CULLIN_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IBN3_LEIIN

TriTrypDb:

LINF_350039700

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBN3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	489	493	PF00656	0.642
CLV_C14_Caspase3-7	539	543	PF00656	0.462
CLV_C14_Caspase3-7	81	85	PF00656	0.622
CLV_NRD_NRD_1	190	192	PF00675	0.542
CLV_NRD_NRD_1	284	286	PF00675	0.543
CLV_NRD_NRD_1	378	380	PF00675	0.448
CLV_NRD_NRD_1	516	518	PF00675	0.672
CLV_NRD_NRD_1	534	536	PF00675	0.376
CLV_PCSK_KEX2_1	164	166	PF00082	0.534
CLV_PCSK_KEX2_1	240	242	PF00082	0.555
CLV_PCSK_KEX2_1	284	286	PF00082	0.543
CLV_PCSK_KEX2_1	378	380	PF00082	0.448
CLV_PCSK_KEX2_1	516	518	PF00082	0.672
CLV_PCSK_KEX2_1	534	536	PF00082	0.376
CLV_PCSK_KEX2_1	56	58	PF00082	0.527
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.534
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.614
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.527
CLV_PCSK_SKI1_1	353	357	PF00082	0.547
CLV_PCSK_SKI1_1	402	406	PF00082	0.566
CLV_PCSK_SKI1_1	486	490	PF00082	0.656
CLV_PCSK_SKI1_1	508	512	PF00082	0.583
DEG_APCC_DBOX_1	362	370	PF00400	0.396
DEG_Nend_UBRbox_3	1	3	PF02207	0.618
DEG_SPOP_SBC_1	181	185	PF00917	0.545
DOC_CDC14_PxL_1	322	330	PF14671	0.370
DOC_CYCLIN_RxL_1	503	515	PF00134	0.579
DOC_MAPK_gen_1	133	141	PF00069	0.527
DOC_MAPK_gen_1	213	221	PF00069	0.574
DOC_MAPK_gen_1	378	386	PF00069	0.352
DOC_MAPK_gen_1	534	540	PF00069	0.468
DOC_MAPK_gen_1	99	108	PF00069	0.431
DOC_MAPK_MEF2A_6	102	110	PF00069	0.446
DOC_MAPK_MEF2A_6	357	366	PF00069	0.492
DOC_PP1_RVXF_1	218	224	PF00149	0.535
DOC_PP1_SILK_1	359	364	PF00149	0.497
DOC_PP2B_LxvP_1	434	437	PF13499	0.579
DOC_USP7_MATH_1	167	171	PF00917	0.627
DOC_USP7_MATH_1	181	185	PF00917	0.685
DOC_USP7_MATH_1	39	43	PF00917	0.662
DOC_USP7_MATH_1	392	396	PF00917	0.568
DOC_USP7_MATH_1	525	529	PF00917	0.594
DOC_USP7_MATH_1	553	557	PF00917	0.512
DOC_WW_Pin1_4	254	259	PF00397	0.606
DOC_WW_Pin1_4	397	402	PF00397	0.564
DOC_WW_Pin1_4	408	413	PF00397	0.587
DOC_WW_Pin1_4	496	501	PF00397	0.594
DOC_WW_Pin1_4	509	514	PF00397	0.690
LIG_14-3-3_CanoR_1	153	161	PF00244	0.502
LIG_14-3-3_CanoR_1	220	224	PF00244	0.571
LIG_14-3-3_CanoR_1	241	245	PF00244	0.521
LIG_14-3-3_CanoR_1	284	293	PF00244	0.473
LIG_14-3-3_CanoR_1	314	318	PF00244	0.628
LIG_14-3-3_CanoR_1	363	367	PF00244	0.408
LIG_14-3-3_CanoR_1	394	401	PF00244	0.521
LIG_14-3-3_CanoR_1	453	457	PF00244	0.443
LIG_14-3-3_CanoR_1	527	533	PF00244	0.564
LIG_BRCT_BRCA1_1	50	54	PF00533	0.545
LIG_BRCT_BRCA1_2	50	56	PF00533	0.534
LIG_eIF4E_1	323	329	PF01652	0.422
LIG_eIF4E_1	331	337	PF01652	0.337
LIG_FHA_1	209	215	PF00498	0.503
LIG_FHA_1	263	269	PF00498	0.473
LIG_FHA_1	356	362	PF00498	0.467
LIG_FHA_1	398	404	PF00498	0.615
LIG_FHA_1	467	473	PF00498	0.418
LIG_FHA_1	483	489	PF00498	0.568
LIG_FHA_1	91	97	PF00498	0.569
LIG_FHA_1	99	105	PF00498	0.420
LIG_FHA_2	122	128	PF00498	0.461
LIG_FHA_2	339	345	PF00498	0.416
LIG_FHA_2	487	493	PF00498	0.630
LIG_FHA_2	502	508	PF00498	0.542
LIG_FHA_2	527	533	PF00498	0.567
LIG_FHA_2	6	12	PF00498	0.550
LIG_LIR_Gen_1	222	231	PF02991	0.568
LIG_LIR_Gen_1	291	302	PF02991	0.531
LIG_LIR_Gen_1	456	466	PF02991	0.455
LIG_LIR_Gen_1	479	488	PF02991	0.581
LIG_LIR_Nem_3	222	226	PF02991	0.573
LIG_LIR_Nem_3	25	30	PF02991	0.587
LIG_LIR_Nem_3	291	297	PF02991	0.552
LIG_LIR_Nem_3	319	325	PF02991	0.422
LIG_LIR_Nem_3	4	9	PF02991	0.555
LIG_LIR_Nem_3	456	462	PF02991	0.454
LIG_LIR_Nem_3	479	483	PF02991	0.594
LIG_NRBOX	267	273	PF00104	0.481
LIG_NRBOX	365	371	PF00104	0.389
LIG_PDZ_Wminus1_1	584	586	PF00595	0.564
LIG_SH2_CRK	307	311	PF00017	0.433
LIG_SH2_CRK	377	381	PF00017	0.338
LIG_SH2_SRC	323	326	PF00017	0.473
LIG_SH2_STAP1	15	19	PF00017	0.508
LIG_SH2_STAP1	331	335	PF00017	0.435
LIG_SH2_STAT5	137	140	PF00017	0.533
LIG_SH2_STAT5	323	326	PF00017	0.404
LIG_SH2_STAT5	572	575	PF00017	0.453
LIG_SH2_STAT5	577	580	PF00017	0.400
LIG_SH3_3	18	24	PF00018	0.546
LIG_SH3_3	403	409	PF00018	0.566
LIG_SH3_3	430	436	PF00018	0.704
LIG_SH3_3	462	468	PF00018	0.424
LIG_SH3_3	55	61	PF00018	0.601
LIG_SUMO_SIM_anti_2	18	23	PF11976	0.579
LIG_SUMO_SIM_par_1	121	128	PF11976	0.501
LIG_SUMO_SIM_par_1	259	265	PF11976	0.566
LIG_SUMO_SIM_par_1	460	467	PF11976	0.423
LIG_TRAF2_1	124	127	PF00917	0.483
LIG_TRFH_1	278	282	PF08558	0.516
LIG_TRFH_1	322	326	PF08558	0.400
LIG_TYR_ITIM	305	310	PF00017	0.414
LIG_WRC_WIRS_1	537	542	PF05994	0.475
MOD_CDK_SPK_2	254	259	PF00069	0.606
MOD_CDK_SPK_2	397	402	PF00069	0.633
MOD_CDK_SPxxK_3	509	516	PF00069	0.668
MOD_CK1_1	175	181	PF00069	0.567
MOD_CK1_1	185	191	PF00069	0.517
MOD_CK1_1	25	31	PF00069	0.569
MOD_CK1_1	32	38	PF00069	0.620
MOD_CK1_1	396	402	PF00069	0.582
MOD_CK1_1	41	47	PF00069	0.542
MOD_CK1_1	447	453	PF00069	0.510
MOD_CK1_1	48	54	PF00069	0.546
MOD_CK1_1	484	490	PF00069	0.562
MOD_CK1_1	512	518	PF00069	0.749
MOD_CK2_1	121	127	PF00069	0.482
MOD_CK2_1	146	152	PF00069	0.477
MOD_CK2_1	313	319	PF00069	0.526
MOD_CK2_1	338	344	PF00069	0.391
MOD_CK2_1	5	11	PF00069	0.485
MOD_CK2_1	501	507	PF00069	0.576
MOD_GlcNHglycan	118	121	PF01048	0.463
MOD_GlcNHglycan	27	30	PF01048	0.572
MOD_GlcNHglycan	290	293	PF01048	0.522
MOD_GlcNHglycan	33	37	PF01048	0.609
MOD_GlcNHglycan	344	347	PF01048	0.567
MOD_GlcNHglycan	371	374	PF01048	0.434
MOD_GlcNHglycan	390	393	PF01048	0.400
MOD_GlcNHglycan	395	398	PF01048	0.553
MOD_GlcNHglycan	406	409	PF01048	0.548
MOD_GlcNHglycan	446	449	PF01048	0.615
MOD_GlcNHglycan	555	558	PF01048	0.547
MOD_GlcNHglycan	80	83	PF01048	0.595
MOD_GSK3_1	167	174	PF00069	0.662
MOD_GSK3_1	181	188	PF00069	0.583
MOD_GSK3_1	227	234	PF00069	0.608
MOD_GSK3_1	240	247	PF00069	0.493
MOD_GSK3_1	249	256	PF00069	0.600
MOD_GSK3_1	25	32	PF00069	0.431
MOD_GSK3_1	284	291	PF00069	0.712
MOD_GSK3_1	308	315	PF00069	0.485
MOD_GSK3_1	338	345	PF00069	0.386
MOD_GSK3_1	34	41	PF00069	0.691
MOD_GSK3_1	353	360	PF00069	0.619
MOD_GSK3_1	365	372	PF00069	0.365
MOD_GSK3_1	388	395	PF00069	0.562
MOD_GSK3_1	404	411	PF00069	0.481
MOD_GSK3_1	44	51	PF00069	0.555
MOD_GSK3_1	482	489	PF00069	0.601
MOD_GSK3_1	5	12	PF00069	0.569
MOD_GSK3_1	536	543	PF00069	0.547
MOD_GSK3_1	553	560	PF00069	0.529
MOD_GSK3_1	573	580	PF00069	0.431
MOD_GSK3_1	61	68	PF00069	0.401
MOD_GSK3_1	73	80	PF00069	0.545
MOD_LATS_1	351	357	PF00433	0.557
MOD_N-GLC_1	116	121	PF02516	0.445
MOD_NEK2_1	115	120	PF00069	0.529
MOD_NEK2_1	146	151	PF00069	0.488
MOD_NEK2_1	171	176	PF00069	0.656
MOD_NEK2_1	180	185	PF00069	0.548
MOD_NEK2_1	208	213	PF00069	0.490
MOD_NEK2_1	295	300	PF00069	0.447
MOD_NEK2_1	342	347	PF00069	0.460
MOD_NEK2_1	355	360	PF00069	0.603
MOD_NEK2_1	362	367	PF00069	0.379
MOD_NEK2_1	369	374	PF00069	0.337
MOD_NEK2_1	43	48	PF00069	0.674
MOD_NEK2_1	446	451	PF00069	0.726
MOD_NEK2_1	573	578	PF00069	0.486
MOD_NEK2_2	338	343	PF00069	0.346
MOD_PIKK_1	165	171	PF00454	0.602
MOD_PIKK_1	208	214	PF00454	0.464
MOD_PIKK_1	295	301	PF00454	0.588
MOD_PIKK_1	355	361	PF00454	0.472
MOD_PIKK_1	519	525	PF00454	0.675
MOD_PIKK_1	61	67	PF00454	0.513
MOD_PK_1	240	246	PF00069	0.507
MOD_PK_1	357	363	PF00069	0.461
MOD_PKA_1	240	246	PF00069	0.619
MOD_PKA_1	284	290	PF00069	0.488
MOD_PKA_2	219	225	PF00069	0.613
MOD_PKA_2	240	246	PF00069	0.652
MOD_PKA_2	284	290	PF00069	0.516
MOD_PKA_2	313	319	PF00069	0.532
MOD_PKA_2	362	368	PF00069	0.404
MOD_PKA_2	393	399	PF00069	0.507
MOD_PKA_2	452	458	PF00069	0.520
MOD_PKA_2	526	532	PF00069	0.600
MOD_PKA_2	9	15	PF00069	0.549
MOD_PKA_2	98	104	PF00069	0.444
MOD_PKB_1	151	159	PF00069	0.414
MOD_Plk_1	146	152	PF00069	0.469
MOD_Plk_1	338	344	PF00069	0.391
MOD_Plk_2-3	5	11	PF00069	0.554
MOD_Plk_2-3	536	542	PF00069	0.482
MOD_Plk_4	185	191	PF00069	0.648
MOD_Plk_4	313	319	PF00069	0.526
MOD_Plk_4	357	363	PF00069	0.484
MOD_Plk_4	365	371	PF00069	0.397
MOD_Plk_4	447	453	PF00069	0.510
MOD_Plk_4	536	542	PF00069	0.557
MOD_Plk_4	573	579	PF00069	0.492
MOD_Plk_4	9	15	PF00069	0.549
MOD_ProDKin_1	254	260	PF00069	0.603
MOD_ProDKin_1	397	403	PF00069	0.566
MOD_ProDKin_1	408	414	PF00069	0.585
MOD_ProDKin_1	496	502	PF00069	0.594
MOD_ProDKin_1	509	515	PF00069	0.687
MOD_SUMO_rev_2	382	391	PF00179	0.448
TRG_DiLeu_BaEn_1	18	23	PF01217	0.541
TRG_DiLeu_BaEn_2	535	541	PF01217	0.489
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.518
TRG_ENDOCYTIC_2	307	310	PF00928	0.426
TRG_ENDOCYTIC_2	322	325	PF00928	0.402
TRG_ENDOCYTIC_2	377	380	PF00928	0.410
TRG_ER_diArg_1	278	281	PF00400	0.547
TRG_ER_diArg_1	377	379	PF00400	0.435
TRG_ER_diArg_1	533	535	PF00400	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V6	Leptomonas seymouri	32%	99%
A0A3Q8IVE9	Leishmania donovani	99%	100%
A4HN10	Leishmania braziliensis	68%	99%
E9AFG7	Leishmania major	90%	100%
E9B6M2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%