LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Cullin family - putative
Species:
Leishmania infantum
UniProt:
A4IBR4_LEIIN
TriTrypDb:
LINF_350042900
Length:
875

Annotations

Annotations by Jardim et al.

Protein modification, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0000151 ubiquitin ligase complex 3 1
GO:0000152 nuclear ubiquitin ligase complex 3 1
GO:0005680 anaphase-promoting complex 4 1
GO:0005737 cytoplasm 2 1
GO:0031461 cullin-RING ubiquitin ligase complex 4 1
GO:0032991 protein-containing complex 1 1
GO:0051286 cell tip 3 1
GO:0060187 cell pole 2 1
GO:0110165 cellular anatomical entity 1 1
GO:0140513 nuclear protein-containing complex 2 1
GO:0140535 intracellular protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1990234 transferase complex 3 1

Expansion

Sequence features

A4IBR4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBR4

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 10
GO:0006511 ubiquitin-dependent protein catabolic process 7 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0008152 metabolic process 1 10
GO:0009056 catabolic process 2 10
GO:0009057 macromolecule catabolic process 4 10
GO:0009987 cellular process 1 10
GO:0019538 protein metabolic process 3 10
GO:0019941 modification-dependent protein catabolic process 6 10
GO:0043170 macromolecule metabolic process 3 10
GO:0043632 modification-dependent macromolecule catabolic process 5 10
GO:0044237 cellular metabolic process 2 10
GO:0044238 primary metabolic process 2 10
GO:0044248 cellular catabolic process 3 10
GO:0044260 obsolete cellular macromolecule metabolic process 3 10
GO:0044265 obsolete cellular macromolecule catabolic process 4 10
GO:0051603 proteolysis involved in protein catabolic process 5 10
GO:0071704 organic substance metabolic process 2 10
GO:1901564 organonitrogen compound metabolic process 3 10
GO:1901575 organic substance catabolic process 3 10
GO:0000209 protein polyubiquitination 8 1
GO:0007091 metaphase/anaphase transition of mitotic cell cycle 5 1
GO:0010564 regulation of cell cycle process 5 1
GO:0010965 regulation of mitotic sister chromatid separation 6 1
GO:0016567 protein ubiquitination 7 1
GO:0022402 cell cycle process 2 1
GO:0032446 protein modification by small protein conjugation 6 1
GO:0033043 regulation of organelle organization 5 1
GO:0033044 regulation of chromosome organization 6 1
GO:0033045 regulation of sister chromatid segregation 5 1
GO:0036211 protein modification process 4 1
GO:0043412 macromolecule modification 4 1
GO:0044770 cell cycle phase transition 3 1
GO:0044772 mitotic cell cycle phase transition 4 1
GO:0044784 metaphase/anaphase transition of cell cycle 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051128 regulation of cellular component organization 4 1
GO:0051726 regulation of cell cycle 4 1
GO:0051983 regulation of chromosome segregation 4 1
GO:0065007 biological regulation 1 1
GO:0070647 protein modification by small protein conjugation or removal 5 1
GO:0070979 protein K11-linked ubiquitination 9 1
GO:1903047 mitotic cell cycle process 3 1
GO:1905818 regulation of chromosome separation 5 1
GO:0007049 cell cycle 2 4
GO:0051301 cell division 2 4
Molecular functions
Term Name Level Count
GO:0005488 binding 1 10
GO:0005515 protein binding 2 10
GO:0019899 enzyme binding 3 10
GO:0031625 ubiquitin protein ligase binding 5 10
GO:0044389 ubiquitin-like protein ligase binding 4 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 19 23 PF00656 0.542
CLV_C14_Caspase3-7 198 202 PF00656 0.739
CLV_C14_Caspase3-7 373 377 PF00656 0.436
CLV_MEL_PAP_1 70 76 PF00089 0.526
CLV_NRD_NRD_1 175 177 PF00675 0.548
CLV_NRD_NRD_1 306 308 PF00675 0.698
CLV_NRD_NRD_1 323 325 PF00675 0.492
CLV_NRD_NRD_1 362 364 PF00675 0.387
CLV_NRD_NRD_1 459 461 PF00675 0.459
CLV_NRD_NRD_1 531 533 PF00675 0.548
CLV_NRD_NRD_1 589 591 PF00675 0.270
CLV_NRD_NRD_1 602 604 PF00675 0.270
CLV_PCSK_KEX2_1 306 308 PF00082 0.698
CLV_PCSK_KEX2_1 323 325 PF00082 0.492
CLV_PCSK_KEX2_1 361 363 PF00082 0.388
CLV_PCSK_KEX2_1 458 460 PF00082 0.463
CLV_PCSK_KEX2_1 531 533 PF00082 0.526
CLV_PCSK_KEX2_1 589 591 PF00082 0.270
CLV_PCSK_KEX2_1 602 604 PF00082 0.270
CLV_PCSK_KEX2_1 675 677 PF00082 0.295
CLV_PCSK_PC1ET2_1 675 677 PF00082 0.295
CLV_PCSK_SKI1_1 140 144 PF00082 0.538
CLV_PCSK_SKI1_1 157 161 PF00082 0.274
CLV_PCSK_SKI1_1 169 173 PF00082 0.401
CLV_PCSK_SKI1_1 225 229 PF00082 0.497
CLV_PCSK_SKI1_1 239 243 PF00082 0.351
CLV_PCSK_SKI1_1 278 282 PF00082 0.464
CLV_PCSK_SKI1_1 352 356 PF00082 0.489
CLV_PCSK_SKI1_1 405 409 PF00082 0.430
CLV_PCSK_SKI1_1 523 527 PF00082 0.421
CLV_PCSK_SKI1_1 531 535 PF00082 0.421
CLV_PCSK_SKI1_1 567 571 PF00082 0.270
CLV_PCSK_SKI1_1 675 679 PF00082 0.295
CLV_PCSK_SKI1_1 726 730 PF00082 0.343
CLV_PCSK_SKI1_1 815 819 PF00082 0.487
CLV_Separin_Metazoa 851 855 PF03568 0.555
DEG_APCC_DBOX_1 246 254 PF00400 0.570
DEG_APCC_DBOX_1 522 530 PF00400 0.423
DEG_SPOP_SBC_1 826 830 PF00917 0.495
DOC_CDC14_PxL_1 683 691 PF14671 0.546
DOC_CKS1_1 126 131 PF01111 0.458
DOC_CKS1_1 389 394 PF01111 0.590
DOC_CYCLIN_RxL_1 518 528 PF00134 0.435
DOC_MAPK_gen_1 516 524 PF00069 0.543
DOC_MAPK_HePTP_8 70 82 PF00069 0.529
DOC_MAPK_MEF2A_6 418 427 PF00069 0.407
DOC_MAPK_MEF2A_6 518 526 PF00069 0.445
DOC_MAPK_MEF2A_6 73 82 PF00069 0.532
DOC_MAPK_MEF2A_6 760 767 PF00069 0.586
DOC_PP1_RVXF_1 262 269 PF00149 0.535
DOC_USP7_MATH_1 187 191 PF00917 0.768
DOC_USP7_MATH_1 202 206 PF00917 0.509
DOC_USP7_MATH_1 330 334 PF00917 0.649
DOC_USP7_MATH_1 622 626 PF00917 0.528
DOC_USP7_MATH_1 826 830 PF00917 0.553
DOC_USP7_MATH_1 831 835 PF00917 0.501
DOC_USP7_UBL2_3 699 703 PF12436 0.574
DOC_USP7_UBL2_3 837 841 PF12436 0.565
DOC_WW_Pin1_4 125 130 PF00397 0.461
DOC_WW_Pin1_4 210 215 PF00397 0.744
DOC_WW_Pin1_4 388 393 PF00397 0.540
DOC_WW_Pin1_4 42 47 PF00397 0.639
DOC_WW_Pin1_4 554 559 PF00397 0.556
DOC_WW_Pin1_4 618 623 PF00397 0.560
DOC_WW_Pin1_4 733 738 PF00397 0.517
DOC_WW_Pin1_4 759 764 PF00397 0.556
LIG_14-3-3_CanoR_1 113 122 PF00244 0.479
LIG_14-3-3_CanoR_1 249 257 PF00244 0.492
LIG_14-3-3_CanoR_1 602 610 PF00244 0.486
LIG_14-3-3_CanoR_1 682 686 PF00244 0.574
LIG_14-3-3_CanoR_1 73 80 PF00244 0.512
LIG_14-3-3_CanoR_1 815 821 PF00244 0.534
LIG_14-3-3_CanoR_1 824 832 PF00244 0.559
LIG_Actin_WH2_2 127 142 PF00022 0.453
LIG_APCC_ABBA_1 29 34 PF00400 0.553
LIG_BIR_III_2 329 333 PF00653 0.652
LIG_BRCT_BRCA1_1 253 257 PF00533 0.553
LIG_BRCT_BRCA1_1 443 447 PF00533 0.424
LIG_BRCT_BRCA1_1 495 499 PF00533 0.568
LIG_BRCT_BRCA1_1 783 787 PF00533 0.568
LIG_CaM_IQ_9 582 598 PF13499 0.481
LIG_CSL_BTD_1 633 636 PF09270 0.556
LIG_CSL_BTD_1 684 687 PF09270 0.546
LIG_FHA_1 126 132 PF00498 0.410
LIG_FHA_1 144 150 PF00498 0.466
LIG_FHA_1 24 30 PF00498 0.517
LIG_FHA_1 257 263 PF00498 0.535
LIG_FHA_1 396 402 PF00498 0.540
LIG_FHA_1 417 423 PF00498 0.393
LIG_FHA_1 602 608 PF00498 0.511
LIG_FHA_1 770 776 PF00498 0.464
LIG_FHA_1 816 822 PF00498 0.444
LIG_FHA_2 148 154 PF00498 0.607
LIG_FHA_2 193 199 PF00498 0.756
LIG_FHA_2 415 421 PF00498 0.444
LIG_FHA_2 554 560 PF00498 0.464
LIG_FHA_2 571 577 PF00498 0.579
LIG_FHA_2 667 673 PF00498 0.493
LIG_FHA_2 67 73 PF00498 0.446
LIG_FHA_2 793 799 PF00498 0.699
LIG_GBD_Chelix_1 131 139 PF00786 0.530
LIG_GBD_Chelix_1 743 751 PF00786 0.233
LIG_LIR_Gen_1 365 375 PF02991 0.408
LIG_LIR_Gen_1 536 546 PF02991 0.356
LIG_LIR_Gen_1 784 794 PF02991 0.689
LIG_LIR_Nem_3 110 115 PF02991 0.480
LIG_LIR_Nem_3 365 371 PF02991 0.400
LIG_LIR_Nem_3 632 637 PF02991 0.463
LIG_LIR_Nem_3 672 677 PF02991 0.527
LIG_MYND_1 608 612 PF01753 0.511
LIG_MYND_3 102 106 PF01753 0.560
LIG_MYND_3 378 382 PF01753 0.519
LIG_NRBOX 350 356 PF00104 0.403
LIG_PCNA_yPIPBox_3 841 853 PF02747 0.485
LIG_Pex14_1 166 170 PF04695 0.345
LIG_Pex14_2 433 437 PF04695 0.495
LIG_Pex14_2 717 721 PF04695 0.511
LIG_Rb_pABgroove_1 711 719 PF01858 0.556
LIG_RPA_C_Fungi 584 596 PF08784 0.467
LIG_SH2_CRK 112 116 PF00017 0.532
LIG_SH2_CRK 674 678 PF00017 0.408
LIG_SH2_CRK 870 874 PF00017 0.498
LIG_SH2_NCK_1 870 874 PF00017 0.558
LIG_SH2_SRC 4 7 PF00017 0.592
LIG_SH2_STAT3 386 389 PF00017 0.532
LIG_SH2_STAT5 386 389 PF00017 0.497
LIG_SH2_STAT5 4 7 PF00017 0.619
LIG_SH3_3 468 474 PF00018 0.605
LIG_SH3_3 477 483 PF00018 0.656
LIG_SH3_3 705 711 PF00018 0.466
LIG_SH3_3 97 103 PF00018 0.558
LIG_SH3_4 549 556 PF00018 0.380
LIG_SUMO_SIM_anti_2 419 427 PF11976 0.411
LIG_SUMO_SIM_anti_2 50 59 PF11976 0.470
LIG_SUMO_SIM_anti_2 625 630 PF11976 0.380
LIG_SUMO_SIM_anti_2 848 855 PF11976 0.465
LIG_SUMO_SIM_par_1 352 358 PF11976 0.402
LIG_SUMO_SIM_par_1 712 718 PF11976 0.419
LIG_SUMO_SIM_par_1 860 866 PF11976 0.553
LIG_SxIP_EBH_1 522 532 PF03271 0.575
LIG_TRAF2_1 150 153 PF00917 0.591
LIG_TRAF2_1 557 560 PF00917 0.327
LIG_TRAF2_1 662 665 PF00917 0.380
LIG_TRAF2_1 795 798 PF00917 0.803
LIG_TRFH_1 870 874 PF08558 0.561
LIG_WRC_WIRS_1 160 165 PF05994 0.511
LIG_WRC_WIRS_1 853 858 PF05994 0.535
MOD_CK1_1 251 257 PF00069 0.500
MOD_CK1_1 299 305 PF00069 0.745
MOD_CK1_1 333 339 PF00069 0.632
MOD_CK1_1 44 50 PF00069 0.593
MOD_CK1_1 448 454 PF00069 0.543
MOD_CK1_1 627 633 PF00069 0.338
MOD_CK2_1 147 153 PF00069 0.563
MOD_CK2_1 192 198 PF00069 0.762
MOD_CK2_1 237 243 PF00069 0.513
MOD_CK2_1 264 270 PF00069 0.537
MOD_CK2_1 281 287 PF00069 0.386
MOD_CK2_1 387 393 PF00069 0.547
MOD_CK2_1 4 10 PF00069 0.574
MOD_CK2_1 553 559 PF00069 0.314
MOD_CK2_1 66 72 PF00069 0.428
MOD_CK2_1 666 672 PF00069 0.408
MOD_CK2_1 792 798 PF00069 0.739
MOD_GlcNHglycan 123 126 PF01048 0.510
MOD_GlcNHglycan 204 207 PF01048 0.621
MOD_GlcNHglycan 210 213 PF01048 0.599
MOD_GlcNHglycan 230 233 PF01048 0.335
MOD_GlcNHglycan 294 297 PF01048 0.772
MOD_GlcNHglycan 34 37 PF01048 0.585
MOD_GlcNHglycan 393 396 PF01048 0.570
MOD_GlcNHglycan 50 53 PF01048 0.523
MOD_GlcNHglycan 58 61 PF01048 0.445
MOD_GlcNHglycan 615 618 PF01048 0.467
MOD_GlcNHglycan 641 644 PF01048 0.411
MOD_GlcNHglycan 647 650 PF01048 0.425
MOD_GlcNHglycan 74 77 PF01048 0.259
MOD_GlcNHglycan 783 786 PF01048 0.624
MOD_GlcNHglycan 796 801 PF01048 0.769
MOD_GlcNHglycan 86 89 PF01048 0.537
MOD_GlcNHglycan 92 95 PF01048 0.585
MOD_GSK3_1 121 128 PF00069 0.543
MOD_GSK3_1 143 150 PF00069 0.552
MOD_GSK3_1 251 258 PF00069 0.559
MOD_GSK3_1 281 288 PF00069 0.580
MOD_GSK3_1 292 299 PF00069 0.603
MOD_GSK3_1 387 394 PF00069 0.538
MOD_GSK3_1 41 48 PF00069 0.599
MOD_GSK3_1 441 448 PF00069 0.463
MOD_GSK3_1 483 490 PF00069 0.684
MOD_GSK3_1 585 592 PF00069 0.338
MOD_GSK3_1 618 625 PF00069 0.447
MOD_GSK3_1 681 688 PF00069 0.428
MOD_GSK3_1 699 706 PF00069 0.187
MOD_GSK3_1 72 79 PF00069 0.513
MOD_GSK3_1 727 734 PF00069 0.428
MOD_GSK3_1 769 776 PF00069 0.463
MOD_GSK3_1 777 784 PF00069 0.478
MOD_GSK3_1 792 799 PF00069 0.686
MOD_GSK3_1 816 823 PF00069 0.554
MOD_GSK3_1 827 834 PF00069 0.488
MOD_GSK3_1 90 97 PF00069 0.403
MOD_LATS_1 724 730 PF00433 0.358
MOD_N-GLC_1 228 233 PF02516 0.571
MOD_N-GLC_1 296 301 PF02516 0.670
MOD_NEK2_1 237 242 PF00069 0.467
MOD_NEK2_1 269 274 PF00069 0.536
MOD_NEK2_1 291 296 PF00069 0.747
MOD_NEK2_1 32 37 PF00069 0.572
MOD_NEK2_1 355 360 PF00069 0.362
MOD_NEK2_1 400 405 PF00069 0.428
MOD_NEK2_1 407 412 PF00069 0.416
MOD_NEK2_1 426 431 PF00069 0.360
MOD_NEK2_1 525 530 PF00069 0.462
MOD_NEK2_1 56 61 PF00069 0.490
MOD_NEK2_1 570 575 PF00069 0.467
MOD_NEK2_1 585 590 PF00069 0.139
MOD_NEK2_1 629 634 PF00069 0.303
MOD_NEK2_1 717 722 PF00069 0.322
MOD_NEK2_1 777 782 PF00069 0.474
MOD_NEK2_1 816 821 PF00069 0.489
MOD_NEK2_1 842 847 PF00069 0.520
MOD_NEK2_1 852 857 PF00069 0.392
MOD_NEK2_1 90 95 PF00069 0.557
MOD_PIKK_1 171 177 PF00454 0.481
MOD_PIKK_1 331 337 PF00454 0.686
MOD_PIKK_1 483 489 PF00454 0.732
MOD_PIKK_1 589 595 PF00454 0.404
MOD_PKA_1 589 595 PF00069 0.338
MOD_PKA_2 187 193 PF00069 0.654
MOD_PKA_2 248 254 PF00069 0.488
MOD_PKA_2 292 298 PF00069 0.688
MOD_PKA_2 589 595 PF00069 0.338
MOD_PKA_2 601 607 PF00069 0.338
MOD_PKA_2 638 644 PF00069 0.424
MOD_PKA_2 681 687 PF00069 0.462
MOD_PKA_2 72 78 PF00069 0.506
MOD_PKA_2 792 798 PF00069 0.775
MOD_Plk_1 192 198 PF00069 0.489
MOD_Plk_1 269 275 PF00069 0.505
MOD_Plk_1 440 446 PF00069 0.477
MOD_Plk_1 717 723 PF00069 0.352
MOD_Plk_2-3 666 672 PF00069 0.271
MOD_Plk_2-3 792 798 PF00069 0.775
MOD_Plk_4 215 221 PF00069 0.603
MOD_Plk_4 264 270 PF00069 0.453
MOD_Plk_4 441 447 PF00069 0.436
MOD_Plk_4 624 630 PF00069 0.386
MOD_Plk_4 66 72 PF00069 0.423
MOD_Plk_4 681 687 PF00069 0.467
MOD_Plk_4 703 709 PF00069 0.320
MOD_Plk_4 712 718 PF00069 0.330
MOD_Plk_4 816 822 PF00069 0.471
MOD_ProDKin_1 125 131 PF00069 0.456
MOD_ProDKin_1 210 216 PF00069 0.736
MOD_ProDKin_1 388 394 PF00069 0.542
MOD_ProDKin_1 42 48 PF00069 0.629
MOD_ProDKin_1 554 560 PF00069 0.443
MOD_ProDKin_1 618 624 PF00069 0.448
MOD_ProDKin_1 733 739 PF00069 0.387
MOD_ProDKin_1 759 765 PF00069 0.443
MOD_SUMO_for_1 396 399 PF00179 0.569
MOD_SUMO_rev_2 231 237 PF00179 0.435
TRG_DiLeu_BaEn_1 808 813 PF01217 0.593
TRG_DiLeu_BaEn_4 665 671 PF01217 0.380
TRG_DiLeu_BaLyEn_6 349 354 PF01217 0.529
TRG_ENDOCYTIC_2 112 115 PF00928 0.507
TRG_ENDOCYTIC_2 538 541 PF00928 0.322
TRG_ENDOCYTIC_2 674 677 PF00928 0.357
TRG_ER_diArg_1 137 140 PF00400 0.537
TRG_ER_diArg_1 322 324 PF00400 0.581
TRG_ER_diArg_1 361 363 PF00400 0.419
TRG_ER_diArg_1 457 460 PF00400 0.548
TRG_ER_diArg_1 516 519 PF00400 0.616
TRG_ER_diArg_1 530 532 PF00400 0.583
TRG_ER_diArg_1 589 591 PF00400 0.330
TRG_ER_diArg_1 601 603 PF00400 0.306
TRG_NES_CRM1_1 68 81 PF08389 0.534
TRG_NES_CRM1_1 712 727 PF08389 0.359
TRG_NES_CRM1_1 851 866 PF08389 0.470
TRG_Pf-PMV_PEXEL_1 15 19 PF00026 0.478
TRG_Pf-PMV_PEXEL_1 194 198 PF00026 0.490
TRG_Pf-PMV_PEXEL_1 532 536 PF00026 0.521
TRG_Pf-PMV_PEXEL_1 589 593 PF00026 0.408

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I206 Leptomonas seymouri 55% 95%
A0A0S4J0P6 Bodo saltans 30% 100%
A0A1X0P5D0 Trypanosomatidae 37% 100%
A0A3S7X9N5 Leishmania donovani 100% 100%
A0A422MYM3 Trypanosoma rangeli 38% 100%
A4HN46 Leishmania braziliensis 81% 100%
C9ZYV9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9AFJ9 Leishmania major 94% 100%
V5BTC2 Trypanosoma cruzi 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS