LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IBR1_LEIIN
TriTrypDb:
LINF_350042600
Length:
440

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005856 cytoskeleton 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 316

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IBR1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBR1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 225 229 PF00656 0.549
CLV_C14_Caspase3-7 68 72 PF00656 0.553
CLV_NRD_NRD_1 184 186 PF00675 0.482
CLV_NRD_NRD_1 258 260 PF00675 0.444
CLV_NRD_NRD_1 276 278 PF00675 0.445
CLV_NRD_NRD_1 345 347 PF00675 0.437
CLV_NRD_NRD_1 431 433 PF00675 0.678
CLV_NRD_NRD_1 438 440 PF00675 0.727
CLV_NRD_NRD_1 85 87 PF00675 0.413
CLV_PCSK_KEX2_1 128 130 PF00082 0.659
CLV_PCSK_KEX2_1 184 186 PF00082 0.485
CLV_PCSK_KEX2_1 258 260 PF00082 0.444
CLV_PCSK_KEX2_1 276 278 PF00082 0.445
CLV_PCSK_KEX2_1 394 396 PF00082 0.537
CLV_PCSK_KEX2_1 438 440 PF00082 0.534
CLV_PCSK_KEX2_1 85 87 PF00082 0.414
CLV_PCSK_PC1ET2_1 128 130 PF00082 0.659
CLV_PCSK_PC1ET2_1 394 396 PF00082 0.537
CLV_PCSK_SKI1_1 169 173 PF00082 0.480
CLV_PCSK_SKI1_1 243 247 PF00082 0.452
CLV_PCSK_SKI1_1 300 304 PF00082 0.576
CLV_PCSK_SKI1_1 347 351 PF00082 0.448
CLV_PCSK_SKI1_1 391 395 PF00082 0.556
CLV_Separin_Metazoa 338 342 PF03568 0.511
DEG_Nend_UBRbox_2 1 3 PF02207 0.687
DOC_MAPK_gen_1 166 174 PF00069 0.451
DOC_MAPK_gen_1 184 191 PF00069 0.419
DOC_MAPK_gen_1 346 352 PF00069 0.434
DOC_PP1_RVXF_1 127 134 PF00149 0.626
DOC_USP7_MATH_1 305 309 PF00917 0.569
LIG_Actin_WH2_2 66 83 PF00022 0.424
LIG_CaM_IQ_9 363 379 PF13499 0.399
LIG_CaM_IQ_9 73 88 PF13499 0.443
LIG_FHA_1 16 22 PF00498 0.561
LIG_FHA_1 280 286 PF00498 0.529
LIG_FHA_1 327 333 PF00498 0.433
LIG_FHA_2 109 115 PF00498 0.507
LIG_FHA_2 223 229 PF00498 0.536
LIG_LIR_Gen_1 130 141 PF02991 0.547
LIG_LIR_Gen_1 186 194 PF02991 0.527
LIG_LIR_Nem_3 130 136 PF02991 0.564
LIG_LIR_Nem_3 186 191 PF02991 0.491
LIG_LIR_Nem_3 322 327 PF02991 0.461
LIG_LIR_Nem_3 328 333 PF02991 0.413
LIG_Rb_LxCxE_1 233 252 PF01857 0.540
LIG_SH2_CRK 188 192 PF00017 0.460
LIG_SH2_NCK_1 54 58 PF00017 0.599
LIG_SH2_PTP2 324 327 PF00017 0.538
LIG_SH2_SRC 324 327 PF00017 0.538
LIG_SH2_STAP1 24 28 PF00017 0.439
LIG_SH2_STAT5 324 327 PF00017 0.480
LIG_SUMO_SIM_par_1 170 175 PF11976 0.535
LIG_SUMO_SIM_par_1 348 353 PF11976 0.447
LIG_TRAF2_1 10 13 PF00917 0.518
LIG_TRAF2_1 20 23 PF00917 0.496
LIG_TRAF2_1 308 311 PF00917 0.567
LIG_TRAF2_1 60 63 PF00917 0.499
LIG_TRAF2_1 95 98 PF00917 0.531
LIG_UBA3_1 349 354 PF00899 0.455
LIG_WRC_WIRS_1 327 332 PF05994 0.574
