Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO - N-terminal domain/CRAL/TRIO domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4IBP3_LEIIN

TriTrypDb:

LINF_350041000

Length:

372

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4IBP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBP3

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005319	lipid transporter activity	2	1
GO:0005548	phospholipid transporter activity	3	1
GO:0008526	phosphatidylinositol transfer activity	5	1
GO:0120013	lipid transfer activity	3	1
GO:0120014	phospholipid transfer activity	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.594
CLV_NRD_NRD_1	178	180	PF00675	0.354
CLV_NRD_NRD_1	328	330	PF00675	0.560
CLV_NRD_NRD_1	363	365	PF00675	0.667
CLV_NRD_NRD_1	83	85	PF00675	0.550
CLV_PCSK_KEX2_1	356	358	PF00082	0.678
CLV_PCSK_KEX2_1	363	365	PF00082	0.575
CLV_PCSK_KEX2_1	83	85	PF00082	0.575
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.678
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.477

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHG0	Leptomonas seymouri	74%	97%
A0A0S4IKI1	Bodo saltans	47%	100%
A0A1X0P588	Trypanosomatidae	53%	100%
A0A3Q8IJP6	Leishmania donovani	100%	100%
A0A3R7L5B2	Trypanosoma rangeli	55%	100%
A4HN25	Leishmania braziliensis	77%	100%
C9ZYY3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AFI0	Leishmania major	96%	100%
E9B6N5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q55CU8	Dictyostelium discoideum	22%	100%

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