LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IBN1_LEIIN
TriTrypDb:
LINF_350039500 *
Length:
718

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 9
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBN1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBN1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 188 190 PF00675 0.721
CLV_NRD_NRD_1 476 478 PF00675 0.467
CLV_NRD_NRD_1 669 671 PF00675 0.520
CLV_NRD_NRD_1 713 715 PF00675 0.714
CLV_NRD_NRD_1 90 92 PF00675 0.750
CLV_PCSK_FUR_1 473 477 PF00082 0.484
CLV_PCSK_FUR_1 667 671 PF00082 0.568
CLV_PCSK_KEX2_1 188 190 PF00082 0.724
CLV_PCSK_KEX2_1 475 477 PF00082 0.483
CLV_PCSK_KEX2_1 478 480 PF00082 0.444
CLV_PCSK_KEX2_1 669 671 PF00082 0.494
CLV_PCSK_KEX2_1 713 715 PF00082 0.688
CLV_PCSK_KEX2_1 90 92 PF00082 0.750
CLV_PCSK_PC1ET2_1 478 480 PF00082 0.454
CLV_PCSK_SKI1_1 153 157 PF00082 0.391
CLV_PCSK_SKI1_1 25 29 PF00082 0.408
CLV_PCSK_SKI1_1 349 353 PF00082 0.389
CLV_PCSK_SKI1_1 52 56 PF00082 0.561
CLV_PCSK_SKI1_1 670 674 PF00082 0.504
CLV_PCSK_SKI1_1 696 700 PF00082 0.603
DEG_APCC_DBOX_1 541 549 PF00400 0.501
DEG_APCC_DBOX_1 609 617 PF00400 0.432
DEG_MDM2_SWIB_1 678 686 PF02201 0.521
DOC_CDC14_PxL_1 375 383 PF14671 0.394
DOC_CDC14_PxL_1 602 610 PF14671 0.551
DOC_CKS1_1 29 34 PF01111 0.476
DOC_CYCLIN_RxL_1 19 31 PF00134 0.404
DOC_CYCLIN_RxL_1 346 356 PF00134 0.367
DOC_CYCLIN_yCln2_LP_2 364 367 PF00134 0.583
DOC_CYCLIN_yCln2_LP_2 376 382 PF00134 0.344
DOC_MAPK_DCC_7 637 646 PF00069 0.505
DOC_MAPK_gen_1 667 676 PF00069 0.484
DOC_MAPK_RevD_3 77 91 PF00069 0.565
DOC_PP1_RVXF_1 23 30 PF00149 0.406
DOC_PP1_RVXF_1 347 354 PF00149 0.367
DOC_PP2B_LxvP_1 363 366 PF13499 0.517
DOC_PP2B_LxvP_1 376 379 PF13499 0.373
DOC_PP4_FxxP_1 200 203 PF00568 0.651
DOC_PP4_FxxP_1 29 32 PF00568 0.480
DOC_PP4_FxxP_1 672 675 PF00568 0.466
DOC_USP7_MATH_1 196 200 PF00917 0.672
DOC_USP7_MATH_1 203 207 PF00917 0.670
DOC_USP7_MATH_1 282 286 PF00917 0.688
DOC_USP7_MATH_1 405 409 PF00917 0.761
DOC_USP7_MATH_1 566 570 PF00917 0.635
DOC_USP7_MATH_1 635 639 PF00917 0.655
DOC_USP7_MATH_1 650 654 PF00917 0.664
DOC_USP7_MATH_1 698 702 PF00917 0.627
DOC_USP7_UBL2_3 685 689 PF12436 0.551
DOC_USP7_UBL2_3 692 696 PF12436 0.601
DOC_WW_Pin1_4 103 108 PF00397 0.628
