LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IBS0_LEIIN
TriTrypDb:
LINF_350043600
Length:
320

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBS0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBS0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 284 290 PF00089 0.339
CLV_NRD_NRD_1 22 24 PF00675 0.470
CLV_NRD_NRD_1 243 245 PF00675 0.664
CLV_NRD_NRD_1 263 265 PF00675 0.645
CLV_PCSK_FUR_1 20 24 PF00082 0.536
CLV_PCSK_FUR_1 269 273 PF00082 0.485
CLV_PCSK_KEX2_1 22 24 PF00082 0.464
CLV_PCSK_KEX2_1 227 229 PF00082 0.644
CLV_PCSK_KEX2_1 242 244 PF00082 0.512
CLV_PCSK_KEX2_1 271 273 PF00082 0.565
CLV_PCSK_KEX2_1 310 312 PF00082 0.442
CLV_PCSK_PC1ET2_1 227 229 PF00082 0.579
CLV_PCSK_PC1ET2_1 271 273 PF00082 0.474
CLV_PCSK_PC1ET2_1 310 312 PF00082 0.523
CLV_PCSK_PC7_1 18 24 PF00082 0.488
CLV_PCSK_PC7_1 267 273 PF00082 0.445
CLV_PCSK_SKI1_1 282 286 PF00082 0.452
CLV_PCSK_SKI1_1 297 301 PF00082 0.393
CLV_PCSK_SKI1_1 92 96 PF00082 0.480
DEG_APCC_DBOX_1 266 274 PF00400 0.441
DOC_CDC14_PxL_1 29 37 PF14671 0.517
DOC_CKS1_1 160 165 PF01111 0.546
DOC_CYCLIN_RxL_1 108 121 PF00134 0.426
DOC_MAPK_gen_1 108 117 PF00069 0.473
DOC_MAPK_gen_1 267 276 PF00069 0.467
DOC_MAPK_gen_1 297 307 PF00069 0.551
DOC_USP7_MATH_1 202 206 PF00917 0.461
DOC_USP7_MATH_1 233 237 PF00917 0.638
DOC_USP7_MATH_1 253 257 PF00917 0.502
DOC_USP7_MATH_1 69 73 PF00917 0.451
DOC_USP7_UBL2_3 306 310 PF12436 0.464
DOC_WW_Pin1_4 159 164 PF00397 0.554
DOC_WW_Pin1_4 227 232 PF00397 0.593
LIG_14-3-3_CanoR_1 201 211 PF00244 0.550
LIG_14-3-3_CanoR_1 282 291 PF00244 0.514
LIG_Actin_WH2_2 102 120 PF00022 0.512
LIG_Actin_WH2_2 130 145 PF00022 0.407
LIG_Actin_WH2_2 292 308 PF00022 0.534
LIG_APCC_ABBAyCdc20_2 255 261 PF00400 0.497
LIG_BIR_II_1 1 5 PF00653 0.477
LIG_BRCT_BRCA1_1 255 259 PF00533 0.502
LIG_FHA_1 152 158 PF00498 0.584
LIG_FHA_1 208 214 PF00498 0.478
LIG_FHA_1 246 252 PF00498 0.608
LIG_FHA_1 283 289 PF00498 0.511
LIG_FHA_2 182 188 PF00498 0.498
LIG_FHA_2 220 226 PF00498 0.691
LIG_Integrin_RGD_1 244 246 PF01839 0.484
LIG_LIR_Nem_3 128 133 PF02991 0.536
LIG_SH2_CRK 36 40 PF00017 0.505
LIG_SH2_SRC 138 141 PF00017 0.384
LIG_SH2_STAP1 138 142 PF00017 0.383
LIG_SH3_3 157 163 PF00018 0.550
LIG_SUMO_SIM_anti_2 208 216 PF11976 0.476
LIG_TRAF2_1 206 209 PF00917 0.416
MOD_CK1_1 175 181 PF00069 0.663
MOD_CK2_1 152 158 PF00069 0.703
MOD_CK2_1 181 187 PF00069 0.553
MOD_CK2_1 202 208 PF00069 0.502
MOD_GlcNHglycan 154 157 PF01048 0.679
MOD_GlcNHglycan 174 177 PF01048 0.730
MOD_GlcNHglycan 204 207 PF01048 0.492
MOD_GlcNHglycan 234 238 PF01048 0.700
MOD_GlcNHglycan 246 251 PF01048 0.519
MOD_GlcNHglycan 301 305 PF01048 0.431
MOD_GSK3_1 113 120 PF00069 0.468
MOD_GSK3_1 170 177 PF00069 0.667
MOD_GSK3_1 178 185 PF00069 0.637
MOD_GSK3_1 209 216 PF00069 0.508
MOD_GSK3_1 219 226 PF00069 0.550
MOD_GSK3_1 282 289 PF00069 0.396
MOD_NEK2_1 1 6 PF00069 0.456
MOD_NEK2_1 174 179 PF00069 0.591
MOD_NEK2_1 207 212 PF00069 0.555
MOD_NEK2_1 213 218 PF00069 0.513
MOD_NEK2_1 53 58 PF00069 0.431
MOD_NEK2_2 138 143 PF00069 0.430
MOD_PIKK_1 282 288 PF00454 0.538
MOD_PKA_2 117 123 PF00069 0.583
MOD_PKA_2 202 208 PF00069 0.548
MOD_PKA_2 263 269 PF00069 0.613
MOD_PKA_2 286 292 PF00069 0.409
MOD_Plk_1 113 119 PF00069 0.470
MOD_Plk_1 138 144 PF00069 0.426
MOD_Plk_1 2 8 PF00069 0.621
MOD_Plk_1 207 213 PF00069 0.581
MOD_Plk_1 246 252 PF00069 0.571
MOD_Plk_1 300 306 PF00069 0.415
MOD_Plk_4 209 215 PF00069 0.479
MOD_ProDKin_1 159 165 PF00069 0.554
MOD_ProDKin_1 227 233 PF00069 0.592
TRG_DiLeu_BaEn_1 209 214 PF01217 0.479
TRG_DiLeu_BaEn_4 97 103 PF01217 0.460
TRG_DiLeu_BaLyEn_6 279 284 PF01217 0.566
TRG_ENDOCYTIC_2 130 133 PF00928 0.533
TRG_ENDOCYTIC_2 36 39 PF00928 0.508
TRG_ER_diArg_1 20 23 PF00400 0.469
TRG_ER_diArg_1 242 244 PF00400 0.708
TRG_ER_diArg_1 267 270 PF00400 0.513
TRG_Pf-PMV_PEXEL_1 100 105 PF00026 0.414
TRG_Pf-PMV_PEXEL_1 27 31 PF00026 0.527
TRG_Pf-PMV_PEXEL_1 282 286 PF00026 0.414

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3I4 Leptomonas seymouri 35% 93%
A0A1X0P5H2 Trypanosomatidae 25% 89%
A0A3Q8IIM5 Leishmania donovani 100% 100%
A0A3R7NA43 Trypanosoma rangeli 29% 88%
A4HN53 Leishmania braziliensis 75% 100%
E9AFK6 Leishmania major 92% 100%
E9B6R0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
V5C2S8 Trypanosoma cruzi 29% 88%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS