Putative DNA repair protein RAD2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA repair protein RAD2 - putative

Species:

Leishmania infantum

UniProt:

A4IBP8_LEIIN

TriTrypDb:

LINF_350041300

Length:

930

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7

Previous1Next

Expansion

Sequence features

A4IBP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBP8

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006289	nucleotide-excision repair	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7

Previous1 2 3Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003697	single-stranded DNA binding	5	7
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0004520	DNA endonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0005488	binding	1	7
GO:0016787	hydrolase activity	2	7

Previous1 2 3Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.567
CLV_C14_Caspase3-7	462	466	PF00656	0.625
CLV_NRD_NRD_1	103	105	PF00675	0.529
CLV_NRD_NRD_1	208	210	PF00675	0.745
CLV_NRD_NRD_1	212	214	PF00675	0.661
CLV_NRD_NRD_1	215	217	PF00675	0.583
CLV_NRD_NRD_1	265	267	PF00675	0.578
CLV_NRD_NRD_1	612	614	PF00675	0.564
CLV_NRD_NRD_1	772	774	PF00675	0.351
CLV_NRD_NRD_1	869	871	PF00675	0.341

Previous1 2 3 4 5…29Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Y4	Leptomonas seymouri	49%	99%
A0A3S5H802	Leishmania donovani	100%	100%
A4HN29	Leishmania braziliensis	70%	100%
E9AFI3	Leishmania major	90%	100%
E9B6N8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%

Previous1Next