KH domain-containing protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4IBP5_LEIIN

TriTrypDb:

Length:

221

Annotations

Annotations by Jardim et al.

RNA Processing, Pre-rRNA-processing PNO1 Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Phosphorylation

Promastigote: 81, 83, 84

Expansion

Sequence features

A4IBP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBP5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.695
CLV_C14_Caspase3-7	113	117	PF00656	0.308
CLV_PCSK_SKI1_1	34	38	PF00082	0.366
CLV_PCSK_SKI1_1	95	99	PF00082	0.363
DEG_Nend_Nbox_1	1	3	PF02207	0.559
DEG_SCF_FBW7_2	53	59	PF00400	0.314
DEG_SPOP_SBC_1	80	84	PF00917	0.529
DOC_CKS1_1	53	58	PF01111	0.304
DOC_MAPK_gen_1	47	53	PF00069	0.369
DOC_USP7_MATH_1	7	11	PF00917	0.674
DOC_USP7_MATH_1	80	84	PF00917	0.565
DOC_WW_Pin1_4	198	203	PF00397	0.324
DOC_WW_Pin1_4	52	57	PF00397	0.310
DOC_WW_Pin1_4	76	81	PF00397	0.526
LIG_Actin_WH2_2	62	79	PF00022	0.480
LIG_Clathr_ClatBox_1	120	124	PF01394	0.325
LIG_FHA_1	167	173	PF00498	0.320
LIG_FHA_1	182	188	PF00498	0.331
LIG_FHA_1	22	28	PF00498	0.538
LIG_FHA_1	31	37	PF00498	0.359
LIG_FHA_1	53	59	PF00498	0.330
LIG_FHA_1	69	75	PF00498	0.503
LIG_KLC1_Yacidic_2	124	129	PF13176	0.322
LIG_LIR_Nem_3	52	57	PF02991	0.318
LIG_Pex14_1	50	54	PF04695	0.327
LIG_SH2_CRK	207	211	PF00017	0.332
LIG_SH2_CRK	54	58	PF00017	0.309
LIG_SH2_SRC	127	130	PF00017	0.321
LIG_SH2_STAT5	127	130	PF00017	0.321
LIG_SH2_STAT5	161	164	PF00017	0.345
LIG_SH2_STAT5	207	210	PF00017	0.343
LIG_SH2_STAT5	54	57	PF00017	0.306
LIG_SH3_3	50	56	PF00018	0.424
LIG_SUMO_SIM_anti_2	116	122	PF11976	0.317
MOD_CDK_SPxxK_3	198	205	PF00069	0.330
MOD_CK1_1	79	85	PF00069	0.549
MOD_CK2_1	80	86	PF00069	0.601
MOD_GlcNHglycan	10	13	PF01048	0.529
MOD_GlcNHglycan	152	155	PF01048	0.346
MOD_GlcNHglycan	88	92	PF01048	0.550
MOD_GSK3_1	152	159	PF00069	0.347
MOD_GSK3_1	75	82	PF00069	0.396
MOD_GSK3_1	87	94	PF00069	0.448
MOD_N-GLC_1	143	148	PF02516	0.358
MOD_N-GLC_1	164	169	PF02516	0.328
MOD_N-GLC_1	91	96	PF02516	0.327
MOD_NEK2_1	181	186	PF00069	0.319
MOD_PIKK_1	181	187	PF00454	0.302
MOD_PK_1	70	76	PF00069	0.446
MOD_PKA_2	150	156	PF00069	0.364
MOD_PKA_2	30	36	PF00069	0.405
MOD_ProDKin_1	198	204	PF00069	0.328
MOD_ProDKin_1	52	58	PF00069	0.311
MOD_ProDKin_1	76	82	PF00069	0.527
MOD_SUMO_rev_2	10	20	PF00179	0.644
MOD_SUMO_rev_2	129	136	PF00179	0.330
TRG_ENDOCYTIC_2	207	210	PF00928	0.327
TRG_ENDOCYTIC_2	54	57	PF00928	0.306
TRG_ER_diArg_1	168	171	PF00400	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGS8	Leptomonas seymouri	86%	100%
A0A0S4IKD6	Bodo saltans	72%	100%
A0A1X0P5I9	Trypanosomatidae	77%	100%
A0A3Q8IVF4	Leishmania donovani	100%	100%
A0A422NR21	Trypanosoma rangeli	80%	100%
A4HN23	Leishmania braziliensis	93%	100%
A7RP64	Nematostella vectensis	54%	93%
C9ZYY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	81%	100%
E9AFH8	Leishmania major	97%	100%
E9B6N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
G0S3T2	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	48%	85%
O14044	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	92%
O18216	Caenorhabditis elegans	45%	80%
P0CO46	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	49%	83%
P0CO47	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	49%	83%
Q0UWT7	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	52%	84%
Q1DQZ5	Coccidioides immitis (strain RS)	52%	87%
Q29IG6	Drosophila pseudoobscura pseudoobscura	52%	93%
Q2UMG1	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	52%	85%
Q4IN63	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	53%	87%
Q4PMC9	Ixodes scapularis	47%	94%
Q4WNG7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	51%	88%
Q54K66	Dictyostelium discoideum	54%	92%
Q5ACM4	Candida albicans (strain SC5314 / ATCC MYA-2876)	51%	80%
Q5B0Z5	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	49%	86%
Q5F414	Gallus gallus	55%	91%
Q626C1	Caenorhabditis briggsae	46%	80%
Q6BJ75	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	49%	87%
Q6C7G0	Yarrowia lipolytica (strain CLIB 122 / E 150)	51%	86%
Q6CUA5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	51%	81%
Q6DDB9	Xenopus tropicalis	54%	94%
Q6FMB3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	50%	85%
Q6VBQ6	Oryzias latipes	52%	91%
Q6VBQ8	Rattus norvegicus	54%	89%
Q6VEU3	Danio rerio	51%	88%
Q753C6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	50%	83%
Q7YRD0	Bos taurus	54%	88%
Q8AVH4	Xenopus laevis	54%	94%
Q99216	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	51%	81%
Q9CPS7	Mus musculus	54%	89%
Q9NRX1	Homo sapiens	49%	88%
Q9VR89	Drosophila melanogaster	51%	92%
V5BY96	Trypanosoma cruzi	79%	100%