LeishMANIAdb
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Peroxisomal membrane protein PMP34

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Peroxisomal membrane protein PMP34
Gene product:
Peroxisomal biogenesis factor 11 (PEX11) - putative
Species:
Leishmania infantum
UniProt:
A4IBQ8_LEIIN
TriTrypDb:
LINF_350042300
Length:
253

Annotations

LeishMANIAdb annotations

Publication identifier(s): 11260462
A known glcosomal (peroxisomal) kinetoplastid protein. Known to be a dimeric, essential component of glycosomes (PMID: 11260462). Localization: Peroxisomal (experimental)

Annotations by Jardim et al.

Glycosome membrane, Peroxin 11

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 17
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0005777 peroxisome 6 1
GO:0020015 glycosome 7 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 2

Expansion

Sequence features

A4IBQ8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBQ8

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 15
GO:0009987 cellular process 1 15
GO:0016043 cellular component organization 3 15
GO:0016559 peroxisome fission 6 15
GO:0048285 organelle fission 5 15
GO:0071840 cellular component organization or biogenesis 2 15
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 177 179 PF00675 0.291
CLV_PCSK_KEX2_1 177 179 PF00082 0.289
CLV_PCSK_SKI1_1 137 141 PF00082 0.410
CLV_PCSK_SKI1_1 178 182 PF00082 0.277
CLV_PCSK_SKI1_1 64 68 PF00082 0.262
DOC_CDC14_PxL_1 73 81 PF14671 0.553
DOC_CKS1_1 232 237 PF01111 0.396
DOC_CYCLIN_yCln2_LP_2 224 230 PF00134 0.341
DOC_CYCLIN_yCln2_LP_2 37 43 PF00134 0.469
DOC_MAPK_gen_1 174 183 PF00069 0.470
DOC_MAPK_gen_1 23 32 PF00069 0.481
DOC_PP1_RVXF_1 133 139 PF00149 0.353
DOC_PP2B_LxvP_1 224 227 PF13499 0.427
DOC_PP2B_LxvP_1 37 40 PF13499 0.424
DOC_PP4_FxxP_1 229 232 PF00568 0.382
DOC_USP7_MATH_1 2 6 PF00917 0.648
DOC_USP7_MATH_1 211 215 PF00917 0.375
DOC_WW_Pin1_4 231 236 PF00397 0.377
DOC_WW_Pin1_4 77 82 PF00397 0.457
LIG_14-3-3_CanoR_1 25 30 PF00244 0.466
LIG_14-3-3_CanoR_1 68 75 PF00244 0.461
LIG_14-3-3_CanoR_1 9 17 PF00244 0.559
LIG_Actin_WH2_2 142 159 PF00022 0.401
LIG_Actin_WH2_2 184 200 PF00022 0.365
LIG_BRCT_BRCA1_1 102 106 PF00533 0.349
LIG_BRCT_BRCA1_1 49 53 PF00533 0.416
LIG_FHA_1 106 112 PF00498 0.352
LIG_FHA_1 5 11 PF00498 0.553
LIG_LIR_Gen_1 104 112 PF02991 0.436
LIG_LIR_Gen_1 158 166 PF02991 0.549
LIG_LIR_Gen_1 50 61 PF02991 0.513
LIG_LIR_Gen_1 70 79 PF02991 0.426
LIG_LIR_LC3C_4 70 75 PF02991 0.555
LIG_LIR_Nem_3 103 109 PF02991 0.453
LIG_LIR_Nem_3 11 16 PF02991 0.497
LIG_LIR_Nem_3 158 164 PF02991 0.549
LIG_LIR_Nem_3 50 56 PF02991 0.482
LIG_LIR_Nem_3 70 75 PF02991 0.441
LIG_MYND_1 77 81 PF01753 0.544
LIG_PDZ_Class_1 248 253 PF00595 0.418
LIG_Pex14_2 106 110 PF04695 0.364
LIG_Pex14_2 129 133 PF04695 0.345
LIG_Pex14_2 138 142 PF04695 0.394
LIG_SH2_CRK 161 165 PF00017 0.469
LIG_SH2_CRK 194 198 PF00017 0.455
LIG_SH2_CRK 63 67 PF00017 0.473
LIG_SH2_STAT5 153 156 PF00017 0.519
LIG_SH2_STAT5 16 19 PF00017 0.490
LIG_SH2_STAT5 194 197 PF00017 0.422
LIG_SH2_STAT5 207 210 PF00017 0.303
LIG_SH3_3 199 205 PF00018 0.394
LIG_SH3_3 229 235 PF00018 0.419
LIG_SH3_3 71 77 PF00018 0.553
LIG_Sin3_3 34 41 PF02671 0.378
MOD_CK2_1 164 170 PF00069 0.538
MOD_GlcNHglycan 199 202 PF01048 0.643
MOD_GlcNHglycan 208 211 PF01048 0.562
MOD_GlcNHglycan 213 216 PF01048 0.554
MOD_GlcNHglycan 48 52 PF01048 0.307
MOD_GlcNHglycan 81 84 PF01048 0.313
MOD_GSK3_1 101 108 PF00069 0.448
MOD_GSK3_1 192 199 PF00069 0.434
MOD_GSK3_1 4 11 PF00069 0.594
MOD_GSK3_1 79 86 PF00069 0.505
MOD_LATS_1 62 68 PF00433 0.469
MOD_N-GLC_1 18 23 PF02516 0.277
MOD_N-GLC_1 2 7 PF02516 0.470
MOD_NEK2_1 141 146 PF00069 0.410
MOD_NEK2_1 155 160 PF00069 0.525
MOD_NEK2_1 192 197 PF00069 0.307
MOD_NEK2_1 241 246 PF00069 0.318
MOD_NEK2_1 248 253 PF00069 0.355
MOD_NEK2_2 105 110 PF00069 0.436
MOD_PIKK_1 164 170 PF00454 0.538
MOD_PIKK_1 4 10 PF00454 0.668
MOD_PIKK_1 67 73 PF00454 0.553
MOD_PK_1 25 31 PF00069 0.553
MOD_PKA_2 67 73 PF00069 0.460
MOD_PKA_2 8 14 PF00069 0.558
MOD_PKB_1 23 31 PF00069 0.553
MOD_Plk_1 2 8 PF00069 0.652
MOD_Plk_4 187 193 PF00069 0.339
MOD_Plk_4 25 31 PF00069 0.494
MOD_Plk_4 52 58 PF00069 0.510
MOD_Plk_4 83 89 PF00069 0.492
MOD_ProDKin_1 231 237 PF00069 0.400
MOD_ProDKin_1 77 83 PF00069 0.457
MOD_SUMO_rev_2 166 173 PF00179 0.478
TRG_ENDOCYTIC_2 153 156 PF00928 0.510
TRG_ENDOCYTIC_2 161 164 PF00928 0.477
TRG_ENDOCYTIC_2 194 197 PF00928 0.420
TRG_ENDOCYTIC_2 63 66 PF00928 0.473
TRG_ER_diArg_1 135 138 PF00400 0.353

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4J0 Leptomonas seymouri 72% 100%
A0A0N1IJQ7 Leptomonas seymouri 26% 100%
A0A1X0P585 Trypanosomatidae 27% 100%
A0A1X0P5I2 Trypanosomatidae 27% 100%
A0A3R7K892 Trypanosoma rangeli 25% 100%
A0A3R7MWK0 Trypanosoma rangeli 26% 100%
A0A3S7X9W6 Leishmania donovani 99% 100%
A4HN40 Leishmania braziliensis 84% 100%
A4HN41 Leishmania braziliensis 25% 100%
C9ZYW5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZYW6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZYW7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 23% 100%
E9AFJ3 Leishmania major 94% 100%
E9AFJ4 Leishmania major 26% 95%
E9B6P7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
V5BTC6 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS