LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IBN9_LEIIN
TriTrypDb:
LINF_350040300
Length:
426

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBN9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBN9

PDB structure(s): 7ane_q

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 187 191 PF00656 0.493
CLV_C14_Caspase3-7 207 211 PF00656 0.406
CLV_C14_Caspase3-7 246 250 PF00656 0.643
CLV_C14_Caspase3-7 337 341 PF00656 0.550
CLV_NRD_NRD_1 102 104 PF00675 0.518
CLV_NRD_NRD_1 26 28 PF00675 0.436
CLV_NRD_NRD_1 268 270 PF00675 0.632
CLV_NRD_NRD_1 286 288 PF00675 0.397
CLV_NRD_NRD_1 302 304 PF00675 0.644
CLV_NRD_NRD_1 324 326 PF00675 0.611
CLV_NRD_NRD_1 57 59 PF00675 0.365
CLV_NRD_NRD_1 9 11 PF00675 0.474
CLV_NRD_NRD_1 99 101 PF00675 0.530
CLV_PCSK_FUR_1 100 104 PF00082 0.516
CLV_PCSK_KEX2_1 101 103 PF00082 0.439
CLV_PCSK_KEX2_1 26 28 PF00082 0.436
CLV_PCSK_KEX2_1 286 288 PF00082 0.496
CLV_PCSK_KEX2_1 302 304 PF00082 0.644
CLV_PCSK_KEX2_1 323 325 PF00082 0.619
CLV_PCSK_KEX2_1 362 364 PF00082 0.604
CLV_PCSK_KEX2_1 62 64 PF00082 0.369
CLV_PCSK_KEX2_1 9 11 PF00082 0.474
CLV_PCSK_PC1ET2_1 101 103 PF00082 0.439
CLV_PCSK_PC1ET2_1 323 325 PF00082 0.615
CLV_PCSK_PC1ET2_1 362 364 PF00082 0.604
CLV_PCSK_PC1ET2_1 62 64 PF00082 0.381
CLV_PCSK_PC7_1 282 288 PF00082 0.484
CLV_PCSK_PC7_1 58 64 PF00082 0.363
CLV_PCSK_SKI1_1 112 116 PF00082 0.430
CLV_PCSK_SKI1_1 129 133 PF00082 0.318
CLV_PCSK_SKI1_1 26 30 PF00082 0.406
CLV_PCSK_SKI1_1 298 302 PF00082 0.575
CLV_PCSK_SKI1_1 349 353 PF00082 0.531
DOC_CKS1_1 31 36 PF01111 0.375
DOC_CYCLIN_RxL_1 112 125 PF00134 0.406
DOC_MAPK_gen_1 116 122 PF00069 0.404
DOC_PP4_FxxP_1 301 304 PF00568 0.589
DOC_PP4_FxxP_1 31 34 PF00568 0.382
DOC_USP7_MATH_1 19 23 PF00917 0.448
DOC_USP7_MATH_1 245 249 PF00917 0.637
DOC_USP7_UBL2_3 294 298 PF12436 0.564
DOC_USP7_UBL2_3 345 349 PF12436 0.701
DOC_WW_Pin1_4 30 35 PF00397 0.392
DOC_WW_Pin1_4 309 314 PF00397 0.720
DOC_WW_Pin1_4 317 322 PF00397 0.616
DOC_WW_Pin1_4 385 390 PF00397 0.628
LIG_14-3-3_CanoR_1 137 145 PF00244 0.360
LIG_14-3-3_CanoR_1 400 407 PF00244 0.574
LIG_FHA_1 27 33 PF00498 0.404
LIG_FHA_1 401 407 PF00498 0.612
LIG_FHA_2 212 218 PF00498 0.576
LIG_FHA_2 276 282 PF00498 0.501
LIG_LIR_Apic_2 214 219 PF02991 0.598
LIG_LIR_Apic_2 29 34 PF02991 0.383
LIG_LIR_Apic_2 299 304 PF02991 0.631
LIG_LIR_Gen_1 51 61 PF02991 0.368
LIG_LIR_Nem_3 44 49 PF02991 0.365
LIG_LIR_Nem_3 51 57 PF02991 0.372
LIG_MYND_3 183 187 PF01753 0.445
LIG_MYND_3 379 383 PF01753 0.619
LIG_PDZ_Class_3 421 426 PF00595 0.601
LIG_Pex14_1 65 69 PF04695 0.358
LIG_SH2_CRK 16 20 PF00017 0.423
LIG_SH2_GRB2like 15 18 PF00017 0.431
LIG_SH2_NCK_1 135 139 PF00017 0.353
LIG_SH2_NCK_1 16 20 PF00017 0.407
LIG_SH2_NCK_1 216 220 PF00017 0.544
LIG_SH2_STAT3 150 153 PF00017 0.432
LIG_SH2_STAT3 61 64 PF00017 0.367
LIG_SH2_STAT5 150 153 PF00017 0.397
LIG_SH2_STAT5 167 170 PF00017 0.391
LIG_SH2_STAT5 289 292 PF00017 0.511
LIG_SH2_STAT5 76 79 PF00017 0.371
LIG_TRAF2_1 155 158 PF00917 0.465
LIG_TRAF2_1 235 238 PF00917 0.548
LIG_TRAF2_1 274 277 PF00917 0.594
LIG_TRAF2_1 278 281 PF00917 0.651
LIG_TRAF2_1 334 337 PF00917 0.544
LIG_WRC_WIRS_1 66 71 PF05994 0.361
MOD_CDK_SPxK_1 30 36 PF00069 0.385
MOD_CDK_SPxK_1 317 323 PF00069 0.629
MOD_CDK_SPxxK_3 317 324 PF00069 0.627
MOD_CK1_1 152 158 PF00069 0.517
MOD_CK1_1 381 387 PF00069 0.662
MOD_CK2_1 152 158 PF00069 0.473
MOD_CK2_1 17 23 PF00069 0.483
MOD_CK2_1 211 217 PF00069 0.554
MOD_CK2_1 232 238 PF00069 0.556
MOD_CK2_1 271 277 PF00069 0.620
MOD_Cter_Amidation 24 27 PF01082 0.455
MOD_GlcNHglycan 234 237 PF01048 0.496
MOD_GlcNHglycan 262 265 PF01048 0.675
MOD_GlcNHglycan 314 317 PF01048 0.625
MOD_GlcNHglycan 84 87 PF01048 0.509
MOD_GSK3_1 195 202 PF00069 0.525
MOD_GSK3_1 245 252 PF00069 0.500
MOD_GSK3_1 26 33 PF00069 0.394
MOD_GSK3_1 271 278 PF00069 0.492
MOD_GSK3_1 292 299 PF00069 0.533
MOD_GSK3_1 312 319 PF00069 0.577
MOD_GSK3_1 381 388 PF00069 0.636
MOD_LATS_1 24 30 PF00433 0.432
MOD_N-GLC_1 80 85 PF02516 0.367
MOD_NEK2_1 1 6 PF00069 0.563
MOD_NEK2_1 232 237 PF00069 0.501
MOD_NEK2_2 211 216 PF00069 0.594
MOD_NEK2_2 296 301 PF00069 0.581
MOD_NEK2_2 65 70 PF00069 0.362
MOD_PIKK_1 102 108 PF00454 0.531
MOD_PIKK_1 149 155 PF00454 0.419
MOD_PKA_1 102 108 PF00069 0.531
MOD_PKA_1 26 32 PF00069 0.414
MOD_PKA_1 324 330 PF00069 0.658
MOD_PKA_2 102 108 PF00069 0.531
MOD_PKA_2 136 142 PF00069 0.355
MOD_PKA_2 2 8 PF00069 0.500
MOD_PKA_2 26 32 PF00069 0.542
MOD_PKA_2 324 330 PF00069 0.670
MOD_PKB_1 100 108 PF00069 0.516
MOD_Plk_1 353 359 PF00069 0.600
MOD_Plk_4 211 217 PF00069 0.567
MOD_Plk_4 296 302 PF00069 0.620
MOD_ProDKin_1 30 36 PF00069 0.385
MOD_ProDKin_1 309 315 PF00069 0.724
MOD_ProDKin_1 317 323 PF00069 0.615
MOD_ProDKin_1 385 391 PF00069 0.630
MOD_SUMO_for_1 351 354 PF00179 0.564
MOD_SUMO_rev_2 220 230 PF00179 0.628
TRG_ENDOCYTIC_2 15 18 PF00928 0.431
TRG_ER_diArg_1 100 103 PF00400 0.518
TRG_ER_diArg_1 241 244 PF00400 0.569
TRG_ER_diArg_1 26 28 PF00400 0.538
TRG_ER_diArg_1 301 303 PF00400 0.655
TRG_ER_diArg_1 370 373 PF00400 0.542
TRG_NLS_Bipartite_1 100 120 PF00514 0.436
TRG_NLS_MonoCore_2 322 327 PF00514 0.623
TRG_NLS_MonoExtC_3 115 121 PF00514 0.411
TRG_NLS_MonoExtC_3 324 330 PF00514 0.539
TRG_NLS_MonoExtN_4 321 327 PF00514 0.568

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2P6 Leptomonas seymouri 78% 100%
A0A0S4IKL5 Bodo saltans 51% 91%
A0A1X0P5A6 Trypanosomatidae 61% 96%
A0A3Q8IPV2 Leishmania donovani 100% 100%
A0A3R7NKQ1 Trypanosoma rangeli 62% 97%
A4HN18 Leishmania braziliensis 93% 100%
C9ZYZ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 97%
E9AFH3 Leishmania major 97% 100%
E9B6M8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
V5BY99 Trypanosoma cruzi 61% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS