Putative DNA repair protein RAD2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA repair protein RAD2 - putative

Species:

Leishmania infantum

UniProt:

A4IBP8_LEIIN

TriTrypDb:

LINF_350041300

Length:

930

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4IBP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBP8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006289	nucleotide-excision repair	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003697	single-stranded DNA binding	5	7
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0005488	binding	1	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004520	DNA endonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0017108	5'-flap endonuclease activity	7	1
GO:0048256	flap endonuclease activity	6	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.567
CLV_C14_Caspase3-7	462	466	PF00656	0.625
CLV_NRD_NRD_1	103	105	PF00675	0.529
CLV_NRD_NRD_1	208	210	PF00675	0.745
CLV_NRD_NRD_1	212	214	PF00675	0.661
CLV_NRD_NRD_1	215	217	PF00675	0.583
CLV_NRD_NRD_1	265	267	PF00675	0.578
CLV_NRD_NRD_1	612	614	PF00675	0.564
CLV_NRD_NRD_1	772	774	PF00675	0.351
CLV_NRD_NRD_1	869	871	PF00675	0.341
CLV_NRD_NRD_1	875	877	PF00675	0.360
CLV_NRD_NRD_1	88	90	PF00675	0.268
CLV_NRD_NRD_1	892	894	PF00675	0.420
CLV_PCSK_FUR_1	213	217	PF00082	0.613
CLV_PCSK_KEX2_1	102	104	PF00082	0.535
CLV_PCSK_KEX2_1	190	192	PF00082	0.625
CLV_PCSK_KEX2_1	207	209	PF00082	0.613
CLV_PCSK_KEX2_1	212	214	PF00082	0.596
CLV_PCSK_KEX2_1	215	217	PF00082	0.589
CLV_PCSK_KEX2_1	25	27	PF00082	0.279
CLV_PCSK_KEX2_1	265	267	PF00082	0.551
CLV_PCSK_KEX2_1	772	774	PF00082	0.349
CLV_PCSK_KEX2_1	875	877	PF00082	0.349
CLV_PCSK_KEX2_1	88	90	PF00082	0.269
CLV_PCSK_KEX2_1	892	894	PF00082	0.567
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.497
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.625
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.279
CLV_PCSK_PC7_1	204	210	PF00082	0.723
CLV_PCSK_PC7_1	98	104	PF00082	0.443
CLV_PCSK_SKI1_1	106	110	PF00082	0.481
CLV_PCSK_SKI1_1	306	310	PF00082	0.551
CLV_PCSK_SKI1_1	59	63	PF00082	0.279
CLV_PCSK_SKI1_1	693	697	PF00082	0.335
CLV_PCSK_SKI1_1	717	721	PF00082	0.322
CLV_PCSK_SKI1_1	773	777	PF00082	0.351
CLV_PCSK_SKI1_1	892	896	PF00082	0.519
CLV_PCSK_SKI1_1	906	910	PF00082	0.538
DEG_APCC_DBOX_1	484	492	PF00400	0.643
DEG_COP1_1	143	151	PF00400	0.602
DEG_SPOP_SBC_1	177	181	PF00917	0.601
DEG_SPOP_SBC_1	416	420	PF00917	0.633
DEG_SPOP_SBC_1	561	565	PF00917	0.568
DEG_SPOP_SBC_1	761	765	PF00917	0.403
DEG_SPOP_SBC_1	77	81	PF00917	0.503
DOC_CYCLIN_yCln2_LP_2	857	863	PF00134	0.403
DOC_MAPK_DCC_7	550	560	PF00069	0.633
DOC_MAPK_gen_1	102	110	PF00069	0.510
DOC_MAPK_gen_1	550	558	PF00069	0.629
DOC_MAPK_gen_1	629	637	PF00069	0.604
DOC_MAPK_gen_1	772	778	PF00069	0.351
DOC_MAPK_MEF2A_6	552	560	PF00069	0.629
DOC_MAPK_MEF2A_6	629	637	PF00069	0.552
DOC_MAPK_RevD_3	13	26	PF00069	0.540
DOC_PP1_RVXF_1	60	66	PF00149	0.479
DOC_PP2B_LxvP_1	200	203	PF13499	0.724
DOC_PP2B_LxvP_1	364	367	PF13499	0.639
DOC_PP4_FxxP_1	261	264	PF00568	0.514
DOC_PP4_FxxP_1	74	77	PF00568	0.503
DOC_USP7_MATH_1	126	130	PF00917	0.625
DOC_USP7_MATH_1	147	151	PF00917	0.682
DOC_USP7_MATH_1	177	181	PF00917	0.768
DOC_USP7_MATH_1	252	256	PF00917	0.538
DOC_USP7_MATH_1	323	327	PF00917	0.651
DOC_USP7_MATH_1	424	428	PF00917	0.590
DOC_USP7_MATH_1	450	454	PF00917	0.566
DOC_USP7_MATH_1	503	507	PF00917	0.677
DOC_USP7_MATH_1	582	586	PF00917	0.521
DOC_USP7_MATH_1	722	726	PF00917	0.318
DOC_USP7_MATH_1	761	765	PF00917	0.415
DOC_USP7_MATH_1	77	81	PF00917	0.482
DOC_USP7_MATH_2	494	500	PF00917	0.637
DOC_WW_Pin1_4	369	374	PF00397	0.648
DOC_WW_Pin1_4	395	400	PF00397	0.652
DOC_WW_Pin1_4	518	523	PF00397	0.551
DOC_WW_Pin1_4	595	600	PF00397	0.574
DOC_WW_Pin1_4	653	658	PF00397	0.318
DOC_WW_Pin1_4	832	837	PF00397	0.318
DOC_WW_Pin1_4	856	861	PF00397	0.403
LIG_14-3-3_CanoR_1	265	269	PF00244	0.691
LIG_14-3-3_CanoR_1	392	401	PF00244	0.566
LIG_14-3-3_CanoR_1	550	555	PF00244	0.682
LIG_14-3-3_CanoR_1	613	618	PF00244	0.724
LIG_14-3-3_CanoR_1	780	786	PF00244	0.334
LIG_14-3-3_CanoR_1	88	92	PF00244	0.503
LIG_14-3-3_CanoR_1	884	894	PF00244	0.549
LIG_Actin_WH2_2	219	234	PF00022	0.563
LIG_BIR_III_4	307	311	PF00653	0.559
LIG_BRCT_BRCA1_1	447	451	PF00533	0.679
LIG_CSL_BTD_1	364	367	PF09270	0.633
LIG_deltaCOP1_diTrp_1	476	482	PF00928	0.604
LIG_deltaCOP1_diTrp_1	843	850	PF00928	0.390
LIG_FHA_1	307	313	PF00498	0.627
LIG_FHA_1	375	381	PF00498	0.666
LIG_FHA_1	384	390	PF00498	0.565
LIG_FHA_1	411	417	PF00498	0.743
LIG_FHA_1	481	487	PF00498	0.542
LIG_FHA_1	551	557	PF00498	0.628
LIG_FHA_1	574	580	PF00498	0.607
LIG_FHA_1	628	634	PF00498	0.654
LIG_FHA_1	687	693	PF00498	0.318
LIG_FHA_1	714	720	PF00498	0.322
LIG_FHA_1	730	736	PF00498	0.415
LIG_FHA_2	240	246	PF00498	0.506
LIG_FHA_2	265	271	PF00498	0.532
LIG_FHA_2	332	338	PF00498	0.629
LIG_FHA_2	460	466	PF00498	0.617
LIG_FHA_2	750	756	PF00498	0.403
LIG_LIR_Apic_2	258	264	PF02991	0.519
LIG_LIR_Gen_1	784	792	PF02991	0.318
LIG_LIR_Gen_1	834	842	PF02991	0.352
LIG_LIR_Gen_1	843	851	PF02991	0.349
LIG_LIR_LC3C_4	745	749	PF02991	0.297
LIG_LIR_Nem_3	11	16	PF02991	0.479
LIG_LIR_Nem_3	476	482	PF02991	0.558
LIG_LIR_Nem_3	536	542	PF02991	0.611
LIG_LIR_Nem_3	784	788	PF02991	0.318
LIG_LIR_Nem_3	834	840	PF02991	0.352
LIG_LIR_Nem_3	843	847	PF02991	0.349
LIG_MYND_1	401	405	PF01753	0.654
LIG_NRBOX	487	493	PF00104	0.633
LIG_NRBOX	5	11	PF00104	0.479
LIG_NRBOX	722	728	PF00104	0.318
LIG_Pex14_1	34	38	PF04695	0.479
LIG_REV1ctd_RIR_1	823	833	PF16727	0.351
LIG_RPA_C_Fungi	93	105	PF08784	0.449
LIG_SH2_CRK	539	543	PF00017	0.694
LIG_SH2_SRC	539	542	PF00017	0.616
LIG_SH2_STAT5	600	603	PF00017	0.530
LIG_SH2_STAT5	653	656	PF00017	0.318
LIG_SH2_STAT5	731	734	PF00017	0.307
LIG_SH3_2	286	291	PF14604	0.523
LIG_SH3_3	13	19	PF00018	0.318
LIG_SH3_3	283	289	PF00018	0.596
LIG_SH3_3	553	559	PF00018	0.592
LIG_SH3_3	576	582	PF00018	0.606
LIG_SH3_3	630	636	PF00018	0.545
LIG_SH3_3	651	657	PF00018	0.333
LIG_SH3_3	775	781	PF00018	0.318
LIG_SUMO_SIM_anti_2	343	349	PF11976	0.710
LIG_SUMO_SIM_par_1	294	299	PF11976	0.752
LIG_SUMO_SIM_par_1	343	349	PF11976	0.615
LIG_SUMO_SIM_par_1	641	647	PF11976	0.344
LIG_SUMO_SIM_par_1	718	725	PF11976	0.327
LIG_TRAF2_1	195	198	PF00917	0.690
LIG_TRAF2_1	302	305	PF00917	0.532
LIG_TRAF2_1	456	459	PF00917	0.809
LIG_TRAF2_1	784	787	PF00917	0.377
LIG_TRFH_1	653	657	PF08558	0.318
LIG_WRC_WIRS_1	10	15	PF05994	0.318
LIG_WW_3	620	624	PF00397	0.641
LIG_WW_3	780	784	PF00397	0.351
MOD_CDK_SPK_2	518	523	PF00069	0.553
MOD_CDK_SPxxK_3	595	602	PF00069	0.575
MOD_CK1_1	180	186	PF00069	0.779
MOD_CK1_1	255	261	PF00069	0.475
MOD_CK1_1	299	305	PF00069	0.671
MOD_CK1_1	325	331	PF00069	0.618
MOD_CK1_1	368	374	PF00069	0.671
MOD_CK1_1	393	399	PF00069	0.610
MOD_CK1_1	410	416	PF00069	0.612
MOD_CK1_1	419	425	PF00069	0.651
MOD_CK1_1	440	446	PF00069	0.790
MOD_CK1_1	453	459	PF00069	0.539
MOD_CK1_1	505	511	PF00069	0.643
MOD_CK1_1	521	527	PF00069	0.529
MOD_CK1_1	563	569	PF00069	0.614
MOD_CK1_1	608	614	PF00069	0.568
MOD_CK2_1	239	245	PF00069	0.487
MOD_CK2_1	264	270	PF00069	0.515
MOD_CK2_1	299	305	PF00069	0.590
MOD_CK2_1	312	318	PF00069	0.647
MOD_CK2_1	331	337	PF00069	0.616
MOD_CK2_1	426	432	PF00069	0.719
MOD_CK2_1	453	459	PF00069	0.805
MOD_CK2_1	563	569	PF00069	0.588
MOD_CK2_1	653	659	PF00069	0.318
MOD_CK2_1	749	755	PF00069	0.403
MOD_CK2_1	781	787	PF00069	0.377
MOD_Cter_Amidation	188	191	PF01082	0.609
MOD_Cter_Amidation	23	26	PF01082	0.318
MOD_GlcNHglycan	128	131	PF01048	0.586
MOD_GlcNHglycan	183	186	PF01048	0.751
MOD_GlcNHglycan	222	225	PF01048	0.567
MOD_GlcNHglycan	280	283	PF01048	0.641
MOD_GlcNHglycan	298	301	PF01048	0.689
MOD_GlcNHglycan	318	321	PF01048	0.599
MOD_GlcNHglycan	325	328	PF01048	0.740
MOD_GlcNHglycan	368	371	PF01048	0.727
MOD_GlcNHglycan	381	384	PF01048	0.592
MOD_GlcNHglycan	422	425	PF01048	0.678
MOD_GlcNHglycan	428	431	PF01048	0.641
MOD_GlcNHglycan	447	450	PF01048	0.507
MOD_GlcNHglycan	579	582	PF01048	0.582
MOD_GlcNHglycan	602	605	PF01048	0.775
MOD_GlcNHglycan	710	713	PF01048	0.322
MOD_GlcNHglycan	755	758	PF01048	0.304
MOD_GlcNHglycan	764	767	PF01048	0.367
MOD_GSK3_1	176	183	PF00069	0.690
MOD_GSK3_1	220	227	PF00069	0.539
MOD_GSK3_1	252	259	PF00069	0.537
MOD_GSK3_1	312	319	PF00069	0.601
MOD_GSK3_1	323	330	PF00069	0.622
MOD_GSK3_1	365	372	PF00069	0.784
MOD_GSK3_1	379	386	PF00069	0.576
MOD_GSK3_1	403	410	PF00069	0.687
MOD_GSK3_1	411	418	PF00069	0.626
MOD_GSK3_1	420	427	PF00069	0.640
MOD_GSK3_1	433	440	PF00069	0.637
MOD_GSK3_1	441	448	PF00069	0.702
MOD_GSK3_1	450	457	PF00069	0.628
MOD_GSK3_1	498	505	PF00069	0.614
MOD_GSK3_1	514	521	PF00069	0.540
MOD_GSK3_1	546	553	PF00069	0.656
MOD_GSK3_1	573	580	PF00069	0.745
MOD_GSK3_1	608	615	PF00069	0.588
MOD_GSK3_1	749	756	PF00069	0.325
MOD_N-GLC_1	573	578	PF02516	0.580
MOD_NEK2_1	175	180	PF00069	0.658
MOD_NEK2_1	253	258	PF00069	0.572
MOD_NEK2_1	438	443	PF00069	0.542
MOD_NEK2_1	560	565	PF00069	0.757
MOD_NEK2_1	696	701	PF00069	0.351
MOD_NEK2_1	9	14	PF00069	0.302
MOD_PIKK_1	224	230	PF00454	0.600
MOD_PIKK_1	299	305	PF00454	0.676
MOD_PIKK_1	390	396	PF00454	0.712
MOD_PIKK_1	480	486	PF00454	0.587
MOD_PKA_1	613	619	PF00069	0.561
MOD_PKA_1	892	898	PF00069	0.490
MOD_PKA_2	181	187	PF00069	0.681
MOD_PKA_2	264	270	PF00069	0.515
MOD_PKA_2	612	618	PF00069	0.573
MOD_PKA_2	87	93	PF00069	0.351
MOD_PKA_2	883	889	PF00069	0.350
MOD_PKA_2	892	898	PF00069	0.564
MOD_PKB_1	191	199	PF00069	0.690
MOD_Plk_1	29	35	PF00069	0.318
MOD_Plk_1	383	389	PF00069	0.605
MOD_Plk_1	573	579	PF00069	0.593
MOD_Plk_1	705	711	PF00069	0.403
MOD_Plk_2-3	337	343	PF00069	0.689
MOD_Plk_2-3	454	460	PF00069	0.634
MOD_Plk_4	226	232	PF00069	0.597
MOD_Plk_4	256	262	PF00069	0.536
MOD_Plk_4	29	35	PF00069	0.465
MOD_Plk_4	412	418	PF00069	0.640
MOD_Plk_4	687	693	PF00069	0.290
MOD_Plk_4	715	721	PF00069	0.322
MOD_Plk_4	722	728	PF00069	0.333
MOD_Plk_4	790	796	PF00069	0.351
MOD_ProDKin_1	369	375	PF00069	0.650
MOD_ProDKin_1	395	401	PF00069	0.653
MOD_ProDKin_1	518	524	PF00069	0.551
MOD_ProDKin_1	595	601	PF00069	0.574
MOD_ProDKin_1	653	659	PF00069	0.318
MOD_ProDKin_1	832	838	PF00069	0.318
MOD_ProDKin_1	856	862	PF00069	0.403
MOD_SUMO_rev_2	119	126	PF00179	0.488
MOD_SUMO_rev_2	46	53	PF00179	0.297
MOD_SUMO_rev_2	608	616	PF00179	0.540
MOD_SUMO_rev_2	823	830	PF00179	0.351
TRG_DiLeu_BaEn_1	343	348	PF01217	0.698
TRG_DiLeu_BaEn_4	197	203	PF01217	0.661
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.308
TRG_ENDOCYTIC_2	539	542	PF00928	0.693
TRG_ER_diArg_1	103	106	PF00400	0.593
TRG_ER_diArg_1	207	209	PF00400	0.739
TRG_ER_diArg_1	212	215	PF00400	0.607
TRG_ER_diArg_1	264	266	PF00400	0.527
TRG_ER_diArg_1	38	41	PF00400	0.318
TRG_ER_diArg_1	771	773	PF00400	0.349
TRG_ER_diArg_1	846	849	PF00400	0.403
TRG_ER_diArg_1	874	876	PF00400	0.508
TRG_ER_diArg_1	892	894	PF00400	0.401
TRG_ER_diArg_1	903	906	PF00400	0.573
TRG_NLS_Bipartite_1	88	106	PF00514	0.488
TRG_NLS_MonoExtC_3	101	106	PF00514	0.490
TRG_Pf-PMV_PEXEL_1	215	220	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	808	812	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	892	896	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Y4	Leptomonas seymouri	49%	99%
A0A3S5H802	Leishmania donovani	100%	100%
A4HN29	Leishmania braziliensis	70%	100%
E9AFI3	Leishmania major	90%	100%
E9B6N8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%