Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase - putative

Species:

Leishmania infantum

UniProt:

A4IBP7_LEIIN

TriTrypDb:

LINF_350040600

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBP7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.651
CLV_NRD_NRD_1	466	468	PF00675	0.571
CLV_NRD_NRD_1	558	560	PF00675	0.465
CLV_NRD_NRD_1	81	83	PF00675	0.681
CLV_PCSK_KEX2_1	110	112	PF00082	0.673
CLV_PCSK_KEX2_1	123	125	PF00082	0.542
CLV_PCSK_KEX2_1	465	467	PF00082	0.547
CLV_PCSK_KEX2_1	558	560	PF00082	0.465
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.673
CLV_PCSK_PC7_1	461	467	PF00082	0.320
CLV_PCSK_SKI1_1	83	87	PF00082	0.606
DOC_CYCLIN_RxL_1	224	235	PF00134	0.552
DOC_MAPK_gen_1	123	131	PF00069	0.560
DOC_MAPK_gen_1	435	443	PF00069	0.405
DOC_MAPK_gen_1	82	88	PF00069	0.546
DOC_MAPK_MEF2A_6	286	295	PF00069	0.591
DOC_MAPK_MEF2A_6	380	389	PF00069	0.344
DOC_MAPK_MEF2A_6	522	530	PF00069	0.476
DOC_PP1_RVXF_1	550	557	PF00149	0.418
DOC_PP2B_PxIxI_1	382	388	PF00149	0.405
DOC_USP7_MATH_1	115	119	PF00917	0.621
DOC_USP7_MATH_1	454	458	PF00917	0.344
DOC_USP7_MATH_1	501	505	PF00917	0.593
DOC_USP7_UBL2_3	338	342	PF12436	0.405
DOC_WW_Pin1_4	161	166	PF00397	0.629
DOC_WW_Pin1_4	175	180	PF00397	0.522
DOC_WW_Pin1_4	197	202	PF00397	0.545
DOC_WW_Pin1_4	221	226	PF00397	0.602
DOC_WW_Pin1_4	267	272	PF00397	0.463
DOC_WW_Pin1_4	279	284	PF00397	0.369
DOC_WW_Pin1_4	417	422	PF00397	0.344
DOC_WW_Pin1_4	42	47	PF00397	0.612
DOC_WW_Pin1_4	53	58	PF00397	0.569
LIG_14-3-3_CanoR_1	116	121	PF00244	0.668
LIG_14-3-3_CanoR_1	123	129	PF00244	0.664
LIG_14-3-3_CanoR_1	13	21	PF00244	0.571
LIG_14-3-3_CanoR_1	143	148	PF00244	0.501
LIG_14-3-3_CanoR_1	202	209	PF00244	0.575
LIG_14-3-3_CanoR_1	477	486	PF00244	0.511
LIG_14-3-3_CanoR_1	489	498	PF00244	0.487
LIG_14-3-3_CanoR_1	539	547	PF00244	0.410
LIG_Actin_WH2_2	423	440	PF00022	0.260
LIG_BIR_III_2	206	210	PF00653	0.553
LIG_Clathr_ClatBox_1	128	132	PF01394	0.542
LIG_Clathr_ClatBox_1	352	356	PF01394	0.380
LIG_DLG_GKlike_1	124	131	PF00625	0.641
LIG_FHA_1	182	188	PF00498	0.575
LIG_FHA_1	21	27	PF00498	0.639
LIG_FHA_1	290	296	PF00498	0.443
LIG_FHA_1	302	308	PF00498	0.310
LIG_FHA_1	4	10	PF00498	0.522
LIG_FHA_1	438	444	PF00498	0.365
LIG_FHA_1	501	507	PF00498	0.653
LIG_FHA_1	523	529	PF00498	0.471
LIG_FHA_1	54	60	PF00498	0.715
LIG_FHA_2	232	238	PF00498	0.636
LIG_FHA_2	494	500	PF00498	0.598
LIG_LIR_Gen_1	348	358	PF02991	0.405
LIG_LIR_Gen_1	514	524	PF02991	0.472
LIG_LIR_Nem_3	101	107	PF02991	0.677
LIG_LIR_Nem_3	334	340	PF02991	0.362
LIG_LIR_Nem_3	348	353	PF02991	0.315
LIG_LIR_Nem_3	356	361	PF02991	0.383
LIG_LIR_Nem_3	381	385	PF02991	0.432
LIG_LIR_Nem_3	514	520	PF02991	0.482
LIG_MYND_1	161	165	PF01753	0.602
LIG_MYND_1	279	283	PF01753	0.433
LIG_MYND_1	46	50	PF01753	0.607
LIG_PCNA_TLS_4	344	351	PF02747	0.405
LIG_PCNA_yPIPBox_3	438	452	PF02747	0.405
LIG_PTB_Apo_2	271	278	PF02174	0.507
LIG_RPA_C_Fungi	119	131	PF08784	0.557
LIG_SH2_CRK	104	108	PF00017	0.602
LIG_SH2_CRK	43	47	PF00017	0.545
LIG_SH2_CRK	455	459	PF00017	0.405
LIG_SH2_STAP1	370	374	PF00017	0.405
LIG_SH2_STAT5	280	283	PF00017	0.494
LIG_SH2_STAT5	426	429	PF00017	0.320
LIG_SH2_STAT5	43	46	PF00017	0.568
LIG_SH3_3	22	28	PF00018	0.674
LIG_SH3_3	220	226	PF00018	0.540
LIG_SH3_3	304	310	PF00018	0.392
LIG_SH3_3	448	454	PF00018	0.405
LIG_SUMO_SIM_anti_2	126	133	PF11976	0.620
LIG_SUMO_SIM_par_1	250	255	PF11976	0.384
LIG_SUMO_SIM_par_1	291	296	PF11976	0.405
LIG_SUMO_SIM_par_1	439	444	PF11976	0.405
LIG_SUMO_SIM_par_1	5	10	PF11976	0.499
LIG_TRAF2_1	233	236	PF00917	0.585
LIG_WRC_WIRS_1	546	551	PF05994	0.444
MOD_CDC14_SPxK_1	164	167	PF00782	0.635
MOD_CDC14_SPxK_1	224	227	PF00782	0.517
MOD_CDK_SPK_2	197	202	PF00069	0.578
MOD_CDK_SPxK_1	161	167	PF00069	0.632
MOD_CDK_SPxK_1	221	227	PF00069	0.519
MOD_CDK_SPxxK_3	279	286	PF00069	0.389
MOD_CDK_SPxxK_3	42	49	PF00069	0.545
MOD_CK1_1	119	125	PF00069	0.588
MOD_CK1_1	15	21	PF00069	0.661
MOD_CK1_1	215	221	PF00069	0.615
MOD_CK1_1	282	288	PF00069	0.418
MOD_CK1_1	331	337	PF00069	0.417
MOD_CK1_1	392	398	PF00069	0.637
MOD_CK1_1	493	499	PF00069	0.602
MOD_CK1_1	95	101	PF00069	0.650
MOD_CK2_1	231	237	PF00069	0.585
MOD_CK2_1	493	499	PF00069	0.644
MOD_CK2_1	538	544	PF00069	0.476
MOD_Cter_Amidation	108	111	PF01082	0.672
MOD_GlcNHglycan	107	110	PF01048	0.623
MOD_GlcNHglycan	145	148	PF01048	0.635
MOD_GlcNHglycan	17	20	PF01048	0.634
MOD_GlcNHglycan	172	176	PF01048	0.658
MOD_GlcNHglycan	333	336	PF01048	0.426
MOD_GlcNHglycan	394	397	PF01048	0.705
MOD_GlcNHglycan	492	495	PF01048	0.638
MOD_GSK3_1	115	122	PF00069	0.581
MOD_GSK3_1	155	162	PF00069	0.703
MOD_GSK3_1	171	178	PF00069	0.509
MOD_GSK3_1	191	198	PF00069	0.515
MOD_GSK3_1	227	234	PF00069	0.565
MOD_GSK3_1	297	304	PF00069	0.435
MOD_GSK3_1	3	10	PF00069	0.649
MOD_GSK3_1	327	334	PF00069	0.392
MOD_GSK3_1	94	101	PF00069	0.675
MOD_N-GLC_1	267	272	PF02516	0.463
MOD_N-GLC_1	99	104	PF02516	0.645
MOD_N-GLC_2	447	449	PF02516	0.320
MOD_NEK2_1	195	200	PF00069	0.576
MOD_NEK2_1	252	257	PF00069	0.487
MOD_NEK2_1	297	302	PF00069	0.405
MOD_NEK2_1	30	35	PF00069	0.623
MOD_NEK2_1	36	41	PF00069	0.588
MOD_NEK2_1	363	368	PF00069	0.405
MOD_NEK2_1	389	394	PF00069	0.534
MOD_NEK2_1	437	442	PF00069	0.405
MOD_NEK2_1	478	483	PF00069	0.541
MOD_NEK2_1	510	515	PF00069	0.574
MOD_NEK2_1	550	555	PF00069	0.472
MOD_NEK2_1	59	64	PF00069	0.670
MOD_NEK2_1	99	104	PF00069	0.722
MOD_NEK2_2	454	459	PF00069	0.344
MOD_PIKK_1	252	258	PF00454	0.408
MOD_PIKK_1	398	404	PF00454	0.580
MOD_PIKK_1	478	484	PF00454	0.507
MOD_PIKK_1	538	544	PF00454	0.415
MOD_PIKK_1	59	65	PF00454	0.601
MOD_PKA_1	123	129	PF00069	0.597
MOD_PKA_2	115	121	PF00069	0.655
MOD_PKA_2	12	18	PF00069	0.563
MOD_PKA_2	123	129	PF00069	0.621
MOD_PKA_2	142	148	PF00069	0.485
MOD_PKA_2	289	295	PF00069	0.405
MOD_PKA_2	437	443	PF00069	0.405
MOD_PKA_2	478	484	PF00069	0.507
MOD_PKA_2	538	544	PF00069	0.415
MOD_PKB_1	114	122	PF00069	0.618
MOD_Plk_1	297	303	PF00069	0.405
MOD_Plk_1	501	507	PF00069	0.607
MOD_Plk_1	522	528	PF00069	0.478
MOD_Plk_1	74	80	PF00069	0.685
MOD_Plk_1	99	105	PF00069	0.601
MOD_Plk_4	124	130	PF00069	0.556
MOD_Plk_4	227	233	PF00069	0.612
MOD_Plk_4	289	295	PF00069	0.405
MOD_Plk_4	297	303	PF00069	0.322
MOD_Plk_4	437	443	PF00069	0.263
MOD_Plk_4	522	528	PF00069	0.478
MOD_Plk_4	545	551	PF00069	0.449
MOD_ProDKin_1	161	167	PF00069	0.632
MOD_ProDKin_1	175	181	PF00069	0.522
MOD_ProDKin_1	197	203	PF00069	0.544
MOD_ProDKin_1	221	227	PF00069	0.603
MOD_ProDKin_1	267	273	PF00069	0.468
MOD_ProDKin_1	279	285	PF00069	0.374
MOD_ProDKin_1	417	423	PF00069	0.344
MOD_ProDKin_1	42	48	PF00069	0.613
MOD_ProDKin_1	53	59	PF00069	0.569
MOD_SUMO_for_1	166	169	PF00179	0.582
TRG_DiLeu_BaEn_1	523	528	PF01217	0.466
TRG_DiLeu_BaLyEn_6	248	253	PF01217	0.512
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.585
TRG_ENDOCYTIC_2	104	107	PF00928	0.626
TRG_ENDOCYTIC_2	337	340	PF00928	0.405
TRG_ENDOCYTIC_2	455	458	PF00928	0.477
TRG_ENDOCYTIC_2	517	520	PF00928	0.465
TRG_ER_diArg_1	465	467	PF00400	0.523
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	376	381	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIK2	Leishmania donovani	99%	100%
A4HN21	Leishmania braziliensis	59%	90%
E9AFH6	Leishmania major	88%	100%
E9B6N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%