DOC_WW_Pin1_4 116 121 PF00397 0.511
DOC_WW_Pin1_4 262 267 PF00397 0.582
DOC_WW_Pin1_4 28 33 PF00397 0.477
DOC_WW_Pin1_4 319 324 PF00397 0.719
DOC_WW_Pin1_4 417 422 PF00397 0.613
DOC_WW_Pin1_4 489 494 PF00397 0.426
DOC_WW_Pin1_4 639 644 PF00397 0.672
DOC_WW_Pin1_4 646 651 PF00397 0.762
DOC_WW_Pin1_4 81 86 PF00397 0.717
DOC_WW_Pin1_4 95 100 PF00397 0.640
LIG_14-3-3_CanoR_1 16 22 PF00244 0.430
LIG_14-3-3_CanoR_1 25 30 PF00244 0.397
LIG_14-3-3_CanoR_1 269 275 PF00244 0.551
LIG_14-3-3_CanoR_1 463 470 PF00244 0.596
LIG_14-3-3_CanoR_1 7 13 PF00244 0.498
LIG_Actin_WH2_2 497 513 PF00022 0.551
LIG_APCC_ABBA_1 624 629 PF00400 0.534
LIG_BIR_III_2 418 422 PF00653 0.603
LIG_CtBP_PxDLS_1 643 647 PF00389 0.530
LIG_EH1_1 613 621 PF00400 0.553
LIG_FHA_1 106 112 PF00498 0.569
LIG_FHA_1 28 34 PF00498 0.476
LIG_FHA_1 292 298 PF00498 0.557
LIG_FHA_1 360 366 PF00498 0.479
LIG_FHA_1 534 540 PF00498 0.511
LIG_FHA_2 244 250 PF00498 0.575
LIG_FHA_2 271 277 PF00498 0.538
LIG_FHA_2 284 290 PF00498 0.701
LIG_FHA_2 345 351 PF00498 0.528
LIG_FHA_2 572 578 PF00498 0.511
LIG_GBD_Chelix_1 500 508 PF00786 0.455
LIG_HCF-1_HBM_1 298 301 PF13415 0.571
LIG_LIR_Apic_2 199 203 PF02991 0.650
LIG_LIR_Apic_2 235 239 PF02991 0.391
LIG_LIR_Apic_2 28 32 PF02991 0.480
LIG_LIR_Apic_2 383 389 PF02991 0.604
LIG_LIR_Apic_2 671 675 PF02991 0.497
LIG_LIR_Gen_1 125 132 PF02991 0.446
LIG_LIR_Gen_1 298 309 PF02991 0.548
LIG_LIR_Gen_1 370 380 PF02991 0.505
LIG_LIR_Gen_1 428 435 PF02991 0.544
LIG_LIR_Gen_1 8 18 PF02991 0.484
LIG_LIR_Nem_3 125 129 PF02991 0.464
LIG_LIR_Nem_3 231 236 PF02991 0.329
LIG_LIR_Nem_3 298 304 PF02991 0.498
LIG_LIR_Nem_3 336 340 PF02991 0.428
LIG_LIR_Nem_3 370 375 PF02991 0.465
LIG_LIR_Nem_3 428 433 PF02991 0.543
LIG_LIR_Nem_3 8 13 PF02991 0.496
LIG_MAD2 258 266 PF02301 0.549
LIG_PCNA_yPIPBox_3 610 624 PF02747 0.551
LIG_Pex14_2 672 676 PF04695 0.492
LIG_Pex14_2 678 682 PF04695 0.512
LIG_REV1ctd_RIR_1 10 20 PF16727 0.482
LIG_SH2_CRK 386 390 PF00017 0.603
LIG_SH2_NCK_1 386 390 PF00017 0.530
LIG_SH2_PTP2 301 304 PF00017 0.483
LIG_SH2_STAP1 159 163 PF00017 0.523
LIG_SH2_STAT3 690 693 PF00017 0.576
LIG_SH2_STAT5 236 239 PF00017 0.481
LIG_SH2_STAT5 301 304 PF00017 0.452
LIG_SH2_STAT5 430 433 PF00017 0.532
LIG_SH2_STAT5 487 490 PF00017 0.467
LIG_SH2_STAT5 494 497 PF00017 0.372
LIG_SH2_STAT5 690 693 PF00017 0.576
LIG_SH3_1 600 606 PF00018 0.595
LIG_SH3_3 104 110 PF00018 0.587
LIG_SH3_3 117 123 PF00018 0.374
LIG_SH3_3 141 147 PF00018 0.600
LIG_SH3_3 199 205 PF00018 0.706
LIG_SH3_3 317 323 PF00018 0.647
LIG_SH3_3 39 45 PF00018 0.488
LIG_SH3_3 600 606 PF00018 0.562
LIG_SUMO_SIM_anti_2 622 627 PF11976 0.456
LIG_SUMO_SIM_anti_2 629 636 PF11976 0.421
LIG_SUMO_SIM_par_1 642 649 PF11976 0.528
LIG_SxIP_EBH_1 122 134 PF03271 0.499
LIG_TRAF2_1 447 450 PF00917 0.521
LIG_TRAF2_1 574 577 PF00917 0.480
LIG_TRFH_1 505 509 PF08558 0.476
LIG_WRC_WIRS_1 26 31 PF05994 0.481
MOD_CDK_SPxxK_3 262 269 PF00069 0.596
MOD_CDK_SPxxK_3 319 326 PF00069 0.731
MOD_CK1_1 106 112 PF00069 0.556
MOD_CK1_1 283 289 PF00069 0.713
MOD_CK1_1 322 328 PF00069 0.684
MOD_CK1_1 569 575 PF00069 0.477
MOD_CK1_1 584 590 PF00069 0.396
MOD_CK1_1 639 645 PF00069 0.694
MOD_CK1_1 649 655 PF00069 0.669
MOD_CK1_1 708 714 PF00069 0.726
MOD_CK1_1 97 103 PF00069 0.690
MOD_CK2_1 243 249 PF00069 0.560
MOD_CK2_1 270 276 PF00069 0.475
MOD_CK2_1 284 290 PF00069 0.613
MOD_CK2_1 344 350 PF00069 0.519
MOD_CK2_1 571 577 PF00069 0.491
MOD_Cter_Amidation 667 670 PF01082 0.557
MOD_GlcNHglycan 206 209 PF01048 0.760
MOD_GlcNHglycan 286 289 PF01048 0.654
MOD_GlcNHglycan 33 36 PF01048 0.480
MOD_GlcNHglycan 353 356 PF01048 0.486
MOD_GlcNHglycan 376 379 PF01048 0.414
MOD_GlcNHglycan 393 396 PF01048 0.545
MOD_GlcNHglycan 403 406 PF01048 0.686
MOD_GlcNHglycan 409 412 PF01048 0.677
MOD_GlcNHglycan 465 468 PF01048 0.578
MOD_GlcNHglycan 49 52 PF01048 0.448
MOD_GlcNHglycan 516 519 PF01048 0.501
MOD_GSK3_1 101 108 PF00069 0.565
MOD_GSK3_1 210 217 PF00069 0.672
MOD_GSK3_1 27 34 PF00069 0.478
MOD_GSK3_1 280 287 PF00069 0.640
MOD_GSK3_1 387 394 PF00069 0.587
MOD_GSK3_1 401 408 PF00069 0.665
MOD_GSK3_1 413 420 PF00069 0.732
MOD_GSK3_1 421 428 PF00069 0.653
MOD_GSK3_1 594 601 PF00069 0.588
MOD_GSK3_1 635 642 PF00069 0.685
MOD_GSK3_1 645 652 PF00069 0.667
MOD_GSK3_1 684 691 PF00069 0.510
MOD_GSK3_1 77 84 PF00069 0.746
MOD_GSK3_1 93 100 PF00069 0.598
MOD_N-GLC_1 533 538 PF02516 0.490
MOD_N-GLC_1 639 644 PF02516 0.501
MOD_NEK2_1 243 248 PF00069 0.550
MOD_NEK2_1 27 32 PF00069 0.481
MOD_NEK2_1 425 430 PF00069 0.588
MOD_NEK2_1 519 524 PF00069 0.546
MOD_NEK2_1 644 649 PF00069 0.742
MOD_NEK2_2 270 275 PF00069 0.480
MOD_NEK2_2 698 703 PF00069 0.629
MOD_NEK2_2 85 90 PF00069 0.703
MOD_PK_1 216 222 PF00069 0.617
MOD_PKA_2 180 186 PF00069 0.690
MOD_PKA_2 283 289 PF00069 0.728
MOD_PKA_2 6 12 PF00069 0.496
MOD_PKA_2 636 642 PF00069 0.485
MOD_PKB_1 179 187 PF00069 0.547
MOD_PKB_1 703 711 PF00069 0.672
MOD_Plk_1 291 297 PF00069 0.596
MOD_Plk_1 448 454 PF00069 0.584
MOD_Plk_4 232 238 PF00069 0.383
MOD_Plk_4 359 365 PF00069 0.505
MOD_Plk_4 425 431 PF00069 0.592
MOD_Plk_4 448 454 PF00069 0.601
MOD_Plk_4 77 83 PF00069 0.526
MOD_ProDKin_1 103 109 PF00069 0.611
MOD_ProDKin_1 116 122 PF00069 0.508
MOD_ProDKin_1 262 268 PF00069 0.580
MOD_ProDKin_1 28 34 PF00069 0.476
MOD_ProDKin_1 319 325 PF00069 0.715
MOD_ProDKin_1 417 423 PF00069 0.600
MOD_ProDKin_1 489 495 PF00069 0.421
MOD_ProDKin_1 639 645 PF00069 0.677
MOD_ProDKin_1 646 652 PF00069 0.757
MOD_ProDKin_1 81 87 PF00069 0.718
MOD_ProDKin_1 95 101 PF00069 0.637
MOD_SUMO_rev_2 161 168 PF00179 0.544
TRG_DiLeu_BaEn_1 359 364 PF01217 0.494
TRG_DiLeu_BaEn_2 116 122 PF01217 0.451
TRG_DiLeu_BaLyEn_6 151 156 PF01217 0.450
TRG_DiLeu_BaLyEn_6 22 27 PF01217 0.406
TRG_ENDOCYTIC_2 301 304 PF00928 0.464
TRG_ENDOCYTIC_2 430 433 PF00928 0.532
TRG_ER_diArg_1 174 177 PF00400 0.439
TRG_ER_diArg_1 178 181 PF00400 0.564
TRG_ER_diArg_1 255 258 PF00400 0.572
TRG_ER_diArg_1 473 476 PF00400 0.555
TRG_ER_diArg_1 666 669 PF00400 0.549
TRG_ER_diArg_1 702 705 PF00400 0.667
TRG_ER_diArg_1 713 715 PF00400 0.676
TRG_ER_diArg_1 89 91 PF00400 0.745
TRG_NLS_MonoCore_2 476 481 PF00514 0.476
TRG_NLS_MonoExtN_4 475 482 PF00514 0.460
TRG_Pf-PMV_PEXEL_1 134 139 PF00026 0.611
TRG_Pf-PMV_PEXEL_1 479 484 PF00026 0.439
TRG_Pf-PMV_PEXEL_1 498 502 PF00026 0.374
TRG_Pf-PMV_PEXEL_1 658 662 PF00026 0.627

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HUU2 Leptomonas seymouri 53% 100%
A0A1X0P6R1 Trypanosomatidae 30% 100%
A0A3Q8IMM0 Leishmania donovani 99% 100%
A0A3R7L599 Trypanosoma rangeli 31% 100%
A4HN08 Leishmania braziliensis 81% 100%
C9ZZ00 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AFG5 Leishmania major 94% 100%
E9B6M0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
V5BY91 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS