Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO - N-terminal domain/CRAL/TRIO domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4IBP3_LEIIN

TriTrypDb:

LINF_350041000

Length:

372

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IBP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBP3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005319	lipid transporter activity	2	1
GO:0005548	phospholipid transporter activity	3	1
GO:0008526	phosphatidylinositol transfer activity	5	1
GO:0120013	lipid transfer activity	3	1
GO:0120014	phospholipid transfer activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.594
CLV_NRD_NRD_1	178	180	PF00675	0.354
CLV_NRD_NRD_1	328	330	PF00675	0.560
CLV_NRD_NRD_1	363	365	PF00675	0.667
CLV_NRD_NRD_1	83	85	PF00675	0.550
CLV_PCSK_KEX2_1	356	358	PF00082	0.678
CLV_PCSK_KEX2_1	363	365	PF00082	0.575
CLV_PCSK_KEX2_1	83	85	PF00082	0.575
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.678
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.477
CLV_PCSK_SKI1_1	256	260	PF00082	0.482
CLV_PCSK_SKI1_1	334	338	PF00082	0.582
CLV_PCSK_SKI1_1	345	349	PF00082	0.651
DEG_MDM2_SWIB_1	251	259	PF02201	0.366
DOC_CKS1_1	14	19	PF01111	0.529
DOC_CKS1_1	309	314	PF01111	0.499
DOC_MAPK_FxFP_2	38	41	PF00069	0.422
DOC_MAPK_MEF2A_6	220	227	PF00069	0.433
DOC_PP1_RVXF_1	164	171	PF00149	0.347
DOC_PP1_RVXF_1	267	273	PF00149	0.349
DOC_PP2B_LxvP_1	257	260	PF13499	0.451
DOC_PP2B_LxvP_1	31	34	PF13499	0.480
DOC_PP4_FxxP_1	38	41	PF00568	0.407
DOC_PP4_FxxP_1	47	50	PF00568	0.339
DOC_USP7_MATH_1	15	19	PF00917	0.740
DOC_USP7_MATH_1	277	281	PF00917	0.541
DOC_USP7_MATH_2	2	8	PF00917	0.711
DOC_USP7_UBL2_3	330	334	PF12436	0.614
DOC_USP7_UBL2_3	337	341	PF12436	0.614
DOC_USP7_UBL2_3	344	348	PF12436	0.612
DOC_USP7_UBL2_3	355	359	PF12436	0.623
DOC_WW_Pin1_4	13	18	PF00397	0.722
DOC_WW_Pin1_4	178	183	PF00397	0.368
DOC_WW_Pin1_4	308	313	PF00397	0.491
LIG_CSL_BTD_1	314	317	PF09270	0.504
LIG_deltaCOP1_diTrp_1	202	210	PF00928	0.347
LIG_EVH1_2	247	251	PF00568	0.388
LIG_FHA_1	309	315	PF00498	0.494
LIG_FHA_2	135	141	PF00498	0.502
LIG_FHA_2	14	20	PF00498	0.683
LIG_FHA_2	206	212	PF00498	0.347
LIG_FHA_2	266	272	PF00498	0.479
LIG_LIR_Apic_2	304	309	PF02991	0.627
LIG_LIR_Apic_2	36	41	PF02991	0.405
LIG_LIR_Apic_2	45	50	PF02991	0.350
LIG_LIR_Gen_1	105	115	PF02991	0.302
LIG_LIR_Gen_1	122	131	PF02991	0.388
LIG_LIR_Gen_1	189	198	PF02991	0.372
LIG_LIR_Gen_1	202	210	PF02991	0.344
LIG_LIR_Gen_1	211	221	PF02991	0.298
LIG_LIR_Nem_3	105	110	PF02991	0.333
LIG_LIR_Nem_3	122	127	PF02991	0.370
LIG_LIR_Nem_3	189	193	PF02991	0.350
LIG_LIR_Nem_3	202	207	PF02991	0.344
LIG_LIR_Nem_3	208	213	PF02991	0.276
LIG_LIR_Nem_3	252	258	PF02991	0.355
LIG_LIR_Nem_3	283	288	PF02991	0.412
LIG_MYND_1	286	290	PF01753	0.521
LIG_Pex14_2	251	255	PF04695	0.331
LIG_Pex14_2	285	289	PF04695	0.397
LIG_SH2_CRK	306	310	PF00017	0.624
LIG_SH2_NCK_1	306	310	PF00017	0.624
LIG_SH2_SRC	112	115	PF00017	0.312
LIG_SH2_STAT5	112	115	PF00017	0.347
LIG_SH2_STAT5	296	299	PF00017	0.388
LIG_SH2_STAT5	51	54	PF00017	0.436
LIG_SH3_1	306	312	PF00018	0.617
LIG_SH3_3	11	17	PF00018	0.555
LIG_SH3_3	306	312	PF00018	0.606
LIG_TRAF2_1	55	58	PF00917	0.425
LIG_UBA3_1	250	256	PF00899	0.426
LIG_WRC_WIRS_1	187	192	PF05994	0.396
MOD_CDC14_SPxK_1	181	184	PF00782	0.368
MOD_CDK_SPxK_1	178	184	PF00069	0.368
MOD_CK1_1	7	13	PF00069	0.770
MOD_CK2_1	122	128	PF00069	0.469
MOD_CK2_1	134	140	PF00069	0.336
MOD_CK2_1	205	211	PF00069	0.347
MOD_CK2_1	265	271	PF00069	0.451
MOD_CK2_1	277	283	PF00069	0.540
MOD_CK2_1	51	57	PF00069	0.401
MOD_GlcNHglycan	9	12	PF01048	0.771
MOD_GSK3_1	134	141	PF00069	0.504
MOD_GSK3_1	205	212	PF00069	0.327
MOD_GSK3_1	277	284	PF00069	0.516
MOD_GSK3_1	291	298	PF00069	0.483
MOD_N-GLC_1	5	10	PF02516	0.669
MOD_NEK2_1	127	132	PF00069	0.415
MOD_NEK2_1	169	174	PF00069	0.426
MOD_NEK2_1	186	191	PF00069	0.148
MOD_PIKK_1	291	297	PF00454	0.461
MOD_Plk_1	127	133	PF00069	0.383
MOD_Plk_1	5	11	PF00069	0.752
MOD_Plk_2-3	122	128	PF00069	0.405
MOD_ProDKin_1	13	19	PF00069	0.718
MOD_ProDKin_1	178	184	PF00069	0.368
MOD_ProDKin_1	308	314	PF00069	0.481
MOD_SUMO_rev_2	100	104	PF00179	0.358
MOD_SUMO_rev_2	172	182	PF00179	0.451
MOD_SUMO_rev_2	214	222	PF00179	0.451
MOD_SUMO_rev_2	338	347	PF00179	0.611
MOD_SUMO_rev_2	87	92	PF00179	0.520
TRG_ENDOCYTIC_2	213	216	PF00928	0.347
TRG_ER_diArg_1	363	366	PF00400	0.621
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHG0	Leptomonas seymouri	74%	97%
A0A0S4IKI1	Bodo saltans	47%	100%
A0A1X0P588	Trypanosomatidae	53%	100%
A0A3Q8IJP6	Leishmania donovani	100%	100%
A0A3R7L5B2	Trypanosoma rangeli	55%	100%
A4HN25	Leishmania braziliensis	77%	100%
C9ZYY3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AFI0	Leishmania major	96%	100%
E9B6N5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q55CU8	Dictyostelium discoideum	22%	100%
V5BCV8	Trypanosoma cruzi	55%	100%