MOD_CK1_1 160 166 PF00069 0.554
MOD_CK2_1 108 114 PF00069 0.572
MOD_CK2_1 131 137 PF00069 0.502
MOD_CK2_1 144 150 PF00069 0.353
MOD_CK2_1 238 244 PF00069 0.543
MOD_CK2_1 281 287 PF00069 0.463
MOD_CK2_1 305 311 PF00069 0.580
MOD_Cter_Amidation 126 129 PF01082 0.650
MOD_Cter_Amidation 436 439 PF01082 0.520
MOD_GlcNHglycan 174 177 PF01048 0.560
MOD_GlcNHglycan 300 303 PF01048 0.532
MOD_GlcNHglycan 305 308 PF01048 0.531
MOD_GlcNHglycan 384 387 PF01048 0.565
MOD_GlcNHglycan 435 438 PF01048 0.716
MOD_GSK3_1 156 163 PF00069 0.483
MOD_GSK3_1 222 229 PF00069 0.549
MOD_GSK3_1 277 284 PF00069 0.456
MOD_GSK3_1 353 360 PF00069 0.512
MOD_GSK3_1 378 385 PF00069 0.513
MOD_N-GLC_2 193 195 PF02516 0.542
MOD_NEK2_1 108 113 PF00069 0.464
MOD_NEK2_1 119 124 PF00069 0.490
MOD_NEK2_1 167 172 PF00069 0.548
MOD_NEK2_1 339 344 PF00069 0.480
MOD_NEK2_1 378 383 PF00069 0.513
MOD_NEK2_1 411 416 PF00069 0.471
MOD_NEK2_2 326 331 PF00069 0.571
MOD_NEK2_2 386 391 PF00069 0.495
MOD_PIKK_1 426 432 PF00454 0.472
MOD_PKA_2 15 21 PF00069 0.585
MOD_PKA_2 183 189 PF00069 0.496
MOD_PKA_2 411 417 PF00069 0.532
MOD_Plk_1 144 150 PF00069 0.461
MOD_Plk_1 167 173 PF00069 0.538
MOD_Plk_1 232 238 PF00069 0.483
MOD_Plk_1 378 384 PF00069 0.567
MOD_Plk_1 386 392 PF00069 0.519
MOD_Plk_1 55 61 PF00069 0.434
MOD_Plk_2-3 2 8 PF00069 0.581
MOD_Plk_2-3 34 40 PF00069 0.545
MOD_Plk_4 144 150 PF00069 0.523
MOD_Plk_4 167 173 PF00069 0.462
MOD_Plk_4 353 359 PF00069 0.534
MOD_SUMO_for_1 223 226 PF00179 0.548
MOD_SUMO_rev_2 150 160 PF00179 0.485
MOD_SUMO_rev_2 247 256 PF00179 0.473
MOD_SUMO_rev_2 398 405 PF00179 0.478
TRG_DiLeu_BaEn_1 400 405 PF01217 0.479
TRG_DiLeu_BaLyEn_6 328 333 PF01217 0.461
TRG_ENDOCYTIC_2 188 191 PF00928 0.431
TRG_ENDOCYTIC_2 324 327 PF00928 0.431
TRG_ER_diArg_1 184 187 PF00400 0.496
TRG_ER_diArg_1 276 278 PF00400 0.585
TRG_NES_CRM1_1 71 84 PF08389 0.474
TRG_Pf-PMV_PEXEL_1 19 23 PF00026 0.543
TRG_Pf-PMV_PEXEL_1 283 287 PF00026 0.463
TRG_Pf-PMV_PEXEL_1 395 400 PF00026 0.449
TRG_Pf-PMV_PEXEL_1 406 410 PF00026 0.503
TRG_Pf-PMV_PEXEL_1 49 53 PF00026 0.472
TRG_Pf-PMV_PEXEL_1 99 103 PF00026 0.531

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJ51 Leptomonas seymouri 71% 100%
A0A0S4JDF0 Bodo saltans 40% 99%
A0A1X0P5H1 Trypanosomatidae 43% 100%
A0A3Q8IFE4 Leishmania donovani 100% 100%
A0A3R7N172 Trypanosoma rangeli 43% 100%
A4HN43 Leishmania braziliensis 81% 100%
C9ZYW3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AFJ6 Leishmania major 93% 100%
E9B6Q0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
V5BXZ9 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS