	Encephalitozoon cuniculi (strain GB-M1)	37%	100%
Q8W1D5	Arabidopsis thaliana	35%	78%
Q8WU08	Homo sapiens	34%	96%
Q91819	Xenopus laevis	39%	94%
Q91820	Xenopus laevis	36%	94%
Q91VB2	Mus musculus	32%	80%
Q91VJ4	Mus musculus	35%	82%
Q91YS8	Mus musculus	34%	100%
Q922R0	Mus musculus	50%	100%
Q94C40	Arabidopsis thaliana	32%	88%
Q96BR1	Homo sapiens	39%	77%
Q96GD4	Homo sapiens	36%	100%
Q96NX5	Homo sapiens	33%	80%
Q98TY9	Xenopus laevis	42%	79%
Q9ERE3	Mus musculus	42%	77%
Q9FJ55	Arabidopsis thaliana	37%	79%
Q9FLZ3	Arabidopsis thaliana	35%	77%
Q9GNR4	Leishmania major	98%	100%
Q9HBY8	Homo sapiens	44%	100%
Q9JJX8	Mus musculus	35%	92%
Q9LDI3	Arabidopsis thaliana	35%	86%
Q9LGV5	Oryza sativa subsp. japonica	35%	83%
Q9LWM4	Oryza sativa subsp. japonica	34%	83%
Q9MZD9	Ovis aries	49%	100%
Q9N0X0	Sus scrofa	36%	100%
Q9N2N1	Leishmania major	33%	100%
Q9NAH6	Caenorhabditis elegans	41%	69%
Q9NBK5	Drosophila melanogaster	35%	83%
Q9NY57	Homo sapiens	35%	92%
Q9P7J8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	67%
Q9QZS5	Mus musculus	44%	100%
Q9SEZ7	Arabidopsis thaliana	34%	81%
Q9TXJ0	Caenorhabditis elegans	34%	100%
Q9UBS0	Homo sapiens	42%	79%
Q9UQB9	Homo sapiens	35%	100%
Q9USX7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	73%
Q9VKN7	Drosophila melanogaster	36%	100%
Q9WUA6	Mus musculus	42%	80%
Q9WVC6	Mus musculus	42%	89%
Q9XF67	Arabidopsis thaliana	38%	78%
Q9XIW0	Arabidopsis thaliana	34%	89%
Q9XT18	Oryctolagus cuniculus	41%	89%
Q9XTG7	Caenorhabditis elegans	36%	72%
Q9Y243	Homo sapiens	42%	80%
Q9Y2H1	Homo sapiens	36%	82%
Q9Y7J6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	69%
Q9Z1M4	Mus musculus	43%	79%
Q9Z265	Mus musculus	36%	70%
Q9Z2A0	Mus musculus	40%	68%
V5B871	Trypanosoma cruzi	32%	89%
V5BAZ8	Trypanosoma cruzi	29%	99%
V5BCH2	Trypanosoma cruzi	34%	97%
V5BEK5	Trypanosoma cruzi	58%	100%
V5BG98	Trypanosoma cruzi	33%	100%
V5BI43	Trypanosoma cruzi	30%	76%
V5BNV8	Trypanosoma cruzi	33%	100%
V5BQH6	Trypanosoma cruzi	30%	88%
V5BWC2	Trypanosoma cruzi	34%	100%
V5C234	Trypanosoma cruzi	27%	70%
V5DI55	Trypanosoma cruzi	30%	92%
V5DPP5	Trypanosoma cruzi	33%	88%
V5DQT5	Trypanosoma cruzi	45%	83%
V5DUH0	Trypanosoma cruzi	29%	70%
W0LYS5	Macrobrachium nipponense	36%	100%