MMS19 nucleotide excision repair protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IBM9_LEIIN

TriTrypDb:

LINF_350039300

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBM9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.704
CLV_NRD_NRD_1	228	230	PF00675	0.595
CLV_PCSK_KEX2_1	228	230	PF00082	0.595
CLV_PCSK_SKI1_1	183	187	PF00082	0.599
CLV_PCSK_SKI1_1	228	232	PF00082	0.491
CLV_PCSK_SKI1_1	28	32	PF00082	0.635
CLV_Separin_Metazoa	15	19	PF03568	0.648
DEG_SCF_FBW7_1	172	179	PF00400	0.735
DEG_SPOP_SBC_1	176	180	PF00917	0.675
DOC_CKS1_1	173	178	PF01111	0.749
DOC_PP4_FxxP_1	146	149	PF00568	0.561
DOC_PP4_FxxP_1	93	96	PF00568	0.759
DOC_PP4_MxPP_1	235	238	PF00568	0.536
DOC_USP7_MATH_1	122	126	PF00917	0.541
DOC_USP7_MATH_1	160	164	PF00917	0.699
DOC_USP7_MATH_1	176	180	PF00917	0.675
DOC_WW_Pin1_4	127	132	PF00397	0.479
DOC_WW_Pin1_4	172	177	PF00397	0.756
DOC_WW_Pin1_4	83	88	PF00397	0.710
DOC_WW_Pin1_4	92	97	PF00397	0.618
LIG_14-3-3_CanoR_1	121	127	PF00244	0.470
LIG_14-3-3_CanoR_1	189	193	PF00244	0.515
LIG_14-3-3_CanoR_1	28	37	PF00244	0.557
LIG_BIR_II_1	1	5	PF00653	0.635
LIG_EVH1_1	146	150	PF00568	0.482
LIG_FHA_1	194	200	PF00498	0.657
LIG_FHA_2	10	16	PF00498	0.647
LIG_FHA_2	51	57	PF00498	0.595
LIG_LIR_Apic_2	90	96	PF02991	0.760
LIG_LIR_Gen_1	115	124	PF02991	0.467
LIG_LIR_Gen_1	31	39	PF02991	0.579
LIG_LIR_Nem_3	115	119	PF02991	0.472
LIG_LIR_Nem_3	12	16	PF02991	0.600
LIG_LIR_Nem_3	31	37	PF02991	0.539
LIG_LIR_Nem_3	42	47	PF02991	0.529
LIG_REV1ctd_RIR_1	41	49	PF16727	0.472
LIG_SH2_PTP2	123	126	PF00017	0.476
LIG_SH2_STAT5	123	126	PF00017	0.482
LIG_SH2_STAT5	127	130	PF00017	0.518
LIG_SH2_STAT5	184	187	PF00017	0.463
LIG_SH3_3	141	147	PF00018	0.540
LIG_SH3_3	170	176	PF00018	0.691
LIG_SH3_3	227	233	PF00018	0.527
LIG_SH3_3	8	14	PF00018	0.663
LIG_WRC_WIRS_1	113	118	PF05994	0.363
MOD_CK1_1	35	41	PF00069	0.487
MOD_CK2_1	105	111	PF00069	0.684
MOD_CK2_1	255	261	PF00069	0.531
MOD_CK2_1	50	56	PF00069	0.608
MOD_CK2_1	75	81	PF00069	0.504
MOD_CK2_1	9	15	PF00069	0.584
MOD_Cter_Amidation	226	229	PF01082	0.580
MOD_DYRK1A_RPxSP_1	83	87	PF00069	0.615
MOD_GlcNHglycan	160	163	PF01048	0.685
MOD_GSK3_1	101	108	PF00069	0.415
MOD_GSK3_1	122	129	PF00069	0.437
MOD_GSK3_1	172	179	PF00069	0.681
MOD_GSK3_1	28	35	PF00069	0.648
MOD_GSK3_1	50	57	PF00069	0.483
MOD_GSK3_1	83	90	PF00069	0.642
MOD_N-GLC_1	256	261	PF02516	0.551
MOD_NEK2_1	126	131	PF00069	0.464
MOD_NEK2_1	22	27	PF00069	0.509
MOD_NEK2_2	122	127	PF00069	0.434
MOD_OFUCOSY	128	135	PF10250	0.518
MOD_PIKK_1	193	199	PF00454	0.436
MOD_PKA_1	228	234	PF00069	0.411
MOD_PKA_2	188	194	PF00069	0.515
MOD_PKA_2	228	234	PF00069	0.557
MOD_PKB_1	52	60	PF00069	0.527
MOD_Plk_1	255	261	PF00069	0.535
MOD_Plk_2-3	256	262	PF00069	0.464
MOD_Plk_2-3	9	15	PF00069	0.601
MOD_Plk_4	122	128	PF00069	0.444
MOD_Plk_4	231	237	PF00069	0.560
MOD_Plk_4	39	45	PF00069	0.636
MOD_ProDKin_1	127	133	PF00069	0.470
MOD_ProDKin_1	172	178	PF00069	0.745
MOD_ProDKin_1	83	89	PF00069	0.713
MOD_ProDKin_1	92	98	PF00069	0.619
MOD_SUMO_rev_2	208	216	PF00179	0.521
TRG_ENDOCYTIC_2	123	126	PF00928	0.525
TRG_ER_diArg_1	228	230	PF00400	0.595
TRG_NES_CRM1_1	66	81	PF08389	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1X1	Leptomonas seymouri	38%	97%
A0A3Q8II73	Leishmania donovani	98%	100%
A4HN06	Leishmania braziliensis	73%	100%
E9AFG3	Leishmania major	89%	100%
E9B6L8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BYA4	Trypanosoma cruzi	24%	100%