Putative nucleoside diphosphate kinase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleoside diphosphate kinase - putative

Species:

Leishmania infantum

UniProt:

A4IBS5_LEIIN

TriTrypDb:

LINF_350044100

Length:

337

Annotations

Annotations by Jardim et al.

Pyrimidine metabolism, nucleoside diphosphate kinase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4IBS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBS5

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0044237	cellular metabolic process	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004550	nucleoside diphosphate kinase activity	5	8
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	8
GO:0019205	nucleobase-containing compound kinase activity	5	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	236	240	PF00656	0.453
CLV_NRD_NRD_1	83	85	PF00675	0.422
CLV_PCSK_KEX2_1	43	45	PF00082	0.399
CLV_PCSK_KEX2_1	48	50	PF00082	0.342
CLV_PCSK_KEX2_1	85	87	PF00082	0.474
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.399
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.342
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.570
CLV_PCSK_PC7_1	44	50	PF00082	0.389
CLV_PCSK_SKI1_1	43	47	PF00082	0.374
CLV_PCSK_SKI1_1	85	89	PF00082	0.535
DOC_MAPK_gen_1	140	148	PF00069	0.392
DOC_PP1_RVXF_1	118	124	PF00149	0.474
DOC_PP4_FxxP_1	69	72	PF00568	0.514
DOC_USP7_MATH_1	106	110	PF00917	0.470
DOC_USP7_MATH_1	16	20	PF00917	0.511
DOC_USP7_MATH_1	188	192	PF00917	0.541
DOC_USP7_MATH_1	207	211	PF00917	0.349
DOC_USP7_MATH_1	229	233	PF00917	0.528
DOC_USP7_MATH_1	323	327	PF00917	0.439
DOC_USP7_MATH_1	51	55	PF00917	0.397
DOC_WW_Pin1_4	53	58	PF00397	0.513
LIG_14-3-3_CanoR_1	120	124	PF00244	0.435
LIG_Actin_WH2_2	107	122	PF00022	0.357
LIG_Actin_WH2_2	59	76	PF00022	0.363
LIG_BRCT_BRCA1_1	325	329	PF00533	0.442
LIG_FHA_1	114	120	PF00498	0.448
LIG_FHA_1	190	196	PF00498	0.406
LIG_FHA_1	40	46	PF00498	0.431
LIG_FHA_1	6	12	PF00498	0.502
LIG_FHA_1	63	69	PF00498	0.355
LIG_FHA_2	234	240	PF00498	0.470
LIG_FHA_2	314	320	PF00498	0.442
LIG_LIR_Apic_2	12	16	PF02991	0.381
LIG_LIR_Gen_1	122	129	PF02991	0.475
LIG_LIR_Gen_1	23	32	PF02991	0.411
LIG_LIR_Gen_1	241	251	PF02991	0.442
LIG_LIR_Nem_3	122	126	PF02991	0.470
LIG_LIR_Nem_3	23	29	PF02991	0.394
LIG_LIR_Nem_3	241	246	PF02991	0.442
LIG_LIR_Nem_3	253	257	PF02991	0.453
LIG_LIR_Nem_3	326	332	PF02991	0.439
LIG_LYPXL_yS_3	52	55	PF13949	0.393
LIG_MLH1_MIPbox_1	325	329	PF16413	0.442
LIG_MYND_1	53	57	PF01753	0.508
LIG_SH2_CRK	247	251	PF00017	0.442
LIG_SH2_CRK	254	258	PF00017	0.442
LIG_SH2_STAT5	13	16	PF00017	0.429
LIG_SH2_STAT5	226	229	PF00017	0.495
LIG_SH2_STAT5	28	31	PF00017	0.270
LIG_SH2_STAT5	61	64	PF00017	0.481
LIG_SH3_3	182	188	PF00018	0.500
LIG_SH3_3	199	205	PF00018	0.381
LIG_SH3_3	280	286	PF00018	0.435
LIG_SH3_3	291	297	PF00018	0.427
LIG_SUMO_SIM_par_1	125	130	PF11976	0.392
LIG_SUMO_SIM_par_1	144	150	PF11976	0.375
LIG_SUMO_SIM_par_1	93	99	PF11976	0.410
LIG_TRAF2_1	177	180	PF00917	0.534
MOD_CK1_1	173	179	PF00069	0.426
MOD_CK2_1	106	112	PF00069	0.479
MOD_CK2_1	313	319	PF00069	0.442
MOD_CK2_1	53	59	PF00069	0.424
MOD_GlcNHglycan	103	106	PF01048	0.406
MOD_GlcNHglycan	149	152	PF01048	0.434
MOD_GlcNHglycan	165	168	PF01048	0.424
MOD_GlcNHglycan	175	178	PF01048	0.486
MOD_GlcNHglycan	209	212	PF01048	0.267
MOD_GlcNHglycan	227	230	PF01048	0.267
MOD_GlcNHglycan	262	265	PF01048	0.245
MOD_GlcNHglycan	90	93	PF01048	0.501
MOD_GSK3_1	157	164	PF00069	0.427
MOD_GSK3_1	16	23	PF00069	0.469
MOD_GSK3_1	167	174	PF00069	0.333
MOD_GSK3_1	225	232	PF00069	0.510
MOD_GSK3_1	27	34	PF00069	0.298
MOD_NEK2_1	119	124	PF00069	0.338
MOD_NEK2_1	129	134	PF00069	0.350
MOD_NEK2_1	20	25	PF00069	0.475
MOD_NEK2_1	225	230	PF00069	0.442
MOD_NEK2_1	328	333	PF00069	0.443
MOD_PIKK_1	113	119	PF00454	0.438
MOD_PIKK_1	167	173	PF00454	0.504
MOD_PK_1	157	163	PF00069	0.504
MOD_PKA_1	85	91	PF00069	0.565
MOD_PKA_2	119	125	PF00069	0.367
MOD_PKA_2	5	11	PF00069	0.409
MOD_PKA_2	85	91	PF00069	0.565
MOD_Plk_1	31	37	PF00069	0.365
MOD_Plk_2-3	31	37	PF00069	0.364
MOD_Plk_4	106	112	PF00069	0.366
MOD_Plk_4	5	11	PF00069	0.458
MOD_ProDKin_1	53	59	PF00069	0.510
MOD_SUMO_rev_2	174	184	PF00179	0.471
TRG_DiLeu_BaEn_1	253	258	PF01217	0.442
TRG_DiLeu_BaEn_4	319	325	PF01217	0.442
TRG_ENDOCYTIC_2	247	250	PF00928	0.442
TRG_ENDOCYTIC_2	254	257	PF00928	0.442
TRG_ENDOCYTIC_2	52	55	PF00928	0.378
TRG_ER_diArg_1	84	87	PF00400	0.523
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.267

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJQ8	Leptomonas seymouri	28%	98%
A0A0N1PC23	Leptomonas seymouri	73%	100%
A0A0S4IXH2	Bodo saltans	55%	100%
A0A1X0P5C0	Trypanosomatidae	58%	100%
A0A1X0PAT4	Trypanosomatidae	27%	96%
A0A3Q8IJQ8	Leishmania donovani	100%	100%
A0A3R7M6K1	Trypanosoma rangeli	27%	97%
A0A3R7N390	Trypanosoma rangeli	60%	100%
A0A3S7X855	Leishmania donovani	28%	98%
A4HB17	Leishmania braziliensis	29%	100%
A4HN58	Leishmania braziliensis	91%	100%
A4IA74	Leishmania infantum	28%	100%
C9ZM33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	97%
C9ZYU7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AFL1	Leishmania major	99%	100%
E9B587	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B6R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q2P6	Leishmania major	29%	100%
Q5E9Y9	Bos taurus	34%	89%
Q9QXL7	Rattus norvegicus	36%	85%
Q9QXL8	Mus musculus	34%	85%
Q9Y5B8	Homo sapiens	35%	90%
V5BXY9	Trypanosoma cruzi	59%	97%
V5DLW4	Trypanosoma cruzi	28%	96%