Peroxisomal membrane protein PMP34

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Peroxisomal biogenesis factor 11 (PEX11) - putative

Species:

Leishmania infantum

UniProt:

A4IBQ8_LEIIN

TriTrypDb:

LINF_350042300

Length:

253

Annotations

LeishMANIAdb annotations

Publication identifier(s): 11260462
A known glcosomal (peroxisomal) kinetoplastid protein. Known to be a dimeric, essential component of glycosomes (PMID: 11260462). Localization: Peroxisomal (experimental)

Annotations by Jardim et al.

Glycosome membrane, Peroxin 11

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

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Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0016020	membrane	2	2
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	3

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Expansion

Sequence features

A4IBQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBQ8

Function

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Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	15
GO:0009987	cellular process	1	15
GO:0016043	cellular component organization	3	15
GO:0016559	peroxisome fission	6	15
GO:0048285	organelle fission	5	15
GO:0071840	cellular component organization or biogenesis	2	15

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	177	179	PF00675	0.291
CLV_PCSK_KEX2_1	177	179	PF00082	0.289
CLV_PCSK_SKI1_1	137	141	PF00082	0.410
CLV_PCSK_SKI1_1	178	182	PF00082	0.277
CLV_PCSK_SKI1_1	64	68	PF00082	0.262
DOC_CDC14_PxL_1	73	81	PF14671	0.553
DOC_CKS1_1	232	237	PF01111	0.396
DOC_CYCLIN_yCln2_LP_2	224	230	PF00134	0.341
DOC_CYCLIN_yCln2_LP_2	37	43	PF00134	0.469
DOC_MAPK_gen_1	174	183	PF00069	0.470

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J0	Leptomonas seymouri	72%	100%
A0A0N1IJQ7	Leptomonas seymouri	26%	100%
A0A1X0P585	Trypanosomatidae	27%	100%
A0A1X0P5I2	Trypanosomatidae	27%	100%
A0A3R7K892	Trypanosoma rangeli	25%	100%
A0A3R7MWK0	Trypanosoma rangeli	26%	100%
A0A3S7X9W6	Leishmania donovani	99%	100%
A4HN40	Leishmania braziliensis	84%	100%
A4HN41	Leishmania braziliensis	25%	100%
C9ZYW5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%

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