ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IBR2_LEIIN

TriTrypDb:

LINF_350042700

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBR2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.471
CLV_NRD_NRD_1	164	166	PF00675	0.438
CLV_NRD_NRD_1	171	173	PF00675	0.432
CLV_NRD_NRD_1	23	25	PF00675	0.418
CLV_NRD_NRD_1	254	256	PF00675	0.417
CLV_NRD_NRD_1	282	284	PF00675	0.517
CLV_NRD_NRD_1	3	5	PF00675	0.369
CLV_NRD_NRD_1	35	37	PF00675	0.326
CLV_NRD_NRD_1	351	353	PF00675	0.375
CLV_NRD_NRD_1	361	363	PF00675	0.352
CLV_NRD_NRD_1	400	402	PF00675	0.369
CLV_NRD_NRD_1	410	412	PF00675	0.349
CLV_NRD_NRD_1	423	425	PF00675	0.322
CLV_NRD_NRD_1	429	431	PF00675	0.388
CLV_NRD_NRD_1	437	439	PF00675	0.369
CLV_PCSK_FUR_1	252	256	PF00082	0.385
CLV_PCSK_FUR_1	280	284	PF00082	0.355
CLV_PCSK_KEX2_1	131	133	PF00082	0.522
CLV_PCSK_KEX2_1	164	166	PF00082	0.430
CLV_PCSK_KEX2_1	171	173	PF00082	0.453
CLV_PCSK_KEX2_1	18	20	PF00082	0.359
CLV_PCSK_KEX2_1	254	256	PF00082	0.433
CLV_PCSK_KEX2_1	282	284	PF00082	0.517
CLV_PCSK_KEX2_1	3	5	PF00082	0.369
CLV_PCSK_KEX2_1	35	37	PF00082	0.294
CLV_PCSK_KEX2_1	351	353	PF00082	0.375
CLV_PCSK_KEX2_1	361	363	PF00082	0.325
CLV_PCSK_KEX2_1	400	402	PF00082	0.369
CLV_PCSK_KEX2_1	409	411	PF00082	0.360
CLV_PCSK_KEX2_1	423	425	PF00082	0.318
CLV_PCSK_KEX2_1	429	431	PF00082	0.388
CLV_PCSK_KEX2_1	436	438	PF00082	0.375
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.320
CLV_PCSK_PC7_1	127	133	PF00082	0.582
CLV_PCSK_PC7_1	250	256	PF00082	0.516
CLV_PCSK_PC7_1	347	353	PF00082	0.397
CLV_PCSK_PC7_1	405	411	PF00082	0.482
CLV_PCSK_SKI1_1	127	131	PF00082	0.560
CLV_PCSK_SKI1_1	132	136	PF00082	0.605
CLV_PCSK_SKI1_1	172	176	PF00082	0.467
CLV_PCSK_SKI1_1	221	225	PF00082	0.517
CLV_PCSK_SKI1_1	24	28	PF00082	0.501
CLV_PCSK_SKI1_1	316	320	PF00082	0.360
CLV_PCSK_SKI1_1	347	351	PF00082	0.375
CLV_PCSK_SKI1_1	35	39	PF00082	0.351
CLV_PCSK_SKI1_1	62	66	PF00082	0.552
CLV_PCSK_SKI1_1	70	74	PF00082	0.576
DEG_APCC_DBOX_1	126	134	PF00400	0.420
DEG_APCC_DBOX_1	23	31	PF00400	0.485
DEG_APCC_DBOX_1	257	265	PF00400	0.379
DEG_Nend_UBRbox_3	1	3	PF02207	0.408
DOC_CYCLIN_RxL_1	280	291	PF00134	0.510
DOC_MAPK_gen_1	280	290	PF00069	0.384
DOC_MAPK_gen_1	3	9	PF00069	0.361
DOC_MAPK_gen_1	320	330	PF00069	0.399
DOC_MAPK_gen_1	451	461	PF00069	0.499
DOC_MAPK_MEF2A_6	323	330	PF00069	0.363
DOC_MAPK_MEF2A_6	454	463	PF00069	0.502
DOC_USP7_MATH_1	111	115	PF00917	0.482
DOC_USP7_MATH_1	192	196	PF00917	0.509
DOC_WW_Pin1_4	453	458	PF00397	0.492
LIG_14-3-3_CanoR_1	138	146	PF00244	0.494
LIG_14-3-3_CanoR_1	323	329	PF00244	0.364
LIG_14-3-3_CanoR_1	4	10	PF00244	0.482
LIG_14-3-3_CanoR_1	409	415	PF00244	0.303
LIG_14-3-3_CanoR_1	436	441	PF00244	0.401
LIG_14-3-3_CanoR_1	62	67	PF00244	0.527
LIG_14-3-3_CanoR_1	86	94	PF00244	0.584
LIG_BRCT_BRCA1_1	11	15	PF00533	0.317
LIG_BRCT_BRCA1_1	41	45	PF00533	0.492
LIG_CaM_IQ_9	354	370	PF13499	0.342
LIG_deltaCOP1_diTrp_1	443	448	PF00928	0.453
LIG_FHA_1	114	120	PF00498	0.500
LIG_FHA_1	325	331	PF00498	0.465
LIG_FHA_1	352	358	PF00498	0.370
LIG_FHA_1	390	396	PF00498	0.505
LIG_FHA_1	9	15	PF00498	0.474
LIG_FHA_2	386	392	PF00498	0.381
LIG_FHA_2	90	96	PF00498	0.480
LIG_LIR_Gen_1	413	422	PF02991	0.292
LIG_LIR_Nem_3	245	249	PF02991	0.406
LIG_LIR_Nem_3	32	37	PF02991	0.573
LIG_LIR_Nem_3	413	419	PF02991	0.294
LIG_PDZ_Class_2	458	463	PF00595	0.513
LIG_Pex14_1	60	64	PF04695	0.503
LIG_RPA_C_Fungi	227	239	PF08784	0.378
LIG_SH2_SRC	265	268	PF00017	0.366
LIG_SH2_STAP1	154	158	PF00017	0.366
LIG_SH2_STAP1	265	269	PF00017	0.460
LIG_SH2_STAT3	154	157	PF00017	0.396
LIG_SH2_STAT5	154	157	PF00017	0.489
LIG_SH2_STAT5	384	387	PF00017	0.378
LIG_SH3_3	439	445	PF00018	0.453
LIG_SUMO_SIM_anti_2	102	108	PF11976	0.463
LIG_UBA3_1	9	18	PF00899	0.318
MOD_CK1_1	324	330	PF00069	0.462
MOD_CK1_1	8	14	PF00069	0.344
MOD_CK2_1	177	183	PF00069	0.530
MOD_CK2_1	385	391	PF00069	0.359
MOD_CK2_1	89	95	PF00069	0.490
MOD_GlcNHglycan	113	116	PF01048	0.637
MOD_GlcNHglycan	199	202	PF01048	0.627
MOD_GlcNHglycan	228	231	PF01048	0.571
MOD_GSK3_1	111	118	PF00069	0.610
MOD_GSK3_1	324	331	PF00069	0.512
MOD_GSK3_1	385	392	PF00069	0.375
MOD_GSK3_1	453	460	PF00069	0.488
MOD_GSK3_1	5	12	PF00069	0.348
MOD_NEK2_1	20	25	PF00069	0.558
MOD_NEK2_1	288	293	PF00069	0.452
MOD_NEK2_1	321	326	PF00069	0.396
MOD_NEK2_1	357	362	PF00069	0.416
MOD_NEK2_1	80	85	PF00069	0.565
MOD_NEK2_1	9	14	PF00069	0.477
MOD_PIKK_1	152	158	PF00454	0.490
MOD_PIKK_1	204	210	PF00454	0.497
MOD_PIKK_1	75	81	PF00454	0.625
MOD_PIKK_1	87	93	PF00454	0.495
MOD_PKA_1	351	357	PF00069	0.341
MOD_PKA_1	410	416	PF00069	0.295
MOD_PKA_1	436	442	PF00069	0.399
MOD_PKA_2	324	330	PF00069	0.428
MOD_PKA_2	351	357	PF00069	0.372
MOD_PKA_2	410	416	PF00069	0.341
MOD_PKA_2	425	431	PF00069	0.409
MOD_PKA_2	436	442	PF00069	0.361
MOD_PKA_2	5	11	PF00069	0.541
MOD_PKA_2	87	93	PF00069	0.647
MOD_Plk_4	115	121	PF00069	0.501
MOD_Plk_4	457	463	PF00069	0.508
MOD_Plk_4	5	11	PF00069	0.392
MOD_Plk_4	89	95	PF00069	0.614
MOD_ProDKin_1	453	459	PF00069	0.494
MOD_SUMO_for_1	450	453	PF00179	0.474
TRG_DiLeu_BaEn_1	102	107	PF01217	0.461
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.429
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.342
TRG_ENDOCYTIC_2	265	268	PF00928	0.366
TRG_ER_diArg_1	130	132	PF00400	0.472
TRG_ER_diArg_1	137	140	PF00400	0.426
TRG_ER_diArg_1	164	166	PF00400	0.458
TRG_ER_diArg_1	171	173	PF00400	0.450
TRG_ER_diArg_1	178	181	PF00400	0.512
TRG_ER_diArg_1	249	252	PF00400	0.372
TRG_ER_diArg_1	280	283	PF00400	0.481
TRG_ER_diArg_1	3	5	PF00400	0.382
TRG_ER_diArg_1	322	325	PF00400	0.409
TRG_ER_diArg_1	34	36	PF00400	0.376
TRG_ER_diArg_1	350	352	PF00400	0.394
TRG_ER_diArg_1	399	401	PF00400	0.377
TRG_ER_diArg_1	409	411	PF00400	0.382
TRG_ER_diArg_1	422	424	PF00400	0.317
TRG_ER_diArg_1	435	438	PF00400	0.368
TRG_ER_diArg_1	84	87	PF00400	0.548
TRG_Pf-PMV_PEXEL_1	171	176	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	438	443	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IQ74	Bodo saltans	25%	72%
A0A1X0P570	Trypanosomatidae	27%	82%
A0A3Q8IJQ1	Leishmania donovani	99%	100%
A0A422MYK4	Trypanosoma rangeli	28%	78%
C9ZYW1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	69%
E9AFJ7	Leishmania major	90%	100%
V5DUN3	Trypanosoma cruzi	26%	78%